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Our Science – Appella Website

Ettore Appella, M.D.

Selected Publications

1)  Horikawa I, Fujita K, Miller Jenkins L, Hiyoshi Y, Mondal A, Vojtesek B, Lane D, Appella E, Harris C.
Autophagic degradation of the inhibitory p53 isoform delta133p53alpha as a regulatory mechanism for p53-mediated senescence.
Nat. Commun. 2014.
In Press. [Journal]
2)  Sakai H, Fujigaki H, Mazur SJ, Appella E.
Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.
Cell Cycle. 13: 1015-29, 2014.
3)  Tanoue K, Miller Jenkins LM, Durell SR, Debnath S, Sakai H, Tagad HD, Ishida K, Appella E, Mazur SJ.
Binding of a Third Metal Ion by the Human Phosphatases PP2Ca and Wip1 Is Required for Phosphatase Activity.
Biochemistry. 52: 5830-43, 2013.
4)  Dudgeon C, Shreeram S, Tanoue K, Mazur SJ, Sayadi A, Robinson RC, Appella E, Bulavin DV.
Genetic variants and mutations of PPM1D control the response to DNA damage.
Cell Cycle. 12: 2656-64, 2013.
5)  Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.
Multipoint binding of the SLP-76 SH2 domain to ADAP is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T cells.
Mol. Cell. Biol. 33: 4140-51, 2013.
6)  Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.
J. Clin. Invest. 123: 5247-57, 2013.
7)  Castoria G, Giovannelli P, Di Donato M, Hayashi R, Arra C, Appella E, Auricchio F, Migliaccio A.
Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells.
PLoS ONE. 8: e76899, 2013.
8)  Lu X, Mazur SJ, Lin T, Appella E, Xu Y.
The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.
Oncogene. [Epub ahead of print], 2013.
9)  Jenkins LM, Durell SR, Mazur SJ, Appella E.
p53 N-terminal phosphorylation: a defining layer of complex regulation.
Carcinogenesis. 33: 1441-9, 2012.
10)  Migliaccio A, Castoria G, de Falco A, Bilancio A, Giovannelli P, Di Donato M, Marino I, Yamaguchi H, Appella E, Auricchio F.
Polyproline and Tat transduction peptides in the study of the rapid actions of steroid receptors.
Steroids. 77: 974-8, 2012.
Click Here to View Expanded Bibliography.

This page was last updated on 8/5/2014.