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Our Science – Cuttitta Website

Frank Cuttitta, Ph.D.

Selected Publications
1)  Zhou S, Nissao E, Jackson IL, Leong W, Dancy L, Cuttitta F, Vujaskovic Z, Sunday ME.
Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide.
Am. J. Pathol. 182: 1248-54, 2013. [Journal]
2)  Portal-Nuñez S, Shankavaram UT, Rao M, Datrice N, Atay S, Aparicio M, Camphausen KA, Fernández-Salguero PM, Chang H, Lin P, Schrump DS, Garantziotis S, Cuttitta F, Zudaire E.
Aryl hydrocarbon receptor-induced adrenomedullin mediates cigarette smoke carcinogenicity in humans and mice.
Cancer Res. 72: 5790-800, 2012. [Journal]
3)  Zhou S, Potts EN, Cuttitta F, Foster WM, Sunday ME.
Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma.
Proc. Natl. Acad. Sci. U.S.A. 108: 2100-5, 2011. [Journal]
4)  Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B.
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Proc. Natl. Acad. Sci. U.S.A. 108: 5759-64, 2011. [Journal]
5)  El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J.
Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.
Proc. Natl. Acad. Sci. U.S.A. 106: 3958-63, 2009. [Journal]
6)  Fang C, Miguel MA, Avis I, Martinez A, Zudaire E, Cuttitta F.
Non-peptide small molecule regulators of lymphangiogenesis.
Lymphat Res Biol. 7: 189-96, 2009. [Journal]
7)  Kandalaft LE, Zudaire E, Portal-Nunez S, Cuttitta F, Jakowlew SB.
Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis.
Carcinogenesis. 29: 1282-9, 2008. [Journal]
8)  Kwon M, Hanna E, Lorang D, He M, Quick JS, Adem A, Stevenson C, Chung JY, Hewitt SM, Zudaire E, Esposito D, Cuttitta F, Libutti SK.
Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy.
Cancer Res. 68: 7332-41, 2008. [Journal]
9)  Sackett DL, Ozbun L, Zudaire E, Wessner L, Chirgwin JM, Cuttitta F, Martinez A.
Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.
Endocrinology. 149: 2888-98, 2008. [Journal]
10)  Fernández AP, Serrano J, Tessarollo L, Cuttitta F, Martínez A.
Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.
Proc. Natl. Acad. Sci. U.S.A. 105: 12581-6, 2008. [Journal]
11)  Garantziotis S, Zudaire E, Trempus CS, Hollingsworth JW, Jiang D, Lancaster LH, Richardson E, Zhuo L, Cuttitta F, Brown KK, Noble PW, Kimata K, Schwartz DA.
Serum Inter-{alpha}-trypsin Inhibitor and Matrix Hyaluronan Promote Angiogenesis in Fibrotic Lung Injury.
Am. J. Respir. Crit. Care Med. 178: 939-47, 2008. [Journal]
12)  Zudaire E, Cuesta N, Murty V, Woodson K, Adams L, Gonzalez N, Martinez A, Narayan G, Kirsch I, Franklin W, Hirsch F, Birrer M, Cuttitta F.
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
J. Clin. Invest. 118: 640-50, 2008. [Journal]
13)  Elsasser TH, Capuco AV, Caperna TJ, Martinez A, Cuttitta F, Kahl S.
Adrenomedullin (AM) and adrenomedullin binding protein (AM-BP) in the bovine mammary gland and milk: Effects of stage of lactation and experimental intramammary E. coli infection.
Domest Anim Endocrinol. 32: 138-54, 2007. [Journal]
14)  Subramaniam M, Bausch C, Twomey A, Andreeva S, Yoder BA, Chang L, Crapo JD, Pierce RA, Cuttitta F, Sunday ME.
Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia.
Am. J. Respir. Crit. Care Med. 176: 902-12, 2007. [Journal]
15)  Cuesta N, Nhu QM, Zudaire E, Polumuri S, Cuttitta F, Vogel SN.
IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism.
J. Immunol. 178: 3602-11, 2007. [Journal]
16)  Cuttitta F, Porta-Nunez S, Falco C, Garayoa M, Pio R, Montuenga L, Julian M, Martinez A, Zudaire E.
Kastin A, eds.
Adrenomedullin: An Esoteric Juggernaut of Human Cancers. In: Handbook of Biologically Active Peptides.
San Diego: Elsevier; 2006. p. 1640 pp. [Book Chapter]
17)  Rosen D, Lee JH, Cuttitta F, Rafiqi F, Degan S, Sunday ME.
Accelerated thymic maturation and autoreactive T cells in bronchopulmonary dysplasia.
Am. J. Respir. Crit. Care Med. 174: 75-83, 2006. [Journal]
18)  Zudaire E, Martinez A, Garayoa M, Pio R, Kaur G, Woolhiser MR, Metcalfe DD, Hook WA, Siraganian RP, Guise TA, Chirgwin JM, Cuttitta F.
Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.
Am J Pathol. 168: 280-91, 2006. [Journal]
19)  Martinez A, Bengoechea JA, Cuttitta F.
Molecular evolution of proadrenomedullin N-terminal 20 peptide (PAMP): evidence for gene co-option.
Endocrinology. 147: 3457-61, 2006. [Journal]
20)  Zudaire E, Portal-Nunez S, Cuttitta F.
The central role of adrenomedullin in host defense.
J Leukoc Biol. 80: 237-44, 2006. [Journal]
21)  Julian M, Cacho M, Garcia MA, Martin-Santamaria S, de Pascual-Teresa B, Ramos A, Martinez A, Cuttitta F.
Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities.
Eur J Med Chem. 40: 737-50, 2005. [Journal]
22)  Zudaire E, Cuesta N, Martinez A, Cuttitta F.
Characterization of adrenomedullin in birds.
Gen Comp Endocrinol. 143: 10-20, 2005. [Journal]
23)  Martinez A, Zudaire E, Julian M, Moody TW, Cuttitta F.
Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo.
Oncogene. 24: 4106-13, 2005. [Journal]
24)  Cuesta N, Martinez A, Cuttitta F, Zudaire E.
Identification of adrenomedullin in avian type II pneumocytes: increased expression after exposure to air pollutants.
J Histochem Cytochem. 53: 773-80, 2005. [Journal]
25)  Zudaire E, Martinez A, Ozbun LL, Cuttitta F.
Characterization of adrenomedullin in non-human primates.
Biochem Biophys Res Commun. 321: 859-69, 2004. [Journal]
26)  Ajona D, Castano Z, Garayoa M, Zudaire E, Pajares MJ, Martinez A, Cuttitta F, Montuenga LM, Pio R.
Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement.
Cancer Res. 64: 6310-8, 2004. [Journal]
27)  Martinez A, Julian M, Bregonzio C, Notari L, Moody TW, Cuttitta F.
Identification of vasoactive nonpeptidic positive and negative modulators of adrenomedullin using a neutralizing antibody-based screening strategy.
Endocrinology. 145: 3858-65, 2004. [Journal]
28)  Martinez A, Oh H, Unsworth EJ, Bregonzio C, Saavedra JM, Stetler-Stevenson WG, Cuttitta F.
Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator.
Biochem J. 383 (Pt. 3): e5-7, 2004. [Journal]
29)  Martinez A, Zudaire E, Portal-Nunez S, Guedez L, Libutti SK, Stetler-Stevenson WG, Cuttitta F.
Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth.
Cancer Res. 64: 6489-94, 2004. [Journal]
30)  Zudaire E, Martinez A, Cuttitta F.
Adrenomedullin and cancer.
Regul Pept. 112: 175-83, 2003. [Journal]
31)  Martinez A, Saldise L, Ramirez MJ, Belzunegui S, Zudaire E, Luquin MR, Cuttitta F.
Adrenomedullin expression and function in the rat carotid body.
J Endocrinol. 176: 95-102, 2003. [Journal]
32)  Macpherson GR, Ng SS, Forbes SL, Melillo G, Karpova T, McNally J, Conrads TP, Veenstra TD, Martinez A, Cuttitta F, Price DK, Figg WD.
Anti-angiogenic activity of human endostatin is HIF-1-independent in vitro and sensitive to timing of treatment in a human saphenous vein assay.
Mol Cancer Ther. 2: 845-54, 2003. [Journal]
33)  Serrano J, Encinas JM, Fernandez AP, Castro-Blanco S, Alonso D, Fernandez-Vizarra P, Richart A, Bentura ML, Santacana M, Cuttitta F, Martinez A, Rodrigo J.
Distribution of immunoreactivity for the adrenomedullin binding protein, complement factor H, in the rat brain.
Neuroscience. 116: 947-62, 2003. [Journal]
34)  Garayoa M, Man Y, Martinez A, Cuttitta F, Mulshine JL.
Downregulation of hnRNP A2/B1 Expression in Tumor Cells under Prolonged Hypoxia.
Am J Respir Cell Mol Biol. 28: 80-5, 2003. [Journal]
35)  Martinez A, Pio R, Zipfel PF, Cuttitta F.
Mapping of the adrenomedullin-binding domains in human complement factor H.
Hypertens Res. 26 Suppl: S55-9, 2003. [Journal]
36)  Abasolo I, Yang L, Haleem R, Xiao W, Pio R, Cuttitta F, Montuenga LM, Kozlowski JM, Calvo A, Wang Z.
Overexpression of adrenomedullin gene markedly inhibits proliferation of PC3 prostate cancer cells in vitro and in vivo.
Mol. Cell Endocrinol. 199: 179-187, 2003. [Journal]
37)  Zudaire E, Cuttitta F, Martinez A.
Regulation of pancreatic physiology by adrenomedullin and its binding protein.
Regul Pept. 112: 121-30, 2003. [Journal]
38)  Serrano J, Alonso D, Encinas JM, Lopez JC, Fernandez AP, Castro-Blanco S, Fernandez-Vizarra P, Richart A, Bentura ML, Santacana M, Uttenthal LO, Cuttitta F, Rodrigo J, Martinez A.
Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat.
Neuroscience. 109: 717-31, 2002. [Journal]
39)  Cuttitta F, Pio R, Garayoa M, Zudaire E, Julian M, Elsasser TH, Montuenga LM, Martinez A.
Adrenomedullin functions as an important tumor survival factor in human carcinogenesis.
Microsc Res Tech. 57: 110-9, 2002. [Journal]
40)  Welsch U, Unterberger P, Hofter E, Cuttitta F, Martinez A.
Adrenomedullin in mammalian and human skin glands including the mammary gland.
Acta Histochem. 104: 65-72, 2002. [Journal]
41)  Garayoa M, Bodegas E, Cuttitta F, Montuenga LM.
Adrenomedullin in mammalian embryogenesis.
Microsc Res Tech. 57: 40-54, 2002. [Journal]
42)  Kane S, Prentice MA, Mariano JM, Cuttitta F, Jakowlew SB.
Differential induction of early response genes by adrenomedullin and transforming growth factor-beta1 in human lung cancer cells.
Anticancer Res. 22: 1433-44, 2002. [Journal]
43)  Seghatoleslami MR, Martinez A, Cuttitta F, Kosher RA.
Distribution and possible function of an adrenomedullin-like peptide in the developing chick limb bud.
Int J Dev Biol. 46: 957-61, 2002. [Journal]
44)  Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM.
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.
J Biol Chem. 277: 29936-44, 2002. [Journal]
45)  Pio R, Elsasser TH, Martinez A, Cuttitta F.
Identification, characterization, and physiological actions of factor H as an adrenomedullin binding protein present in human plasma.
Microsc Res Tech. 57: 23-7, 2002. [Journal]
46)  Mulshine JL, Cuttitta F, Tockman MS, De Luca LM.
Lung cancer evolution to preinvasive management.
Clin Chest Med. 23: 37-48, 2002. [Journal]
47)  Martinez A, Vos M, Guedez L, Kaur G, Chen Z, Garayoa M, Pio R, Moody T, Stetler-Stevenson WG, Kleinman HK, Cuttitta F.
The effects of adrenomedullin overexpression in breast tumor cells.
J Natl Cancer Inst. 94: 1226-37, 2002. [Journal]
48)  Martinez A, Hodge DL, Garayoa M, Young HA, Cuttitta F.
Alternative splicing of the proadrenomedullin gene results in differential expression of gene products.
J Mol Endocrinol. 27: 31-41, 2001. [Journal]
49)  Pio R, Martinez A, Cuttitta F.
Cancer and diabetes: two pathological conditions in which adrenomedullin may be involved.
Peptides. 22: 1719-29, 2001. [Journal]
50)  Pio R, Martinez A, Unsworth EJ, Kowalak JA, Bengoechea JA, Zipfel PF, Elsasser TH, Cuttitta F.
Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners.
J Biol Chem. 276: 12292-300, 2001. [Journal]
51)  Munoz M, Martinez A, Cuttitta F, Gonzalez A.
Distribution of adrenomedullin-like immunoreactivity in the central nervous system of the frog.
J Chem Neuroanat. 21: 105-23, 2001. [Journal]
52)  Mulshine JL, Hong S, Martinez A, Tauler J, Avis I, Tockman MS, De Luca LM, Placke ME, Cuttitta F.
Moving to the routine management of pre symptomatic lung cancer.
Lung Cancer. 34 Suppl 2: S1-5, 2001. [Journal]
53)  Jimenez N, Jongsma J, Calvo A, van der Kwast TH, Treston AM, Cuttitta F, Schroder FH, Montuenga LM, van Steenbrugge GJ.
Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate.
Int J Cancer. 94: 28-34, 2001. [Journal]
54)  Chu DQ, Legon S, Smith DM, Costa SK, Cuttitta F, Brain SD.
The calcitonin gene-related peptide (CGRP) antagonist CGRP(8-37) blocks vasodilatation in inflamed rat skin: involvement of adrenomedullin in addition to CGRP.
Neurosci Lett. 310: 169-72, 2001. [Journal]
55)  Martinez A, Kapas S, Miller MJ, Ward Y, Cuttitta F.
Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells.
Endocrinology. 141: 406-11, 2000. [Journal]
56)  Serrano J, Uttenthal LO, Martinez A, Fernandez AP, Martinez de Velasco J, Alonso D, Bentura ML, Santacana M, Gallardo JR, Martinez-Murillo R, Cuttitta F, Rodrigo J.
Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system by light and electron microscopy.
Brain Res. 853: 245-68, 2000. [Journal]
57)  Montuenga LM, Burrell MA, Garayoa M, Llopiz D, Vos M, Moody T, Garcia-Ros D, Martinez A, Villaro AC, Elsasser T, Cuttitta F.
Expression of proadrenomedullin derived peptides in the mammalian pituitary: co-localization of follicle stimulating hormone and proadrenomedullin N-20 terminal peptide-like peptide in the same secretory granules of the gonadotropes.
J Neuroendocrinol. 12: 607-17, 2000. [Journal]
58)  Garayoa M, Martinez A, Lee S, Pio R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, Gassmann M, Cuttitta F.
Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.
Mol Endocrinol. 14: 848-62, 2000. [Journal]
59)  Elkas J, Armstrong A, Pohl J, Cuttitta F, Martinez A, Gray K.
Modulation of endometrial steroid receptors and growth regulatory genes by tamoxifen.
Obstet Gynecol. 95: 697-703, 2000. [Journal]
60)  Man YG, Martinez A, Avis IM, Hong SH, Cuttitta F, Venzon DJ, Mulshine JL.
Phenotypically different cells with heterogeneous nuclear ribonucleoprotein A2/B1 overexpression show similar genetic alterations.
Am J Respir Cell Mol Biol. 23: 636-45, 2000. [Journal]
61)  Pio R, Martinez A, Elsasser TH, Cuttitta F.
Presence of immunoreactive adrenomedullin in human and bovine milk.
Peptides. 21: 1859-63, 2000. [Journal]
62)  Moody TW, Coy D, Cuttitta F, Montuenga LM.
Proadrenomedullin NH(2)-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells.
Peptides. 21: 101-7, 2000. [Journal]
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This page was last updated on 5/13/2013.