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Thomas Ried, M.D.

Selected Publications

1)  Chowdhury SA, Shackney SE, Heselmeyer-Haddad K, Ried T, Schäffer AA, Schwartz R.
Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics.
PLoS Comput. Biol. 10: e1003740, 2014.
2)  Tang J, Li Y, Lyon K, Camps J, Dalton S, Ried T, Zhao S.
Cancer driver-passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer.
Oncogene. 33: 814-22, 2014.
3)  Gemoll T, Habermann JK, Becker S, Szymczak S, Upender MB, Bruch H, Hellman U, Ried T, Auer G, Jörnvall H, Roblick UJ.
Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells.
Anal Cell Pathol (Amst). [Epub ahead of print], 2014.
4)  Akagi K, Li J, Broutian TR, Padilla-Nash H, Xiao W, Jiang B, Rocco JW, Teknos TN, Kumar B, Wangsa D, He D, Ried T, Symer DE, Gillison ML.
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Genome Res. 24: 185-99, 2014.
5)  Hirsch D, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T.
LGR5 positivity defines stem-like cells in colorectal cancer.
Carcinogenesis. 35: 849-58, 2014.
6)  Camps J, Wangsa D, Falke M, Brown M, Case CM, Erdos MR, Ried T.
Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories.
FASEB J. [Epub ahead of print], 2014.
7)  Heselmeyer-Haddad KM, Berroa Garcia LY, Bradley A, Hernandez L, Hu Y, Habermann JK, Dumke C, Thorns C, Perner S, Pestova E, Burke C, Chowdhury SA, Schwartz R, Schäffer AA, Paris PL, Ried T.
Single-Cell Genetic Analysis Reveals Insights into Clonal Development of Prostate Cancers and Indicates Loss of PTEN as a Marker of Poor Prognosis.
Am. J. Pathol. [Epub ahead of print], 2014.
8)  Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M.
STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.
Int. J. Cancer. 134: 997-1007, 2014.
9)  Zhang Y, Calado R, Rao M, Hong JA, Meeker AK, Dumitriu B, Atay S, McCormick PJ, Garfield SH, Wangsa D, Padilla-Nash HM, Burkett S, Zhang M, Kunst TF, Peterson NR, Xi S, Inchauste S, Altorki NK, Casson AG, Beer DG, Harris CC, Ried T, Young NS, Schrump DS.
Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.
PLoS ONE. 9: e101010, 2014.
10)  Padilla-Nash HM, McNeil NE, Yi M, Nguyen Q, Hu Y, Wangsa D, Mack DL, Hummon AB, Case C, Cardin E, Stephens R, Difilippantonio MJ, Ried T.
Aneuploidy, Oncogene Amplification, and Epithelial to Mesenchymal Transition Define Spontaneous Transformation of Murine Epithelial Cells.
Carcinogenesis. 34: 1929-39, 2013.
11)  Gerling M, Nousiainen K, Hautaniemi S, Krüger S, Fritzsche B, Homann N, Bruch HP, Auer G, Roblick UJ, Ried T, Habermann JK.
Aneuploidy-associated gene expression signatures characterize malignant transformation in ulcerative colitis.
Inflamm. Bowel Dis. 19: 691-703, 2013.
12)  Case CM, Sackett DL, Wangsa D, Karpova T, McNally JG, Ried T, Camps J.
CKAP2 Ensures Chromosomal Stability by Maintaining the Integrity of Microtubule Nucleation Sites.
PLoS ONE. 8: e64575, 2013.
13)  Bowen S, Wangsa D, Ried T, Livak F, Hodes RJ.
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.
Nucleic Acids Res. 41: 4535-48, 2013.
14)  Winkler T, Hong SG, Decker JE, Morgan MJ, Wu C, Hughes WM, Yang Y, Wangsa D, Padilla-Nash HM, Ried T, Young NS, Dunbar CE, Calado RT.
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.
J. Clin. Invest. 123: 1952-63, 2013.
15)  Zhang G, He P, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Hanna N, Alexander HR, Hussain SP.
FOXL1, a Novel Candidate Tumor Suppressor, Inhibits Tumor Aggressiveness and Predicts Outcome in Human Pancreatic Cancer.
Cancer Res. 73: 5416-25, 2013.
16)  Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beissbarth T, Difilippantonio MJ, Caplen NJ, Ried T.
Genetic amplication of the NOTCH modulator LNX2 upregulates the WNT/β-catenin pathway in colorectal cancer.
Cancer Res. 73: 2003-13, 2013.
17)  Achyut BR, Bader DA, Robles AI, Wangsa D, Harris CC, Ried T, Yang L.
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-ß signaling.
PLoS Genet. 9: e1003251, 2013.
18)  Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM, Ried T, Yfantis HG, Lee DH, Maitra A, Hanna N, Alexander HR, Hussain SP.
Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer.
Clin. Cancer Res. 19: 4983-93, 2013.
19)  Camps J, Ried T, Castells A.
Intratumor heterogeneity: finding the needle in a haystack for cancer treatment.
Gastroenterology. 145: 242-4, 2013.
20)  Gaiser T, Meinhardt S, Hirsch D, Killian JK, Gaedcke J, Jo P, Ponsa I, Miró R, Rüschoff J, Seitz G, Hu Y, Camps J, Ried T.
Molecular patterns in the evolution of serrated lesion of the colorectum.
Int. J. Cancer. 132: 1800-10, 2013.
21)  Chowdhury SA, Shackney SE, Heselmeyer-Haddad K, Ried T, Schäffer AA, Schwartz R.
Phylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations.
Bioinformatics. 29: i189-i198, 2013.
22)  Hirsch D, Camps J, Varma S, Kemmerling R, Stapleton M, Ried T, Gaiser T.
A new whole genome amplification method for studying clonal evolution patterns in malignant colorectal polyps.
Genes Chromosomes Cancer. 51: 490-500, 2012.
23)  Ried T, Gaiser T.
A recurrent fusion gene in high-grade endometrial stromal sarcoma: a new tool for diagnosis and therapy?.
Genome Med. 4: 20, 2012.
24)  Coleman AE, McNeil N, Kovalchuck AL, Wangsa D, Ried T, Wang H.
Cellular exposure to muscle relaxants and propofol could lead to genomic instability in vitro.
J Biomed Res. 26: 117-24, 2012.
25)  Hirsch D, Kemmerling R, Davis S, Camps J, Meltzer PS, Ried T, Gaiser T.
Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma.
Cancer Res. 73: 1454-60, 2012.
26)  Zhang G, Schetter A, He P, Funamizu N, Gaedcke J, Ghadimi BM, Ried T, Hassan R, Yfantis HG, Lee DH, Lacy C, Maitra A, Hanna N, Alexander HR, Hussain SP.
DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma.
PLoS ONE. 7: e31507, 2012.
27)  Olnes MJ, Poon A, Miranda SJ, Pfannes L, Tucker Z, Loeliger K, Padilla-Nash H, Yau YY, Ried T, Leitman SF, Young NS, Sloand EM.
Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors.
Transfusion. 52: 537-41, 2012.
28)  Funamizu N, Hu C, Lacy C, Schetter A, Zhang G, He P, Gaedcke J, Ghadimi MB, Ried T, Yfantis HG, Lee DH, Subleski J, Chan T, Weiss JM, Back TC, Yanaga K, Hanna N, Alexander HR, Maitra A, Hussain SP.
Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma.
Int. J. Cancer. [Epub ahead of print], 2012.
29)  Xie Y, Tobin LA, Camps J, Wangsa D, Yang J, Rao M, Witasp E, Awad KS, Yoo N, Ried T, Kwong KF.
MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells.
Oncogene. [Epub ahead of print], 2012.
30)  Peickert S, Waurig J, Dittfeld C, Dietrich A, Garbe Y, Kabus L, Baumann M, Grade M, Ried T, Kunz-Schughart LA.
Rapid re-expression of CD133 protein in colorectal cancer cell lines in vitro and in vivo.
Lab. Invest. 92: 1607-22, 2012.
31)  Sharon E, Zhang J, Hollevoet K, Steinberg SM, Pastan I, Onda M, Gaedcke J, Ghadimi BM, Ried T, Hassan R.
Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers.
Clin. Chem. Lab. Med. 50: 721-5, 2012.
32)  Calado RT, Cooper JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS.
Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.
Leukemia. 26: 700-7, 2012.
33)  Heselmeyer-Haddad K, Berroa Garcia LY, Bradley A, Ortiz-Melendez C, Lee WJ, Christensen R, Prindiville SA, Calzone KA, Soballe PW, Hu Y, Chowdhury SA, Schwartz R, Schäffer AA, Ried T.
Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.
Am. J. Pathol. 181: 1807-22, 2012.
34)  Padilla-Nash HM, Hathcock K, McNeil NE, Mack D, Hoeppner D, Ravin R, Knutsen T, Yonescu R, Wangsa D, Dorritie K, Barenboim L, Hu Y, Ried T.
Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances.
Genes Chromosomes Cancer. 51: 353-74, 2012.
35)  Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ.
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Mol. Cancer. 11: 1, 2012.
36)  Ried T, Hu Y, Difilippantonio MJ, Ghadimi BM, Grade M, Camps J.
The consequences of chromosomal aneuploidy on the transcriptome of cancer cells.
Biochim. Biophys. Acta. 1819: 784-93, 2012.
37)  Gaedcke J, Grade M, Camps J, Søkilde R, Kaczkowski B, Schetter AJ, Difilippantonio MJ, Harris CC, Ghadimi BM, Møller S, Beissbarth T, Ried T, Litman T.
The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa.
Clin. Cancer Res. 18: 4919-30, 2012.
38)  Gaiser T, Berroa-Garcia L, Kemmerling R, Dutta A, Ried T, Heselmeyer-Haddad K.
Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.
Cell Oncol (Dordr). 34: 337-42, 2011.
39)  Liu Z, Yang X, Li Z, McMahon C, Sizer C, Barenboim-Stapleton L, Bliskovsky V, Mock B, Ried T, London WB, Maris J, Khan J, Thiele CJ.
CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression.
Cell Death Differ. 18: 1174-83, 2011.
40)  Derfoul A, Juan A, Difilippantonio MJ, Palanisamy N, Ried T, Sartorelli V.
Decreased MicroRNA-214 Levels In Breast Cancer Cells Coincides with Increased Cell Proliferation, Invasion, and Accumulation of the Polycomb Ezh2 Methyltransferase.
Carcinogenesis. 32: 1607-14, 2011.
41)  Gaiser T, Camps J, Meinhardt S, Wangsa D, Nguyen QT, Varma S, Dittfeld C, Kunz-Schughart LA, Kemmerling R, Becker MR, Heselmeyer-Haddad K, Ried T.
Genome and transcriptome profiles of CD133-positive colorectal cancer cells.
Am. J. Pathol. 178: 1478-88, 2011.
42)  Habermann JK, Brucker CA, Freitag-Wolf S, Heselmeyer-Haddad K, Krüger S, Barenboim L, Downing T, Bruch HP, Auer G, Roblick UJ, Ried T.
Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma.
Mod. Pathol. 24: 542-55, 2011.
43)  Habermann JK, Bündgen NK, Gemoll T, Hautaniemi S, Lundgren C, Wangsa D, Doering J, Bruch HP, Nordstroem B, Roblick UJ, Jörnvall H, Auer G, Ried T.
Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes.
Mol. Cancer. 10: 132, 2011.
44)  Gemoll T, Roblick UJ, Szymczak S, Braunschweig T, Becker S, Igl B, Bruch H, Ziegler A, Hellman U, Difilippantonio MJ, Ried T, Jörnvall H, Auer G, Habermann JK.
HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers.
Cell Mol Life Sci. 68: 3261-74, 2011.
45)  Goldenberg DM, Zagzag D, Heselmeyer-Haddad KM, Berroa Garcia LY, Ried T, Loo M, Chang C, Gold DV.
Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells In Vivo.
Int J Cancer. 131: 49-58, 2011.
46)  Garman KS, Acharya CR, Edelman E, Grade M, Gaedcke J, Sud S, Barry W, Diehl AM, Provenzale D, Ginsburg GS, Ghadimi BM, Ried T, Nevins JR, Mukherjee S, Hsu D, Potti A.
Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.
Proc. Natl. Acad. Sci. U.S.A. 108: 17569, 2011.
47)  Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, Kramer F, Wolff HA, Becker H, Beissbarth T, Ebner R, Ghadimi BM, Pukrop T, Ried T, Grade M.
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.
Carcinogenesis. 32: 1824-31, 2011.
48)  Mettu RK, Wan YW, Habermann JK, Ried T, Guo NL.
A 12-gene genomic instability signature predicts clinical outcomes in multiple cancer types.
Int. J. Biol. Markers. 25: 219-28, 2010.
49)  Spitzner M, Emons G, Kramer F, Gaedcke J, Rave-Fränk M, Scharf JG, Burfeind P, Becker H, Beissbarth T, Ghadimi BM, Ried T, Grade M.
A gene expression signature for chemoradiosensitivity of colorectal cancer cells.
Int. J. Radiat. Oncol. Biol. Phys. 78: 1184-92, 2010.
50)  Grade M, Hummon AB, Camps J, Emons G, Spitzner M, Gaedcke J, Hoermann P, Ebner R, Becker H, Difilippantonio MJ, Ghadimi BM, Beissbarth T, Caplen NJ, Ried T.
A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.
Int J Cancer. 128: 1069-79, 2010.
51)  Gaiser T, Berroa-Garcia L, Kemmerling R, Dutta A, Ried T, Heselmeyer-Haddad K.
Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.
Anal Cell Pathol (Amst). 33: 105-12, 2010.
52)  Gaiser T, Berroa-Garcia L, Kemmerling R, Dutta A, Ried T, Heselmeyer-Haddad K.
Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.
Cell Oncol. [Epub ahead of print], 2010.
53)  Dittfeld C, Dietrich A, Peickert S, Hering S, Baumann M, Grade M, Ried T, Kunz-Schughart LA.
CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell line HCT-116.
Radiother Oncol. 94: 375-83, 2010.
54)  Fishler T, Li YY, Wang RH, Kim HS, Sengupta K, Vassilopoulos A, Lahusen T, Xu X, Lee MH, Liu Q, Elledge SJ, Ried T, Deng CX.
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.
Oncogene. 29: 4007-17, 2010.
55)  Takizawa M, Kim JS, Tessarollo L, McNeil N, Waldschmidt TJ, Casellas R, Ried T, Janz S.
Genetic reporter system for oncogenic Igh-Myc translocations in mice.
Oncogene. 29: 4113-20, 2010.
56)  Prindiville SA, Ried T.
Interphase cytogenetics of sputum cells for the early detection of lung carcinogenesis.
Cancer Prev Res (Phila). 3: 416-9, 2010.
57)  Gaedcke J, Grade M, Jung K, Schirmer M, Jo P, Obermeyer C, Wolff HA, Herrmann MK, Beissbarth T, Becker H, Ried T, Ghadimi M.
KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.
Radiother Oncol. 94: 76-81, 2010.
58)  Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM.
Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
Genes Chromosomes Cancer. 49: 1024-34, 2010.
59)  Cheng L, Zhou Z, Flesken-Nikitin A, Toshkov IA, Wang W, Camps J, Ried T, Nikitin AY.
Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.
Oncogene. 29: 5700-11, 2010.
60)  Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.
Cancer Genet. Cytogenet. 196: 45-55, 2010.
61)  Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC.
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.
Mol. Cell. 36: 631-41, 2009.
62)  Dierov J, Sanchez PV, Burke BA, Padilla-Nash H, Putt ME, Ried T, Carroll M.
BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold.
Leukemia. 23: 279-86, 2009.
63)  Dittfeld C, Dietrich A, Peickert S, Hering S, Baumann M, Grade M, Ried T, Kunz-Schughart LA.
CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116.
Radiother Oncol. 92: 353-61, 2009.
64)  Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A.
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.
Cell Cycle. 8: 2408-12, 2009.
65)  Grade M, Gaedcke J, Wangsa D, Varma S, Beckmann J, Liersch T, Hess C, Becker H, Difilippantonio MJ, Ried T, Ghadimi BM.
Chromosomal copy number changes of locally advanced rectal cancers treated with preoperative chemoradiotherapy.
Cancer Genet. Cytogenet. 193: 19-28, 2009.
66)  Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J.
Chromosomal instability determines taxane response.
Proc. Natl. Acad. Sci. U.S.A. 106: 8671-6, 2009.
67)  Knutsen T, Padilla-Nash HM, Wangsa D, Barenboim-Stapleton L, Camps J, McNeil N, Difilippantonio MJ, Ried T.
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Genes Chromosomes Cancer. 49: 204-223, 2009.
68)  Andersson S, Sowjanya P, Wangsa D, Hjerpe A, Johansson B, Auer G, Gravitt PE, Larsson C, Wallin KL, Ried T, Heselmeyer-Haddad K.
Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears.
Am. J. Pathol. 175: 1831-47, 2009.
69)  Ryott M, Wangsa D, Heselmeyer-Haddad K, Lindholm J, Elmberger G, Auer G, Lundqvist EV, Ried T, Munck-Wikland E.
EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.
Eur. J. Cancer. 45: 1700-8, 2009.
70)  To KK, Robey RW, Knutsen T, Zhan Z, Ried T, Bates SE.
Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2.
Mol. Cancer Ther. 8: 2959-68, 2009.
71)  Gertz EM, Sengupta K, Difilippantonio MJ, Ried T, Schäffer AA.
Evaluating annotations of an Agilent expression chip suggests that many features cannot be interpreted.
BMC Genomics. 10: 566, 2009.
72)  Wangsa D, Heselmeyer-Haddad K, Ried P, Eriksson E, Schäffer AA, Morrison LE, Luo J, Auer G, Munck-Wikland E, Ried T, Lundqvist EA.
Fluorescence in situ hybridization markers for prediction of cervical lymph node metastases.
Am. J. Pathol. 175: 2637-45, 2009.
73)  Ried T.
Homage to Theodor Boveri (1862-1915): Boveri's theory of cancer as a disease of the chromosomes, and the landscape of genomic imbalances in human carcinomas.
Environ. Mol. Mutagen. 50: 593-601, 2009.
74)  Camps J, Tri Nguyen Q, Padilla-Nash HM, Knutsen T, McNeil NE, Wangsa D, Hummon AB, Grade M, Ried T, Difilippantonio MJ.
Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer.
Genes Chromosomes Cancer. 48: 1002-17, 2009.
75)  Difilippantonio MJ, Ghadimi BM, Howard T, Camps J, Nguyen QT, Ferris DK, Sackett DL, Ried T.
Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells.
Environ. Mol. Mutagen. 50: 672-96, 2009.
76)  Liersch T, Grade M, Gaedcke J, Varma S, Difilippantonio MJ, Langer C, Hess CF, Becker H, Ried T, Ghadimi BM.
Preoperative chemoradiotherapy in locally advanced rectal cancer: correlation of a gene expression-based response signature with recurrence.
Cancer Genet. Cytogenet. 190: 57-65, 2009.
77)  Habermann JK, Doering J, Hautaniemi S, Roblick UJ, Bündgen NK, Nicorici D, Kronenwett U, Rathnagiriswaran S, Mettu RK, Ma Y, Krüger S, Bruch HP, Auer G, Guo NL, Ried T.
The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome.
Int. J. Cancer. 124: 1552-64, 2009.
78)  Garman KS, Acharya CR, Edelman E, Grade M, Gaedcke J, Sud S, Barry W, Diehl AM, Provenzale D, Ginsburg GS, Ghadimi BM, Ried T, Nevins JR, Mukherjee S, Hsu D, Potti A.
A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.
Proc. Natl. Acad. Sci. U.S.A. 105: 19432-7, 2008.
79)  Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta KJ, Mills GB, Bajsarowicz K, Kobayashi Y, Sridharan S, Paris PL, Tao Q, Aerni SJ, Brown RP, Bashir A, Gray JW, Cheng JF, de Jong P, Nefedov M, Ried T, Padilla-Nash HM, Collins CC.
A sequence-based survey of the complex structural organization of tumor genomes.
Genome Biol. 9: R59, 2008.
80)  Xu M, Yu Q, Subrahmanyam R, Difilippantonio MJ, Ried T, Sen JM.
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo.
Mol. Cell. Biol. 28: 1713-23, 2008.
81)  Camps J, Grade M, Nguyen QT, Hormann P, Becker S, Hummon AB, Rodriguez V, Chandrasekharappa S, Chen Y, Difilippantonio MJ, Becker H, Ghadimi BM, Ried T.
Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome.
Cancer Res. 68: 1284-95, 2008.
82)  Habermann JK, Bader FG, Franke C, Zimmermann K, Gemoll T, Fritzsche B, Ried T, Auer G, Bruch H, Roblick UJ.
From the genome to the proteome-biomarkers in colorectal cancer.
Langenbecks Arch Surg. 393: 93-104, 2008.
83)  Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX.
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Cancer Cell. 14: 312-23, 2008.
84)  Wangsa D, Ryott M, Avall-Lundqvist E, Petersson F, Elmberger G, Luo J, Ried T, Auer G, Munck-Wikland E.
Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma.
Br. J. Cancer. 99: 1121-8, 2008.
85)  Sengupta K, Camps J, Mathews P, Barenboim-Stapleton L, Nguyen QT, Difilippantonio MJ, Ried T.
Position of human chromosomes is conserved in mouse nuclei indicating a species-independent mechanism for maintaining genome organization.
Chromosoma. 117: 499-509, 2008.
86)  Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF.
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Nature. 452: 492-6, 2008.
87)  Yang Y, Padilla-Nash HM, Vira MA, Abu-Asab MS, Val D, Worrell R, Tsokos M, Merino MJ, Pavlovich CP, Ried T, Linehan WM, Vocke CD.
The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dube gene pathway.
Cancer Genet. Cytogenet. 180: 100-9, 2008.
88)  Gill RK, Vazquez MF, Kramer A, Hames M, Zhang L, Heselmeyer-Haddad K, Ried T, Shilo K, Henschke C, Yankelevitz D, Jen J.
The use of genetic markers to identify lung cancer in fine needle aspiration samples.
Clin. Cancer Res. 14: 7481-7, 2008.
89)  Roblick UJ, Bader FG, Lenander C, Hellman U, Zimmermann K, Becker S, Ost A, Alaiya A, Bruch H, Keller R, Mirow L, Franzén B, Ried T, Auer G, Habermann JK.
Undifferentiated pelvic adenocarcinomas: diagnostic potential of protein profiling and multivariate analysis.
Int J Colorectal Dis. 23: 483-91, 2008.
90)  Duelli DM, Padilla-Nash HM, Berman D, Murphy KM, Ried T, Lazebnik Y.
A virus causes cancer by inducing massive chromosomal instability through cell fusion.
Curr. Biol. 17: 431-7, 2007.
91)  Dundr M, Ospina JK, Sung MH, John S, Upender M, Ried T, Hager GL, Matera AG.
Actin-dependent intranuclear repositioning of an active gene locus in vivo.
J. Cell Biol. 179: 1095-103, 2007.
92)  Kovalchuk AL, duBois W, Mushinski E, McNeil NE, Hirt C, Qi CF, Li Z, Janz S, Honjo T, Muramatsu M, Ried T, Behrens T, Potter M.
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements.
J. Exp. Med. 204: 2989-3001, 2007.
93)  Sengupta K, Upender MB, Barenboim-Stapleton L, Nguyen QT, Wincovitch SM, Garfield SH, Difilippantonio MJ, Ried T.
Artificially introduced aneuploid chromosomes assume a conserved position in colon cancer cells.
PLoS ONE. 2: e199, 2007.
94)  Callen E, Jankovic M, Difilippantonio S, Daniel JA, Chen H, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Cell. 130: 63-75, 2007.
95)  Martin CL, Reshmi SC, Ried T, Gottberg W, Wilson JW, Reddy JK, Khanna P, Johnson JT, Myers EN, Gollin SM.
Chromosomal imbalances in oral squamous cell carcinoma: Examination of 31 cell lines and review of the literature.
Oral Oncol. 44: 369-82, 2007.
96)  Chen MJ, Dumitrache LC, Wangsa D, Ma SM, Padilla-Nash H, Ried T, Hasty P.
Cisplatin depletes TREX2 and causes Robertsonian translocations as seen in TREX2 knockout cells.
Cancer Res. 67: 9077-83, 2007.
97)  Hsu C, Jones SA, Cohen CJ, Zheng Z, Kerstann K, Zhou J, Robbins PF, Peng PD, Shen X, Gomes TJ, Dunbar CE, Munroe DJ, Stewart C, Cornetta K, Wangsa D, Ried T, Rosenberg SA, Morgan RA.
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.
Blood. 109: 5168-77, 2007.
98)  Ebner R, Ried T.
Drug Discov Today Dis Mech. 4: 259-260, 2007.
99)  Grade M, Hormann P, Becker S, Hummon AB, Wangsa D, Varma S, Simon R, Liersch T, Becker H, Difilippantonio MJ, Ghadimi BM, Ried T.
Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas.
Cancer Res. 67: 41-56, 2007.
100)  Wang X, Liu L, Montagna C, Ried T, Deng CX.
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Cell Death Differ. 14: 924-31, 2007.
101)  Hummon AB, Lim SR, Difilippantonio MJ, Ried T.
Isolation and solubilization of proteins after TRIzol extraction of RNA and DNA from patient material following prolonged storage.
BioTechniques. 42: 467-70, 472, 2007.
102)  Griffin CA, Morsberger L, Hawkins AL, Haddadin M, Patel A, Ried T, Schrock E, Perlman EJ, Jaffee E.
Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations.
Cytogenet. Genome Res. 118: 148-56, 2007.
103)  Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
Positional stability of single double-strand breaks in mammalian cells.
Nat. Cell Biol. 9: 675-82, 2007.
104)  Sudbo J, Ried T, Bryne M, Kildal W, Danielsen H, Reith A.
Retraction notice to 'Abnormal DNA content predicts the occurrence of carcinomas in non-dysplastic oral white patches' [Oral Oncol. 37 (2001) 558-565].
Oral Oncol. 43: 418, 2007.
105)  Padilla-Nash HM, Wu K, Just H, Ried T, Thestrup-Pedersen K.
Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma.
Exp. Dermatol. 16: 98-103, 2007.
106)  Habermann JK, Paulsen U, Roblick UJ, Upender MB, McShane LM, Korn EL, Wangsa D, Kruger S, Duchrow M, Bruch H, Auer G, Ried T.
Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis.
Genes Chromosomes Cancer. 46: 10-26, 2007.
107)  Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B.
The XIST noncoding RNA functions independently of BRCA1 in X inactivation.
Cell. 128: 977-89, 2007.
108)  Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, Patel V, Seo BM, Sonoyama W, Zheng JJ, Baker CC, Chen W, Ried T, Shi S.
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation.
Stem Cells. 24: 1095-103, 2006.
109)  Grade M, Ghadimi BM, Varma S, Simon R, Wangsa D, Barenboim-Stapleton L, Liersch T, Becker H, Ried T, Difilippantonio MJ.
Aneuploidy-dependent massive deregulation of the cellular transcriptome and apparent divergence of the Wnt/beta-catenin signaling pathway in human rectal carcinomas.
Cancer Res. 66: 267-82, 2006.
110)  Danforth DN, Abati A, Filie A, Prindiville SA, Palmieri D, Simon R, Ried T, Steeg PS.
Combined breast ductal lavage and ductal endoscopy for the evaluation of the high-risk breast: a feasibility study.
J Surg Oncol. 94: 555-64, 2006.
111)  Helou K, Padilla-Nash H, Wangsa D, Karlsson E, Osterberg L, Karlsson P, Ried T, Knutsen T.
Comparative genome hybridization reveals specific genomic imbalances during the genesis from benign through borderline to malignant ovarian tumors.
Cancer Genet. Cytogenet. 170: 1-8, 2006.
112)  Knutsen T, Vakulchuk A, Mosijczuk AD, Gabrea A, Ried T, Tretyak N.
Complex rearrangements involving der(8)t(8;20) and der(14)t(8;14)t(11;14), CCND1, and duplication of IgH constant region in acute plasmablastic leukemia.
Cancer Genet. Cytogenet. 164: 137-41, 2006.
113)  Andersson S, Wallin KL, Hellström AC, Morrison LE, Hjerpe A, Auer G, Ried T, Larsson C, Heselmeyer-Haddad K.
Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas.
Br. J. Cancer. 95: 331-8, 2006.
114)  Habermann JK, Roblick UJ, Upender M, Ried T, Auer G.
From genome to proteome in tumor profiling: molecular events in colorectal cancer genesis.
Adv. Exp. Med. Biol. 587: 161-77, 2006.
115)  Habermann JK, Roblick UJ, Luke BT, Prieto DA, Finlay WJ, Podust VN, Roman JM, Oevermann E, Schiedeck T, Homann N, Duchrow M, Conrads TP, Veenstra TD, Burt SK, Bruch HP, Auer G, Ried T.
Increased serum levels of complement C3a anaphylatoxin indicate the presence of colorectal tumors.
Gastroenterology. 131: 1020-9; quiz 1284, 2006.
116)  Jang W, Yonescu R, Knutsen T, Brown T, Reppert T, Sirotkin K, Schuler GD, Ried T, Kirsch IR.
Linking the human cytogenetic map with nucleotide sequence: the CCAP clone set.
Cancer Genet. Cytogenet. 168: 89-97, 2006.
117)  Grade M, Becker H, Liersch T, Ried T, Ghadimi BM.
Molecular cytogenetics: Genomic imbalances in colorectal cancer and their clinical impact.
Cell. Oncol. 28: 71-84, 2006.
118)  Focarelli ML, Montagna C, Colombo R, Ried T, Vezzoni P, Musio A.
SMC1 inhibition results in FRA3B expression but has no effect on its delayed replication.
Mutat. Res. 595: 23-8, 2006.
119)  Padilla-Nash HM, Barenboim-Stapleton L, Difilippantonio MJ, Ried T.
Spectral karyotyping analysis of human and mouse chromosomes.
Nat Protoc. 1: 3129-42, 2006.
120)  Mazumdar M, Lee JH, Sengupta K, Ried T, Rane S, Misteli T.
Tumor formation via loss of a molecular motor protein.
Curr. Biol. 16: 1559-64, 2006.
121)  Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J.
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.
Mol. Cell. Biol. 25: 10079-86, 2005.
122)  Desper R, Difilippantonio MJ, Ried T, Schäffer AA.
A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis.
Math Biosci. 197: 67-87, 2005.
123)  Bowen TJ, Yakushiji H, Montagna C, Jain S, Ried T, Wynshaw-Boris A.
Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching.
Cancer Res. 65: 8736-46, 2005.
124)  Kronenwett U, Huwendiek S, Castro J, Ried T, Auer G.
Characterisation of breast fine-needle aspiration biopsies by centrosome aberrations and genomic instability.
Br J Cancer. 92: 389-95, 2005.
125)  Rao VK, Wangsa D, Robey RW, Huff L, Honjo Y, Hung J, Knutsen T, Ried T, Bates SE.
Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.
Cancer Genet. Cytogenet. 160: 126-33, 2005.
126)  Wang Z, Li Q, Huang GS, Liu SJ, Guo HZ, Zhang J, Cheng H, Xu J, Barenboim-Stapleton L, Ried T.
Clinical report of congenital lymphatic malformations and partial gigantism of the hands associated with a heterogeneous karyotype.
Am J Med Genet A. 132: 106-7, 2005.
127)  Ghadimi BM, Grade M, Difilippantonio MJ, Varma S, Simon R, Montagna C, Füzesi L, Langer C, Becker H, Liersch T, Ried T.
Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy.
J Clin Oncol. 23: 1826-38, 2005.
128)  McNeil N, Kim JS, Ried T, Janz S.
Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation.
Genes Chromosomes Cancer. 43: 137-46, 2005.
129)  Stoltzfus P, Heselmeyer-Haddad K, Castro J, White N, Silfverswärd C, Sjövall K, Einhorn N, Tryggvason K, Auer G, Ried T, Nordström B.
Gain of chromosome 3q is an early and consistent genetic aberration in carcinomas of the vulva.
Int J Gynecol Cancer. 15: 120-6, 2005.
130)  Chen KG, Wang YC, Schaner ME, Francisco B, Durán GE, Juric D, Huff LM, Padilla-Nash H, Ried T, Fojo T, Sikic BI.
Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line.
Cancer Res. 65: 9388-97, 2005.
131)  Heselmeyer-Haddad K, Sommerfeld K, White NM, Chaudhri N, Morrison LE, Palanisamy N, Wang ZY, Auer G, Steinberg W, Ried T.
Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.
Am J Pathol. 166: 1229-38, 2005.
132)  Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC, Janz S.
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.
Cancer Res. 65: 1306-15, 2005.
133)  McNamara G, Difilippantonio MJ, Ried T.
Microscopy and image analysis.
Curr Protoc Hum Genet. Chapter 4: Unit 4.4, 2005.
134)  Han SS, Shaffer AL, Peng L, Chung ST, Lim JH, Maeng S, Kim JS, McNeil N, Ried T, Staudt LM, Janz S.
Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1.
Mol. Cancer. 4: 40, 2005.
135)  Barenboim-Stapleton L, Yang X, Tsokos M, Wigginton JM, Padilla-Nash H, Ried T, Thiele CJ.
Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line.
Cancer Genet Cytogenet. 157: 109-17, 2005.
136)  Musio A, Montagna C, Mariani T, Tilenni M, Focarelli ML, Brait L, Indino E, Benedetti PA, Chessa L, Albertini A, Ried T, Vezzoni P.
SMC1 involvement in fragile site expression.
Hum Mol Genet. 14: 525-33, 2005.
137)  Rao VK, Knutsen T, Ried T, Wangsa D, Flynn BM, Langham G, Egorin MJ, Cole D, Balis F, Steinberg SM, Bates S, Fojo T.
The extent of chromosomal aberrations induced by chemotherapy in non-human primates depends on the schedule of administration.
Mutat Res. 583: 105-19, 2005.
138)  Knutsen T, Gobu V, Knaus R, Padilla-Nash H, Augustus M, Strausberg RL, Kirsch IR, Sirotkin K, Ried T.
The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence.
Genes Chromosomes Cancer. 44: 52-64, 2005.
139)  Habermann JK, Hellman K, Freitag S, Heselmeyer-Haddad K, Hellström AC, Shah K, Auer G, Ried T.
A recurrent gain of chromosome arm 3q in primary squamous carcinoma of the vagina.
Cancer Genet Cytogenet. 148: 7-13, 2004.
140)  Dorritie K, Montagna C, Difilippantonio MJ, Ried T.
Advanced molecular cytogenetics in human and mouse.
Expert Rev Mol Diagn. 4: 663-76, 2004.
141)  Guda K, Upender MB, Belinsky G, Flynn C, Nakanishi M, Marino JN, Ried T, Rosenberg DW.
Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability.
Oncogene. 23: 3813-21, 2004.
142)  Upender MB, Habermann JK, McShane LM, Korn EL, Barrett JC, Difilippantonio MJ, Ried T.
Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells.
Cancer Res. 64: 6941-9, 2004.
143)  Ried T.
Cytogenetics--in color and digitized.
N Engl J Med. 350: 1597-600, 2004.
144)  Schaeffer AJ, Nguyen M, Liem A, Lee D, Montagna C, Lambert PF, Ried T, Difilippantonio MJ.
E6 and e7 oncoproteins induce distinct patterns of chromosomal aneuploidy in skin tumors from transgenic mice.
Cancer Res. 64: 538-46, 2004.
145)  Janicki SM, Tsukamoto T, Salghetti SE, Tansey WP, Sachidanandam R, Prasanth KV, Ried T, Shav-Tal Y, Bertrand E, Singer RH, Spector DL.
From silencing to gene expression: real-time analysis in single cells.
Cell. 116: 683-98, 2004.
146)  Huang A, Montagna C, Sharan S, Ni Y, Ried T, Sterneck E.
Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability.
Oncogene. 23: 1549-57, 2004.
147)  Ried T, Dorritie K, Weaver Z, Wangsa D, Difilippantonio MJ, Montagna C.
Molecular cytogenetics of mouse models of breast cancer.
Breast Dis. 19: 59-67, 2004.
148)  Korn EL, Habermann JK, Upender MB, Ried T, McShane LM.
Objective method of comparing DNA microarray image analysis systems.
Biotechniques. 36: 960-7, 2004.
149)  Musio A, Mariani T, Montagna C, Zambroni D, Ascoli C, Ried T, Vezzoni P.
Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.
Gene. 331: 33-40, 2004.
150)  Roblick UJ, Hirschberg D, Habermann JK, Palmberg C, Becker S, Krüger S, Gustafsson M, Bruch HP, Franzén B, Ried T, Bergmann T, Auer G, Jörnvall H.
Sequential proteome alterations during genesis and progression of colon cancer.
Cell Mol Life Sci. 61: 1246-55, 2004.
151)  Pack SD, Alper OM, Stromberg K, Augustus M, Ozdemirli M, Miermont AM, Klus G, Rusin M, Slack R, Hacker NF, Ried T, Szallasi Z, Alper O.
Simultaneous suppression of epidermal growth factor receptor and c-erbB-2 reverses aneuploidy and malignant phenotype of a human ovarian carcinoma cell line.
Cancer Res. 64: 789-94, 2004.
152)  Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM.
Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location.
Hum Mutat. 23: 40-6, 2004.
153)  Lucas PJ, McNeil N, Hilgenfeld E, Choudhury B, Kim SJ, Eckhaus MA, Ried T, Gress RE.
Transforming growth factor-beta pathway serves as a primary tumor suppressor in CD8+ T cell tumorigenesis.
Cancer Res. 64: 6524-9, 2004.
154)  Dahlgren L, Mellin H, Wangsa D, Heselmeyer-Haddad K, Björnestål L, Lindholm J, Munck-Wikland E, Auer G, Ried T, Dalianis T.
Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors.
Int J Cancer. 107: 244-9, 2003.
155)  Knutsen T, Pack S, Petropavlovskaja M, Padilla-Nash H, Knight C, Mickley LA, Ried T, Elwood PC, Roberts SJ.
Cytogenetic, spectral karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization characterization of two new secondary leukemia cell lines with 5q deletions, and MYC and MLL amplification.
Genes Chromosomes Cancer. 37: 270-81, 2003.
156)  Heselmeyer-Haddad K, Janz V, Castle PE, Chaudhri N, White N, Wilber K, Morrison LE, Auer G, Burroughs FH, Sherman ME, Ried T.
Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia.
Am J Pathol. 163: 1405-16, 2003.
157)  Blegen H, Will JS, Ghadimi BM, Nash HP, Zetterberg A, Auer G, Ried T.
DNA amplifications and aneuploidy, high proliferative activity and impaired cell cycle control characterize breast carcinomas with poor prognosis.
Anal Cell Pathol. 25: 103-114, 2003.
158)  Difilippantonio S, Chen Y, Pietas A, Schlüns K, Pacyna-Gengelbach M, Deutschmann N, Padilla-Nash HM, Ried T, Petersen I.
Gene expression profiles in human non-small and small-cell lung cancers.
Eur J Cancer. 39: 1936-47, 2003.
159)  Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Cell. 114: 371-83, 2003.
160)  Srivastava M, Montagna C, Leighton X, Glasman M, Naga S, Eidelman O, Ried T, Pollard HB.
Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse.
Proc Natl Acad Sci U S A. 100: 14287-92, 2003.
161)  Musio A, Montagna C, Zambroni D, Indino E, Barbieri O, Citti L, Villa A, Ried T, Vezzoni P.
Inhibition of BUB1 Results in Genomic Instability and Anchorage-independent Growth of Normal Human Fibroblasts.
Cancer Res. 63: 2855-63, 2003.
162)  Forgues M, Difilippantonio MJ, Linke SP, Ried T, Nagashima K, Feden J, Valerie K, Fukasawa K, Wang XW.
Involvement of Crm1 in Hepatitis B Virus X Protein-Induced Aberrant Centriole Replication and Abnormal Mitotic Spindles.
Mol Cell Biol. 23: 5282-5292, 2003.
163)  Tchinda J, Volpert S, McNeil N, Neumann T, Kennerknecht I, Ried T, Büchner T, Serve H, Berdel WE, Horst J, Hilgenfeld E.
Multicolor karyotyping in acute myeloid leukemia.
Leuk Lymphoma. 44: 1843-53, 2003.
164)  Toretsky JA, Everly EM, Padilla-Nash HM, Chen A, Abruzzo LV, Eskenazi AE, Frantz C, Ried T, Stamberg J.
Novel translocation in acute megakaryoblastic leukemia (AML-M7).
J Pediatr Hematol Oncol. 25: 396-402, 2003.
165)  Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.
Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Mol Cell Biol. 23: 6075-85, 2003.
166)  Pavlovich CP, Padilla-Nash H, Wangsa D, Nickerson ML, Matrosova V, Linehan WM, Ried T, Phillips JL.
Patterns of aneuploidy in stage IV clear cell renal cell carcinoma revealed by comparative genomic hybridization and spectral karyotyping.
Genes Chromosomes Cancer. 37: 252-60, 2003.
167)  Habermann JK, Upender MB, Roblick UJ, Krüger S, Freitag S, Blegen H, Bruch HP, Schimmelpenning H, Auer G, Ried T.
Pronounced chromosomal instability and multiple gene amplifications characterize ulcerative colitis-associated colorectal carcinomas.
Cancer Genet Cytogenet. 147: 9-17, 2003.
168)  Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD, Carroll M, Liu M, Osheroff N, Cheung NK, Slater DJ, Ried T, Knutsen T, Blair IA, Felix CA.
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Oncogene. 22: 8448-59, 2003.
169)  Montagna C, Lyu MS, Hunter K, Lukes L, Lowther W, Reppert T, Hissong B, Weaver Z, Ried T.
The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines.
Cancer Res. 63: 2179-87, 2003.
170)  Montagna C, Andrechek ER, Padilla-Nash H, Muller WJ, Ried T.
Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu.
Oncogene. 21: 890-898, 2002.
171)  Fehm T, Sagalowsky A, Clifford E, Beitsch P, Saboorian H, Euhus D, Meng S, Morrison L, Tucker T, Lane N, Ghadimi BM, Heselmeyer-Haddad K, Ried T, Rao C, Uhr J.
Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant.
Clin Cancer Res. 8: 2073-84, 2002.
172)  Heselmeyer-Haddad K, Chaudhri N, Stoltzfus P, Cheng JC, Wilber K, Morrison L, Auer G, Ried T.
Detection of chromosomal aneuploidies and gene copy number changes in fine needle aspirates is a specific, sensitive, and objective genetic test for the diagnosis of breast cancer.
Cancer Res. 62: 2365-2369, 2002.
173)  Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A.
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.
J Exp Med. 196: 469-80, 2002.
174)  Rockwood LD, Torrey TA, Kim JS, Coleman AE, Kovalchuk AL, Xiang S, Ried T, Morse HC, Janz S.
Genomic instability in mouse Burkitt lymphoma is dominated by illegitimate genetic recombinations, not point mutations.
Oncogene. 21: 7235-40, 2002.
175)  Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Deng CX, Ried T.
Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
Oncogene. 21: 5097-107, 2002.
176)  Staebler A, Heselmeyer-Haddad K, Bell K, Riopel M, Perlman E, Ried T, Kurman RJ.
Micropapillary serous carcinoma of the ovary has distinct patterns of chromosomal imbalances by comparative genomic hybridization compared with atypical proliferative serous tumors and serous carcinomas.
Hum Pathol. 33: 47-59, 2002.
177)  Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA.
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
Oncogene. 21: 4706-4714, 2002.
178)  Petiniot LK, Weaver Z, Vacchio M, Shen R, Wangsa D, Barlow C, Eckhaus M, Steinberg SM, Wynshaw-Boris A, Ried T, Hodes RJ.
RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
Mol Cell Biol. 22: 3174-3177, 2002.
179)  Day KC, McCabe MT, Zhao X, Wang Y, Davis JN, Phillips J, Von Geldern M, Ried T, KuKuruga MA, Cunha GR, Hayward SW, Day ML.
Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis.
J Biol Chem. 277: 44475-84, 2002.
180)  Platzer P, Upender MB, Wilson K, Willis J, Lutterbaugh J, Nosrati A, Willson JK, Mack D, Ried T, Markowitz S.
Silence of chromosomal amplifications in colon cancer.
Cancer Res. 62: 1134-1138, 2002.
181)  Hilgenfeld E, Montagna C, Padilla-Nash H, Stapleton L, Heselmeyer-Haddad K, Ried T.
Spectral karyotyping in cancer cytogenetics.
Methods Mol Med. 68: 29-44, 2002.
182)  Ghadimi BM, Uhr J, Tucker T, Heselmeyer-Haddad K, Auer G, Ried T, Becker H.
[Interphase cytogenetics with DNA-probes for chromosome 8 to detect circulating tumor cells in breast cancer patients.
Zentralbl Chir. 126: 922-925, 2001.
183)  Montgomery KT, Lee E, Miller A, Lau S, Shim C, Decker J, Chiu D, Emerling S, Sekhon M, Kim R, Lenz J, Han J, Ioshikhes I, Renault B, Marondel I, Yoon SJ, Song K, Murty VV, Scherer S, Yonescu R, Kirsch IR, Ried T, McPherson J, Gibbs R, Kucherlapati R.
A high-resolution map of human chromosome 12.
Nature. 409: 945-6, 2001.
184)  Sudbø J, Ried T, Bryne M, Kildal W, Danielsen H, Reith A.
Abnormal DNA content predicts the occurrence of carcinomas in non-dysplastic oral white patches.
Oral Oncol. 37: 558-565, 2001.
185)  Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature. 414: 660-665, 2001.
186)  Allen DM, van Praag H, Ray J, Weaver Z, Winrow CJ, Carter TA, Braquet R, Harrington E, Ried T, Brown KD, Gage FH, Barlow C.
Ataxia telangiectasia mutated is essential during adult neurogenesis.
Genes Dev. 15: 554-566, 2001.
187)  Blegen H, Ghadimi BM, Jauho A, Zetterberg A, Eriksson E, Auer G, Ried T.
Genetic instability promotes the acquisition of chromosomal imbalances in T1b and T1c breast adenocarcinomas.
Anal Cell Pathol. 22: 123-131, 2001.
188)  Felix K, Kovalchuk AL, Park SS, Coleman AE, Ramsay ES, Qian M, Kelliher KA, Jones GM, Ried T, Bornkamm GW, Janz S.
Inducible mutagenesis in TEPC 2372, a mouse plasmacytoma cell line that harbors the transgenic shuttle vector lambdaLIZ.
Mutat Res. 473: 121-136, 2001.
189)  Cheung VG, Nowak N, Jang W, Kirsch IR, Zhao S, Chen XN, Furey TS, Kim UJ, Kuo WL, Olivier M, Conroy J, Kasprzyk A, Massa H, Yonescu R, Sait S, Thoreen C, Snijders A, Lemyre E, Bailey JA, Bruzel A, Burrill WD, Clegg SM, Collins S, Dhami P, Friedman C, Han CS, Herrick S, Lee J, Ligon AH, Lowry S, Morley M, Narasimhan S, Osoegawa K, Peng Z, Plajzer-Frick I, Quade BJ, Scott D, Sirotkin K, Thorpe AA, Gray JW, Hudson J, Pinkel D, Ried T, Rowen L, Shen-Ong GL, Strausberg RL, Birney E, Callen DF, Cheng JF, Cox DR, Doggett NA, Carter NP, Eichler EE, Haussler D, Korenberg JR, Morton CC, Albertson D, Schuler G, de Jong PJ, Trask BJ, .
Integration of cytogenetic landmarks into the draft sequence of the human genome.
Nature. 409: 953-8, 2001.
190)  Padilla-Nash HM, Heselmeyer-Haddad K, Wangsa D, Zhang H, Ghadimi BM, Macville M, Augustus M, Schröck E, Hilgenfeld E, Ried T.
Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms.
Genes Chromosomes Cancer. 30: 349-363, 2001.
191)  Phillips JL, Ghadimi BM, Wangsa D, Padilla-Nash H, Worrell R, Hewitt S, Walther M, Linehan WM, Klausner RD, Ried T.
Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease.
Genes Chromosomes Cancer. 31: 1-9, 2001.
192)  Stolzfus PK, Rust D, Ried T.
Molecular cytogenetics and gene analysis: implications for oncology nurses.
Clin J Oncol Nurs. 5: 201-206, 2001.
193)  Macville MV, Van der Laak JA, Speel EJ, Katzir N, Garini Y, Soenksen D, McNamara G, de Wilde PC, Hanselaar AG, Hopman AH, Ried T.
Spectral imaging of multi-color chromogenic dyes in pathological specimens.
Anal Cell Pathol. 22: 133-142, 2001.
194)  Hilgenfeld E, Padilla-Nash H, McNeil N, Knutsen T, Montagna C, Tchinda J, Horst J, Ludwig WD, Serve H, Büchner T, Berdel WE, Schröck E, Ried T.
Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2.
Br J Haematol. 113: 305-317, 2001.
195)  Phillips JL, Hayward SW, Wang Y, Vasselli J, Pavlovich C, Padilla-Nash H, Pezullo JR, Ghadimi BM, Grossfeld GD, Rivera A, Linehan WM, Cunha GR, Ried T.
The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis.
Cancer Res. 61: 8143-8149, 2001.
196)  Phillips JL, Pavlovich CP, Walther M, Ried T, Linehan WM.
The genetic basis of renal epithelial tumors: advances in research and its impact on prognosis and therapy.
Curr Opin Urol. 11: 463-469, 2001.
197)  Kovalchuk AL, Esa A, Coleman AE, Park SS, Ried T, Cremer CC, Janz S.
Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610.
Genes Chromosomes Cancer. 30: 283-291, 2001.
198)  Kirsch IR, Green ED, Yonescu R, Strausberg R, Carter N, Bentley D, Leversha MA, Dunham I, Braden VV, Hilgenfeld E, Schuler G, Lash AE, Shen GL, Martelli M, Kuehl WM, Klausner RD, Ried T.
A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome.
Nat Genet. 24: 339-340, 2000.
199)  Liyanage M, Weaver Z, Barlow C, Coleman A, Pankratz DG, Anderson S, Wynshaw-Boris A, Ried T.
Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice.
Blood. 96: 1940-1946, 2000.
200)  Knutsen T, Rao VK, Ried T, Mickley L, Schneider E, Miyake K, Ghadimi BM, Padilla-Nash H, Pack S, Greenberger L, Cowan K, Dean M, Fojo T, Bates S.
Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines.
Genes Chromosomes Cancer. 27: 110-116, 2000.
201)  Ghadimi BM, Sackett DL, Difilippantonio MJ, Schröck E, Neumann T, Jauho A, Auer G, Ried T.
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Genes Chromosomes Cancer. 27: 183-190, 2000.
202)  Coleman AE, Ried T, Janz S.
Chromosomes 1 and 5 harbor plasmacytoma progressor genes in mice.
Genes Chromosomes Cancer. 29: 70-74, 2000.
203)  Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A.
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
Nature. 404: 510-514, 2000.
204)  Hu N, Roth MJ, Polymeropolous M, Tang ZZ, Emmert-Buck MR, Wang QH, Goldstein AM, Feng SS, Dawsey SM, Ding T, Zhuang ZP, Han XY, Ried T, Giffen C, Taylor PR.
Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population.
Genes Chromosomes Cancer. 27: 217-228, 2000.
205)  Kirsch IR, Ried T.
Integration of cytogenetic data with genome maps and available probes: present status and future promise.
Semin Hematol. 37: 420-428, 2000.
206)  McNeil N, Ried T.
Novel molecular cytogenetic techniques for identifying complex chromosomal rearrangements: technology and applications in molecular medicine.
Expert Rev Mol Med. 2: 1-14, 2000.
207)  Blegen H, Einhorn N, Sjövall K, Roschke A, Ghadimi BM, McShane LM, Nilsson B, Shah K, Ried T, Auer G.
Prognostic significance of cell cycle proteins and genomic instability in borderline, early and advanced stage ovarian carcinomas.
Int J Gynecol Cancer. 10: 477-487, 2000.
208)  Petiniot LK, Weaver Z, Barlow C, Shen R, Eckhaus M, Steinberg SM, Ried T, Wynshaw-Boris A, Hodes RJ.
Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
Proc Natl Acad Sci U S A. 97: 6664-6669, 2000.
209)  Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A.
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Science. 290: 1962-1965, 2000.
210)  Vermeesch JR, Petit P, Dutra A, Schröck E, Ried T, Fryns JP.
A mosaic extra ring chromosome 4 in a female patient with postnatal overgrowth.
Genet Couns. 10: 195-196, 1999.
211)  Weaver ZA, McCormack SJ, Liyanage M, du Manoir S, Coleman A, Schröck E, Dickson RB, Ried T.
A recurring pattern of chromosomal aberrations in mammary gland tumors of MMTV-cmyc transgenic mice.
Genes Chromosomes Cancer. 25: 251-260, 1999.
212)  Peschka B, Leygraaf J, Hansmann D, Hansmann M, Schröck E, Ried T, Engels H, Schwanitz G, Schubert R.
Analysis of a de novo complex chromosome rearrangement involving chromosomes 4, 11, 12 and 13 and eight breakpoints by conventional cytogenetic, fluorescence in situ hybridization and spectral karyotyping.
Prenat Diagn. 19: 1143-1149, 1999.
213)  Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T.
Analysis of B-cell neoplasias by spectral karyotyping (SKY).
Curr Top Microbiol Immunol. 246: 169-174, 1999.
214)  Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX.
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.
Mol Cell. 3: 389-395, 1999.
215)  Simbulan-Rosenthal CM, Haddad BR, Rosenthal DS, Weaver Z, Coleman A, Luo R, Young HM, Wang ZQ, Ried T, Smulson ME.
Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.
Proc Natl Acad Sci U S A. 96: 13191-13196, 1999.
216)  Macville M, Schröck E, Padilla-Nash H, Keck C, Ghadimi BM, Zimonjic D, Popescu N, Ried T.
Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping.
Cancer Res. 59: 141-150, 1999.
217)  Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX.
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.
Nat Genet. 22: 37-43, 1999.
218)  Coleman AE, Forest ST, McNeil N, Kovalchuk AL, Ried T, Janz S.
Cytogenetic analysis of the bipotential murine pre-B cell lymphoma, P388, and its derivative macrophage-like tumor, P388D1, using SKY and CGH.
Leukemia. 13: 1592-1600, 1999.
219)  Ried T, Heselmeyer-Haddad K, Blegen H, Schröck E, Auer G.
Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation.
Genes Chromosomes Cancer. 25: 195-204, 1999.
220)  Ghadimi BM, Heselmeyer-Haddad K, Auer G, Ried T.
Interphase cytogenetics: at the interface of genetics and morphology.
Anal Cell Pathol. 19: 3-6, 1999.
221)  Coleman AE, Kovalchuk AL, Janz S, Palini A, Ried T.
Jumping translocation breakpoint regions lead to amplification of rearranged Myc.
Blood. 93: 4442-4444, 1999.
222)  Padilla-Nash HM, Nash WG, Padilla GM, Roberson KM, Robertson CN, Macville M, Schröck E, Ried T.
Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping.
Genes Chromosomes Cancer. 25: 53-59, 1999.
223)  Ning Y, Laundon CH, Schröck E, Buchanan P, Ried T.
Prenatal diagnosis of a mosaic extra structurally abnormal chromosome by spectral karyotyping.
Prenat Diagn. 19: 480-482, 1999.
224)  Coleman AE, Ried T, Janz S.
Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas.
Curr Top Microbiol Immunol. 246: 175-180, 1999.
225)  Ghadimi BM, Schröck E, Walker RL, Wangsa D, Jauho A, Meltzer PS, Ried T.
Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.
Am J Pathol. 154: 525-536, 1999.
226)  Liang JC, Ning Y, Wang RY, Padilla-Nash HM, Schröck E, Soenksen D, Nagarajan L, Ried T.
Spectral karyotypic study of the HL-60 cell line: detection of complex rearrangements involving chromosomes 5, 7, and 16 and delineation of critical region of deletion on 5q31.1.
Cancer Genet Cytogenet. 113: 105-109, 1999.
227)  Schriml LM, Padilla-Nash HM, Coleman A, Moen P, Nash WG, Menninger J, Jones G, Ried T, Dean M.
Tyramide signal amplification (TSA)-FISH applied to mapping PCR-labeled probes less than 1 kb in size.
Biotechniques. 27: 608-613, 1999.
228)  Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX.
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.
Oncogene. 17: 3115-3124, 1998.
229)  Liu ML, Von Lintig FC, Liyanage M, Shibata MA, Jorcyk CL, Ried T, Boss GR, Green JE.
Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice.
Oncogene. 17: 2403-2411, 1998.
230)  Barlow C, Liyanage M, Moens PB, Tarsounas M, Nagashima K, Brown K, Rottinghaus S, Jackson SP, Tagle D, Ried T, Wynshaw-Boris A.
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.
Development. 125: 4007-4017, 1998.
231)  Ning Y, Liang JC, Nagarajan L, Schröck E, Ried T.
Characterization of 5q deletions by subtelomeric probes and spectral karyotyping.
Cancer Genet Cytogenet. 103: 170-172, 1998.
232)  Ried T, Schröck E, Ning Y, Wienberg J.
Chromosome painting: a useful art.
Hum Mol Genet. 7: 1619-1626, 1998.
233)  Agarwal SK, Schröck E, Kester MB, Burns AL, Heffess CS, Ried T, Marx SJ.
Comparative genomic hybridization analysis of human parathyroid tumors.
Cancer Genet Cytogenet. 106: 30-36, 1998.
234)  Knutsen T, Mickley LA, Ried T, Green ED, du Manoir S, Schröck E, Macville M, Ning Y, Robey R, Polymeropoulos M, Torres R, Fojo T.
Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL.
Genes Chromosomes Cancer. 23: 44-54, 1998.
235)  Allen RJ, Smith SD, Moldwin RL, Lu MM, Giordano L, Vignon C, Suto Y, Harden A, Tomek R, Veldman T, Ried T, Larson RA, Le Beau MM, Rowley JD, Zeleznik-Le N.
Establishment and characterization of a megakaryoblast cell line with amplification of MLL.
Leukemia. 12: 1119-1127, 1998.
236)  Phelan MC, Blackburn W, Rogers RC, Crawford EC, Cooley NR, Schrock E, Ning Y, Ried T.
FISH analysis of a complex chromosome rearrangement involving nine breakpoints on chromosomes 6, 12, 14 and 16.
Prenat Diagn. 18: 1174-1180, 1998.
237)  Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried T, Kuehl WM.
Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma.
Blood. 91: 4457-4463, 1998.
238)  Huang B, Ning Y, Lamb AN, Sandlin CJ, Jamehdor M, Ried T, Bartley J.
Identification of an unusual marker chromosome by spectral karyotyping.
Am J Med Genet. 80: 368-372, 1998.
239)  Haddad BR, Schröck E, Meck J, Cowan J, Young H, Ferguson-Smith MA, du Manoir S, Ried T.
Identification of de novo chromosomal markers and derivatives by spectral karyotyping.
Hum Genet. 103: 619-625, 1998.
240)  Ried T.
Interphase cytogenetics and its role in molecular diagnostics of solid tumors.
Am J Pathol. 152: 325-327, 1998.
241)  Rao PH, Cigudosa JC, Ning Y, Calasanz MJ, Iida S, Tagawa S, Michaeli J, Klein B, Dalla-Favera R, Jhanwar SC, Ried T, Chaganti RS.
Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma.
Blood. 92: 1743-1748, 1998.
242)  McCormack SJ, Weaver Z, Deming S, Natarajan G, Torri J, Johnson MD, Liyanage M, Ried T, Dickson RB.
Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability.
Oncogene. 16: 2755-2766, 1998.
243)  Heselmeyer K, Hellström AC, Blegen H, Schröck E, Silfverswärd C, Shah K, Auer G, Ried T.
Primary carcinoma of the fallopian tube: comparative genomic hybridization reveals high genetic instability and a specific, recurring pattern of chromosomal aberrations.
Int J Gynecol Pathol. 17: 245-254, 1998.
244)  Blaschke RJ, Monaghan AP, Schiller S, Schechinger B, Rao E, Padilla-Nash H, Ried T, Rappold GA.
SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.
Proc Natl Acad Sci U S A. 95: 2406-2411, 1998.
245)  Heselmeyer K, du Manoir S, Blegen H, Friberg B, Svensson C, Schröck E, Veldman T, Shah K, Auer G, Ried T.
A recurrent pattern of chromosomal aberrations and immunophenotypic appearance defines anal squamous cell carcinomas.
Br J Cancer. 76: 1271-1278, 1997.
246)  Heselmeyer K, Macville M, Schröck E, Blegen H, Hellström AC, Shah K, Auer G, Ried T.
Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q.
Genes Chromosomes Cancer. 19: 233-240, 1997.
247)  Packenham JP, du Manoir S, Schrock E, Risinger JI, Dixon D, Denz DN, Evans JA, Berchuck A, Barrett JC, Devereux TR, Ried T.
Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization.
Mol Carcinog. 19: 273-279, 1997.
248)  Chesi M, Nardini E, Brents LA, Schröck E, Ried T, Kuehl WM, Bergsagel PL.
Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.
Nat Genet. 16: 260-264, 1997.
249)  Veldman T, Vignon C, Schröck E, Rowley JD, Ried T.
Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping.
Nat Genet. 15: 406-10, 1997.
250)  Ried T.
Images in neuroscience. Molecular biology, VI. Metaphase preparation of normal human chromosomes with spectral karyotyping.
Am J Psychiatry. 154: 447, 1997.
251)  Ried T.
Images in neuroscience. Spectral karyotyping analysis in diagnostic cytogenetics.
Am J Psychiatry. 154: 594, 1997.
252)  Barlow C, Liyanage M, Moens PB, Deng CX, Ried T, Wynshaw-Boris A.
Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles.
Nat Genet. 17: 462-466, 1997.
253)  Petersen I, Bujard M, Petersen S, Wolf G, Goeze A, Schwendel A, Langreck H, Gellert K, Reichel M, Just K, du Manoir S, Cremer T, Dietel M, Ried T.
Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung.
Cancer Res. 57: 2331-2335, 1997.
254)  Coleman AE, Schröck E, Weaver Z, du Manoir S, Yang F, Ferguson-Smith MA, Ried T, Janz S.
Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping.
Cancer Res. 57: 4585-4592, 1997.
255)  Schwendel A, Langreck H, Reichel M, Schröck E, Ried T, Dietel M, Petersen I.
Primary small-cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterations.
Int J Cancer. 74: 86-93, 1997.
256)  Petersen I, Langreck H, Wolf G, Schwendel A, Psille R, Vogt P, Reichel MB, Ried T, Dietel M.
Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p.
Br J Cancer. 75: 79-86, 1997.
257)  Schröck E, Veldman T, Padilla-Nash H, Ning Y, Spurbeck J, Jalal S, Shaffer LG, Papenhausen P, Kozma C, Phelan MC, Kjeldsen E, Schonberg SA, O'Brien P, Biesecker L, du Manoir S, Ried T.
Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities.
Hum Genet. 101: 255-262, 1997.
258)  Macville M, Veldman T, Padilla-Nash H, Wangsa D, O'Brien P, Schröck E, Ried T.
Spectral karyotyping, a 24-colour FISH technique for the identification of chromosomal rearrangements.
Histochem Cell Biol. 108: 299-305, 1997.
259)  Ried T, Liyanage M, du Manoir S, Heselmeyer K, Auer G, Macville M, Schröck E.
Tumor cytogenetics revisited: comparative genomic hybridization and spectral karyotyping.
J Mol Med. 75: 801-814, 1997.
260)  Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, Collins F, Shiloh Y, Crawley JN, Ried T, Tagle D, Wynshaw-Boris A.
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Cell. 86: 159-171, 1996.
261)  Giollant M, Bertrand S, Verrelle P, Tchirkov A, du Manoir S, Ried T, Mornex F, Doré JF, Cremer T, Malet P.
Characterization of double minute chromosomes' DNA content in a human high grade astrocytoma cell line by using comparative genomic hybridization and fluorescence in situ hybridization.
Hum Genet. 98: 265-270, 1996.
262)  Ried T, Knutzen R, Steinbeck R, Blegen H, Schröck E, Heselmeyer K, du Manoir S, Auer G.
Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors.
Genes Chromosomes Cancer. 15: 234-245, 1996.
263)  Wijmenga C, Gregory PE, Hajra A, Schröck E, Ried T, Eils R, Liu PP, Collins FS.
Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells.
Proc Natl Acad Sci U S A. 93: 1630-1635, 1996.
264)  Decker HJ, Neuhaus C, Jauch A, Speicher M, Ried T, Bujard M, Brauch H, Störkel S, Stöckle M, Seliger B, Huber C.
Detection of a germline mutation and somatic homozygous loss of the von Hippel-Lindau tumor-suppressor gene in a family with a de novo mutation. A combined genetic study, including cytogenetics, PCR/SSCP, FISH, and CGH.
Hum Genet. 97: 770-776, 1996.
265)  Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T.
Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.
Proc Natl Acad Sci U S A. 93: 479-484, 1996.
266)  Zhan S, Vazquez N, Zhan S, Wientjes FB, Budarf ML, Schrock E, Ried T, Green ED, Chanock SJ.
Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex.
Blood. 88: 2714-2721, 1996.
267)  Pecker I, Avraham KB, Gilbert DJ, Savitsky K, Rotman G, Harnik R, Fukao T, Schröck E, Hirotsune S, Tagle DA, Collins FS, Wynshaw-Boris A, Ried T, Copeland NG, Jenkins NA, Shiloh Y, Ziv Y.
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Genomics. 35: 39-45, 1996.
268)  Schröck E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T.
Multicolor spectral karyotyping of human chromosomes.
Science. 273: 494-497, 1996.
269)  Liyanage M, Coleman A, du Manoir S, Veldman T, McCormack S, Dickson RB, Barlow C, Wynshaw-Boris A, Janz S, Wienberg J, Ferguson-Smith MA, Schröck E, Ried T.
Multicolour spectral karyotyping of mouse chromosomes.
Nat Genet. 14: 312-315, 1996.
270)  Schröck E, Blume C, Meffert MC, du Manoir S, Bersch W, Kiessling M, Lozanowa T, Thiel G, Witkowski R, Ried T, Cremer T.
Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization.
Genes Chromosomes Cancer. 15: 199-205, 1996.
271)  Schröck E, Badger P, Larson D, Erdos M, Wynshaw-Boris A, Ried T, Brody L.
The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.
Hum Genet. 97: 256-259, 1996.
272)  Eils R, Dietzel S, Bertin E, Schröck E, Speicher MR, Ried T, Robert-Nicoud M, Cremer C, Cremer T.
Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X chromosome territories have similar volumes but differ in shape and surface structure.
J Cell Biol. 135: 1427-1440, 1996.
273)  Ried T, Just KE, Holtgreve-Grez H, du Manoir S, Speicher MR, Schröck E, Latham C, Blegen H, Zetterberg A, Cremer T.
Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas.
Cancer Res. 55: 5415-5423, 1995.
274)  Speicher MR, Jauch A, Walt H, du Manoir S, Ried T, Jochum W, Sulser T, Cremer T.
Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics.
Am J Pathol. 146: 1332-1340, 1995.
275)  du Manoir S, Schröck E, Bentz M, Speicher MR, Joos S, Ried T, Lichter P, Cremer T.
Quantitative analysis of comparative genomic hybridization.
Cytometry. 19: 27-41, 1995.
276)  Levy FO, Holtgreve-Grez H, Taskén K, Solberg R, Ried T, Gudermann T.
Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15.
Genomics. 22: 637-640, 1994.
277)  Hoefler G, Forstner M, McGuinness MC, Hulla W, Hiden M, Krisper P, Kenner L, Ried T, Lengauer C, Zechner R.
cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.
Genomics. 19: 60-67, 1994.
278)  Golsteyn RM, Schultz SJ, Bartek J, Ziemiecki A, Ried T, Nigg EA.
Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.
J Cell Sci. 107: 1509-1517, 1994.
279)  Schultz SJ, Fry AM, Sütterlin C, Ried T, Nigg EA.
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.
Cell Growth Differ. 5: 625-635, 1994.
280)  Ashley T, Ried T, Ward DC.
Detection of nondisjunction and recombination in meiotic and postmeiotic cells from XYSxr [XY,Tp(Y)1Ct] mice using multicolor fluorescence in situ hybridization.
Proc Natl Acad Sci U S A. 91: 524-528, 1994.
281)  Kircheisen R, Ried T.
Hydatidiform moles.
Hum Reprod. 9: 1783-1784, 1994.
282)  Gromoll J, Ried T, Holtgreve-Grez H, Nieschlag E, Gudermann T.
Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10.
J Mol Endocrinol. 12: 265-271, 1994.
283)  Ried T, Petersen I, Holtgreve-Grez H, Speicher MR, Schröck E, du Manoir S, Cremer T.
Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization.
Cancer Res. 54: 1801-1806, 1994.
284)  Lichter P, Ried T.
Molecular analysis of chromosome aberrations. In situ hybridization.
Methods Mol Biol. 29: 449-478, 1994.
285)  Tocharoentanaphol C, Cremer M, Schröck E, Blonden L, Kilian K, Cremer T, Ried T.
Multicolor fluorescence in situ hybridization on metaphase chromosomes and interphase Halo-preparations using cosmid and YAC clones for the simultaneous high resolution mapping of deletions in the dystrophin gene.
Hum Genet. 93: 229-235, 1994.
286)  Taruscio D, Carcangiu ML, Ried T, Ward DC.
Numerical chromosomal aberrations in thyroid tumors detected by double fluorescence in situ hybridization.
Genes Chromosomes Cancer. 9: 180-185, 1994.
287)  Speicher MR, Schoell B, du Manoir S, Schröck E, Ried T, Cremer T, Störkel S, Kovacs A, Kovacs G.
Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.
Am J Pathol. 145: 356-364, 1994.
288)  Baldini A, Ried T, Shridhar V, Ogura K, D'Aiuto L, Rocchi M, Ward DC.
An alphoid DNA sequence conserved in all human and great ape chromosomes: evidence for ancient centromeric sequences at human chromosomal regions 2q21 and 9q13.
Hum Genet. 90: 577-583, 1993.
289)  Bellefroid EJ, Marine JC, Ried T, Lecocq PJ, Rivière M, Amemiya C, Poncelet DA, Coulie PG, de Jong P, Szpirer C.
Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.
EMBO J. 12: 1363-1374, 1993.
290)  Ried T, Arnold N, Ward DC, Wienberg J.
Comparative high-resolution mapping of human and primate chromosomes by fluorescence in situ hybridization.
Genomics. 18: 381-386, 1993.
291)  Ried T, Lengauer C, Lipp M, Fischer C, Cremer T, Ward DC.
Evaluation of the utility of interphase cytogenetics to detect residual cells with a malignant genotype in mixed cell populations: a Burkitt lymphoma model.
DNA Cell Biol. 12: 637-643, 1993.
292)  Vaughan KT, Weber FE, Ried T, Ward DC, Reinach FC, Fischman DA.
Human myosin-binding protein H (MyBP-H): complete primary sequence, genomic organization, and chromosomal localization.
Genomics. 16: 34-40, 1993.
293)  Ried T, Rudy B, Vega-Saenz de Miera E, Lau D, Ward DC, Sen K.
Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15.
Genomics. 15: 405-411, 1993.
294)  Speicher MR, du Manoir S, Schröck E, Holtgreve-Grez H, Schoell B, Lengauer C, Cremer T, Ried T.
Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumors by comparative genomic hybridization after universal DNA-amplification.
Hum Mol Genet. 2: 1907-1914, 1993.
295)  Lichter P, Bray P, Ried T, Dawid IB, Ward DC.
Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.
Genomics. 13: 999-1007, 1992.
296)  Bellefroid EJ, Ried T, Rivière M, Marine JC, Levan G, Szpirer J, Szpirer C, Ward DC, Martial JA.
Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2.
Genomics. 14: 780-781, 1992.
297)  Ried T, Landes G, Dackowski W, Klinger K, Ward DC.
Multicolor fluorescence in situ hybridization for the simultaneous detection of probe sets for chromosomes 13, 18, 21, X and Y in uncultured amniotic fluid cells.
Hum Mol Genet. 1: 307-313, 1992.
298)  Ried T, Baldini A, Rand TC, Ward DC.
Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.
Proc Natl Acad Sci U S A. 89: 1388-1392, 1992.
299)  Ried T, Lengauer C, Cremer T, Wiegant J, Raap AK, van der Ploeg M, Groitl P, Lipp M.
Specific metaphase and interphase detection of the breakpoint region in 8q24 of Burkitt lymphoma cells by triple-color fluorescence in situ hybridization.
Genes Chromosomes Cancer. 4: 69-74, 1992.
300)  Rudy B, Sen K, Vega-Saenz de Miera E, Lau D, Ried T, Ward DC.
Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21.
J Neurosci Res. 29: 401-412, 1991.
301)  Wiegant J, Ried T, Nederlof PM, van der Ploeg M, Tanke HJ, Raap AK.
In situ hybridization with fluoresceinated DNA.
Nucleic Acids Res. 19: 3237-3241, 1991.
302)  Ried T, Mahler V, Vogt P, Blonden L, van Ommen GJ, Cremer T, Cremer M.
Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus.
Hum Genet. 85: 581-586, 1990.
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