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Our Science – McVicar Website

Daniel W. McVicar, Ph.D.

Selected Publications

1)  Sen SK, Boelte KC, Barb JJ, Joehanes R, Zhao X, Cheng Q, Adams L, Teer JK, Accame DS, Chowdhury S, Singh LN, Kavousi M, Peyser PA, Quigley L, Priel DL, Lau K, Kuhns DB, Yoshimura T, Johnson AD, Hwang SJ, Chen MY, Arai AE, Green ED, Mullikin JC, Kolodgie FD, O'Donnell CJ, Virmani R, Munson PJ, McVicar DW, Biesecker LG.
Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.
Am. J. Hum. Genet. 95: 66-76, 2014.
[Journal]
2)  O'Connor GM, Vivian JP, Widjaja JM, Bridgeman JS, Gostick E, Lafont BA, Anderson SK, Price DA, Brooks AG, Rossjohn J, McVicar DW.
Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity.
J. Immunol. 192: 2875-84, 2014.
[Journal]
3)  Montalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.
Environmental Factors Determine DAP12 Deficiency To Either Enhance or Suppress Immunopathogenic Processes.
Immunology. 2013.
[Journal]
4)  Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW.
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-? production by repressing ß-catenin activation in dendritic cells.
PLoS Pathog. 9: e1003357, 2013.
[Journal]
5)  O'Connor GM, Basatena NS, Olavarria V, Macnamara A, Vine A, Ying Q, Hisada M, Galvão-Castro B, Asquith B, McVicar DW.
In Contrast to HIV, KIR3DS1 Does Not Influence Outcome In HTLV-1 Retroviral Infection.
Hum. Immunol. 73: 783-7, 2012.
[Journal]
6)  Derive M, Bouazza Y, Sennoun N, Marchionni S, Quigley L, Washington V, Massin F, Max JP, Ford J, Alauzet C, Levy B, McVicar DW, Gibot S.
Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis.
J. Immunol. 188: 5585-92, 2012.
[Journal]
7)  O'Connor GM, Yamada E, Rampersaud A, Thomas R, Carrington M, McVicar DW.
Analysis of Binding of KIR3DS1*014 to HLA Suggests Distinct Evolutionary History of KIR3DS1.
J. Immunol. 187: 2162-71, 2011.
[Journal]
8)  Fadda L, O'Connor GM, Kumar S, Piechocka-Trocha A, Gardiner CM, Carrington M, McVicar DW, Altfeld M.
Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules.
J. Virol. 85: 5970-4, 2011.
[Journal]
9)  Vivian JP, Duncan RC, Berry R, O'Connor GM, Reid HH, Beddoe T, Gras S, Saunders PM, Olshina MA, Widjaja JM, Harpur CM, Lin J, Maloveste SM, Price DA, Lafont BA, McVicar DW, Clements CS, Brooks AG, Rossjohn J.
Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.
Nature. 479: 401-5, 2011.
[Journal]
10)  Orr SJ, Roessler S, Quigley L, Chan T, Ford JW, O'Connor GM, McVicar DW.
Implications for gene therapy-limiting expression of IL-2Rgammac delineate differences in signaling thresholds required for lymphocyte development and maintenance.
J. Immunol. 185: 1393-403, 2010.
[Journal]
11)  Orr SJ, McVicar DW.
LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?.
J. Leukoc. Biol. 89: 11-9, 2010.
[Journal]
12)  Whittaker GC, Orr SJ, Quigley L, Hughes L, Francischetti IM, Zhang W, McVicar DW.
The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
J. Biol. Chem. 285: 2976-85, 2010.
[Journal]
13)  Smrz D, Iwaki S, McVicar DW, Metcalfe DD, Gilfillan AM.
TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release.
Eur. J. Immunol. 40: 3557-69, 2010.
[Journal]
14)  Ranatunga D, Hedrich CM, Wang F, McVicar DW, Nowak N, Joshi T, Feigenbaum L, Grant LR, Stäger S, Bream JH.
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
Proc. Natl. Acad. Sci. U.S.A. 106: 17123-8, 2009.
[Journal]
15)  McVicar DW, Trinchieri G.
CSF-1R, DAP12 and beta-catenin: a menage a trois.
Nat. Immunol. 10: 681-3, 2009.
[Journal]
16)  Thomas R, Apps R, Qi Y, Gao X, Male V, O'hUigin C, O'Connor G, Ge D, Fellay J, Martin JN, Margolick J, Goedert JJ, Buchbinder S, Kirk GD, Martin MP, Telenti A, Deeks SG, Walker BD, Goldstein D, McVicar DW, Moffett A, Carrington M.
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
Nat. Genet. 41: 1290-4, 2009.
[Journal]
17)  Orr SJ, Quigley L, McVicar DW.
In vivo expression of signaling proteins in reconstituted NK cells.
J. Immunol. Methods. 340: 158-63, 2009.
[Journal]
18)  Ford JW, McVicar DW.
TREM and TREM-like receptors in inflammation and disease.
Curr. Opin. Immunol. 21: 38-46, 2009.
[Journal]
19)  Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW.
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.
J. Clin. Invest. 119: 1489-501, 2009.
[Journal]
20)  Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK.
Visualization and identification of IL-7 producing cells in reporter mice.
PLoS ONE. 4: e7637, 2009.
[Journal]
21)  Gómez-Rodríguez J, Washington V, Cheng J, Dutra A, Pak E, Liu P, McVicar DW, Schwartzberg PL.
Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs.
Nucleic Acids Res. 36: e117, 2008.
[Journal]
22)  Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW.
Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Blood. 112: 2869-77, 2008.
[Journal]
23)  Thomas R, Yamada E, Alter G, Martin MP, Bashirova AA, Norman PJ, Altfeld M, Parham P, Anderson SK, McVicar DW, Carrington M.
Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?.
J. Immunol. 180: 6743-50, 2008.
[Journal]
24)  Yamada E, McVicar DW.
Paired receptor systems of the innate immune system.
Curr. Protoc. Immunol. Chapter 1: Appendix 1X, 2008.
[Journal]
25)  Nurden AT, Nurden P, Bermejo E, Combrié R, McVicar DW, Washington AV.
Phenotypic heterogeneity in the gray platelet syndrome extends to the expression of TREM family member, TLT-1.
Thromb. Haemost. 100: 45-51, 2008.
[Journal]
26)  Tai LH, Goulet ML, Belanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, Makrigiannis AP.
Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
J. Exp. Med. 205: 3187-99, 2008.
[Journal]
27)  McVicar DW.
Rafting with the IL-12 receptor.
Blood. 111: 3911-2, 2008.
[Journal]
28)  Orr SJ, Morgan NM, Elliott J, Burrows JF, Scott CJ, McVicar DW, Johnston JA.
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.
Blood. 109: 1061-8, 2007.
[Journal]
29)  Thananchai H, Gillespie G, Martin MP, Bashirova A, Yawata N, Yawata M, Easterbrook P, McVicar DW, Maenaka K, Parham P, Carrington M, Dong T, Rowland-Jones S.
Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.
J. Immunol. 178: 33-7, 2007.
[Journal]
30)  Pascal V, Yamada E, Martin MP, Alter G, Altfeld M, Metcalf JA, Baseler MW, Adelsberger JW, Carrington M, Anderson SK, McVicar DW.
Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection.
J. Immunol. 179: 1625-33, 2007.
[Journal]
31)  Giomarelli B, Washington VA, Chisholm MM, Quigley L, McMahon JB, Mori T, McVicar DW.
Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.
Thromb. Haemost. 97: 955-63, 2007.
[Journal]
32)  Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, O'Brien SJ, Walker BD, Parham P, Deeks SG, McVicar DW, Carrington M.
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
Nat. Genet. 39: 733-40, 2007.
[Journal]
33)  Gillespie GM, Bashirova A, Dong T, McVicar DW, Rowland-Jones SL, Carrington M.
Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8+ T cell epitopes.
AIDS Res. Hum. Retroviruses. 23: 451-5, 2007.
[Journal]
34)  Mason LH, Willette-Brown J, Taylor LS, McVicar DW.
Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
J. Immunol. 176: 6615-23, 2006.
[Journal]
35)  Bashirova AA, Martin MP, McVicar DW, Carrington M.
The Killer Immunoglobulin-Like Receptor Gene Cluster: Tuning the Genome for Defense (*).
Annu Rev Genomics Hum Genet. 7: 277-300, 2006.
[Journal]
36)  Gattis JL, Washington AV, Chisholm MM, Quigley L, Szyk A, McVicar DW, Lubkowski J.
The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.
J. Biol. Chem. 281: 13396-403, 2006.
[Journal]
37)  Hiremath MM, Mikhael AI, Taylor LS, Musso T, McVicar DW.
Complex regulation of the Csk homologous kinase (Chk) by IL-4 family cytokines and IFN-γ in human peripheral blood monocytes.
Mol Immunol. 41: 901-10, 2004.
[Journal]
38)  Washington AV, McVicar DW.
Receptors involved in the regulation of murine NK cells.
Curr. Protoc. Immunol. Appendix 1: Appendix 1R, 2004.
[Journal]
39)  Washington AV, Schubert RL, Quigley L, Disipio T, Feltz R, Cho EH, McVicar DW.
TREM Family Member, TLT-1, Is Found Exclusively in the Alpha Granules of Megakaryocytes and Platelets.
Blood. 41: 901-10, 2004.
[Journal]
40)  McFarland HI, Hansal SA, Morris DI, McVicar DW, Love PE, Rosenberg AS.
Signaling through MHC in transgenic mice generates a population of memory phenotype cytolytic cells that lack TCR.
Blood. 101: 4520-8, 2003.
[Journal]
41)  Haan S, Ferguson P, Sommer U, Hiremath M, McVicar DW, Heinrich PC, Johnston JA, Cacalano NA.
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
J Biol Chem. 278: 31972-9, 2003.
[Journal]
42)  Makrigiannis AP, Pau AT, Schwartzberg PL, McVicar DW, Beck TW, Anderson SK.
A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice.
Genomics. 79: 437-44, 2002.
[Journal]
43)  McVicar DW, Winkler-Pickett R, Taylor LS, Makrigiannis A, Bennett M, Anderson SK, Ortaldo JR.
Aberrant DAP12 signaling in the 129 strain of mice: implications for the analysis of gene-targeted mice.
J Immunol. 169: 1721-8, 2002.
[Journal]
44)  Washington AV, Quigley L, McVicar DW.
Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. Triggering receptors expressed on myeloid cells.
Blood. 100: 3822-4, 2002.
[Journal]
45)  Washington AV, McVicar DW.
Receptors involved in the regulation of murine NK cells.
Current Protocol in Immunology. A.1R.1-A.1R.8, 2002.
[Journal]
46)  McVicar DW, Burshtyn DN.
Intracellular signaling by the killer immunoglobulin-like receptors and Ly49.
Sci STKE. 2001: RE1, 2001.
[Journal]
47)  Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL.
Mutation of Tec family kinases alters T helper cell differentiation.
Nat Immunol. 2: 1183-8, 2001.
[Journal]
48)  Anderson SK, Ortaldo JR, McVicar DW.
The ever-expanding Ly49 gene family: repertoire and signaling.
Immunol Rev. 181: 79-89, 2001.
[Journal]
49)  Mason LH, Willette-Brown J, Mason AT, McVicar D, Ortaldo JR.
Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion.
J Immunol. 164: 603-11, 2000.
[Journal]
50)  Paul SP, Taylor LS, Stansbury EK, McVicar DW.
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
Blood. 96: 483-90, 2000.
[Journal]
51)  Taylor LS, Paul SP, McVicar DW.
Paired inhibitory and activating receptor signals.
Rev Immunogenet. 2: 204-19, 2000.
[Journal]
52)  Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, Biron CA, Sher A, Vande Woude GF.
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proc Natl Acad Sci U S A. 97: 751-5, 2000.
[Journal]
53)  Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL.
Tec family kinases modulate thresholds for thymocyte development and selection.
J Exp Med. 192: 987-1000, 2000.
[Journal]
54)  Makrigiannis AP, Gosselin P, Mason LH, Taylor LS, McVicar DW, Ortaldo JR, Anderson SK.
Cloning and characterization of a novel activating Ly49 closely related to Ly49A.
J. Immunol. 163: 4931-8, 1999.
[Journal]
55)  Taylor LS, McVicar DW.
Functional association of FcepsilonRIgamma with arginine(632) of paired immunoglobulin-like receptor (PIR)-A3 in murine macrophages.
Blood. 94: 1790-6, 1999.
[Journal]
56)  Gosselin P, Mason LH, Willette-Brown J, Ortaldo JR, McVicar DW, Anderson SK.
Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H.
J. Leukoc. Biol. 66: 165-71, 1999.
[Journal]
57)  Ortaldo JR, Winkler-Pickett R, Willette-Brown J, Wange RL, Anderson SK, Palumbo GJ, Mason LH, McVicar DW.
Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors.
J. Immunol. 163: 5269-77, 1999.
[Journal]
58)  Grgurevich S, Mikhael A, McVicar DW.
The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells.
Biochem. Biophys. Res. Commun. 256: 668-75, 1999.
[Journal]
59)  Mason LH, Willette-Brown J, Anderson SK, Gosselin P, Shores EW, Love PE, Ortaldo JR, McVicar DW.
Characterization of an associated 16-kDa tyrosine phosphoprotein required for Ly-49D signal transduction.
J. Immunol. 160: 4148-52, 1998.
[Journal]
60)  McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH.
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase.
J. Biol. Chem. 273: 32934-42, 1998.
[Journal]
61)  Mason LH, Gosselin P, Anderson SK, Fogler WE, Ortaldo JR, McVicar DW.
Differential tyrosine phosphorylation of inhibitory versus activating Ly-49 receptor proteins and their recruitment of SHP-1 phosphatase.
J. Immunol. 159: 4187-96, 1997.
[Journal]
62)  Grgurevich S, Linnekin D, Musso T, Zhang X, Modi W, Varesio L, Ruscetti FW, Ortaldo JR, McVicar DW.
The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e.
Growth Factors. 14: 103-15, 1997.
[Journal]
63)  Sayers TJ, Lloyd AR, McVicar DW, O'Connor MD, Kelly JM, Carter CR, Wiltrout TA, Wiltrout RH, Smyth MJ.
Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3.
J. Leukoc. Biol. 59: 763-8, 1996.
[Journal]
64)  McVicar DW, Blake TB, Burns CM, Conlon KC, Ortaldo JR, O'Shea JJ.
Differential basal protein tyrosine phosphorylation in natural killer (NK) and T cells: a biochemical correlate of lymphoid functional activity.
Cell. Immunol. 169: 302-8, 1996.
[Journal]
65)  Ortaldo JR, Mason AT, Longo DL, Beckwith M, Creekmore SP, McVicar DW.
T cell activation via the disialoganglioside GD3: analysis of signal transduction.
J. Leukoc. Biol. 60: 533-9, 1996.
[Journal]
66)  Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA.
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
J. Exp. Med. 181: 399-404, 1995.
[Journal]
67)  Xu LL, McVicar DW, Ben-Baruch A, Kuhns DB, Johnston J, Oppenheim JJ, Wang JM.
Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors: binding and signaling of MCP3 through shared as well as unique receptors on monocytes and neutrophils.
Eur. J. Immunol. 25: 2612-7, 1995.
[Journal]
68)  Tortolani PJ, Lal BK, Riva A, Johnston JA, Chen YQ, Reaman GH, Beckwith M, Longo D, Ortaldo JR, Bhatia K, McGrath I, Kehrl J, Tuscano J, McVicar DW, O'Shea JJ.
Regulation of JAK3 expression and activation in human B cells and B cell malignancies.
J. Immunol. 155: 5220-6, 1995.
[Journal]
69)  Musso T, Johnston JA, Linnekin D, Varesio L, Rowe TK, O'Shea JJ, McVicar DW.
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7.
J. Exp. Med. 181: 1425-31, 1995.
[Journal]
70)  Mason AT, McVicar DW, Smith CA, Young HA, Ware CF, Ortaldo JR.
Regulation of NK cells through the 80-kDa TNFR (CD120b).
J. Leukoc. Biol. 58: 249-55, 1995.
[Journal]
71)  Tortolani PJ, Johnston JA, Bacon CM, McVicar DW, Shimosaka A, Linnekin D, Longo DL, O'Shea JJ.
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Blood. 85: 3444-51, 1995.
[Journal]
72)  McVicar DW, Mason AT, Bere EW, Ortaldo JR.
Activation of peripheral large granular lymphocytes with the serine/threonine phosphatase inhibitor, okadaic acid.
Eur. J. Immunol. 24: 165-70, 1994.
[Journal]
73)  Musso T, Varesio L, Zhang X, Rowe TK, Ferrara P, Ortaldo JR, O'Shea JJ, McVicar DW.
IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.
J. Exp. Med. 180: 2383-8, 1994.
[Journal]
74)  Norihisa Y, McVicar DW, Ghosh P, Houghton AN, Longo DL, Creekmore SP, Blake T, Ortaldo JR, Young HA.
Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3).
J. Immunol. 152: 485-95, 1994.
[Journal]
75)  Murphy WJ, Durum SK, Anver MR, Ferris DK, McVicar DW, O'Shea JJ, Ruscetti SK, Smith MR, Young HA, Longo DL.
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID).
J. Immunol. 153: 1004-14, 1994.
[Journal]
76)  Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O.
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Science. 266: 1042-5, 1994.
[Journal]
77)  Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR.
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
Proc. Natl. Acad. Sci. U.S.A. 91: 6374-8, 1994.
[Journal]
78)  McVicar DW, Lal BK, Lloyd A, Kawamura M, Chen YQ, Zhang X, Staples JE, Ortaldo JR, O'Shea JJ.
Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes.
Oncogene. 9: 2037-44, 1994.
[Journal]
79)  Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ.
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
Nature. 370: 151-3, 1994.
[Journal]
80)  Wang JM, McVicar DW, Oppenheim JJ, Kelvin DJ.
Identification of RANTES receptors on human monocytic cells: competition for binding and desensitization by homologous chemotactic cytokines.
J. Exp. Med. 177: 699-705, 1993.
[Journal]
81)  O'Shea JJ, McVicar DW, Kuhns DB, Ortaldo JR.
A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A.
J. Immunol. 148: 2497-502, 1992.
[Journal]
82)  O'Shea JJ, McVicar DW, Bailey TL, Burns C, Smyth MJ.
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.
Proc. Natl. Acad. Sci. U.S.A. 89: 10306-10, 1992.
[Journal]
83)  Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC.
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Science. 258: 1795-8, 1992.
[Journal]
84)  McVicar DW, McCrady CW, Merchant RE.
Corticosteroids inhibit the delivery of short-term activational pulses of phorbol ester and calcium ionophore to human peripheral T cells.
Cell. Immunol. 140: 145-57, 1992.
[Journal]
85)  McVicar DW, Davis DF, Merchant RE.
In vitro analysis of the proliferative potential of T cells from patients with brain tumor: glioma-associated immunosuppression unrelated to intrinsic cellular defect.
J. Neurosurg. 76: 251-60, 1992.
[Journal]
86)  Merchant RE, McVicar DW, Merchant LH, Young HF.
Treatment of recurrent malignant glioma by repeated intracerebral injections of human recombinant interleukin-2 alone or in combination with systemic interferon-alpha. Results of a phase I clinical trial.
J. Neurooncol. 12: 75-83, 1992.
[Journal]
87)  McVicar DW, Li F, McCrady CW, Merchant RE.
A comparison of serum-free media for the support of in vitro mitogen-induced blastogenic expansion of cytolytic lymphocytes.
Cytotechnology. 6: 105-13, 1991.
[Journal]
88)  McVicar DW, Merchant RE, Merchant LH, Young HF.
Corticosteroids inhibit the generation of lymphokine-activated killer activity in vitro.
Cancer Immunol. Immunother. 29: 211-8, 1989.
[Journal]
89)  Merchant RE, Merchant LH, Cook SH, McVicar DW, Young HF.
Intralesional infusion of lymphokine-activated killer (LAK) cells and recombinant interleukin-2 (rIL-2) for the treatment of patients with malignant brain tumor.
Neurosurgery. 23: 725-32, 1988.
[Journal]
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This page was last updated on 8/19/2014.