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Our Science – Gottesman Website

Susan Gottesman, Ph.D.

Selected Publications

1)  Battesti A, Hoskins JR, Tong S, Milanesio P, Mann JM, Kravats A, Tsegaye YM, Bougdour A, Wickner S, Gottesman S.
Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein.
Genes Dev. 27: 2722-35, 2013.
2)  Zhang A, Schu DJ, Tjaden BC, Storz G, Gottesman S.
Mutations in Interaction Surfaces Differentially Impact E. coli Hfq Association with Small RNAs and Their mRNA Targets.
J. Mol. Biol. 425: 3678-97, 2013.
3)  Soper T, Mandin P, Majdalani N, Gottesman S, Woodson SA.
Positive regulation by small RNAs and the role of Hfq.
Proc. Natl. Acad. Sci. U.S.A. 107: 9602-7, 2010.
4)  Battesti A, Majdalani N, Gottesman S.
The RpoS-Mediated General Stress Response in Escherichia coli.
Annu Rev Microbiol. 65:: 189-213, 2011.
5)  De Lay N, Gottesman S.
A complex network of small non-coding RNAs regulate motility in Escherichia coli.
Mol. Microbiol. 86: 524-38, 2012.
6)  Thompson KM, Gottesman S.
The MiaA tRNA modification enzyme is necessary for robust RpoS expression in Escherichia coli.
J. Bacteriol. 196: 754-61, 2014.
7)  De Lay N, Schu DJ, Gottesman S.
Bacterial Small RNA-based Negative Regulation: Hfq and Its Accomplices.
J. Biol. Chem. 288: 7996-8003, 2013.
8)  Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S.
Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification.
Mol. Microbiol. 89: 52-64, 2013.
9)  Battesti A, Gottesman S.
Roles of adaptor proteins in regulation of bacterial proteolysis.
Curr. Opin. Microbiol. 2013.
10)  Thomason MK, Fontaine F, De Lay N, Storz G.
A small RNA that regulates motility and biofilm formation in response to changes in nutrient availability in Escherichia coli.
Mol. Microbiol. 84: 17-35, 2012.
11)  Battesti A, Tsegaye YM, Packer DG, Majdalani N, Gottesman S.
H-NS regulation of IraD and IraM antiadaptors for control of RpoS degradation.
J. Bacteriol. 194: 2470-8, 2012.
12)  De Lay N, Gottesman S.
RNase E finds some sRNAs stimulating.
Mol. Cell. 47: 825-6, 2012.
13)  Moon K, Gottesman S.
Competition among Hfq-binding small RNAs in Escherichia coli.
Mol. Microbiol. 82: 1545-62, 2011.
14)  Gottesman S.
Microbiology: Dicing defence in bacteria.
Nature. 471: 588-9, 2011.
15)  De Lay N, Gottesman S.
Role of polynucleotide phosphorylase in sRNA function in Escherichia coli.
RNA. 17: 1172-89, 2011.
16)  Gottesman S, Storz G.
Bacterial Small RNA Regulators: Versatile Roles and Rapidly Evolving Variations.
Cold Spring Harb Perspect Biol. 1-16, 2010.
17)  Mandin P, Gottesman S.
Integrating anaerobic/aerobic sensing and the general stress response through the ArcZ small RNA.
EMBO J. [Epub ahead of print], 2010.
18)  McCullen CA, Benhammou JN, Majdalani N, Gottesman S.
Mechanism of positive regulation by DsrA and RprA small noncoding RNAs: pairing increases translation and protects rpoS mRNA from degradation.
J. Bacteriol. 192: 5559-71, 2010.
19)  Coornaert A, Lu A, Mandin P, Springer M, Gottesman S, Guillier M.
MicA sRNA links the PhoP regulon to cell envelope stress.
Mol. Microbiol. 76: 467-79, 2010.
20)  Mandin P, Gottesman S.
A genetic approach for finding small RNAs regulators of genes of interest identifies RybC as regulating the DpiA/DpiB two-component system.
Mol. Microbiol. 72: 551-65, 2009.
21)  Moon K, Gottesman S.
A PhoQ/P-regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides.
Mol. Microbiol. 74: 1314-30, 2009.
22)  Mandin P, Gottesman S.
Regulating the regulator: an RNA decoy acts as an OFF switch for the regulation of an sRNA.
Genes Dev. 23: 1981-5, 2009.
23)  De Lay N, Gottesman S.
The Crp-activated small noncoding regulatory RNA CyaR (RyeE) links nutritional status to group behavior.
J. Bacteriol. 191: 461-76, 2009.
24)  Bougdour A, Cunning C, Baptiste PJ, Elliott T, Gottesman S.
Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors.
Mol. Microbiol. 68: 298-313, 2008.
25)  Guillier M, Gottesman S.
The 5' end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator.
Nucleic Acids Res. 36: 6781-94, 2008.
26)  Majdalani N, Gottesman S.
Genetic dissection of signaling through the rcs phosphorelay.
Meth. Enzymol. 423: 349-62, 2007.
27)  Bougdour A, Gottesman S.
ppGpp regulation of RpoS degradation via anti-adaptor protein IraP.
Proc. Natl. Acad. Sci. U.S.A. 104: 12896-901, 2007.
28)  Thompson KM, Rhodius VA, Gottesman S.
SigmaE regulates and is regulated by a small RNA in Escherichia coli.
J. Bacteriol. 189: 4243-56, 2007.
29)  Vanderpool CK, Gottesman S.
The novel transcription factor SgrR coordinates the response to glucose-phosphate stress.
J. Bacteriol. 189: 2238-48, 2007.
30)  Ranquet C, Gottesman S.
Translational regulation of the Escherichia coli stress factor RpoS: a role for SsrA and Lon.
J. Bacteriol. 189: 4872-9, 2007.
31)  Hu Z, Zhang A, Storz G, Gottesman S, Leppla SH.
An antibody-based microarray assay for small RNA detection.
Nucleic Acids Res. 34: e52, 2006.
32)  Zhou Y, Gottesman S.
Modes of Regulation of RpoS by H-NS.
J. Bacteriol. 188: 7022-5, 2006.
33)  Bougdour A, Wickner S, Gottesman S.
Modulating RssB activity: IraP, a novel regulator of sigma(S) stability in Escherichia coli.
Genes Dev. 20: 884-97, 2006.
34)  Guillier M, Gottesman S, Storz G.
Modulating the outer membrane with small RNAs.
Genes Dev. 20: 2338-48, 2006.
35)  Guillier M, Gottesman S.
Remodelling of the Escherichia coli outer membrane by two small regulatory RNAs.
Mol. Microbiol. 59: 231-47, 2006.
36)  Gottesman S, McCullen CA, Guillier M, Vanderpool CK, Majdalani N, Benhammou J, Thompson KM, FitzGerald PC, Sowa NA, FitzGerald DJ.
Small RNA regulators and the bacterial response to stress.
Cold Spring Harb. Symp. Quant. Biol. 71: 1-11, 2006.
37)  Tjaden B, Goodwin SS, Opdyke JA, Guillier M, Fu DX, Gottesman S, Storz G.
Target prediction for small, noncoding RNAs in bacteria.
Nucleic Acids Res. 34: 2791-802, 2006.
38)  Tu X, Latifi T, Bougdour A, Gottesman S, Groisman EA.
The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica.
Proc. Natl. Acad. Sci. U.S.A. 103: 13503-8, 2006.
39)  Munavar H, Zhou Y, Gottesman S.
Analysis of the Escherichia coli Alp phenotype: heat shock induction in ssrA mutants.
J Bacteriol. 187: 4739-51, 2005.
40)  Majdalani N, Vanderpool CK, Gottesman S.
Bacterial small RNA regulators.
Crit Rev Biochem Mol Biol. 40: 93-113, 2005.
41)  Massé E, Vanderpool CK, Gottesman S.
Effect of RyhB small RNA on global iron use in Escherichia coli.
J. Bacteriology. 187: 6962-6971, 2005.
42)  Gottesman S.
Micros for microbes: non-coding regulatory RNAs in bacteria.
Trends Genet. 21: 399-404, 2005.
43)  Vanderpool CK, Gottesman S.
Noncoding RNAs at the membrane.
Nat Struct Mol Biol. 12: 285-6, 2005.
44)  Majdalani N, Heck M, Stout V, Gottesman S.
Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli.
J. Bacteriology. 187: 6770-6778, 2005.
45)  Majdalani N, Gottesman S.
The Rcs phosphorelay: a complex signal transduction system.
Annu. Rev. Microbiol. 59: 379-405, 2005.
46)  Majdalani N, Gottesman S.
The Rcs Phosphorelay: A Complex Signal Transduction System.
Annu Rev Microbiol. 59: 379-405, 2005.
47)  Wilderman PJ, Sowa NA, FitzGerald DJ, FitzGerald PC, Gottesman S, Ochsner UA, Vasil ML.
Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis.
Proc Natl Acad Sci U S A. 101: 9792-7, 2004.
48)  Vanderpool CK, Gottesman S.
Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system.
Molecular Microbiology. 54: 1076-1089, 2004.
49)  Christensen SK, Maenhaut-Michel G, Mine N, Gottesman S, Gerdes K, Van Melderen L.
Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system.
Mol Microbiol. 51: 1705-17, 2004.
50)  Gottesman S.
Small RNAs shed some light.
Cell. 118: 1-2, 2004.
51)  Gottesman S.
The small RNA regulators of Escherichia coli: Roles and mechanisms.
Annual Rev. Microbiology. 58: 303-328, 2004.
52)  Gottesman S.
The small RNA regulators of Escherichia coli: roles and mechanisms*.
Annu. Rev. Microbiol. 58: 303-28, 2004.
53)  Massé E, Escorcia FE, Gottesman S.
Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli.
Genes Dev. 17: 2374-83, 2003.
54)  Zhang A, Wassarman KM, Rosenow C, Tjaden BC, Storz G, Gottesman S.
Global analysis of small RNA and mRNA targets of Hfq.
Mol Microbiol. 50: 1111-24, 2003.
55)  Gottesman S.
Proteolysis in bacterial regulatory circuits.
Annu Rev Cell Dev Biol. 19: 565-87, 2003.
56)  Massé E, Majdalani N, Gottesman S.
Regulatory roles for small RNAs in bacteria.
Curr. Opin. Microbiol. 6: 120-4, 2003.
57)  Repoila F, Majdalani N, Gottesman S.
Small non-coding RNAs, co-ordinators of adaptation processes in Escherichia coli: the RpoS paradigm.
Mol Microbiol. 48: 855-61, 2003.
58)  Repoila F, Gottesman S.
Temperature sensing by the dsrA promoter.
J Bacteriol. 185: 6609-14, 2003.
59)  Massé E, Gottesman S.
A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli.
Proc. Natl. Acad. Sci. U.S.A. 99: 4620-5, 2002.
60)  Majdalani N, Hernandez D, Gottesman S.
Regulation and mode of action of the second small RNA activator of RpoS translation, RprA.
Mol. Microbiol. 46: 813-26, 2002.
61)  Gottesman S.
Stealth regulation: biological circuits with small RNA switches.
Genes Dev. 16: 2829-42, 2002.
62)  Gottesman S, Maurizi MR.
Cell biology. Surviving starvation.
Science. 293: 614-5, 2001.
63)  Wassarman KM, Repoila F, Rosenow C, Storz G, Gottesman S.
Identification of novel small RNAs using comparative genomics and microarrays.
Genes Dev. 15: 1637-51, 2001.
64)  Majdalani N, Chen S, Murrow J, St John K, Gottesman S.
Regulation of RpoS by a novel small RNA: the characterization of RprA.
Mol. Microbiol. 39: 1382-94, 2001.
65)  Repoila F, Gottesman S.
Signal transduction cascade for regulation of RpoS: temperature regulation of DsrA.
J. Bacteriol. 183: 4012-23, 2001.
66)  Gottesman S, Storz G, Rosenow C, Majdalani N, Repoila F, Wassarman KM.
Small RNA regulators of translation: mechanisms of action and approaches for identifying new small RNAs.
Cold Spring Harb. Symp. Quant. Biol. 66: 353-62, 2001.
67)  Zhou Y, Gottesman S, Hoskins JR, Maurizi MR, Wickner S.
The RssB response regulator directly targets sigma(S) for degradation by ClpXP.
Genes Dev. 15: 627-37, 2001.
68)  Wickner S, Maurizi MR, Gottesman S.
Posttranslational quality control: folding, refolding, and degrading proteins.
Science. 286: 1888-93, 1999.
69)  Wu WF, Zhou Y, Gottesman S.
Redundant in vivo proteolytic activities of Escherichia coli Lon and the ClpYQ (HslUV) protease.
J. Bacteriol. 181: 3681-7, 1999.
70)  Gottesman S.
Regulation by proteolysis: developmental switches.
Curr. Opin. Microbiol. 2: 142-7, 1999.
71)  Van Melderen L, Gottesman S.
Substrate sequestration by a proteolytically inactive Lon mutant.
Proc. Natl. Acad. Sci. U.S.A. 96: 6064-71, 1999.
72)  Majdalani N, Cunning C, Sledjeski D, Elliott T, Gottesman S.
DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription.
Proc. Natl. Acad. Sci. U.S.A. 95: 12462-7, 1998.
73)  Leffers GG, Gottesman S.
Lambda Xis degradation in vivo by Lon and FtsH.
J. Bacteriol. 180: 1573-7, 1998.
74)  Gottesman S.
Protecting the neighborhood: extreme measures.
Proc. Natl. Acad. Sci. U.S.A. 95: 2731-2, 1998.
75)  Zhou Y, Gottesman S.
Regulation of proteolysis of the stationary-phase sigma factor RpoS.
J. Bacteriol. 180: 1154-8, 1998.
76)  Gottesman S, Roche E, Zhou Y, Sauer RT.
The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system.
Genes Dev. 12: 1338-47, 1998.
77)  Gottesman S, Wickner S, Maurizi MR.
Protein quality control: triage by chaperones and proteases.
Genes Dev. 11: 815-23, 1997.
78)  Gottesman S, Maurizi MR, Wickner S.
Regulatory subunits of energy-dependent proteases.
Cell. 91: 435-8, 1997.
79)  Van Melderen L, Thi MH, Lecchi P, Gottesman S, Couturier M, Maurizi MR.
ATP-dependent degradation of CcdA by Lon protease. Effects of secondary structure and heterologous subunit interactions.
J. Biol. Chem. 271: 27730-8, 1996.
80)  Sledjeski DD, Gottesman S.
Osmotic shock induction of capsule synthesis in Escherichia coli K-12.
J. Bacteriol. 178: 1204-6, 1996.
81)  Gottesman S.
Proteases and their targets in Escherichia coli.
Annu. Rev. Genet. 30: 465-506, 1996.
82)  Jubete Y, Maurizi MR, Gottesman S.
Role of the heat shock protein DnaJ in the lon-dependent degradation of naturally unstable proteins.
J. Biol. Chem. 271: 30798-803, 1996.
83)  Kessel M, Wu W, Gottesman S, Kocsis E, Steven AC, Maurizi MR.
Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY.
FEBS Lett. 398: 274-8, 1996.
84)  Sledjeski DD, Gupta A, Gottesman S.
The small RNA, DsrA, is essential for the low temperature expression of RpoS during exponential growth in Escherichia coli.
EMBO J. 15: 3993-4000, 1996.
85)  Sledjeski D, Gottesman S.
A small RNA acts as an antisilencer of the H-NS-silenced rcsA gene of Escherichia coli.
Proc. Natl. Acad. Sci. U.S.A. 92: 2003-7, 1995.
86)  Gottesman S, Wickner S, Jubete Y, Singh SK, Kessel M, Maurizi M.
Selective, energy-dependent proteolysis in Escherichia coli.
Cold Spring Harb. Symp. Quant. Biol. 60: 533-48, 1995.
87)  Wickner S, Gottesman S, Skowyra D, Hoskins J, McKenney K, Maurizi MR.
A molecular chaperone, ClpA, functions like DnaK and DnaJ.
Proc. Natl. Acad. Sci. U.S.A. 91: 12218-22, 1994.
88)  Trempy JE, Kirby JE, Gottesman S.
Alp suppression of Lon: dependence on the slpA gene.
J. Bacteriol. 176: 2061-7, 1994.
89)  Kirby JE, Trempy JE, Gottesman S.
Excision of a P4-like cryptic prophage leads to Alp protease expression in Escherichia coli.
J. Bacteriol. 176: 2068-81, 1994.
90)  Wang N, Gottesman S, Willingham MC, Gottesman MM, Maurizi MR.
A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.
Proc. Natl. Acad. Sci. U.S.A. 90: 11247-51, 1993.
91)  Painbéni E, Mouray E, Gottesman S, Rouvière-Yaniv J.
An imbalance of HU synthesis induces mucoidy in Escherichia coli.
J. Mol. Biol. 234: 1021-37, 1993.
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This page was last updated on 6/13/2014.