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Our Science – Neckers Website

Leonard M. Neckers, Ph.D.

Selected Publications

1)  Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM.
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
Proc. Natl. Acad. Sci. U.S.A. 91: 8324-8, 1994.
2)  Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L.
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu.
Proc Natl Acad Sci U S A. 99: 12847-52, 2002.
3)  Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung Y, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L.
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.
Cancer Cell. 8: 143-53, 2005.
4)  Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee M, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
Englerin A stimulates PKCtheta to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.
Cancer Cell. 23: 228-37, 2013.
5)  Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L.
Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.
Mol. Cell. 53: 317-29, 2014.
6)  Wang Y, Xu W, Zhou D, Neckers L, Chen S.
Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex.
J. Biol. Chem. 289: 4815-26, 2014.
7)  Rasola A, Neckers L, Picard D.
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells.
Trends Cell Biol. [Epub ahead of print], 2014.
8)  Khiati S, Dalla Rosa I, Sourbier C, Ma X, Rao VA, Neckers LM, Zhang H, Pommier Y.
Mitochondrial topoisomerase I (Top1mt) is a novel limiting factor of doxorubicin cardiotoxicity.
Clin. Cancer Res. [Epub ahead of print], 2014.
9)  Neckers L, Trepel JB.
Stressing the development of small molecules targeting HSP90.
Clin. Cancer Res. 20: 275-7, 2014.
10)  Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M.
Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.
Future Med Chem. 5: 1059-71, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 6/30/2014.