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Our Science – Pastan Website

Ira Pastan, M.D.

Selected Publications

1)  Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I.
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with Deletion of WDR85.
J. Biol. Chem. [Epub ahead of print], 2013.
[Journal]
2)  Weldon JE, Xiang L, Zhang J, Beers R, Walker DA, Onda M, Hassan R, Pastan I.
A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity.
Mol. Cancer Ther. 12: 48-57, 2013.
[Journal]
3)  Ueno T, Kobayashi N, Nakayama M, Takashima Y, Ohse T, Pastan I, Pippin JW, Shankland SJ, Uesugi N, Matsusaka T, Nagata M.
Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss.
Kidney Int. [Epub ahead of print], 2013.
[Journal]
4)  Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH, Dimitrov DS, Morgan RA, FitzGerald DJ, Barrett DM, Wayne AS, Mackall CL, Orentas RJ.
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia.
Blood. 121: 1165-74, 2013.
[Journal]
5)  Yamaguchi T, Danjo T, Pastan I, Hikida T, Nakanishi S.
Distinct Roles of Segregated Transmission of the Septo-Habenular Pathway in Anxiety and Fear.
Neuron. [Epub ahead of print], 2013.
[Journal]
6)  Chandramohan V, Bao X, Kato Kaneko M, Kato Y, Keir ST, Szafranski SE, Kuan CT, Pastan IH, Bigner DD.
Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.
Int. J. Cancer. 132: 2339-48, 2013.
[Journal]
7)  Choi BD, Kuan CT, Cai M, Archer GE, Mitchell DA, Gedeon PC, Sanchez-Perez L, Pastan I, Bigner DD, Sampson JH.
Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.
Proc. Natl. Acad. Sci. U.S.A. 110: 270-5, 2013.
[Journal]
8)  Liu XF, Fitzgerald DJ, Pastan I.
The insulin receptor negatively regulates the action of pseudomonas toxin-based immunotoxins and native pseudomonas toxin.
Cancer Res. 73: 2281-8, 2013.
[Journal]
9)  Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I.
A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.
Protein Eng. Des. Sel. 25: 1-6, 2012.
[Journal]
10)  Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I.
ANKRD26 and Its Interacting Partners TRIO, GPS2, HMMR and DIPA Regulate Adipogenesis in 3T3-L1 Cells.
PLoS ONE. 7: e38130, 2012.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 4/26/2013.