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Our Science – Adhya Website

Sankar Adhya, Ph.D.

Selected Publications

1)  Adhya S, Merril CR, Biswas B.
Therapeutic and prophylactic applications of bacteriophage components in modern medicine.
Cold Spring Harb Perspect Med. 4: a012518, 2014.
2)  Adhya S, Biswas B, Merril C.
Maloy S, Cossart P, eds.
Therapeutic and prophylactic applications of bacteriophage and its components in modern medicine. In: In Bacterial Pathogenesis.
New York: Cold Spring Harbor Press; 2013. In Press. [Book Chapter]
3)  Barupal DK, Lee SJ, Karoly ED, Adhya S.
Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network.
PLoS ONE. 8: e78360, 2013.
4)  Lee SJ, Trostel A, Adhya S.
Metabolite changes signal genetic regulatory mechanisms for robust cell behavior.
MBio. 5: e00972-13, 2013.
5)  Mazumder A, Bandyopadhyay S, Dhar A, Lewis DE, Deb S, Dey S, Chakrabarti P, Roy S.
A genetic network that balances two outcomes utilizes asymmetric recognition of operator sites.
Biophys. J. 102: 1580-9, 2012.
6)  Macvanin M, Adhya S.
Architectural organization in E. coli nucleoid.
Biochim Biophys Acta. 1819: 830-5, 2012.
7)  Qian Z, Dimitriadis EK, Edgar R, Eswaramoorthy P, Adhya S.
Galactose repressor mediated intersegmental chromosomal connections in Escherichia coli.
Proc. Natl. Acad. Sci. U.S.A. 109: 11336-41, 2012.
8)  Macvanin M, Edgar R, Cui F, Trostel A, Zhurkin V, Adhya S.
Noncoding RNAs binding to the nucleoid protein HU in Escherichia coli.
J. Bacteriol. 194: 6046-55, 2012.
9)  Csiszovszki Z, Lewis D, Le P, Sneppen K, Semsey S.
Specific contacts of the -35 region of the galP1 promoter by RNA polymerase inhibit GalR mediated DNA looping repression.
Nucleic Acids Res. 40: 10064-72, 2012.
10)  Koli P, Sudan S, Fitzgerald D, Adhya S, Kar S.
Conversion of Commensal Escherichia coli K-12 to an Invasive Form via Expression of a Mutant Histone-Like Protein.
MBio. 2: e00182-11, 2011.
11)  Lewis D, Le P, Zurla C, Finzi L, Adhya S.
Multilevel autoregulation of lambda repressor protein CI by DNA looping in vitro.
Proc. Natl. Acad. Sci. U.S.A. 108: 14807-12, 2011.
12)  Csiszovszki Z, Krishna S, Orosz L, Adhya S, Semsey S.
Structure and function of the D-galactose network in enterobacteria.
MBio. 2: e00053-11, 2011.
13)  Lewis D, Lee S, Semsey S, Virnik K, Finzi L, Adhya S.
In Dame R, Charles L, eds.
Role of HU in regulation of gal promoters. In: Bacterial Chromatin.
NY: Springer Science; 2010. p. 395-417 [Book Chapter]
14)  Finzi L, Manzo C, Zurla C, Wang H, Lewis D, Adhya S, David D.
Williams W, Maher, III L, eds.
DNA Looping in Prophage Lambda: New Insight from Single-Molecule Microscopy. In: Biophysics of DNA-Protein Interactions.
NY: Springer Science; 2010. p. 93-212 [Book Chapter]
15)  Lee SJ, Trostel A, Le P, Harinarayanan R, Fitzgerald PC, Adhya S.
Cellular stress created by intermediary metabolite imbalances.
Proc. Natl. Acad. Sci. U.S.A. 106: 19515-20, 2009.
16)  Zurla C, Manzo C, Dunlap D, Lewis DE, Adhya S, Finzi L.
Direct demonstration and quantification of long-range DNA looping by the lambda bacteriophage repressor.
Nucleic Acids Res. 37: 2789-95, 2009.
17)  Semsey S, Krishna S, Erdossy J, Horváth P, Orosz L, Sneppen K, Adhya S.
Dominant Negative Autoregulation Limits Steady-State Repression Levels in Gene Networks.
J. Bacteriol. 191: 4487-91, 2009.
18)  Zwieb C, Adhya S.
Plasmid vectors for the analysis of protein-induced DNA bending.
Methods Mol. Biol. 543: 547-62, 2009.
19)  Krishna S, Orosz L, Sneppen K, Adhya S, Semsey S.
Relation of Intracellular Signal Levels and Promoter Activities in the gal Regulon of Escherichia coli.
J. Mol. Biol. 391: 671-8, 2009.
20)  Bair CL, Oppenheim A, Trostel A, Prag G, Adhya S.
A phage display system designed to detect and study protein-protein interactions.
Mol. Microbiol. 67: 719-28, 2008.
21)  Adhya SL, Court DL, Friedman DI, Gottesman ME.
Amos Oppenheim (31 October 1934 to 24 September 2006).
Mol. Microbiol. 67: 685-6, 2008.
22)  Edgar R, Rokney A, Feeney M, Semsey S, Kessel M, Goldberg MB, Adhya S, Oppenheim AB.
Bacteriophage infection is targeted to cellular poles.
Mol. Microbiol. 68: 1107-16, 2008.
23)  Lewis DE, Komissarova N, Le P, Kashlev M, Adhya S.
DNA Sequences in gal Operon Override Transcription Elongation Blocks.
J. Mol. Biol. 2008.
24)  Rokney A, Kobiler O, Amir A, Court DL, Stavans J, Adhya S, Oppenheim AB.
Host responses influence on the induction of lambda prophage.
Mol. Microbiol. 68: 29-36, 2008.
25)  Hong J, Kim KP, Heu S, Lee SJ, Adhya S, Ryu S.
Identification of host receptor and receptor-binding module of a newly sequenced T5-like phage EPS7.
FEMS Microbiol. Lett. 289: 202-9, 2008.
26)  Lee SJ, Lewis DE, Adhya S.
Induction of the galactose enzymes in Escherichia coli is independent of the C-1-hydroxyl optical configuration of the inducer D-galactose.
J. Bacteriol. 190: 7932-8, 2008.
27)  Lia G, Semsey S, Lewis DE, Adhya S, Bensimon D, Dunlap D, Finzi L.
The antiparallel loops in gal DNA.
Nucleic Acids Res. 36: 4204-10, 2008.
28)  Court DL, Oppenheim AB, Adhya SL.
A new look at bacteriophage lambda genetic networks.
J. Bacteriol. 189: 298-304, 2007.
29)  Semsey S, Krishna S, Sneppen K, Adhya S.
Signal integration in the galactose network of Escherichia coli.
Mol. Microbiol. 65: 465-76, 2007.
30)  Guo F, Adhya S.
Spiral structure of Escherichia coli HUalphabeta provides foundation for DNA supercoiling.
Proc. Natl. Acad. Sci. U.S.A. 104: 4309-14, 2007.
31)  Edgar R, McKinstry M, Hwang J, Oppenheim AB, Fekete RA, Giulian G, Merril C, Nagashima K, Adhya S.
High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes.
Proc. Natl. Acad. Sci. U.S.A. 103: 4841-5, 2006.
32)  Wilder PT, Lin J, Bair CL, Charpentier TH, Yang D, Liriano M, Varney KM, Lee A, Oppenheim AB, Adhya S, Carrier F, Weber DJ.
Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.
Biochim. Biophys. Acta. 1763: 1284-97, 2006.
33)  Sukhodolets MV, Garges S, Adhya S.
Ribosomal protein S1 promotes transcriptional cycling.
RNA. 12: 1505-13, 2006.
34)  Kar S, Choi EJ, Guo F, Dimitriadis EK, Kotova SL, Adhya S.
Right-handed DNA supercoiling by an octameric form of histone-like protein HU: modulation of cellular transcription.
J. Biol. Chem. 281: 40144-53, 2006.
35)  Semsey S, Virnik K, Adhya S.
Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA.
J. Mol. Biol. 358: 355-63, 2006.
36)  Semsey S, Virnik K, Adhya S.
A gamut of loops: meandering DNA.
Trends Biochem. Sci. 30: 334-41, 2005.
37)  Tolstorukov MY, Virnik KM, Adhya S, Zhurkin VB.
A-tract clusters may facilitate DNA packaging in bacterial nucleoid.
Nucleic Acids Res. 33: 3907-18, 2005.
38)  Vitiello CL, Merril CR, Adhya S.
An amino acid substitution in a capsid protein enhances phage survival in mouse circulatory system more than a 1000-fold.
Virus Res. 114: 101-3, 2005.
39)  Scholl D, Adhya S, Merril C.
Escherichia coli K1's capsule is a barrier to bacteriophage T7.
Appl. Environ. Microbiol. 71: 4872-4, 2005.
40)  Roy S, Dimitriadis EK, Kar S, Geanacopoulos M, Lewis MS, Adhya S.
Gal repressor-operator-HU ternary complex: pathway of repressosome formation.
Biochemistry. 44: 5373-80, 2005.
41)  Kar S, Edgar R, Adhya S.
Nucleoid remodeling by an altered HU protein: reorganization of the transcription program.
Proc. Natl. Acad. Sci. U.S.A. 102: 16397-402, 2005.
42)  Svenningsen SL, Costantino N, Court DL, Adhya S.
On the role of Cro in lambda prophage induction.
Proc. Natl. Acad. Sci. U.S.A. 102: 4465-9, 2005.
43)  Oppenheim AB, Kobiler O, Stavans J, Court DL, Adhya S.
Switches in bacteriophage lambda development.
Annu. Rev. Genet. 39: 409-29, 2005.
44)  Rao S, Hu S, McHugh L, Lueders K, Henry K, Zhao Q, Fekete RA, Kar S, Adhya S, Hamer DH.
Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide.
Proc. Natl. Acad. Sci. U.S.A. 102: 11993-8, 2005.
45)  Lee HJ, Lim HM, Adhya S.
An unsubstituted C2 hydrogen of adenine is critical and sufficient at the -11 position of a promoter to signal base pair deformation.
J. Biol. Chem. 279: 16899-902, 2004.
46)  Lewis DE, Adhya S.
Axiom of determining transcription start points by RNA polymerase in Escherichia coli.
Mol. Microbiol. 54: 692-701, 2004.
47)  Semsey S, Tolstorukov MY, Virnik K, Zhurkin VB, Adhya S.
DNA trajectory in the Gal repressosome.
Genes Dev. 18: 1898-907, 2004.
48)  Virnik K, Lyubchenko YL, Karymov MA, Dahlgren P, Tolstorukov MY, Semsey S, Zhurkin VB, Adhya S.
"Antiparallel" DNA loop in gal repressosome visualized by atomic force microscopy.
J. Mol. Biol. 334: 53-63, 2003.
49)  Gupta A, Onda M, Pastan I, Adhya S, Chaudhary VK.
High-density functional display of proteins on bacteriophage lambda.
J. Mol. Biol. 334: 241-54, 2003.
50)  Adhya S.
Suboperonic regulatory signals.
Sci. STKE. 2003: pe22, 2003.
51)  Merril CR, Scholl D, Adhya SL.
The prospect for bacteriophage therapy in Western medicine.
Nat Rev Drug Discov. 2: 489-97, 2003.
52)  Lim HM, Lee HJ, Roy S, Adhya S.
A "master" in base unpairing during isomerization of a promoter upon RNA polymerase finding.
Proc. Natl. Acad. Sci. U.S.A. 98: 14849-52, 2001.
53)  Geanacopoulos M, Vasmatzis G, Zhurkin VB, Adhya S.
Gal repressosome contains an antiparallel DNA loop.
Nat. Struct. Biol. 8: 432-6, 2001.
54)  Kar S, Adhya S.
Recruitment of HU by piggyback: a special role of GalR in repressosome assembly.
Genes Dev. 15: 2273-81, 2001.
55)  Lewis DE, Geanacopoulos M, Adhya S.
Role of HU and DNA supercoiling in transcription repression: specialized nucleoprotein repression complex at gal promoters in Escherichia coli.
Mol. Microbiol. 31: 451-61, 1999.
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This page was last updated on 4/21/2014.