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Our Science – Wiltrout Website

Robert H. Wiltrout, Ph.D.

Selected Publications

1)  Weiss JM, Back TC, Scarzello AJ, Subleski JJ, Hall VL, Stauffer JK, Chen X, Micic D, Alderson K, Murphy WJ, Wiltrout RH.
Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment.
Proc. Natl. Acad. Sci. U.S.A. 106: 19455-60, 2009.
2)  Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
J. Exp. Med. 207: 2455-67, 2010.
3)  Stauffer JK, Scarzello AJ, Andersen JB, De Kluyver RL, Back TC, Weiss JM, Thorgeirsson SS, Wiltrout RH.
Coactivation of AKT and beta-catenin in mice rapidly induces formation of lipogenic liver tumors.
Cancer Res. 71: 2718-27, 2011.
4)  Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song N, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong K, Young HA, Trinchieri G, Wiltrout RH, Hu Y.
The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas.
Cancer Cell. 23: 527-40, 2013.
5)  Weiss JM, Subleski JJ, Back T, Chen X, Watkins SK, Yagita H, Sayers TJ, Murphy WJ, Wiltrout RH.
Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/alphaCD40 therapy.
J. Immunol. 192: 5821-29, 2014.
6)  Weiss JM, Gregory Alvord W, Quiñones OA, Stauffer JK, Wiltrout RH.
CD40 expression in renal cell carcinoma is associated with tumor apoptosis, CD8(+) T cell frequency and patient survival.
Hum. Immunol. 75: 614-20, 2014.
7)  Ortaldo JR, Wiltrout RH, Reynolds CW.
Natural killer activity: early days, advances, and seminal observations.
Crit Rev Oncog. 19: 1-13, 2014.
8)  Bouchlaka MN, Sckisel GD, Chen M, Mirsoian A, Zamora AE, Maverakis E, Wilkins DE, Alderson KL, Hsiao HH, Weiss JM, Monjazeb AM, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Redelman D, Taub DD, Murphy WJ.
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
J. Exp. Med. 210: 2223-37, 2013.
9)  Jiang Q, Weiss JM, Wiltrout RH.
A matched couple: Combining kinase inhibitors with immunotherapy for cancer treatment.
Oncoimmunology. 1: 115-117, 2012.
10)  Stauffer JK, Scarzello AJ, Jiang Q, Wiltrout RH.
Chronic inflammation, immune escape and oncogenesis in the liver: A unique neighborhood for novel intersections.
Hepatology. 56: 1567-74, 2012.
Click Here to View Expanded Bibliography.

This page was last updated on 7/14/2014.