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Curtis C. Harris, M.D.

Selected Publications

1)  Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.
J. Clin. Invest. 2013.
[Journal]
2)  Akagi I, Okayama H, Schetter AJ, Robles AI, Kohno T, Bowman ED, Kazandjian D, Welsh JA, Oue N, Saito M, Miyashita M, Uchida E, Takizawa T, Takenoshita S, Skaug V, Mollerup S, Haugen A, Yokota J, Harris CC.
Combination of Protein Coding and Noncoding Gene Expression as a Robust Prognostic Classifier in Stage I Lung Adenocarcinoma.
Cancer Res. 2013.
[Journal]
3)  Oue N, Anami K, Schetter AJ, Moehler M, Okayama H, Khan MA, Bowman ED, Mueller A, Schad A, Shimomura M, Hinoi T, Aoyagi K, Sasaki H, Okajima M, Ohdan H, Galle PR, Yasui W, Harris CC.
High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer.
Int. J. Cancer. 2013.
[Journal]
4)  Ryan BM, Zanetti KA, Robles AI, Schetter AJ, Goodman J, Hayes RB, Huang WY, Gunter MJ, Yeager M, Burdette L, Berndt SI, Harris CC.
Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.
Int. J. Cancer. 2013.
[Journal]
5)  Taga M, Mechanic LE, Hagiwara N, Vähäkangas KH, Bennett WP, Alavanja MC, Welsh JA, Khan MA, Lee A, Diasio R, Edell E, Bungum A, Jang JS, Yang P, Jen J, Harris CC.
EGFR Somatic Mutations in Lung Tumors: Radon Exposure and Passive Smoking in Former- and Never-Smoking U.S. Women.
Cancer Epidemiol. Biomarkers Prev. 21: 988-92, 2012.
[Journal]
6)  Poudyal D, Cui X, Le PM, Hofseth AB, Windust A, Nagarkatti M, Nagarkatti PS, Schetter AJ, Harris CC, Hofseth LJ.
A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng.
PLoS ONE. 8: e75034, 2013.
[Journal]
7)  Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA.
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Nat. Genet. 45: 690-6, 2013.
[Journal]
8)  Robles AI, Harris CC.
A primate-specific microRNA enters the lung cancer landscape.
Proc. Natl. Acad. Sci. U.S.A. 2013.
[Journal]
9)  Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID.
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Chem. Biol. 20: 55-62, 2013.
[Journal]
10)  Carlsen AL, Schetter AJ, Nielsen CT, Lood C, Knudsen S, Voss A, Harris CC, Hellmark T, Segelmark M, Jacobsen S, Bengtsson AA, Heegaard NH.
Circulating microRNA expression profiles associated with systemic lupus erythematosus.
Arthritis Rheum. [Epub ahead of print], 2013.
[Journal]
11)  Pesatori AC, Carugno M, Consonni D, Hung RJ, Papadoupolos A, Landi MT, Brenner H, Müller H, Harris CC, Duell EJ, Andrew AS, McLaughlin JR, Schwartz AG, Wenzlaff AS, Stucker I.
Hormone use and risk for lung cancer: a pooled analysis from the International Lung Cancer Consortium (ILCCO).
Br. J. Cancer. 109: 1954-64, 2013.
[Journal]
12)  Achyut BR, Bader DA, Robles AI, Wangsa D, Harris CC, Ried T, Yang L.
Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-ß Signaling.
PLoS Genet. 9: e1003251, 2013.
[Journal]
13)  Chang CM, Chia VM, Gunter MJ, Zanetti KA, Ryan BM, Goodman JE, Harris CC, Weissfeld J, Huang WY, Chanock S, Yeager M, Hayes RB, Berndt SI.
Innate immunity gene polymorphisms and the risk of colorectal neoplasia.
Carcinogenesis. 2013.
[Journal]
14)  Yanaihara N, Harris CC.
MicroRNA Involvement in Human Cancers.
Clin. Chem. [Epub ahead of print], 2013.
[Journal]
15)  Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M.
Mutant p53 Prolongs NF-?B Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer.
Cancer Cell. 23: 634-46, 2013.
[Journal]
16)  Ui A, Ogiwara H, Nakajima S, Kanno S, Watanabe R, Harata M, Okayama H, Harris CC, Yokota J, Yasui A, Kohno T.
Possible involvement of LKB1-AMPK signaling in non-homologous end joining.
Oncogene. 2013.
[Journal]
17)  Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ.
The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.
PLoS ONE. 8: e53791, 2013.
[Journal]
18)  Zanetti KA, Haznadar M, Welsh JA, Robles AI, Ryan BM, McClary AC, Bowman ED, Goodman JE, Bernig T, Chanock SJ, Harris CC.
3'-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African Americans.
Cancer Res. 72: 1467-77, 2012.
[Journal]
19)  Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M.
Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Proc. Natl. Acad. Sci. U.S.A. 109: 14007-12, 2012.
[Journal]
20)  Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, Hutchinson A, Deng X, Liu C, Horner MJ, Cullen M, Epstein CG, Burdett L, Dean MC, Chatterjee N, Sampson J, Chung CC, Kovaks J, Gapstur SM, Stevens VL, Teras LT, Gaudet MM, Albanes D, Weinstein SJ, Virtamo J, Taylor PR, Freedman ND, Abnet CC, Goldstein AM, Hu N, Yu K, Yuan JM, Liao L, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Aldrich MC, Amos C, Blot WJ, Bock CH, Gillanders EM, Harris CC, Haiman CA, Henderson BE, Kolonel LN, Le Marchand L, McNeill LH, Rybicki BA, Schwartz AG, Signorello LB, Spitz MR, Wiencke JK, Wrensch M, Wu X, Zanetti KA, Ziegler RG, Figueroa JD, Garcia-Closas M, Malats N, Marenne G, Prokunina-Olsson L, Baris D, Schwenn M, Johnson A, Landi MT, Goldin L, Consonni D, Bertazzi PA, Rotunno M, Rajaraman P, Andersson U, Freeman LE, Berg CD, Buring JE, Butler MA, Carreon T, Feychting M, Ahlbom A, Gaziano JM, Giles GG, Hallmans G, Hankinson SE, Hartge P, Henriksson R, Inskip PD, Johansen C, Landgren A, McKean-Cowdin R, Michaud DS, Melin BS, Peters U, Ruder AM, Sesso HD, Severi G, Shu XO, Visvanathan K, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Silverman DT, Kogevinas M, Gonzalez JR, Villa O, Li D, Duell EJ, Risch HA, Olson SH, Kooperberg C, Wolpin BM, Jiao L, Hassan M, Wheeler W, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross MD, Holly EA, Klein AP, Lacroix A, Mandelson MT, Petersen G, Boutron-Ruault MC, Bracci PM, Canzian F, Chang K, Cotterchio M, Giovannucci EL, Goggins M, Bolton JA, Jenab M, Khaw KT, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Rabe KG, Riboli E, Tjønneland A, Tobias GS, Trichopoulos D, Elena JW, Yu H, Amundadottir L, Stolzenberg-Solomon RZ, Kraft P, Schumacher F, Stram D, Savage SA, Mirabello L, Andrulis IL, Wunder JS, García AP, Sierrasesúmaga L, Barkauskas DA, Gorlick RG, Purdue M, Chow WH, Moore LE, Schwartz KL, Davis FG, Hsing AW, Berndt SI, Black A, Wentzensen N, Brinton LA, Lissowska J, Peplonska B, McGlynn KA, Cook MB, Graubard BI, Kratz CP, Greene MH, Erickson RL, Hunter DJ, Thomas G, Hoover RN, Real FX, Fraumeni JF, Caporaso NE, Tucker M, Rothman N, Pérez-Jurado LA, Chanock SJ.
Detectable clonal mosaicism and its relationship to aging and cancer.
Nat. Genet. 44: 651-8, 2012.
[Journal]
21)  Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng Z, Harris CC.
Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.
Oncogene. [Epub ahead of print], 2012.
[Journal]
22)  Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, Harris CC, Sheu JC, Giaccone G, Luo J.
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 109: E3659-67, 2012.
[Journal]
23)  Jang J, Jeon H, Sun Z, Aubry MC, Tang H, Park C, Rakhshan F, Schultz DA, Kolbert CP, Lupu R, Park JY, Harris CC, Yang P, Jin J.
Increased miR-708 Expression in NSCLC and Its Association with Poor Survival in Lung Adenocarcinoma from Never Smokers.
Clin Cancer Res. [Epub ahead of print], 2012.
[Journal]
24)  Coté ML, Liu M, Bonassi S, Neri M, Schwartz AG, Christiani DC, Spitz MR, Muscat JE, Rennert G, Aben KK, Andrew AS, Bencko V, Bickeböller H, Boffetta P, Brennan P, Brenner H, Duell EJ, Fabianova E, Field JK, Foretova L, Friis S, Harris CC, Holcatova I, Hong Y, Isla D, Janout V, Kiemeney LA, Kiyohara C, Lan Q, Lazarus P, Lissowska J, Le Marchand L, Mates D, Matsuo K, Mayordomo JI, McLaughlin JR, Morgenstern H, Müeller H, Orlow I, Park BJ, Pinchev M, Raji OY, Rennert HS, Rudnai P, Seow A, Stucker I, Szeszenia-Dabrowska N, Dawn Teare M, Tjønnelan A, Ugolini D, van der Heijden HF, Wichmann E, Wiencke JK, Woll PJ, Yang P, Zaridze D, Zhang Z, Etzel CJ, Hung RJ.
Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium.
Eur J Cancer. [Epub ahead of print], 2012.
[Journal]
25)  Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, Iwakawa R, Ogiwara H, Oike T, Enari M, Schetter AJ, Okayama H, Haugen A, Skaug V, Chiku S, Yamanaka I, Arai Y, Watanabe S, Sekine I, Ogawa S, Harris CC, Tsuda H, Yoshida T, Yokota J, Shibata T.
KIF5B-RET fusions in lung adenocarcinoma.
Nat. Med. 18: 375-7, 2012.
[Journal]
26)  Ryan BM, Robles AI, Harris CC.
KRAS-LCS6 Genotype as a Prognostic Marker in Early-Stage CRC-Letter.
Clin Cancer Res. [Epub ahead of print], 2012.
[Journal]
27)  Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
PLoS ONE. 7: e44156, 2012.
[Journal]
28)  Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC.
MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.
Int J Cancer. [Epub ahead of print], 2012.
[Journal]
29)  Zhao Y, Schetter AJ, Yang GB, Nguyen G, Mathé EA, Li P, Cai H, Yu L, Liu F, Hang D, Yang H, Wang XW, Ke Y, Harris CC.
microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma.
Int. J. Cancer. [Epub ahead of print], 2012.
[Journal]
30)  Okayama H, Schetter AJ, Harris CC.
MicroRNAs and inflammation in the pathogenesis and progression of colon cancer.
Dig Dis. 30 Suppl 2: 9-15, 2012.
[Journal]
31)  Okayama H, Saito M, Oue N, Weiss JM, Stauffer J, Takenoshita S, Wiltrout RH, Hussain SP, Harris CC.
NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression.
Int J Cancer. [Epub ahead of print], 2012.
[Journal]
32)  Ryan BM, McClary AC, Valeri N, Robinson D, Paone A, Bowman ED, Robles AI, Croce C, Harris CC.
rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer.
PLoS ONE. 7: e36306, 2012.
[Journal]
33)  Gaedcke J, Grade M, Camps J, Sokilde R, Kaczkowski B, Schetter AJ, Difilippantonio MJ, Harris CC, Ghadimi BM, Moller S, Beissbarth T, Ried T, Litman T.
The rectal cancer microRNAome - microRNA expression in rectal cancer and matched normal mucosa.
Clin. Cancer Res. [Epub ahead of print], 2012.
[Journal]
34)  Schetter AJ, Okayama H, Harris CC.
The Role of MicroRNAs in Colorectal Cancer.
Cancer J. 18: 244-52, 2012.
[Journal]
35)  Schetter AJ, Harris CC.
Tumor suppressor p53 (TP53) at the crossroads of the exposome and the cancer genome.
Proc. Natl. Acad. Sci. U.S.A. 109: 7955-6, 2012.
[Journal]
36)  Zhao X, Elmore LW, Harris CC, Wang XW.
Hepatocellular Carcinoma.
eLS. In Press, 2011.
In Press. [Journal]
37)  Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM.
Admixture mapping of lung cancer in 1812 African-Americans.
Carcinogenesis. 32: 312-7, 2011.
[Journal]
38)  Schetter AJ, Harris CC.
Alterations of microRNAs contribute to colon carcinogenesis.
Semin. Oncol. 38: 734-42, 2011.
[Journal]
39)  Woo HG, Wang XW, Budhu A, Kim YH, Kwon SM, Tang ZY, Sun Z, Harris CC, Thorgeirsson SS.
Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.
Gastroenterology. 140: 1063-70, 2011.
[Journal]
40)  Saleh AD, Savage JE, Cao L, Soule BP, Ly D, DeGraff W, Harris CC, Mitchell JB, Simone NL.
Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.
PLoS ONE. 6: e24429, 2011.
[Journal]
41)  Heegaard NH, Schetter AJ, Welsh JA, Yoneda M, Bowman ED, Harris CC.
Circulating microRNA expression profiles in early stage non-small cell lung cancer.
Int J Cancer. [Epub ahead of print], 2011.
[Journal]
42)  Cheng H, Zhang L, Cogdell DE, Zheng H, Schetter AJ, Nykter M, Harris CC, Chen K, Hamilton SR, Zhang W.
Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis.
PLoS ONE. 6: e17745, 2011.
[Journal]
43)  Gill RK, Yang S, Meerzaman D, Mechanic LE, Bowman ED, Jeon H, Roy Chowdhuri S, Shakoori A, Dracheva T, Hong K, Fukuoka J, Zhang J, Harris CC, Jen J.
Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.
Oncogene. 30: 3784-91, 2011.
[Journal]
44)  Pine SR, Mechanic LE, Enewold L, Chaturvedi AK, Katki HA, Zheng YL, Bowman ED, Engels EA, Caporaso NE, Harris CC.
Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.
J. Natl. Cancer Inst. 103: 1112-22, 2011.
[Journal]
45)  Zhang C, Elkahloun AG, Robertson M, Gills JJ, Tsurutani J, Shih JH, Fukuoka J, Hollander MC, Harris CC, Travis WD, Jen J, Dennis PA.
Loss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistance.
PLoS ONE. 6: e23849, 2011.
[Journal]
46)  Schetter AJ, Harris CC.
MicroRNAs as molecular classifiers for cancer.
Cell Cycle. 10: 2827-8, 2011.
[Journal]
47)  Horikawa I, Fujita K, Harris CC.
p53 governs telomere regulation feedback too, via TRF2.
Aging (Albany NY). 3: 26-32, 2011.
[Journal]
48)  Au AY, Hackl T, Yeager TR, Cohen SB, Pass HI, Harris CC, Reddel RR.
Telomerase activity in pleural malignant mesotheliomas.
Lung Cancer. 73: 283-8, 2011.
[Journal]
49)  Saito M, Schetter AJ, Mollerup S, Kohno T, Skaug V, Bowman ED, Mathé EA, Takenoshita S, Yokota J, Haugen A, Harris CC.
The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts.
Clin. Cancer Res. 17: 1875-82, 2011.
[Journal]
50)  Hinch AG, Tandon A, Patterson N, Song Y, Rohland N, Palmer CD, Chen GK, Wang K, Buxbaum SG, Akylbekova EL, Aldrich MC, Ambrosone CB, Amos C, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Bock CH, Boerwinkle E, Cai Q, Caporaso N, Casey G, Cupples LA, Deming SL, Diver WR, Divers J, Fornage M, Gillanders EM, Glessner J, Harris CC, Hu JJ, Ingles SA, Isaacs W, John EM, Kao WH, Keating B, Kittles RA, Kolonel LN, Larkin E, Le Marchand L, McNeill LH, Millikan RC, Murphy A, Musani S, Neslund-Dudas C, Nyante S, Papanicolaou GJ, Press MF, Psaty BM, Reiner AP, Rich SS, Rodriguez-Gil JL, Rotter JI, Rybicki BA, Schwartz AG, Signorello LB, Spitz M, Strom SS, Thun MJ, Tucker MA, Wang Z, Wiencke JK, Witte JS, Wrensch M, Wu X, Yamamura Y, Zanetti KA, Zheng W, Ziegler RG, Zhu X, Redline S, Hirschhorn JN, Henderson BE, Taylor HA, Price AL, Hakonarson H, Chanock SJ, Haiman CA, Wilson JG, Reich D, Myers SR.
The landscape of recombination in African Americans.
Nature. 476: 170-5, 2011.
[Journal]
51)  Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H.
Tumor-suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.
Cancer Res. 71: 4628-39, 2011.
[Journal]
52)  Butkiewicz D, Krześniak M, Vaitiekunaite R, Sikora B, Bowman ED, Harris CC, Rusin M.
A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene.
Cell. Mol. Biol. Lett. 15: 611-29, 2010.
[Journal]
53)  Langevin SM, Ioannidis JP, Vineis P, Taioli E.
Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines.
Pharmacogenet. Genomics. 20: 586-97, 2010.
[Journal]
54)  Robles AI, Harris CC.
Clinical Outcomes and Correlates of TP53 Mutations and Cancer.
Cold Spring Harb Perspect Biol. 2: a001016, 2010.
[Journal]
55)  Jiang W, Wang XW, Unger T, Forgues M, Kim JW, Hussain SP, Bowman E, Spillare EA, Lipsky MM, Meck JM, Cavalli LR, Haddad BR, Harris CC.
Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.
Int. J. Cancer. 127: 1011-20, 2010.
[Journal]
56)  Wang X, Tian X, Liu F, Zhao Y, Sun M, Chen D, Lu C, Wang Z, Shi X, Zhang Q, Zhang D, Shen Z, Li F, Harris CC, Cai H, Ke Y.
Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study.
BMC Cancer. 10: 19, 2010.
[Journal]
57)  Zheng YL, Kosti O, Loffredo CA, Bowman E, Mechanic L, Perlmutter D, Jones R, Shields PG, Harris CC.
Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study.
Int. J. Cancer. 126: 2199-210, 2010.
[Journal]
58)  Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X, Yang P.
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study.
Lancet Oncol. 11: 321-30, 2010.
[Journal]
59)  Ryan BM, Robles AI, Harris CC.
Genetic variation in microRNA networks: the implications for cancer research.
Nat. Rev. Cancer. 10: 389-402, 2010.
[Journal]
60)  Nguyen GH, Schetter AJ, Chou DB, Bowman ED, Zhao R, Hawkes JE, Mathé EA, Kumamoto K, Zhao Y, Budhu A, Hagiwara N, Wang XW, Miyashita M, Casson AG, Harris CC.
Inflammatory and microRNA gene expression as prognostic classifier of Barrett's-associated esophageal adenocarcinoma.
Clin. Cancer Res. 16: 5824-34, 2010.
[Journal]
61)  Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
J. Exp. Med. 207: 2455-67, 2010.
[Journal]
62)  Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.
Microenvironmental modulation of asymmetric cell division in human lung cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010.
[Journal]
63)  Voortman J, Goto A, Mendiboure J, Sohn JJ, Schetter AJ, Saito M, Dunant A, Pham TC, Petrini I, Lee A, Khan MA, Hainaut P, Pignon JP, Brambilla E, Popper HH, Filipits M, Harris CC, Giaccone G.
MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma.
Cancer Res. 70: 8288-98, 2010.
[Journal]
64)  Fujita K, Horikawa I, Mondal AM, Jenkins LM, Appella E, Vojtesek B, Bourdon JC, Lane DP, Harris CC.
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.
Nat. Cell Biol. 12: 1205-12, 2010.
[Journal]
65)  Tahara E, Yasui W, Ito H, Harris CC.
Recent progress in carcinogenesis, progression and therapy of lung cancer: the 19th Hiroshima Cancer Seminar: the 3rd Three Universities' Consortium International Symposium, November 2009.
Jpn. J. Clin. Oncol. 40: 702-8, 2010.
[Journal]
66)  Meinhold CL, Berrington de González A, Bowman ED, Brenner AV, Jones RT, Lacey JV, Loffredo CA, Perlmutter D, Schonfeld SJ, Trivers GE, Harris CC.
Reproductive and hormonal factors and the risk of nonsmall cell lung cancer.
International journal of cancer. Journal international du cancer. 2010.
[Journal]
67)  Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, Iorio MV, Taccioli C, Garzon R, Di Leva G, Fabbri M, Catozzi M, Previati M, Ambs S, Palumbo T, Garofalo M, Veronese A, Bottoni A, Gasparini P, Harris CC, Visone R, Pekarsky Y, de la Chapelle A, Bloomston M, Dillhoff M, Rassenti LZ, Kipps TJ, Huebner K, Pichiorri F, Lenze D, Cairo S, Buendia MA, Pineau P, Dejean A, Zanesi N, Rossi S, Calin GA, Liu CG, Palatini J, Negrini M, Vecchione A, Rosenberg A, Croce CM.
Reprogramming of miRNA networks in cancer and leukemia.
Genome Res. 20: 589-99, 2010.
[Journal]
68)  Olivo-Marston SE, Mechanic LE, Mollerup S, Bowman ED, Remaley AT, Forman MR, Skaug V, Zheng YL, Haugen A, Harris CC.
Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.
Carcinogenesis. 31: 1778-86, 2010.
[Journal]
69)  Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC.
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.
PLoS ONE. 5: e15541, 2010.
[Journal]
70)  Sander M, Slaga TJ, Harris CC.
The 24th Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy 2009.
Mol. Carcinog. 49: 410-28, 2010.
[Journal]
71)  Ambrosone CB, Harris CC.
The development of molecular epidemiology to elucidate cancer risk and prognosis: a historical perspective.
Int J Mol Epidemiol Genet. 1: 84-91, 2010.
[Journal]
72)  Schetter AJ, Nguyen GH, Bowman ED, Mathé EA, Yuen ST, Hawkes JE, Croce CM, Leung SY, Harris CC.
Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma.
Clin. Cancer Res. 15: 5878-87, 2009.
[Journal]
73)  Olivo-Marston SE, Yang P, Mechanic LE, Bowman ED, Pine SR, Loffredo CA, Alberg AJ, Caporaso N, Shields PG, Chanock S, Wu Y, Jiang R, Cunningham J, Jen J, Harris CC.
Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk.
Cancer Epidemiol. Biomarkers Prev. 18: 3375-83, 2009.
[Journal]
74)  Jones LE, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD.
Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.
Carcinogenesis. 30: 2123-9, 2009.
[Journal]
75)  Olivo-Marston SE, Hursting SD, Lavigne J, Perkins SN, Maarouf RS, Yakar S, Harris CC.
Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice.
Mol. Carcinog. 48: 1071-6, 2009.
[Journal]
76)  Schetter AJ, Heegaard NH, Harris CC.
Inflammation and Cancer: Interweaving microRNA, free radical, cytokine and p53 pathways.
Carcinogenesis. 2009.
[Journal]
77)  Unoki M, Kumamoto K, Harris CC.
ING proteins as potential anticancer drug targets.
Current drug targets. 10: 442-54, 2009.
[Journal]
78)  Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC.
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Int. J. Cancer. 125: 1306-15, 2009.
[Journal]
79)  Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB.
Ionizing radiation-induced oxidative stress alters miRNA expression.
PLoS ONE. 4: e6377, 2009.
[Journal]
80)  Rudin CM, Avila-Tang E, Harris CC, Herman JG, Hirsch FR, Pao W, Schwartz AG, Vahakangas KH, Samet JM.
Lung cancer in never smokers: molecular profiles and therapeutic implications.
Clin. Cancer Res. 15: 5646-61, 2009.
[Journal]
81)  Mathé EA, Nguyen GH, Bowman ED, Zhao Y, Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, Altorki NK, Casson AG, Liu CG, Wang XW, Yanaihara N, Hagiwara N, Dannenberg AJ, Miyashita M, Croce CM, Harris CC.
MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival.
Clin. Cancer Res. 15: 6192-200, 2009.
[Journal]
82)  Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC.
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
Proc. Natl. Acad. Sci. U.S.A. 106: 12085-90, 2009.
[Journal]
83)  Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC.
p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.
Nat. Cell Biol. 11: 1135-42, 2009.
[Journal]
84)  Schetter AJ, Harris CC.
Plasma microRNAs: a potential biomarker for colorectal cancer?.
Gut. 58: 1318-9, 2009.
[Journal]
85)  Unoki M, Kumamoto K, Takenoshita S, Harris CC.
Reviewing the current classification of inhibitor of growth family proteins.
Cancer Sci. 100: 1173-9, 2009.
[Journal]
86)  Enewold L, Mechanic LE, Bowman ED, Zheng YL, Yu Z, Trivers G, Alberg AJ, Harris CC.
Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians.
Cancer Epidemiol. Biomarkers Prev. 18: 215-22, 2009.
[Journal]
87)  Zeng S, Xiang T, Pandita TK, Gonzalez-Suarez I, Gonzalo S, Harris CC, Yang Q.
Telomere recombination requires the MUS81 endonuclease.
Nat. Cell Biol. 11: 616-23, 2009.
[Journal]
88)  Binet R, Ythier D, Robles AI, Collado M, Larrieu D, Fonti C, Brambilla E, Brambilla C, Serrano M, Harris CC, Pedeux R.
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway.
Cancer Res. 69: 9183-91, 2009.
[Journal]
89)  Unoki M, Kumamoto K, Robles AI, Shen JC, Zheng ZM, Harris CC.
A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
FEBS Lett. 582: 3868-3874, 2008.
[Journal]
90)  Loeb LA, Harris CC.
Advances in chemical carcinogenesis: a historical review and prospective.
Cancer Res. 68: 6863-72, 2008.
[Journal]
91)  Ellis NA, Sander M, Harris CC, Bohr VA.
Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases.
Mech. Ageing Dev. 129: 681-91, 2008.
[Journal]
92)  Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P.
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
Cancer Epidemiol. Biomarkers Prev. 17: 3081-9, 2008.
[Journal]
93)  Vanmeter AJ, Rodriguez AS, Bowman ED, Harris CC, Deng J, Calvert VS, Silvestri A, Fredolini C, Chandhoke V, Petricoin EF, Liotta LA, Espina V.
LCM and protein microarray analysis of human NSCLC: Differential EGFR phosphorylation events associated with mutated EGFR compared to wild type.
Mol. Cell Proteomics. 2008.
[Journal]
94)  Martin RC, Barker DF, Doll MA, Pine SR, Mechanic L, Bowman ED, Harris CC, Hein DW.
Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population.
DNA Cell Biol. 27: 321-3, 2008.
[Journal]
95)  Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC.
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.
JAMA. 299: 425-36, 2008.
[Journal]
96)  Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, Gruys E, Laubach VE, Wiltrout RH, Harris CC.
Nitric oxide is a key component in inflammation-accelerated tumorigenesis.
Cancer Res. 68: 7130-6, 2008.
[Journal]
97)  Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E, Nagashima M, Takenoshita S, Yokota J, Harris CC.
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
Cancer Res. 68: 3193-203, 2008.
[Journal]
98)  Amr S, Wolpert B, Loffredo CA, Zheng YL, Shields PG, Jones R, Harris CC.
Occupation, Gender, Race, and Lung Cancer.
J. Occup. Environ. Med. 50: 1167-1175, 2008.
[Journal]
99)  Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V.
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.
Mol. Syst. Biol. 4: 229, 2008.
[Journal]
100)  Mechanic LE, Luke BT, Goodman JE, Chanock SJ, Harris CC.
Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.
BMC Bioinformatics. 9: 146, 2008.
[Journal]
101)  Sander M, Trump BF, Harris CC, Tennant RW.
The 20th Aspen Cancer Conference: Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention, and Cancer Therapy 2005.
Mol. Carcinog. 47: 707-32, 2008.
[Journal]
102)  Sander M, Trump BF, Harris CC.
The 23rd Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy 2008.
Mol. Carcinog. 2008.
[Journal]
103)  Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C, Paolocci N, Ambs S, Colton CA, Harris CC, Roberts DD, Wink DA.
The chemical biology of nitric oxide: Implications in cellular signaling.
Free Radic. Biol. Med. 45: 18-31, 2008.
[Journal]
104)  Wink DA, Ridnour LA, Hussain SP, Harris CC.
The reemergence of nitric oxide and cancer.
Nitric Oxide. 19: 65-7, 2008.
[Journal]
105)  Mechanic LE, Bowman ED, Welsh JA, Khan MA, Hagiwara N, Enewold L, Shields PG, Burdette L, Chanock S, Harris CC.
Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors.
Cancer Epidemiol. Biomarkers Prev. 16: 214-22, 2007.
[Journal]
106)  Yang Q, Zhang R, Horikawa I, Fujita K, Afshar Y, Kokko A, Laiho P, Aaltonen LA, Harris CC.
Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
Cancer Res. 67: 11677-86, 2007.
[Journal]
107)  Budhu A, Chen Y, Kim JW, Forgues M, Valerie K, Harris CC, Wang XW.
Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins.
Carcinogenesis. 28: 1552-60, 2007.
[Journal]
108)  Perwez Hussain S, Harris CC.
Inflammation and cancer: an ancient link with novel potentials.
Int. J. Cancer. 121: 2373-80, 2007.
[Journal]
109)  Shen JC, Unoki M, Ythier D, Duperray A, Varticovski L, Kumamoto K, Pedeux R, Harris CC.
Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.
Cancer Res. 67: 2552-8, 2007.
[Journal]
110)  Pine SR, Mechanic LE, Ambs S, Bowman ED, Chanock SJ, Loffredo C, Shields PG, Harris CC.
Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene.
J. Natl. Cancer Inst. 99: 1401-9, 2007.
[Journal]
111)  Sander M, Trump BF, Harris CC.
The twenty-first Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis, cancer prevention, and cancer therapy, 2006.
Mol. Carcinog. 46: 415-35, 2007.
[Journal]
112)  Sander M, Slaga TJ, Trump BF, Harris CC.
The twenty-second aspen cancer conference: Mechanisms of toxicity, carcinogenesis, cancer prevention, and cancer therapy, 2007.
Mol Carcinog. 2007.
[Journal]
113)  Hussain SP, Schwank J, Staib F, Wang XW, Harris CC.
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer.
Oncogene. 26: 2166-76, 2007.
[Journal]
114)  Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, Yokota J, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW, Harris CC.
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.
J. Natl. Cancer Inst. 99: 1257-69, 2007.
[Journal]
115)  Yoshikawa H, Matsubara K, Zhou X, Okamura S, Kubo T, Murase Y, Shikauchi Y, Esteller M, Herman JG, Wei Wang X, Harris CC.
WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer.
Mol. Biol. Cell. 18: 4292-303, 2007.
[Journal]
116)  Weston A, Harris CC.
Holland JF, Frei E, Bast R, Kufe D, Pollock R, Weichselbaum R, eds.
Chemical Carcinogenesis. In: Cancer Medicine, 7th Edition.
Ontario, Canada: B.C. Decker, Inc.; 2006. p. 1-13 [Book Chapter]
117)  Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM.
A microRNA expression signature of human solid tumors defines cancer gene targets.
Proc Natl Acad Sci U S A. 103: 2257-61, 2006.
[Journal]
118)  Okano T, Gemma A, Hosoya Y, Hosomi Y, Nara M, Kokubo Y, Yoshimura A, Shibuya M, Nagashima M, Harris CC, Kudoh S.
Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer.
Oncol Rep. 15: 545-9, 2006.
[Journal]
119)  Goodman JE, Mechanic LE, Luke BT, Ambs S, Chanock S, Harris CC.
Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.
Int J Cancer. 118: 1790-7, 2006.
[Journal]
120)  Pine SR, Mechanic LE, Bowman ED, Welsh JA, Chanock SC, Shields PG, Harris CC.
MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk.
Cancer Epidemiol. Biomarkers Prev. 15: 1559-61, 2006.
[Journal]
121)  Unoki M, Shen JC, Zheng ZM, Harris CC.
Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility.
J. Biol. Chem. 281: 34677-86, 2006.
[Journal]
122)  Hussain SP, Harris CC.
p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis.
J Nippon Med Sch. 73: 54-64, 2006.
[Journal]
123)  Harris CC.
Protein-protein interactions for cancer therapy.
Proc Natl Acad Sci U S A. 103: 1659-60, 2006.
[Journal]
124)  Hagiwara N, Mechanic LE, Trivers GE, Cawley HL, Taga M, Bowman ED, Kumamoto K, He P, Bernard M, Doja S, Miyashita M, Tajiri T, Sasajima K, Nomura T, Makino H, Takahashi K, Hussain SP, Harris CC.
Quantitative Detection of p53 Mutations in Plasma DNA from Tobacco Smokers.
Cancer Res. 66: 8309-17, 2006.
[Journal]
125)  Bonner MR, Bennett WP, Xiong W, Lan Q, Brownson RC, Harris CC, Field RW, Lubin JH, Alavanja MC.
Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women.
Int J Cancer. 119: 1462-7, 2006.
[Journal]
126)  Spillare EA, Wang XW, von Kobbe C, Bohr VA, Hickson ID, Harris CC.
Redundancy of DNA helicases in p53-mediated apoptosis.
Oncogene. 25: 2119-23, 2006.
[Journal]
127)  Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, Degraff W, Roberts DD, Mitchell JB, Wink DA.
Superoxide fluxes limit nitric oxide-induced signaling.
J Biol Chem. Epub ahead of print, 2006.
Full Text Article. [Journal]
128)  Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC.
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.
Cancer Cell. 9: 189-98, 2006.
[Journal]
129)  Ewart-Toland A, Dai Q, Gao YT, Nagase H, Dunlop MG, Farrington SM, Barnetson RA, Anton-Culver H, Peel D, Ziogas A, Lin D, Miao X, Sun T, Ostrander EA, Stanford JL, Langlois M, Chan JM, Yuan J, Harris CC, Bowman ED, Clayman GL, Lippman SM, Lee JJ, Zheng W, Balmain A.
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.
Carcinogenesis. 26: 1368-1373, 2005.
[Journal]
130)  Zhang R, Sengupta S, Yang Q, Linke SP, Yanaihara N, Bradsher J, Blais V, McGowan CH, Harris CC.
BLM helicase facilitates Mus81 endonuclease activity in human cells.
Cancer Res. 65: 2526-31, 2005.
[Journal]
131)  Ying L, Marino J, Hussain SP, Khan MA, You S, Hofseth AB, Trivers GE, Dixon DA, Harris CC, Hofseth LJ.
Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation.
Cancer Res. 65: 9132-6, 2005.
[Journal]
132)  Harris CC.
Editorial.
Carcinogenesis. 26: 261, 2005.
[Journal]
133)  Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, Onogi H, Kumamoto K, Wincovitch S, Garfield SH, McMenamin M, Nagashima M, Grossman SR, Appella E, Harris CC.
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.
Mol Cell Biol. 25: 6639-48, 2005.
[Journal]
134)  Zheng YL, Loffredo CA, Alberg AJ, Yu Z, Jones RT, Perlmutter D, Enewold L, Krasna MJ, Yung R, Shields PG, Harris CC.
Less efficient g2-m checkpoint is associated with an increased risk of lung cancer in African Americans.
Cancer Res. 65: 9566-73, 2005.
[Journal]
135)  Yang SH, Mechanic LE, Yang P, Landi MT, Bowman ED, Wampfler J, Meerzaman D, Hong KM, Mann F, Dracheva T, Fukuoka J, Travis W, Caporaso NE, Harris CC, Jen J.
Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer.
Clin Cancer Res. 11: 2106-10, 2005.
[Journal]
136)  Hofseth LJ, Robles AI, Espey MG, Harris CC.
Nitric oxide is a signaling molecule that regulates gene expression.
Methods Enzymol. 396: 326-40, 2005.
[Journal]
137)  Sommers JA, Sharma S, Doherty KM, Karmakar P, Yang Q, Kenny MK, Harris CC, Brosh RM.
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
Cancer Res. 65: 1223-33, 2005.
[Journal]
138)  Sengupta S, Harris CC.
p53: traffic cop at the crossroads of DNA repair and recombination.
Nat Rev Mol Cell Biol. 6: 44-55, 2005.
[Journal]
139)  Mechanic LE, Marrogi AJ, Welsh JA, Bowman ED, Khan MA, Enewold L, Zheng YL, Chanock S, Shields PG, Harris CC.
Polymorphisms in XPD and TP53 and mutation in human lung cancer.
Carcinogenesis. 26: 597-604, 2005.
[Journal]
140)  Yang Q, Zheng YL, Harris CC.
POT1 and TRF2 cooperate to maintain telomeric integrity.
Mol Cell Biol. 25: 1070-80, 2005.
[Journal]
141)  Burke L, Flieder DB, Guinee DG, Brambilla E, Freedman AN, Bennett WP, Jones RT, Borkowski A, Caporaso NA, Fleming M, Trastek V, Pairolero P, Tazelaar H, Midthun D, Jett JR, Liotta LA, Travis WD, Harris CC.
Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma.
Clin Cancer Res. 11: 232-41, 2005.
[Journal]
142)  Spillare EA, Wang XW, von Kobbe C, Bohr VA, Hickson ID, Harris CC.
Redundancy of DNA helicases in p53-mediated apoptosis.
Oncogene. 2005.
[Journal]
143)  Staib F, Robles AI, Varticovski L, Wang XW, Zeeberg BR, Sirotin M, Zhurkin VB, Hofseth LJ, Hussain SP, Weinstein JN, Galle PR, Harris CC.
The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.
Cancer Res. 65: 10255-64, 2005.
[Journal]
144)  Marrogi AJ, Mechanic LE, Welsh JA, Bowman ED, Khan MA, Enewold L, Shields PG, Harris CC.
TP53 mutation spectrum in lung cancer is not different in women and men.
Cancer Epidemiol Biomarkers Prev. 14: 1031-3, 2005.
[Journal]
145)  Milyavsky M, Tabach Y, Shats I, Erez N, Cohen Y, Tang X, Kalis M, Kogan I, Buganim Y, Goldfinger N, Ginsberg D, Harris CC, Domany E, Rotter V.
Transcriptional Programs following Genetic Alterations in p53, INK4A, and H-Ras Genes along Defined Stages of Malignant Transformation.
Cancer Res. 65: 4530-43, 2005.
[Journal]
146)  Sengupta S, Shimamoto A, Koshiji M, Pedeux R, Rusin M, Spillare EA, Shen JC, Huang LE, Lindor NM, Furuichi Y, Harris CC.
Tumor suppressor p53 represses transcription of RECQ4 helicase.
Oncogene. 24: 1738-48, 2005.
[Journal]
147)  Hofseth L, Sawa T, Hussain S, Harris C.
Kelloff G, Hawk E, Sigman C, eds.
Inducible nitric oxide synthase as a target for chemoprevention. In: Cancer Chemoprevention: Promising Cancer Chemopreventive Agents. Volume 1.
Totowa, NJ: The Humana Press; 2004. p. 133-151 [Book Chapter]
148)  Oliver M, Hussain SP, Caron de Fromentel C, Hainaut P, Harris CC.
Buffler P, Rice J, Baan R, Bird M, Boffetta P, eds.
TP53 Mutation Spectra and Load: A Tool for Generating Hypotheses on the Etiology of Cancer. In: Mechanisms of Carcinogenesis: Contributions of Molecular Epidemiology. Volume No. 157.
Lyon: IARC; 2004. p. 247-270 [Book Chapter]
149)  Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC, Wogan GN.
Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.
Cancer Res. 64: 3022-9, 2004.
[Journal]
150)  Goodman JE, Bowman ED, Chanock SJ, Alberg AJ, Harris CC.
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Carcinogenesis. 25: 2467-72, 2004.
[Journal]
151)  Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
J Cell Biol. 166: 801-13, 2004.
[Journal]
152)  Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, Wink DA.
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.
Proc Natl Acad Sci U S A. 101: 8894-9, 2004.
[Journal]
153)  He P, Varticovski L, Bowman ED, Fukuoka J, Welsh JA, Miura K, Jen J, Gabrielson E, Brambilla E, Travis WD, Harris CC.
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.
Hum Pathol. 35: 1196-209, 2004.
[Journal]
154)  Veigl M, Harris C.
Introduction to a special section: Impact of the environment on colon cancer.
Environ Mol Mutagen. 44: 1-2, 2004.
[Journal]
155)  Goodman JE, Hofseth LJ, Hussain SP, Harris CC.
Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease.
Environ Mol Mutagen. 44: 3-9, 2004.
[Journal]
156)  Hussain SP, Trivers GE, Hofseth LJ, He P, Shaikh I, Mechanic LE, Doja S, Jiang W, Subleski J, Shorts L, Haines D, Laubach VE, Wiltrout RH, Djurickovic D, Harris CC.
Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.
Cancer Res. 64: 6849-53, 2004.
[Journal]
157)  de Souza-Pinto NC, Harris CC, Bohr VA.
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria.
Oncogene. 23: 6559-6568, 2004.
[Journal]
158)  Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, Harris CC.
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.
Cancer Res. 64: 2350-6, 2004.
[Journal]
159)  Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci. 25: 177-81, 2004.
[Journal]
160)  Hofseth LJ, Robles AI, Yang Q, Wang XW, Hussain SP, Harris C.
p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.
Chest. 125: 83S-5S, 2004.
[Journal]
161)  Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC.
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
Oncogene. 23: 3749-56, 2004.
[Journal]
162)  Zurer I, Hofseth LJ, Cohen Y, Xu-Welliver M, Hussain SP, Harris CC, Rotter V.
The role of p53 in base excision repair following genotoxic stress.
Carcinogenesis. 25: 11-9, 2004.
[Journal]
163)  West KA, Linnoila IR, Belinsky SA, Harris CC, Dennis PA.
Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.
Cancer Res. 64: 446-51, 2004.
[Journal]
164)  Nagashima M, Shiseki M, Pedeux RM, Okamura S, Kitahama-Shiseki M, Miura K, Yokota J, Harris CC.
A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis.
Oncogene. 22: 343-350, 2003.
[Journal]
165)  Zheng YL, Loffredo CA, Yu Z, Jones RT, Krasna MJ, Alberg AJ, Yung R, Perlmutter D, Enewold L, Harris CC, Shields PG.
Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls.
Carcinogenesis. 24: 269-74, 2003.
[Journal]
166)  Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC.
BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.
EMBO J. 22: 1210-22, 2003.
[Journal]
167)  Weston A, Harris CC.
Chemical Carcinogenesis.
Cancer Medicine, 6th Edition. pp. 267-278, 2003.
[Journal]
168)  Elmore LW, Wang XW, Harris CC.
Hepatocellular Carcinoma.
Nature Encyclopedia of the Human Genome. 3: pp. 216-220, 2003.
[Journal]
169)  Kataoka H, Bonnefin P, Vieyra D, Feng X, Hara Y, Miura Y, Joh T, Nakabayashi H, Vaziri H, Harris CC, Riabowol K.
ING1 Represses Transcription by Direct DNA Binding and through Effects on p53.
Cancer Res. 63: 5785-92, 2003.
[Journal]
170)  Hofseth LJ, Hussain SP, Wogan GN, Harris CC.
Nitric oxide in cancer and chemoprevention1.
Free Radic Biol Med. 34: 955-68, 2003.
[Journal]
171)  Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, Harris CC.
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Proc Natl Acad Sci U S A. 100: 143-148, 2003.
[Journal]
172)  Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC.
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
Cancer Res. 63: 2373-8, 2003.
[Journal]
173)  Linke SP, Sengupta S, Khabie N, Jeffries BA, Buchhop S, Miska S, Henning W, Pedeux R, Wang XW, Hofseth LJ, Yang Q, Garfield SH, Stürzbecher HW, Harris CC.
p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.
Cancer Res. 63: 2596-605, 2003.
[Journal]
174)  Harris C.
Pathogenesis of Respiratory Diseases: New Solutions to Old Problems?.
Exp Lung Res. 29 Suppl 1: 3-92, 2003.
[Journal]
175)  Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, Meerson A, Tabach Y, Goldfinger N, Ginsberg D, Harris CC, Rotter V.
Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.
Cancer Res. 63: 7147-57, 2003.
[Journal]
176)  Hussain SP, Hofseth LJ, Harris CC.
Radical causes of cancer.
Nat Rev Cancer. 3: 276-85, 2003.
[Journal]
177)  West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA.
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
J Clin Invest. 111: 81-90, 2003.
[Journal]
178)  Araki Y, Okamura S, Hussain SP, Nagashima M, He P, Shiseki M, Miura K, Harris CC.
Regulation of cyclooxygenase-2 expression by the wnt and ras pathways.
Cancer Res. 63: 728-734, 2003.
[Journal]
179)  Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, Samson LD, Harris CC.
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.
J Clin Invest. 112: 1887-94, 2003.
[Journal]
180)  Harris CC.
The end game.
Toxicol. Pathol. 31: 144-5, 2003.
[Journal]
181)  Staib F, Hussain SP, Hofseth LJ, Wang XW, Harris CC.
TP53 and liver carcinogenesis.
Hum Mutat. 21: 201-16, 2003.
[Journal]
182)  Seker H, Rubbi C, Linke SP, Bowman ED, Garfield S, Hansen L, Borden KL, Milner J, Harris CC.
UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML.
Oncogene. 22: 1620-8, 2003.
[Journal]
183)  Gruber SB, Ellis NA, Scott KK, Almog R, Kolachana P, Bonner JD, Kirchhoff T, Tomsho LP, Nafa K, Pierce H, Low M, Satagopan J, Rennert H, Huang H, Greenson JK, Groden J, Rapaport B, Shia J, Johnson S, Gregersen PK, Harris CC, Boyd J, Rennert G, Offit K.
BLM heterozygosity and the risk of colorectal cancer.
Science. 297: 2013, 2002.
[Journal]
184)  Ming L, Thorgeirsson SS, Gail MH, Lu P, Harris CC, Wang N, Shao Y, Wu Z, Liu G, Wang X, Sun Z.
Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China.
Hepatology. 36: 1214-20, 2002.
[Journal]
185)  Zheng YL, Seker H, Butkiewicz D, Rusin M, Bowman ED, Hussain SP, Harris CC.
Gene-environment interactions in lung carcinogenesis: A brief review.
INIS Monographs. 23-38, 2002.
[Journal]
186)  Hofseth L, Hussain S, Wang X, Harris C.
Hepatocellular Cancer: Molecular biology and genetics.
Gastrointestinal Oncology: Principles and Practice. pp. 539-558, 2002.
[Journal]
187)  Elmore LW, Harris CC.
Hepatocellular Carcinoma.
The Genetics Basis of Human Cancer. 2nd Ed.: pp. 741-750, 2002.
[Journal]
188)  Lechner JF, Wang Y, Siddiq F, Fugaro JM, Wali A, Lonardo F, Willey JC, Harris CC, Pass HI.
Human lung cancer cells and tissues partially recapitulate the homeobox gene expression profile of embryonic lung.
Lung Cancer. 37: 41-7, 2002.
[Journal]
189)  Miura K, Bowman ED, Simon R, Peng AC, Robles AI, Jones RT, Katagiri T, He P, Mizukami H, Charboneau L, Kikuchi T, Liotta LA, Nakamura Y, Harris CC.
Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.
Cancer Res. 62: 3244-50, 2002.
[Journal]
190)  Wang XW, Hussain SP, Huo TI, Wu CG, Forgues M, Hofseth LJ, Brechot C, Harris CC.
Molecular pathogenesis of human hepatocellular carcinoma.
Toxicology. 181-182: 43-7, 2002.
[Journal]
191)  Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC, Hainaut P.
The IARC TP53 database: new online mutation analysis and recommendations to users.
Hum Mutat. 19: 607-14, 2002.
[Journal]
192)  Robles AI, Linke SP, Harris CC.
The p53 network in lung carcinogenesis.
Oncogene. 21: 6898-907, 2002.
[Journal]
193)  Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM, Karmakar P, Bohr VA, Harris CC.
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
J Biol Chem. 277: 31980-7, 2002.
[Journal]
194)  Harris CC.
Tumor suppressor genes: At the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment.
Cancer and the Environment: Gene-Environment Interaction. pp. 81-4, 2002.
[Journal]
195)  Nicholson SA, Okby NT, Khan MA, Welsh JA, McMenamin MG, Travis WD, Jett JR, Tazelaar HD, Trastek V, Pairolero PC, Corn PG, Herman JG, Liotta LA, Caporaso NE, Harris CC.
Alterations of p14ARF, p53, and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma.
Cancer Res. 61: 5636-43, 2001.
[Journal]
196)  Robles AI, Bemmels NA, Foraker AB, Harris CC.
APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.
Cancer Res. 61: 6660-4, 2001.
[Journal]
197)  Liu J, Akoulitchev S, Weber A, Ge H, Chuikov S, Libutti D, Wang XW, Conaway JW, Harris CC, Conaway RC, Reinberg D, Levens D.
Defective interplay of activators and repressors with TFIIH in xeroderma pigmentosum.
Cell. 104: 353-63, 2001.
[Journal]
198)  Minamoto T, Buschmann T, Habelhah H, Matusevich E, Tahara H, Boerresen-Dale AL, Harris C, Sidransky D, Ronai Z.
Distinct pattern of p53 phosphorylation in human tumors.
Oncogene. 20: 3341-7, 2001.
[Journal]
199)  Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC.
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.
Proc Natl Acad Sci U S A. 98: 9671-6, 2001.
[Journal]
200)  Wang XW, Tseng A, Ellis NA, Spillare EA, Linke SP, Robles AI, Seker H, Yang Q, Hu P, Beresten S, Bemmels NA, Garfield S, Harris CC.
Functional interaction of p53 and BLM DNA helicase in apoptosis.
J Biol Chem. 276: 32948-55, 2001.
[Journal]
201)  Seker H, Butkiewicz D, Bowman ED, Rusin M, Hedayati M, Grossman L, Harris CC.
Functional significance of XPD polymorphic variants: attenuated apoptosis in human lymphoblastoid cells with the XPD 312 Asp/Asp genotype.
Cancer Res. 61: 7430-4, 2001.
[Journal]
202)  Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX.
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.
Nat Genet. 28: 266-71, 2001.
[Journal]
203)  Huo TI, Wang XW, Forgues M, Wu CG, Spillare EA, Giannini C, Brechot C, Harris CC.
Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.
Oncogene. 20: 3620-8, 2001.
[Journal]
204)  Hussain SP, Amstad P, Raja K, Sawyer M, Hofseth L, Shields PG, Hewer A, Phillips DH, Ryberg D, Haugen A, Harris CC.
Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.
Cancer Res. 61: 6350-5, 2001.
[Journal]
205)  Vahakangas KH, Bennett WP, Castren K, Welsh JA, Khan MA, Blomeke B, Alavanja MC, Harris CC.
p53 and K-ras mutations in lung cancers from former and never-smoking women.
Cancer Res. 61: 4350-6, 2001.
[Journal]
206)  Brosh RM, Karmakar P, Sommers JA, Yang Q, Wang XW, Spillare EA, Harris CC, Bohr VA.
p53 Modulates the exonuclease activity of Werner syndrome protein.
J Biol Chem. 276: 35093-102, 2001.
[Journal]
207)  Robles AI, Harris CC.
p53-mediated apoptosis and genomic instability diseases.
Acta Oncol. 40: 696-701, 2001.
[Journal]
208)  Lechner JF, Fugaro JM, Wong Y, Pass HI, Harris CC, Belinsky SA.
Perspective: cell differentiation theory may advance early detection of and therapy for lung cancer.
Radiat Res. 155: 235-238, 2001.
[Journal]
209)  Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC, Herman JG.
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.
Nat Genet. 28: 29-35, 2001.
[Journal]
210)  Offer H, Milyavsky M, Erez N, Matas D, Zurer I, Harris CC, Rotter V.
Structural and functional involvement of p53 in BER in vitro and in vivo.
Oncogene. 20: 581-9, 2001.
[Journal]
211)  Harris CC.
Tobacco smoking and cancer risk in women.
J. Women's Cancer. 3: 1-4, 2001.
[Journal]
212)  Elmore L, Harris C.
Scriver C, Sly W, eds.
Hepatocellular carcinoma. In: The Metabolic and Molecular Bases of Inherited Disease. Volume 8th edition.
New York: McGraw-Hill Professional; 2000. p. 1157-66 [Book Chapter]
213)  Shields PG, Harris CC.
Cancer risk and low-penetrance susceptibility genes in gene-environment interactions.
J Clin Oncol. 18: 2309-15, 2000.
[Journal]
214)  Balmain A, Harris CC.
Carcinogenesis in mouse and human cells: parallels and paradoxes.
Carcinogenesis. 21: 371-7, 2000.
[Journal]
215)  Marrogi A, Pass HI, Khan M, Metheny-Barlow LJ, Harris CC, Gerwin BI.
Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor.
Cancer Res. 60: 3696-700, 2000.
[Journal]
216)  Butkiewicz D, Rusin M, Harris CC, Chorazy M.
Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population.
Hum Mutat. 15: 577-8, 2000.
[Journal]
217)  Hussain SP, Amstad P, Raja K, Ambs S, Nagashima M, Bennett WP, Shields PG, Ham AJ, Swenberg JA, Marrogi AJ, Harris CC.
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.
Cancer Res. 60: 3333-7, 2000.
[Journal]
218)  Hussain SP, Raja K, Amstad PA, Sawyer M, Trudel LJ, Wogan GN, Hofseth LJ, Shields PG, Billiar TR, Trautwein C, Hohler T, Galle PR, Phillips DH, Markin R, Marrogi AJ, Harris CC.
Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases.
Proc Natl Acad Sci U S A. 97: 12770-5, 2000.
[Journal]
219)  Zhou X, Espey MG, Chen JX, Hofseth LJ, Miranda KM, Hussain SP, Wink DA, Harris CC.
Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase.
J Biol Chem. 275: 21241-6, 2000.
[Journal]
220)  Marrogi AJ, Travis WD, Welsh JA, Khan MA, Rahim H, Tazelaar H, Pairolero P, Trastek V, Jett J, Caporaso NE, Liotta LA, Harris CC.
Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma.
Clin Cancer Res. 6: 4739-44, 2000.
[Journal]
221)  Hussain SP, Hollstein MH, Harris CC.
p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment.
Ann N Y Acad Sci. 919: 79-85, 2000.
[Journal]
222)  Gemma A, Seike M, Seike Y, Uematsu K, Hibino S, Kurimoto F, Yoshimura A, Shibuya M, Harris CC, Kudoh S.
Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer.
Genes Chromosomes Cancer. 29: 213-8, 2000.
[Journal]
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This page was last updated on 11/18/2013.