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Our Science – Keefer Website

Larry K. Keefer, Ph.D.

Selected Publications

1)  Holland RJ, Paulisch R, Cao Z, Keefer LK, Saavedra JE, Donzelli S.
Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using ß-galactosidase.
Nitric Oxide. 2013.
[Journal]
2)  Maciag AE, Holland RJ, Robert Cheng YS, Rodriguez LG, Saavedra JE, Anderson LM, Keefer LK.
Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.
Redox Biol. 1: 115-24, 2013.
[Journal]
3)  Biswas D, Holland RJ, Deschamps JR, Cao Z, Keefer LK, Saavedra JE.
O2-Functionalized Methylamine Diazeniumdiolates: Evidence for E<->Z Equilibration in an Acyclic System.
J. Org. Chem. 77: 10804-10, 2012.
[Journal]
4)  Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK.
Cross-Linking Protein Glutathionylation Mediated by O(2)-Arylated Bis-Diazeniumdiolate 'Double JS-K'.
Chem. Res. Toxicol. 25: 2670-7, 2012.
[Journal]
5)  Biswas D, Cao Z, Keefer LK, Saavedra JE.
Nitrous oxide as a primary product in base-mediated beta-elimination reactions of diazeniumdiolated benzylamine derivatives.
Chem Commun (Camb). 48: 5931-5933, 2012.
[Journal]
6)  Kaczmarek MZ, Holland RJ, Lavanier SA, Troxler JA, Fesenkova VI, Hanson CA, Cmarik JL, Saavedra JE, Keefer LK, Ruscetti SK.
Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells.
Leuk. Res. 2013.
[Journal]
7)  Maciag AE, Holland RJ, Kim Y, Kumari V, Luthers CE, Sehareen WS, Biswas D, Morris NL, Ji X, Anderson LM, Saavedra JE, Keefer LK.
Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells.
J. Med. Chem. 2014.
[Journal]
8)  Wang YN, Collins J, Holland RJ, Keefer LK, Ivanic J.
Decoding nitric oxide release rates of amine-based diazeniumdiolates.
J Phys Chem A. 117: 6671-7, 2013.
[Journal]
9)  Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A.
Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.
Nitric Oxide. 30C: 17-25, 2013.
[Journal]
10)  Fuhrman BJ, Pfeiffer RM, Wu AH, Xu X, Keefer LK, Veenstra TD, Ziegler RG.
Green tea intake is associated with urinary estrogen profiles in Japanese-American women.
Nutr J. 12: 25, 2013.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 3/5/2014.