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Our Science – Kuehl Website

W. Michael Kuehl, M.D.

Selected Publications

1)  Affer M, Chesi M, Chen WD, Keats JJ, Demchenko YN, Tamizhmani K, Garbitt VM, Riggs DL, Brents LA, Roschke AV, Van Wier S, Fonseca R, Bergsagel PL, Kuehl WM.
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.
Leukemia. [Epub ahead of print], 2014.
[Journal]
2)  Kuehl WM, Bergsagel PL.
Molecular pathogenesis of multiple myeloma and its premalignant precursor.
J. Clin. Invest. 122: 3456-63, 2012.
[Journal]
3)  Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM.
A monoclonal gammopathy precedes multiple myeloma in most patients.
Blood. 113: 5418-22, 2009.
[Journal]
4)  Gabrea A, Martelli ML, Qi Y, Roschke A, Barlogie B, Shaughnessy JD, Sawyer JR, Kuehl WM.
Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors.
Genes Chromosomes Cancer. 47: 573-90, 2008.
[Journal]
5)  Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J.
Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.
Blood. 106: 296-303, 2005.
[Journal]
6)  Bergsagel PL, Kuehl WM.
Rabbitts T, Rowley J, LeBeau M, eds.
Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis. In: Chromosomal Translocations and Gene Rearrangements in Cancer.
London: Apringer-Verlag; 2014. In Press. [Book Chapter]
7)  Kim GY, Gabrea A, Demchenko YN, Bergsagel L, Roschke AV, Kuehl WM.
Complex IGH rearrangements in multiple myeloma: Frequent detection discrepancies among three different probe sets.
Genes Chromosomes Cancer. 53: 467-74, 2014.
[Journal]
8)  Demchenko YN, Brents LA, Li Z, Bergsagel LP, McGee LR, Kuehl MW.
Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB.
Oncotarget. 2014.
[Journal]
9)  Onozawa M, Zhang Z, Kim YJ, Goldberg L, Varga T, Bergsagel PL, Kuehl WM, Aplan PD.
Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome.
Proc. Natl. Acad. Sci. U.S.A. 111: 7729-34, 2014.
[Journal]
10)  Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G.
Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.
Nat. Med. 20: 599-606, 2014.
[Journal]
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This page was last updated on 7/18/2014.