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Our Science – Keefer Website

Larry K. Keefer, Ph.D.

Selected Publications

1)  Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra M, Dunams TM, Cebula TA, Koch WH, Andrews AW, Allen JS.
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors.
Science. 254: 1001-3, 1991.
2)  Maragos CM, Morley D, Wink DA, Dunams TM, Saavedra JE, Hoffman A, Bove AA, Isaac L, Hrabie JA, Keefer LK.
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.
J. Med. Chem. 34: 3242-7, 1991.
3)  Hrabie JA, Klose JR, Wink DA, Keefer LK.
New nitric oxide-releasing zwitterions derived from polyamines.
Journal of Organic Chemistry. 58: 1472-1476, 1993.
4)  Saavedra JE, Billiar TR, Williams DL, Kim YM, Watkins SC, Keefer LK.
Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver.
J. Med. Chem. 40: 1947-54, 1997.
5)  Keefer LK, Roller PP.
N-nitrosation by nitrite ion in neutral and basic medium.
Science. 181: 1245-7, 1973.
6)  Biswas D, Hrabie JA, Saavedra JE, Cao Z, Keefer LK, Ivanic J, Holland RJ.
Aminolysis of an N-Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia.
J. Org. Chem. [Epub ahead of print], 2014.
7)  Kaczmarek MZ, Holland RJ, Lavanier SA, Troxler JA, Fesenkova VI, Hanson CA, Cmarik JL, Saavedra JE, Keefer LK, Ruscetti SK.
Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells.
Leuk. Res. 38: 377-82, 2014.
8)  Maciag AE, Holland RJ, Kim Y, Kumari V, Luthers CE, Sehareen WS, Biswas D, Morris NL, Ji X, Anderson LM, Saavedra JE, Keefer LK.
Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells.
J. Med. Chem. 57: 2292-302, 2014.
9)  Wang YN, Collins J, Holland RJ, Keefer LK, Ivanic J.
Decoding nitric oxide release rates of amine-based diazeniumdiolates.
J Phys Chem A. 117: 6671-7, 2013.
10)  Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A.
Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.
Nitric Oxide. 30C: 17-25, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 6/11/2014.