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Suresh V. Ambudkar, Ph.D.

Selected Publications

1)  Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I.
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.
Proc. Natl. Acad. Sci. U.S.A. 89: 8472-6, 1992.
2)  Ambudkar SV, Cardarelli CO, Pashinsky I, Stein WD.
Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein.
J. Biol. Chem. 272: 21160-6, 1997.
3)  Sauna ZE, Ambudkar SV.
Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.
Proc Natl Acad Sci U S A. 97: 2515-20, 2000.
4)  Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, Durell SR, Ambudkar SV.
Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
PLoS ONE. 8: e82463, 2013.
5)  Shukla S, Chufan EE, Singh S, Skoumbourdis AP, Kapoor K, Boxer MB, Duveau DY, Thomas CJ, Talele TT, Ambudkar SV.
Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.
Leukemia. 28: 961-4, 2014.
6)  Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, Ambudkar SV, Talele TT.
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.
J. Med. Chem. 57: 4058-72, 2014.
7)  Wang D, Patel A, Shukla S, Zhang Y, Wang Y, Kathawala RJ, Robey RW, Zhang L, Yang D, Talele TT, Bates SE, Ambudkar SV, Xu R, Chen Z.
Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.
Oncotarget. 5: 4529-4542, 2014.
8)  Shukla S, Kouanda A, Silverton L, Talele TT, Ambudkar SV.
Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure-Activity Relationship Approach.
Mol. Pharm. 2014.
9)  Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, Unadkat JD.
Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.
Drug Metab. Dispos. 42: 78-88, 2014.
10)  Kapoor K, Bhatnagar J, Chufan EE, Ambudkar SV.
Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp70.
J. Biol. Chem. 288: 32622-36, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 7/10/2014.