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Our Science – Gonzalez Website

Frank J. Gonzalez, Ph.D.

Selected Publications

1)  Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, Bowman ED, Fearon ER, Harris CC, Shah YM, Gonzalez FJ.
Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.
Gastroenterology. 2014.
In Press. [Journal]
2)  Liu A, Krausz KW, Fang Z, Brocker C, Qu A, Gonzalez FJ.
Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARalpha and its relevance to hepatotoxicity.
Arch. Toxicol. 2014.
In Press. [Journal]
3)  Lee JK, Chung HJ, Fischer L, Fischer J, Gonzalez FJ, Jeong H.
Human placental lactogen induces CYP2E1 expression Via PI 3-kinase pathway in female human hepatocytes.
Drug Metab. Dispos. 2014.
In Press. [Journal]
4)  Fang Z, Krausz KW, Nagaoka K, Tanaka N, Gowda K, Amin SG, Perdew GH, Gonzalez FJ.
In vivo application of the pure aryl hydrocarbon receptor antagonist GNF-351 is limited to the gastrointestinal track.
Br. J. Pharmacol. 2014.
In Press. [Journal]
5)  Ramakrishnan SK, Taylor M, Qu A, Ahn S, Suresh MV, Raghavendran K, Gonzalez FJ, Shah YM.
Loss of Von Hippel-Lindau (VHL) increases systemic cholesterol level through targeting HIF-2a and regulation of bile acid homeostasis.
Mol. Cell. Biol. 2014.
In Press. [Journal]
6)  Ciappio ED, Krausz KW, Rochman M, Furusawa T, Bonzo JA, Tessarollo L, Gonzalez FJ, Bustin M.
Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.
PLoS ONE. 9: e84583, 2014.
[Journal]
7)  Koh KH, Pan X, Shen H, Arnold SL, Yu A, Gonzalez FJ, Isoherranen N, Jeong H.
Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice.
J. Biol. Chem. 2013.
In Press. [Journal]
8)  Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S.
An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity.
Drug Metab. Pharmacokinet. 2013.
In Press. [Journal]
9)  Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo M, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL.
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
Chem. Res. Toxicol. 2013.
In Press. [Journal]
10)  Cheng J, Chen C, Kristopher KW, Manna SK, Scerba M, Friedman FK, Luecke H, Idle JR, Gonzalez FJ.
Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping.
Toxicol. Sci. 2013.
In Press. [Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 1/21/2014.