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Our Science – Gottesman Website

Michael M. Gottesman, M.D.

Selected Publications

1)  Cabral F, Sobel ME, Gottesman MM.
CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin.
Cell. 20: 29-36, 1980.
2)  Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM.
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.
Science. 232: 643-5, 1986.
3)  Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB.
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
Cell. 47: 381-9, 1986.
4)  Thorgeirsson SS, Huber BE, Sorrell S, Fojo A, Pastan I, Gottesman MM.
Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.
Science. 236: 1120-2, 1987.
5)  Kimchi-Sarfaty C, Oh JM, Kim I, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM.
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Science. 315: 525-8, 2007.
6)  Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM.
Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-Resistant Cells to Tiopronin.
J. Biol. Chem. 2014.
7)  Fung KL, Pan J, Ohnuma S, Lund PE, Pixley JN, Kimchi-Sarfaty C, Ambudkar SV, Gottesman MM.
MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer.
Cancer Res. 74: 598-608, 2014.
8)  Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, Goldlust IS, Hoeschele JD, Gottesman MM.
Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin and Other Platinum Complexes.
Cancer Res. 2014.
9)  Salem GH, Dennis JU, Krynitsky J, Garmendia-Cedillos M, Swaroop K, Malley JD, Pajevic S, Abuhatzira L, Bustin M, Gillet J, Gottesman MM, Mitchell JB, Pohida TJ.
SCORHE: A novel and practical approach to video monitoring of laboratory mice housed in vivarium cage racks.
Behav Res Methods. [Epub ahead of print], 2014.
10)  Lavi O, Greene JM, Levy D, Gottesman MM.
Simplifying the complexity of resistance heterogeneity in metastasis.
Trends Mol Med. 20: 129-136, 2014.
Click Here to View Expanded Bibliography.

This page was last updated on 6/23/2014.