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Our Science – Kelly Siebenlist Website

Kathleen Kelly Siebenlist, Ph.D.

Selected Publications

1)  Abou-Kheir WG, Hynes PG, Martin PL, Pierce R, Kelly K.
Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/- prostate cancer model.
Stem Cells. 28: 2129-40, 2010.
2)  Martin P, Liu YN, Pierce R, Abou-Kheir W, Casey O, Seng V, Camacho D, Simpson RM, Kelly K.
Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.
Am. J. Pathol. 179: 422-35, 2011.
3)  Ward Y, Lake R, Yin JJ, Heger CD, Raffeld M, Goldsmith PK, Merino M, Kelly K.
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.
Cancer Res. 71: 7301-11, 2011.
4)  Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.
Mol. Cell. Biol. 32: 941-53, 2012.
5)  Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng S, Santoro M, Garcia-Rostan G, Kelly K.
CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.
Oncogene. 32: 2726-38, 2013.
6)  Ying X, Xiang T, Li L, Su X, Shu X, Luo X, Huang J, Yuan Y, Peng W, Oberst M, Kelly K, Ren G, Tao Q.
DACT1, an antagonist to Wnt/beta-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer.
Breast Cancer Res. 15: R23, 2013.
7)  Liu Y, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, Yi M, Stephens RM, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
Oncogene. 32: 296-306, 2013.
8)  Hynes PG, Kelly K.
Prostate cancer stem cells: The case for model systems.
J Carcinog. 11: 6, 2012.
9)  Xiang T, Li L, Yin X, Yuan C, Tan C, Su X, Xiong L, Putti TC, Oberst M, Kelly K, Ren G, Tao Q.
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
PLoS ONE. 7: e29783, 2012.
10)  Casey OM, Fang L, Hynes PG, Abou-Kheir WG, Martin PL, Tillman HS, Petrovics G, Awwad HO, Ward Y, Lake R, Zhang L, Kelly K.
TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation.
PLoS ONE. 7: e41668, 2012.
11)  Abou-Kheir W, Hynes PG, Martin P, Yin JJ, Liu YN, Seng V, Lake R, Spurrier J, Kelly K.
Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.
PLoS ONE. 6: e26112, 2011.
12)  Yin JJ, Zhang L, Munasinghe J, Linnoila RI, Kelly K.
Cediranib/AZD2171 inhibits bone and brain metastasis in a preclinical model of advanced prostate cancer.
Cancer Res. 70: 8662-73, 2010.
13)  Mishra PJ, Ha L, Rieker J, Sviderskaya EV, Bennett DC, Oberst MD, Kelly K, Merlino G.
Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.
Oncogene. 29: 2449-56, 2010.
14)  JuanYin J, Tracy K, Zhang L, Munasinghe J, Shapiro E, Koretsky A, Kelly K.
Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model.
Clin. Exp. Metastasis. 26: 403-14, 2009.
15)  Woodhouse E, Kelly K.
Deficiency screen reveals genomic region required for tumorigenesis and metastasis of lethal (2) giant larvae brain tumors.
Drosophila Information Service. 91: 6-10, 2008.
16)  Kelly K, Yin JJ.
Prostate cancer and metastasis initiating stem cells.
Cell Res. 18: 528-37, 2008.
17)  Oberst MD, Beberman SJ, Zhao L, Yin JJ, Ward Y, Kelly K.
TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation.
BMC Cancer. 8: 189, 2008.
18)  Yin J, Pollock C, Tracy K, Chock M, Martin P, Oberst M, Kelly K.
Activation of the RalGEF/Ral Pathway Promotes Prostate Cancer Metastasis to Bone.
Mol Cell Biol. 27: 7538-50, 2007.
19)  Wang T, Tian L, Haino M, Gao JL, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, Kelly K.
Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97.
Infect. Immun. 75: 1144-53, 2007.
20)  Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA.
Structure-function studies of the G-domain from human gem, a novel small G-protein.
FEBS Lett. 580: 5959-64, 2006.
21)  Wang T, Ward Y, Tian L, Lake R, Guedez L, Stetler-Stevenson WG, Kelly K.
CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells.
Blood. 105: 2836-44, 2005.
22)  Ward Y, Kelly K.
Gem protein signaling and regulation.
Meth. Enzymol. 407: 468-83, 2005.
23)  Yin JJ, Pollock CB, Kelly K.
Mechanisms of cancer metastasis to the bone.
Cell Res. 15: 57-62, 2005.
24)  Kelly K.
The RGK family: a regulatory tail of small GTP binding proteins.
Trends Cell Biol. 15: 640-3, 2005.
25)  Ward Y, Spinelli B, Quon MJ, Chen H, Ikeda SR, Kelly K.
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
Mol Cell Biol. 24: 651-661, 2004.
26)  Tillinghast GW, Partee J, Albert P, Kelley JM, Burtow KH, Kelly K.
Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.
Genes Chromosomes Cancer. 2: 121-31, 2003.
27)  Ward Y, Yap S, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K.
The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.
J Cell Biol. 157: 291-302, 2002.
28)  Ward Y, Wang W, Woodhouse E, Linnoila I, Liotta L, Kelly K.
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways.
Mol Cell Biol. 17: 5958-69, 2001.
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This page was last updated on 6/30/2014.