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Our Science – Sayers Website

Thomas J. Sayers, Ph.D.

Selected Publications

1)  Sayers K, Brooks A, Sayers T, Chertov O.
Increased Secretory Leukocyte Protease Inhibitor (SLPI) Production by Highly Metastatic Mouse Breast Cancer Cells.
PLOS One. 2014.
In Press. [Journal]
2)  Weiss JM, Subleski JJ, Back T, Chen X, Watkins SK, Yagita H, Sayers TJ, Murphy WJ, Wiltrout RH.
Regulatory T Cells and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Undergo Fas-Dependent Cell Death during IL-2/aCD40 Therapy.
J. Immunol. [Epub ahead of print], 2014.
3)  Mathews LA, Keller JM, Goodwin BL, Guha R, Shinn P, Mull R, Thomas CJ, de Kluyver RL, Sayers TJ, Ferrer M.
A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.
J Biomol Screen. 17: 1231-42, 2012.
4)  Henrich CJ, Thomas CL, Brooks AD, Booth NL, Lowery EM, Pompei RJ, McMahon JB, Sayers TJ.
Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.
Apoptosis. 17: 79-89, 2012.
5)  Malyguine AM, Strobl S, Dunham K, Shurin MR, Sayers TJ.
ELISPOT Assay for Monitoring Cytotoxic T Lymphocytes (CTL) Activity in Cancer Vaccine Clinical Trials.
Cells. 1: 111-26, 2012.
6)  Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC.
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
J. Nat. Prod. 75: 394-9, 2012.
7)  Sayers TJ.
Targeting the extrinsic apoptosis signaling pathway for cancer therapy.
Cancer Immunol. Immunother. 60: 1173-80, 2011.
8)  Seki N, Toh U, Sayers TJ, Fujii T, Miyagi M, Akagi Y, Kusukawa J, Kage M, Shirouzu K, Yamana H.
Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways.
Mol. Cancer Ther. 9: 1842-51, 2010.
9)  Brooks AD, Jacobsen KM, Li W, Shanker A, Sayers TJ.
Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.
Mol. Cancer Res. 8: 729-38, 2010.
10)  de Kluyver RL, Sayers TJ.
Breast cancer bone metastases: Combination therapy targeting cancer cells and the tumor microenvironment.
Cancer Biol Ther. 9: 551-3, 2010.
Click Here to View Expanded Bibliography.

This page was last updated on 8/4/2014.