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Our Science – Xia Website

Di Xia, Ph.D.

Selected Publications

1)  Tang W, Xia D.
Altered Inter-Subunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants.
J. Biol. Chem. 2013.
In Press. [Journal]
2)  Esser L, Yu C, Xia D.
Structural basis of resistance to anti-cytochome bc1 complex inhibitors: implication for drug improvement.
Current Pharmaceutical Design. 19, 2013.
In Press. [Journal]
3)  Yu C, Yu L, Xia D.
Ubiquinol-cytochrome c oxidoreductase (Complex III). In: Encyclopedia of Biophysics.
Berlin Heidelberg: Springer; 2013. p. 2679-2684 [Book Chapter]
4)  Xia D, Esser L, Tang W, Zhou F, Zhou Y, Yu L, Yu C.
Structural analysis of cytochrome bc(1) complexes: Implications to the mechanism of function.
Biochim. Biophys. Acta. 1827: 11-12, 2013.
[Journal]
5)  Bao R, Nair MK, Tang WK, Esser L, Sadhukhan A, Holland RL, Xia D, Schifferli DM.
Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis.
Proc. Natl. Acad. Sci. U.S.A. 110: 1065-70, 2013.
[Journal]
6)  Liu Y, Esser L, Interlandi G, Kisiela DI, Tchesnokova V, Thomas WE, Sokurenko E, Xia D, Savarino SJ.
Tight Conformational Coupling between the Domains of the Enterotoxigenic Escherichia coli Fimbrial Adhesin CfaE Regulates Binding State Transition.
J. Biol. Chem. 288: 9993-10001, 2013.
[Journal]
7)  Tang W, Xia D.
IBMPFD and p97, the structural and molecular basis for functional disruption. In: Neuromuscular Disorders.
New York: InTech; 2012. p. 155-174 [Book Chapter]
8)  Ma J, Tang WK, Esser L, Pastan I, Xia D.
Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68: 950-3, 2012.
[Journal]
9)  Bao R, Esser L, Sadhukhan A, Nair MK, Schifferli DM, Xia D.
Crystallization and preliminary X-ray diffraction analysis of PsaA, the adhesive pilin subunit that forms the pH 6 antigen on the surface of Yersinia pestis.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68: 1243-6, 2012.
[Journal]
10)  Mandal D, Moitra K, Ghosh D, Xia D, Dey S.
Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein.
Biochemistry. 51: 2852-66, 2012.
[Journal]
11)  Su T, Esser L, Xia D, Yu CA, Yu L.
Generation, characterization and crystallization of a cytochrome c(1)-subunit IV fused cytochrome bc(1) complex from Rhodobacter sphaeroides.
Biochim. Biophys. Acta. 1817: 298-305, 2012.
[Journal]
12)  Ma J, Tang WK, Esser L, Pastan I, Xia D.
Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights.
J. Biol. Chem. 287: 33123-31, 2012.
[Journal]
13)  Tang WK, Xia D.
Structural and functional deviations in disease-associated p97 mutants.
J. Struct. Biol. 179: 83-92, 2012.
[Journal]
14)  Esser L, Xia D.
CrysPage: A program for displaying images of crystallization trials, rapid comparisons and analysis.
J. Appl. Cryst. 44: 1130-1131, 2011.
[Journal]
15)  Rutledge RM, Esser L, Ma J, Xia D.
Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study.
J. Struct. Biol. 173: 333-44, 2011.
[Journal]
16)  Tang WK, Li D, Li CC, Esser L, Dai R, Guo L, Xia D.
A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.
EMBO J. 29: 2217-29, 2010.
[Journal]
17)  Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM.
Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance.
J. Cell. Physiol. 225: 822-8, 2010.
[Journal]
18)  Polgar O, Ierano C, Tamaki A, Stanley B, Ward Y, Xia D, Tarasova N, Robey RW, Bates SE.
Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.
Biochemistry. 49: 2235-45, 2010.
[Journal]
19)  Ananthaswamy N, Rutledge R, Sauna ZE, Ambudkar SV, Dine E, Nelson E, Xia D, Golin J.
The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.
Biochemistry. 49: 4440-9, 2010.
[Journal]
20)  Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE.
Arginine 383 is a crucial residue in ABCG2 biogenesis.
Biochim. Biophys. Acta. 1788: 1434-43, 2009.
[Journal]
21)  Yu L, Yang S, Yin Y, Cen X, Zhou F, Xia D, Yu CA.
Chapter 25 Analysis of electron transfer and superoxide generation in the cytochrome bc1 complex.
Meth. Enzymol. 456: 459-73, 2009.
[Journal]
22)  Li YF, Poole S, Rasulova F, McVeigh AL, Savarino SJ, Xia D.
Crystallization and preliminary X-ray diffraction analyses of several forms of the CfaB major subunit of enterotoxigenic Escherichia coli CFA/I fimbriae.
Acta Crystallogr Sect. F Struct Biol Cryst. Commun. 65: 242-7, 2009.
[Journal]
23)  Tang W, Li D, Esser L, Xia D.
Purification, crystallization and preliminary X-ray diffraction analysis of disease-related mutants of p97.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 65: 1166-70, 2009.
[Journal]
24)  Gottesman M, Ambudkar S, Xia D.
Structure of a multidrug transporter.
Nat Biotech. 27: 546-547, 2009.
[Journal]
25)  Li YF, Poole S, Nishio K, Jang K, Rasulova F, McVeigh A, Savarino SJ, Xia D, Bullitt E.
Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli.
Proc. Natl. Acad. Sci. U.S.A. 106: 10793-8, 2009.
[Journal]
26)  Esser L, Elberry M, Zhou F, Yu CA, Yu L, Xia D.
Inhibitor-complexed structures of the cytochrome bc1 from the photosynthetic bacterium Rhodobacter sphaeroides.
J. Biol. Chem. 283: 2846-57, 2008.
[Journal]
27)  Esser L, Yu L, Yu C, Xia D.
Insights into the Mechanisms of Quinol Oxidation in Cytochrome bc1 in Light of the Structure of Bacterial Complex.
Biohysical Review & Letters. 2: 229-257, 2008.
[Journal]
28)  Sauna ZE, Bohn SS, Rutledge R, Dougherty MP, Cronin S, May L, Xia D, Ambudkar SV, Golin J.
Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.
J. Biol. Chem. 283: 35010-22, 2008.
[Journal]
29)  Xia D, Esser L, Elberry M, Zhou F, yu L, Yu C.
The road to the crystal structure of the cytochrome bc1 complex from the anoxigenic photosynthetic bacterium Rhodobacter sphaeroides.
J Bioenerg Biomembr. 40: 485-92, 2008.
[Journal]
30)  Ma J, Xia D.
The use of blue native PAGE in the evaluation of membrane protein aggregation states for crystallization.
J. Appl. Crystallogr. 41: 1150-1160, 2008.
[Journal]
31)  Li YF, Poole S, Rasulova F, McVeigh AL, Savarino SJ, Xia D.
A receptor-binding site as revealed by the crystal structure of CfaE, the colonization factor antigen I fimbrial adhesin of enterotoxigenic Escherichia coli.
J. Biol. Chem. 282: 23970-80, 2007.
[Journal]
32)  Yu CA, Cen X, Ma HW, Yin Y, Yu L, Esser L, Xia D.
Domain conformational switch of the iron-sulfur protein in cytochrome bc1 complex is induced by the electron transfer from cytochrome bL to bH.
Biochim. Biophys. Acta. 1777: 1038-43, 2007.
[Journal]
33)  Xia D, Esser L, Yu L, Yu CA.
Structural basis for the mechanism of electron bifurcation at the quinol oxidation site of the cytochrome bc (1) complex.
Photosyn. Res. 92: 17-34, 2007.
[Journal]
34)  Li YF, Polgar O, Okada M, Esser L, Bates SE, Xia D.
Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study.
J. Mol. Graph. Model. 25: 837-51, 2007.
[Journal]
35)  Li YF, Poole S, Rasulova F, Esser L, Savarino SJ, Xia D.
Crystallization and preliminary X-ray diffraction analysis of CfaE, the adhesive subunit of the CFA/I fimbriae from human enterotoxigenic Escherichia coli.
Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 62: 121-4, 2006.
[Journal]
36)  Gottesman MM, Ludwig J, Xia D, Szakács G.
Defeating drug resistance in cancer.
Discov. Med. 6: 18-23, 2006.
[Journal]
37)  Elberry M, Xiao K, Esser L, Xia D, Yu L, Yu CA.
Generation, characterization and crystallization of a highly active and stable cytochrome bc1 complex mutant from Rhodobacter sphaeroides.
Biochim. Biophys. Acta. 1757: 835-40, 2006.
[Journal]
38)  Esser L, Gong X, Yang S, Yu L, Yu CA, Xia D.
Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex.
Proc. Natl. Acad. Sci. U.S.A. 103: 13045-50, 2006.
[Journal]
39)  Ambudkar SV, Kim IW, Xia D, Sauna ZE.
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.
FEBS Lett. 580: 1049-55, 2006.
[Journal]
40)  Kim IW, Peng XH, Sauna ZE, Fitzgerald PC, Xia D, Müller M, Nandigama K, Ambudkar SV.
The Conserved Tyrosine Residues 401 and 1044 in ATP Sites of Human P-Glycoprotein Are Critical for ATP Binding and Hydrolysis: Evidence for a Conserved Subdomain, the A-Loop in the ATP-Binding Cassette.
Biochemistry. 45: 7605-16, 2006.
[Journal]
41)  Gong X, Yu L, Xia D, Yu CA.
Evidence for electron equilibrium between the two hemes bL in the dimeric cytochrome bc1 complex.
J Biol Chem. 280: 9251-7, 2005.
[Journal]
42)  Gurung B, Yu L, Xia D, Yu CA.
The iron-sulfur cluster of the Rieske iron-sulfur protein functions as a proton-exiting gate in the cytochrome bc(1) complex.
J Biol Chem. 280: 24895-902, 2005.
[Journal]
43)  Xia D, Esser L, Singh SK, Guo F, Maurizi MR.
Crystallographic investigation of peptide binding sites in the N-domain of the ClpA chaperone.
J Struct Biol. 146: 166-79, 2004.
[Journal]
44)  Esser L, Quinn B, Li YF, Zhang M, Elberry M, Yu L, Yu CA, Xia D.
Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex.
J Mol Biol. 341: 281-302, 2004.
[Journal]
45)  Maurizi MR, Xia D.
Protein binding and disruption by Clp/Hsp100 chaperones.
Structure. 12: 175-83, 2004.
[Journal]
46)  Gao X, Wen X, Esser L, Quinn B, Yu L, Yu CA, Xia D.
Structural basis for the quinone reduction in the bc(1) complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc(1) with bound substrate and inhibitors at the Q(i) site.
Biochemistry. 42: 9067-80, 2003.
[Journal]
47)  Guo F, Maurizi MR, Esser L, Xia D.
Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease.
J Biol Chem. 277: 46743-52, 2002.
[Journal]
48)  Guo F, Esser L, Singh SK, Maurizi MR, Xia D.
Crystal structure of the heterodimeric complex of the adaptor, ClpS, with the N-domain of the AAA+ chaperone, ClpA.
J Biol Chem. 277: 46753-62, 2002.
[Journal]
49)  Gao X, Wen X, Yu C, Esser L, Tsao S, Quinn B, Zhang L, Yu L, Xia D.
The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition.
Biochemistry. 41: 11692-702, 2002.
[Journal]
50)  Kim H, Xia D, Yu CA, Xia JZ, Kachurin AM, Zhang L, Yu L, Deisenhofer J.
Inhibitor binding changes domain mobility in the iron-sulfur protein of teh mitochondrial bc1 complex from bovine heart.
Proc Natl Acad Sci USA. 95: 8026-8033, 1998.
[Journal]
51)  Xia D, Yu CA, Kim H, Xia JZ, Kachurin AM, Zhang L, Yu L, Deisenhofer J.
Crystal structure of the ctochrome bc1 complex from bovie heart mitochondria.
Science. 277: 60-66, 1997.
[Journal]
52)  Xia D, Henry LJ, Gerard RD, Deisenhofer J.
Crystal structure of teh receptor-binding domain of adenovirus type 5 fiber protein.
Structure. 2: 1259-1270, 1994.
[Journal]
53)  McKenna R, Xia D, Willingmann P, Ilag LL, Krishnaswamy S, Rossmann MG, Olson NH, Baker TS, Incardona NL.
Atomic structure of single-stranded DNA bacteriophage phiX174 and its functional implications.
Nature. 355: 137-143, 1992.
[Journal]
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This page was last updated on 11/8/2013.