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Our Science – Strathern Website

Jeffrey N. Strathern, Ph.D.

Selected Publications

1)  Imashimizu M, Kireeva ML, Lubkowska L, Gotte D, Parks AR, Strathern JN, Kashlev M.
Intrinsic translocation barrier as an initial step in pausing by RNA polymerase II.
J. Mol. Biol. 425: 697-712, 2013.
[Journal]
2)  Zhou YN, Lubkowska L, Hui M, Court C, Chen S, Court DL, Strathern J, Jin DJ, Kashlev M.
Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli.
J. Biol. Chem. 288: 2700-10, 2013.
[Journal]
3)  Strathern J, Malagon F, Irvin J, Gotte D, Shafer B, Kireeva M, Lubkowska L, Jin DJ, Kashlev M.
The fidelity of transcription: RPB1 (RPO21) mutations that increase transcriptional slippage in S. cerevisiae.
J. Biol. Chem. 288: 2689-99, 2013.
[Journal]
4)  Strathern JN, Jin DJ, Court DL, Kashlev M.
Isolation and characterization of transcription fidelity mutants.
Biochim Biophys Acta B. 1819: 694-9, 2012.
[Journal]
5)  Walmacq C, Cheung AC, Kireeva ML, Lubkowska L, Ye C, Gotte D, Strathern JN, Carell T, Cramer P, Kashlev M.
Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage.
Mol. Cell. 46: 18-29, 2012.
[Journal]
6)  Walmacq C, Kireeva ML, Irvin J, Nedialkov Y, Lubkowska L, Malagon F, Strathern JN, Kashlev M.
Rpb9 Subunit Controls Transcription Fidelity by Delaying NTP Sequestration in RNA Polymerase II.
J. Biol. Chem. 284: 19601-12, 2009.
[Journal]
7)  Ambrose Z, Herman BD, Sheen C, Zelina S, Moore KL, Tachedjian G, Nissley DV, Sluis-Cremer N.
The human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs.
J. Virol. 83: 3826-33, 2009.
[Journal]
8)  Santoyo G, Strathern JN.
Non-homologous end joining is important for repair of Cr(VI)-induced DNA damage in Saccharomyces cerevisiae.
Microbiol. Res. 163: 113-9, 2008.
[Journal]
9)  Kireeva ML, Nedialkov YA, Cremona GH, Purtov YA, Lubkowska L, Malagon F, Burton ZF, Strathern JN, Kashlev M.
Transient reversal of RNA polymerase II active site closing controls fidelity of transcription elongation.
Mol. Cell. 30: 557-66, 2008.
[Journal]
10)  Nissley DV, Radzio J, Ambrose Z, Sheen CW, Hamamouch N, Moore KL, Tachedjian G, Sluis-Cremer N.
Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT.
Biochem. J. 404: 151-7, 2007.
[Journal]
11)  Lobachev KS, Rattray A, Narayanan V.
Hairpin- and cruciform-mediated chromosome breakage: causes and consequences in eukaryotic cells.
Front. Biosci. 12: 4208-20, 2007.
[Journal]
12)  Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT.
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.
Mol. Cell. 28: 638-51, 2007.
[Journal]
13)  Halvas EK, Aldrovandi GM, Balfe P, Beck IA, Boltz VF, Coffin JM, Frenkel LM, Hazelwood JD, Johnson VA, Kearney M, Kovacs A, Kuritzkes DR, Metzner KJ, Nissley DV, Nowicki M, Palmer S, Ziermann R, Zhao RY, Jennings CL, Bremer J, Brambilla D, Mellors JW.
Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency.
J. Clin. Microbiol. 44: 2612-4, 2006.
[Journal]
14)  Malagon F, Kireeva ML, Shafer BK, Lubkowska L, Kashlev M, Strathern JN.
Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil.
Genetics. 172: 2201-9, 2006.
[Journal]
15)  Rattray AJ, Shafer BK, Neelam B, Strathern JN.
A mechanism of palindromic gene amplification in Saccharomyces cerevisiae.
Genes Dev. 19: 1390-1399, 2005.
[Journal]
16)  Rattray AJ, Strathern JN.
Homologous recombination is promoted by translesion polymerase poleta.
Mol. Cell. 20: 658-9, 2005.
[Journal]
17)  Lewis SM, Chen S, Strathern JN, Rattray AJ.
New approaches to the analysis of palindromic sequences from the human genome: evolution and polymorphism of an intronic site at the NF1 locus.
Nucleic Acids Res. 33: e186, 2005.
[Journal]
18)  Flys T, Nissley DV, Claasen CW, Jones D, Shi C, Guay LA, Musoke P, Mmiro F, Strathern JN, Jackson JB, Eshleman JR, Eshleman SH.
Sensitive Drug-Resistance Assays Reveal Long-Term Persistence of HIV-1 Variants with the K103N Nevirapine (NVP) Resistance Mutation in Some Women and Infants after the Administration of Single-Dose NVP: HIVNET 012.
J Infect Dis. 192: 24-9, 2005.
[Journal]
19)  Nissley DV, Halvas EK, Hoppman NL, Garfinkel DJ, Mellors JW, Strathern JN.
Sensitive phenotypic detection of minor drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants.
J. Clin. Microbiol. 43: 5696-704, 2005.
[Journal]
20)  Malagon F, Tong AH, Shafer BK, Strathern JN.
Genetic interactions of DST1 in Saccharomyces cerevisiae suggest a role of TFIIS in the initiation-elongation transition.
Genetics. 166: 1215-27, 2004.
[Journal]
21)  Rattray AJ, Strathern JN.
Error-prone DNA polymerases: when making a mistake is the only way to get ahead.
Annu. Rev. Genet. 37: 31-66, 2003.
[Journal]
22)  Rattray AJ, Shafer BK, McGill CB, Strathern JN.
The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae.
Genetics. 162: 1063-77, 2002.
[Journal]
23)  Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M.
Functional profiling of the Saccharomyces cerevisiae genome.
Nature. 418: 387-91, 2002.
[Journal]
24)  Rattray AJ, McGill CB, Shafer BK, Strathern JN.
Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1.
Genetics. 158: 109-22, 2001.
[Journal]
25)  Davis ES, Shafer BK, Strathern JN.
The Saccharomyces cerevisiae RDN1 locus is sequestered from interchromosomal meiotic ectopic recombination in a SIR2-dependent manner.
Genetics. 155: 1019-32, 2000.
[Journal]
26)  Holbeck SL, Strathern JN.
EXO1 of Saccharomyces cerevisiae functions in mutagenesis during double-strand break repair.
Ann N Y Acad Sci. 870: 375-7, 1999.
[Journal]
27)  Nissley DV, Boyer PL, Garfinkel DJ, Hughes SH, Strathern JN.
Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase.
Proc Natl Acad Sci U S A. 95: 13905-10, 1998.
[Journal]
28)  McGill CB, Holbeck SL, Strathern JN.
The chromosome bias of misincorporations during double-strand break repair is not altered in mismatch repair-defective strains of Saccharomyces cerevisiae.
Genetics. 148: 1525-33, 1998.
[Journal]
29)  Holbeck SL, Strathern JN.
A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae.
Genetics. 147: 1017-24, 1997.
[Journal]
30)  Derbyshire MK, Weinstock KG, Strathern JN.
HST1, a new member of the SIR2 family of genes.
Yeast. 12: 631-40, 1996.
[Journal]
31)  Nissley DV, Garfinkel DJ, Strathern JN.
HIV reverse transcription in yeast.
Nature. 380: 30, 1996.
[Journal]
32)  Strathern JN, Shafer BK, McGill CB.
DNA synthesis errors associated with double-strand-break repair.
Genetics. 140: 965-72, 1995.
[Journal]
33)  La Roche SD, Shafer BK, Strathern JN.
A ste12 allele having a differential effect on a versus alpha cells.
Mol Gen Genet. 246: 80-90, 1995.
[Journal]
34)  Sutrave P, Shafer BK, Strathern JN, Hughes SH.
Isolation, identification and characterization of the FUN12 gene of Saccharomyces cerevisiae.
Gene. 146: 209-13, 1994.
[Journal]
35)  Hastings PJ, McGill C, Shafer B, Strathern JN.
Ends-in vs. ends-out recombination in yeast.
Genetics. 135: 973-80, 1993.
[Journal]
36)  Kawakami K, Pande S, Faiola B, Moore DP, Boeke JD, Farabaugh PJ, Strathern JN, Nakamura Y, Garfinkel DJ.
A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae.
Genetics. 135: 309-20, 1993.
[Journal]
37)  Weinstock KG, Strathern JN.
Molecular genetics in Saccharomyces kluyveri: the HIS3 homolog and its use as a selectable marker gene in S. kluyveri and Saccharomyces cerevisiae.
Yeast. 9: 351-61, 1993.
[Journal]
38)  Derr LK, Strathern JN.
A role for reverse transcripts in gene conversion.
Nature. 361: 170-3, 1993.
[Journal]
39)  Coluccio LM, Conaty C.
Myosin-I in mammalian liver.
Cell Motil Cytoskeleton. 24: 189-99, 1993.
[Journal]
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This page was last updated on 5/1/2013.