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Our Science – Linnoila Website

Ilona Linnoila, M.D.

Selected Publications

1)  Wang XY, Jensen-Taubman SM, Keefe KM, Yang D, Linnoila RI.
Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.
PLoS ONE. 7: e52832, 2012.
2)  Demelash A, Rudrabhatla P, Pant HC, Wang X, Amin ND, McWhite CD, Naizhen X, Linnoila RI.
Achaete-Scute Homolog-1 (ASH1) Stimulates Migration of Lung Cancer Cells through Cdk5/p35 pathway.
Mol Biol Cell. 23: 2856-66, 2012.
3)  Miki M, Ball DW, Linnoila RI.
Insights into the achaete-scute homolog-1 gene (hASH1) in normal and neoplastic human lung.
Lung Cancer. 75: 58-65, 2012.
4)  Li Y, Linnoila RI.
Multidirectional differentiation of Achaete-Scute homologue-1-defined progenitors in lung development and injury repair.
Am. J. Respir. Cell Mol. Biol. 47: 768-75, 2012.
5)  Wang XY, Keefe KM, Jensen-Taubman SM, Yang D, Yan K, Linnoila RI.
Novel method for isolation of murine clara cell secretory protein-expressing cells with traces of stemness.
PLoS ONE. 7: e43008, 2012.
6)  Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA.
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Oncogene. 30: 1812-21, 2011.
7)  Koshiol J, Gulley ML, Zhao Y, Rubagotti M, Marincola FM, Rotunno M, Tang W, Bergen AW, Bertazzi PA, Roy D, Pesatori AC, Linnoila I, Dittmer D, Goldstein AM, Caporaso NE, McShane LM, Wang E, Landi MT.
Epstein-Barr virus microRNAs and lung cancer.
Br. J. Cancer. 105: 320-6, 2011.
8)  Maier CR, Hollander MC, Hobbs EA, Dogan I, Linnoila RI, Dennis PA.
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Cancer Prev Res (Phila). 4: 1743-51, 2011.
9)  Kurotani R, Kumaki N, Naizhen X, Ward JM, Linnoila RI, Kimura S.
Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans.
Lung Cancer. 71: 42-8, 2011.
10)  Jensen-Taubman S, Wang XY, Linnoila RI.
Achaete-scute homologue-1 tapers neuroendocrine cell differentiation in lungs after exposure to naphthalene.
Toxicol. Sci. 117: 238-48, 2010.
11)  Yin JJ, Zhang L, Munasinghe J, Linnoila RI, Kelly K.
Cediranib/AZD2171 inhibits bone and brain metastasis in a preclinical model of advanced prostate cancer.
Cancer Res. 70: 8662-73, 2010.
12)  Linnoila R.
From nicotine to breast cancer: implications of acetylcholine receptor pathways.
J Natl Cancer Inst. 102: 1298-9, 2010.
13)  Rotunno M, Zhao Y, Bergen AW, Koshiol J, Burdette L, Rubagotti M, Linnoila RI, Marincola FM, Bertazzi PA, Pesatori AC, Caporaso NE, McShane LM, Wang E, Landi MT.
Inherited polymorphisms in the RNA-mediated interference machinery affect microRNA expression and lung cancer survival.
Br. J. Cancer. 103: 1870-4, 2010.
14)  Landi MT, Zhao Y, Rotunno M, Koshiol J, Liu H, Bergen AW, Rubagotti M, Goldstein AM, Linnoila I, Marincola FM, Tucker MA, Bertazzi PA, Pesatori AC, Caporaso NE, McShane LM, Wang E.
MicroRNA expression differentiates histology and predicts survival of lung cancer.
Clin. Cancer Res. 16: 430-41, 2010.
15)  Wang XY, Penalva LO, Yuan H, Linnoila RI, Lu J, Okano H, Glazer RI.
Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival.
Mol. Cancer. 9: 221, 2010.
16)  Leaner VD, Chick JF, Donninger H, Linniola I, Mendoza A, Khanna C, Birrer MJ.
Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.
Am. J. Pathol. 174: 265-75, 2009.
17)  Wang XY, Demelash A, Kim H, Jensen-Taubman S, Dakir el H, Ozbun L, Birrer MJ, Linnoila RI.
Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer.
Am. J. Pathol. 175: 592-604, 2009.
18)  Poulsen TT, Naizhen X, Poulsen HS, Linnoila RI.
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Toxicol. Lett. 181: 67-74, 2008.
19)  Darcy KM, Brady WE, McBroom JW, Bell JG, Young RC, McGuire WP, Linnoila RI, Hendricks D, Bonome T, Farley JH.
Associations between p53 overexpression and multiple measures of clinical outcome in high-risk, early stage or suboptimally-resected, advanced stage epithelial ovarian cancers A Gynecologic Oncology Group study.
Gynecol. Oncol. 111: 487-95, 2008.
20)  Dakir EL, Feigenbaum L, Linnoila RI.
Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation.
Carcinogenesis. 29: 2377-84, 2008.
21)  Landi MT, Consonni D, Rotunno M, Bergen AW, Goldstein AM, Lubin JH, Goldin L, Alavanja M, Morgan G, Subar AF, Linnoila I, Previdi F, Corno M, Rubagotti M, Marinelli B, Albetti B, Colombi A, Tucker M, Wacholder S, Pesatori AC, Caporaso NE, Bertazzi PA.
Environment and Genetics in Lung Cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer.
BMC Public Health. 8: 203, 2008.
22)  Hollander MC, Balogh AR, Liwanag J, Han W, Linnoila RI, Anver MR, Dennis PA.
Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.
Neoplasia. 10: 866-72, 2008.
23)  Neptune ER, Podowski M, Calvi C, Cho JH, Garcia JG, Tuder R, Linnoila RI, Tsai MJ, Dietz HC.
Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung.
J. Biol. Chem. 283: 21160-9, 2008.
24)  Wang XY, Dakir el H, Naizhen X, Jensen-Taubman SM, DeMayo FJ, Linnoila RI.
Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium.
Lab. Invest. 87: 527-39, 2007.
25)  Granville CA, Warfel N, Tsurutani J, Hollander MC, Robertson M, Fox SD, Veenstra TD, Issaq HJ, Linnoila RI, Dennis PA.
Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.
Clin. Cancer Res. 13: 2281-9, 2007.
26)  Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE.
Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis.
Cancer Res. 67: 8065-8080, 2007.
27)  Linnoila RI, Jensen-Taubman S, Kazanjian A, Grimes HL.
Loss of GFI1 impairs pulmonary neuroendorine cell proliferation, but the neuroendocrine phenotype has limited impact on post-naphthalene airway repair.
Lab. Invest. 87: 336-44, 2007.
28)  Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong K, Kim K.
BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.
J Thorac Oncol. 1: S2-7, 2006.
29)  Linnoila RI.
Functional facets of the pulmonary neuroendocrine system.
Lab. Invest. 86: 425-44, 2006.
30)  Hollander MC, Philburn RT, Patterson AD, Velasco-Miguel S, Friedberg EC, Linnoila RI, Fornace AJ.
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.
Proc. Natl. Acad. Sci. U.S.A. 102: 13200-5, 2005.
31)  Linnoila RI, Naizhen X, Meuwissen R, Berns A, DeMayo FJ.
Mouse lung neuroendocrine carcinomas: Distinct morphologies, same transcription factors.
Exp Lung Res. 31: 37-55, 2005.
32)  Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T.
Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium.
Cancer Res. 64: 2307-16, 2004.
33)  Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM.
Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium.
Am J Physiol Cell Physiol. 287: C171-81, 2004.
34)  Yang Y, Zhang Z, Mukherjee AB, Linnoila RI.
Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke.
J Biol Chem. 279: 29336-40, 2004.
35)  Mulshine JL, Atkinson JC, Greer RO, Papadimitrakopoulou VA, Van Waes C, Rudy S, Martin JW, Steinberg SM, Liewehr DJ, Avis I, Linnoila RI, Hewitt S, Lippman SM, Frye R, Cavanaugh PF.
Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia.
Clin Cancer Res. 10: 1565-73, 2004.
36)  West KA, Linnoila IR, Belinsky SA, Harris CC, Dennis PA.
Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.
Cancer Res. 64: 446-51, 2004.
37)  West KA, Linnoila IR, Brognard J, Belinsky S, Harris C, Dennis PA.
Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.
Chest. 125: 101S-2S, 2004.
38)  Meuwissen R, Linn SC, Linnoila RI, Zevenhoven J, Mooi WJ, Berns A.
Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.
Cancer Cell. 4: 181-9, 2003.
39)  Means-Markwell M, Linnoila RI, Williams J, Jänne PA, Kaye F, O'Neil K, Johnson BE.
Prospective study of the airways and pulmonary parenchyma of patients at risk for a second lung cancer.
Clin Cancer Res. 9: 5915-21, 2003.
40)  West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA.
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
J Clin Invest. 111: 81-90, 2003.
41)  McCarthy NJ, Yang X, Linnoila IR, Merino MJ, Hewitt SM, Parr AL, Paik S, Steinberg SM, Hartmann DP, Mourali N, Levine PH, Swain SM.
Microvessel density, expression of estrogen receptor alpha, MIB-1, p53, and c-erbB-2 in inflammatory breast cancer.
Clin Cancer Res. 12: 3857-62, 2002.
42)  Ward Y, Wang W, Woodhouse E, Linnoila I, Liotta L, Kelly K.
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways.
Mol. Cell. Biol. 21: 5958-69, 2001.
43)  Linnoila RI, Zhao B, DeMayo JL, Nelkin BD, Baylin SB, DeMayo FJ, Ball DW.
Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice.
Cancer Res. 60: 4005-9, 2000.
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This page was last updated on 4/18/2013.