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Our Science – Liu Website

Zheng-Gang Liu, Ph.D.

Selected Publications

1)  Cai Z, Jitkaew S, Zhao J, Chiang H, Choksi S, Liu J, Ward Y, Wu L, Liu Z.
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Nat. Cell Biol. 16: 55-65, 2014.
2)  Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, Li T, Jitkaew S, Cao X, Kim YS, Kim HS, Levitt P, Shih G, Birre M, Deng CX, Liu ZG.
A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2.
Mol. Cell. 42: 597-609, 2011.
3)  Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, Liu ZG.
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
Nat. Immunol. 11: 799-805, 2010.
4)  Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z.
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.
Nat. Immunol. 9: 1047-54, 2008.
5)  Kim YS, Morgan MJ, Choksi S, Liu ZG.
TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death.
Mol. Cell. 26: 675-87, 2007.
6)  Zhang Y, Choksi S, Liu ZG.
Butylated hydroxyanisole blocks the occurrence of tumor associated macrophages in tobacco smoke carcinogen-induced lung tumorigenesis.
Cancers (Basel). 5: 1643-54, 2013.
7)  Zhang T, Park KA, Li Y, Byun HS, Jeon J, Lee Y, Hong JH, Kim JM, Huang SM, Choi SW, Kim SH, Sohn KC, Ro H, Lee JH, Lu T, Stark GR, Shen HM, Liu ZG, Park J, Min HG.
PHF20 regulates NF-?B signalling by disrupting recruitment of PP2A to p65.
Nat Commun. 4: 2062, 2013.
8)  Zhang Y, Choksi S, Chen K, Pobezinskaya Y, Linnoila I, Liu ZG.
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages.
Cell Res. 23: 898-914, 2013.
9)  Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG.
Induction of autophagy is essential for monocyte-macrophage differentiation.
Blood. 119: 2895-905, 2012.
10)  Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG.
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
Proc. Natl. Acad. Sci. U.S.A. 109: 5322-7, 2012.
11)  Pobezinskaya Y, Liu Z.
The role of TRADD in death receptor signaling.
Cell Cycle. 11: 871-6, 2012.
12)  Sun S, Liu Z.
A special issue on NF-kappaB signaling and function.
Cell Res. 21: 1-2, 2011.
13)  Morgan MJ, Liu Z.
Crosstalk of reactive oxygen species and NF-kappaB signaling.
Cell Res. 21: 103-15, 2011.
14)  Pobezinskaya YL, Choksi S, Morgan MJ, Cao X, Liu ZG.
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.
J. Immunol. 186: 5212-6, 2011.
15)  Cao X, Pobezinskaya YL, Morgan MJ, Liu ZG.
The role of TRADD in TRAIL-induced apoptosis and signaling.
FASEB J. 25: 1353-8, 2011.
16)  Kim J, Morgan M, Kim D, Lee J, Bai L, Lin Y, Liu Z, Kim Y.
TNFalpha induced noncanonical NF-kappaB activation is attenuated by RIP1 through stabilization of TRAF2.
J. Cell. Sci. 124: 647-56, 2011.
17)  Huang Y, Chen L, Zhou Y, Liu H, Yang J, Liu Z, Wang C.
UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
Mol. Biol. Cell. 22: 1389-97, 2011.
18)  Peng Z, Geh E, Chen L, Meng Q, Fan Y, Sartor M, Shertzer HG, Liu ZG, Puga A, Xia Y.
Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione.
Mol. Pharmacol. 77: 784-92, 2010.
19)  Won M, Park KA, Byun HS, Sohn K, Kim Y, Jeon J, Hong JH, Park J, Seok JH, Kim JM, Yoon W, Jang I, Shen HM, Liu ZG, Hur GM.
Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation.
Cell Death Differ. 17: 1830-41, 2010.
20)  Morgan MJ, Liu ZG.
Reactive oxygen species in TNFalpha-induced signaling and cell death.
Mol. Cells. 30: 1-12, 2010.
21)  Morgan MJ, Kim YS, Liu ZG.
Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex.
J. Immunol. 183: 3278-84, 2009.
22)  Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN, Shen HM.
Autophagy plays a protective role during zVAD-induced necrotic cell death.
Autophagy. 4: 457-66, 2008.
23)  Wu YT, Zhang S, Kim YS, Tan HL, Whiteman M, Ong CN, Liu ZG, Ichijo H, Shen HM.
Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death.
Cell Death Differ. 15: 386-97, 2008.
24)  Morgan MJ, Kim YS, Liu ZG.
TNFalpha and reactive oxygen species in necrotic cell death.
Cell Res. 18: 343-9, 2008.
25)  Yamashita M, Fatyol K, Jin C, Wang X, Liu Z, Zhang YE.
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta.
Mol. Cell. 31: 918-24, 2008.
26)  Zhang S, Lin Y, Kim Y, Hande MP, Liu Z, Shen H.
c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation.
Cell Death Differ. 14: 1001-10, 2007.
27)  Shen HM, Z-G LIU.
Oxidative stress, JNK activation and Cell death. In: The JNK signaling pathway.
Georgetown, Texas: Landes Bioscience; 2006. p. 73-82 [Book Chapter]
28)  Song L, Li J, Zhang D, Liu ZG, Ye J, Zhan Q, Shen HM, Whiteman M, Huang C.
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response.
J. Cell Biol. 175: 607-17, 2006.
29)  Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA.
Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: from simple paradigms to complex mechanisms.
Int. Rev. Cytol. 252: 129-61, 2006.
30)  Shen HM, Liu ZG.
JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species.
Free Radic Biol Med. 40: 928-39, 2006.
31)  Zhang D, Li J, Wu K, Ouyang W, Ding J, Liu Z, Costa M, Huang C.
JNK1, but not JNK2, is required for COX-2 induction by nickel compounds.
Carcinogenesis. 28: 883-91, 2006.
32)  Byun HS, Park KA, Won M, Yang KJ, Shin S, Piao L, Kwak JY, Lee ZW, Park J, Seok JH, Liu ZG, Hur GM.
Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C.
Mol. Pharmacol. 70: 1099-108, 2006.
33)  Xu Y, Huang S, Liu ZG, Han J.
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation.
J Biol Chem. 281: 8788-95, 2006.
34)  Hur GM, Kim YS, Won M, Choksi S, Liu ZG.
The death domain kinase RIP has an important role in DNA damage-induced, p53-independent cell death.
J. Biol. Chem. 281: 25011-7, 2006.
35)  Lin Y, Yang Q, Wang X, Liu ZG.
The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation.
J. Biol. Chem. 281: 23525-32, 2006.
36)  Yang Q, Kim Y, Lin Y, Lewis J, Neckers L, Liu Z.
Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK.
EMBO Rep. 7: 622-7, 2006.
37)  Ouyang W, Ma Q, Li J, Zhang D, Liu ZG, Rustgi AK, Huang C.
Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.
Cancer Res. 65: 9287-93, 2005.
38)  Liu ZG.
Molecular mechanism of TNF signaling and beyond.
Cell Res. 15: 24-7, 2005.
39)  Bender LM, Morgan MJ, Thomas LR, Liu ZG, Thorburn A.
The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm.
Cell Death Differ. 12: 473-81, 2005.
40)  Kim YS, Nedospasov SA, Liu ZG.
TRAF2 plays a key, nonredundant role in LIGHT-lymphotoxin beta receptor signaling.
Mol Cell Biol. 25: 2130-7, 2005.
41)  Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B.
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.
Nat Immunol. 5: 98-103, 2004.
42)  Wan J, Sun L, Mendoza JW, Chui YL, Huang DP, Chen ZJ, Suzuki N, Suzuki S, Yeh WC, Akira S, Matsumoto K, Liu ZG, Wu Z.
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1.
Mol Cell Biol. 24: 192-9, 2004.
43)  Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG.
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death.
Mol Cell Biol. 24: 5914-22, 2004.
44)  Kurenova E, Xu LH, Yang X, Baldwin AS, Craven RJ, Hanks SK, Liu ZG, Cance WG.
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
Mol Cell Biol. 24: 4361-71, 2004.
45)  Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS, Tran JH, Nedospasov SA, Liu ZG.
Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation.
J Biol Chem. 279: 10822-8, 2004.
46)  Liu ZG.
Adding facets to TNF signaling. The JNK angle.
Mol Cell. 12: 795-6, 2003.
47)  Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L.
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.
Biochem J. 370: 1011-7, 2003.
48)  Hur GM, Lewis J, Yang Q, Lin Y, Nakano H, Nedospasov S, Liu ZG.
The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation.
Genes Dev. 17: 873-82, 2003.
49)  Devin A, Lin Y, Liu ZG.
The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases.
EMBO Rep. 4: 623-7, 2003.
50)  Lin Y, Ryan J, Lewis J, Wani MA, Lingrel JB, Liu ZG.
TRAF2 exerts its antiapoptotic effect by regulating the expression of Kruppel-like factor LKLF.
Mol Cell Biol. 23: 5849-56, 2003.
51)  Z-G L, Han J.
Cellular response to Tumor Necrosis Factor (TNF).
Curr Issues Mol Biol. 3(4): 79-90, 2001.
52)  Devin A, Lin Y, Yamaoka S, Li Z, Karin M, Z-G LIU.
The a and b subunits of IkB kinase (IKK) mediate TRAF2-dependent IKK recruitment to Tumor Necrosis Factor (TNF) receptor I in response to TNF.
Mol. Cell. Biol. 21: 3986-3994, 2001.
53)  Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B.
The essential role of MEKK3 in TNF-induced NF-kB activation.
Nature Immunol. 2: 620-624, 2001.
54)  Liu Z, Lewis J, T-H W, Cook A.
The Role of C-Jun N-terminal Kinase (JNK) in Apoptosis.
Methods Cell Biol. 66: Apoptosis, Chapter 8, 2001.
55)  Lewis J, Devin A, Miller A, Lin Y, Rodriguez Y, Neckers L, Liu ZG.
Disruption of Heat Shock Protein 90 (Hsp90) Function Results in the Degradation of the Death Domain Kinase RIP and the Blockage of TNF-induced NF-kB Activation.
J. Biol. Chem. 14: 10519-10526, 2000.
56)  Lin Y, Devin A, Keane MM, Lipkowitz S, Kelliher M, Z-G LIU.
The death domain kinase RIP plays an essential role in TRAIL/Apo2L-induced activation of IkB kinase (IKK) and Jun N-terminal kinase (JNK).
Mol. Cell. Biol. 20: 6638-6645, 2000.
57)  Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Z-G LIU.
The distinct roles of TRAF2 and RIP in TNF-R1-mediated IKK activation: IKK is recruited into the TNF-R1 complex via TRAF2 while its activation is mediated by RIP.
Immunity. 12: 419-429, 2000.
58)  Lin Y, Devin A, Rodriguez Y, Liu ZG.
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
Genes Dev. 13: 2514-26, 1999.
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This page was last updated on 6/30/2014.