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Peter D. Aplan, M.D.

Selected Publications

1)  Aplan PD, Lombardi DP, Ginsberg AM, Cossman J, Bertness VL, Kirsch IR.
Disruption of the human SCL locus by.
Science. 250: 1426-9, 1990.
2)  Lin YW, Slape C, Zhang Z, Aplan PD.
NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia.
Blood. 106: 287-95, 2005.
3)  Chung YJ, Choi CW, Slape C, Fry T, Aplan PD.
Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell.
Proc. Natl. Acad. Sci. U.S.A. 105: 14088-93, 2008.
4)  Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD.
NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function.
Cancer Discov. 4: 564-77, 2014.
5)  Onozawa M, Zhang Z, Kim YJ, Goldberg L, Varga T, Bergsagel PL, Kuehl WM, Aplan PD.
Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome.
Proc. Natl. Acad. Sci. U.S.A. 111: 7729-34, 2014.
6)  Maegawa S, Gough SM, Watanabe-Okochi N, Lu Y, Zhang N, Castoro RJ, Estecio MR, Jelinek J, Liang S, Kitamura T, Aplan PD, Issa JP.
Age-related epigenetic drift in the pathogenesis of MDS and AML.
Genome Res. 24: 580-91, 2014.
7)  Bailey EJ, Duffield AS, Greenblatt SM, Aplan PD, Small D.
Effect of FLT3 ligand on survival and disease phenotype in murine models harboring a FLT3 internal tandem duplication mutation.
Comp. Med. 63: 218-26, 2013.
8)  Lacombe J, Krosl G, Tremblay M, Gerby B, Martin R, Aplan PD, Lemieux S, Hoang T.
Genetic interaction between Kit and Scl.
Blood. 122: 1150-61, 2013.
9)  Goldberg L, Tijssen MR, Birger Y, Hannah RL, Kinston SJ, Schütte J, Beck D, Knezevic K, Schiby G, Jacob-Hirsch J, Biran A, Kloog Y, Marcucci G, Bloomfield CD, Aplan PD, Pimanda JE, Göttgens B, Izraeli S.
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Blood. 122: 2694-703, 2013.
10)  Beachy SH, Onozawa M, Silverman D, Chung YJ, Rivera MM, Aplan PD.
Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.
Exp. Hematol. 41: 518-529, 2013.
11)  Levens D, Aplan PD.
Notching up MYC gives a LIC.
Cell Stem Cell. 13: 8-9, 2013.
12)  Chung YJ, Robert C, Gough SM, Rassool FV, Aplan PD.
Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.
Leuk. Res. 38: 95-102, 2013.
13)  Saw J, Curtis DJ, Hussey DJ, Dobrovic A, Aplan PD, Slape CI.
The fusion partner specifies the oncogenic potential of NUP98 fusion proteins.
Leuk. Res. 37: 1668-73, 2013.
14)  Métais JY, Winkler T, Geyer JT, Calado RT, Aplan PD, Eckhaus MA, Dunbar CE.
BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation.
PLoS ONE. 7: e48267, 2012.
15)  Gough SM, Chung YJ, Aplan PD.
Depletion of Cytotoxic T-Cells Does Not Protect NUP98-HOXD13 Mice from Myelodysplastic Syndrome but Reveals a Modest Tumor Immunosurveillance Effect.
PLoS ONE. 7: e36876, 2012.
16)  Beachy SH, Onozawa M, Chung YJ, Slape C, Bilke S, Francis P, Pineda M, Walker RL, Meltzer P, Aplan PD.
Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines and peripheral T-cell lymphoma.
Blood. 120: 1048-59, 2012.
17)  Novak RL, Harper DP, Caudell D, Slape C, Beachy SH, Aplan PD.
Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.
Exp. Hematol. 40: 1016-27, 2012.
18)  Onozawa M, Aplan PD.
Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.
Genes Chromosomes Cancer. 51: 525-35, 2012.
19)  Slape CI, Saw J, Jowett JB, Aplan PD, Strasser A, Jane SM, Curtis DJ.
Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome.
Blood. 120: 2475-83, 2012.
20)  Greenblatt S, Li L, Slape C, Nguyen B, Novak R, Duffield A, Huso D, Desiderio S, Borowitz MJ, Aplan P, Small D.
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood. 119: 2883-94, 2012.
21)  Xu H, Menendez S, Schlegelberger B, Bae N, Aplan PD, Göhring G, Deblasio TR, Nimer SD.
Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model.
Blood. 120: 3089-97, 2012.
22)  Slape C, Aplan P.
Schwab M, eds.
Retroviral Insertional Mutagenesis. In: Encyclopedia of Cancer. Volume 2.
Berlin: Springer-Verlag; 2011. p. 1767 [Book Chapter]
23)  Aplan P, Khan J.
Pizzo P, Poplack D, eds.
Molecular and Genetic Basis of Childhood Cancer. In: Principles and Practice of Pediatric Oncology, 6th Edition.
Philadelphia, PA: Lippincott Williams & Wilkins; 2011. p. 38-77 [Book Chapter]
24)  Landry JW, Banerjee S, Taylor B, Aplan PD, Singer A, Wu C.
Chromatin remodeling complex NURF regulates thymocyte maturation.
Genes Dev. 25: 275-86, 2011.
25)  Gough SM, Slape CI, Aplan PD.
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.
Blood. 118: 6247-57, 2011.
26)  Castiel A, Danieli MM, David A, Moshkovitz S, Aplan PD, Kirsch IR, Brandeis M, Krämer A, Izraeli S.
The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
J. Cell. Sci. 124: 532-9, 2011.
27)  Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, Zhang Z, Aplan PD, Aster JC, Smith CD, Kraft AS.
A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.
Blood. 115: 824-33, 2010.
28)  Cheng Y, Zhang Z, Keenan B, Roschke AV, Nakahara K, Aplan PD.
Efficient repair of DNA double-strand breaks in malignant cells with structural instability.
Mutat. Res. 683: 115-22, 2010.
29)  Gill JA, Lowe L, Nguyen J, Liu PP, Blake T, Venkatesh B, Aplan PD.
Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish.
Zebrafish. 7: 333-41, 2010.
30)  Estécio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JP.
Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.
Genome research. 2010.
31)  Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, Hoang T.
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Genes Dev. 24: 1093-105, 2010.
32)  Beachy SH, Aplan PD.
Mouse models of myelodysplastic syndromes.
Hematol. Oncol. Clin. North Am. 24: 361-75, 2010.
33)  Caudell D, Harper DP, Novak RL, Pierce RM, Slape C, Wolff L, Aplan PD.
Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.
Blood. 115: 1194-203, 2010.
34)  De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cavé H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA.
The TLX1 oncogene drives aneuploidy in T cell transformation.
Nat. Med. 16: 1321-7, 2010.
35)  Choi CW, Chung YJ, Slape C, Aplan PD.
A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement.
J. Immunol. 183: 6227-35, 2009.
36)  Mrózek K, Harper DP, Aplan PD.
Cytogenetics and molecular genetics of acute lymphoblastic leukemia.
Hematol. Oncol. Clin. North Am. 23: 991-1010, v, 2009.
37)  Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ.
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis.
Blood. 114: 2401-10, 2009.
38)  Harper DP, Aplan PD.
Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects.
Cancer Res. 68: 10024-7, 2008.
39)  Choi CW, Chung YJ, Slape C, Aplan PD.
Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome.
Haematologica. 2008.
40)  Slape C, Liu LY, Beachy S, Aplan PD.
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
Blood. 2008.
41)  Slape C, Lin YW, Hartung H, Zhang Z, Wolff L, Aplan PD.
NUP98-HOX Translocations Lead to Myelodysplastic Syndrome in Mice and Men.
J. Natl. Cancer Inst. Monographs. 64-8, 2008.
42)  Hillion J, Dhara S, Sumter TF, Mukherjee M, Di Cello F, Belton A, Turkson J, Jaganathan S, Cheng L, Ye Z, Jove R, Aplan P, Lin YW, Wertzler K, Reeves R, Elbahlouh O, Kowalski J, Bhattacharya R, Resar LM.
The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?.
Cancer Res. 68: 10121-7, 2008.
43)  Erez A, Chaussepied M, Castiel A, Colaizzo-Anas T, Aplan PD, Ginsberg D, Izraeli S.
The mitotic checkpoint gene, SIL is regulated by E2F1.
Int. J. Cancer. 2008.
44)  Caudell D, Aplan PD.
The role of CALM-AF10 gene fusion in acute leukemia.
Leukemia. 22: 678-85, 2008.
45)  Cheng Y, Zhang Z, Slape C, Aplan PD.
Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.
Neoplasia. 9: 315-21, 2007.
46)  Caudell D, Zhang Z, Chung YJ, Aplan PD.
Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice.
Cancer Res. 67: 8022-31, 2007.
47)  Lin YW, Aplan PD.
Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets.
Leukemia. 21: 1276-84, 2007.
48)  Slape C, Chung YJ, Soloway PD, Tessarollo L, Aplan PD.
Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.
Leukemia. 21: 1239-48, 2007.
49)  Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A.
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not preTCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Blood. 2007.
50)  Slape C, Hartung H, Lin YW, Bies J, Wolff L, Aplan PD.
Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.
Cancer Res. 67: 5148-55, 2007.
51)  Oliansky DM, Rizzo JD, Aplan PD, Arceci RJ, Leone L, Ravindranath Y, Sanders JE, Smith FO, Wilmot F, McCarthy PL, Hahn T.
The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute myeloid leukemia in children: an evidence-based review.
Biol. Blood Marrow Transplant. 13: 1-25, 2007.
52)  Aplan PD.
Causes of oncogenic chromosomal translocation.
Trends Genet. 22: 46-55, 2006.
53)  Aplan PD.
Chromosomal translocations involving the MLL gene: molecular mechanisms.
DNA Repair (Amst.). 5: 1265-72, 2006.
54)  Lin YW, Nichols RA, Letterio JJ, Aplan PD.
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.
Blood. 107: 2540-3, 2006.
55)  Varga T, Aplan PD.
Chromosomal aberrations induced by double strand DNA breaks.
DNA Repair (Amst). 2005.
56)  Aplan PD.
Blood. 105: 1843-4, 2005.
57)  Fiorentino S, Chopin M, Dastot H, Boissel N, Reboul M, Legrès L, Janin A, Aplan P, Sigaux F, Regnault A.
Disruption of T cell regulatory pathways is necessary for immunotherapeutic cure of T cell acute lymphoblastic leukemia in mice.
Eur. Cytokine Netw. 16: 300-8, 2005.
58)  Lin YW, Deveney R, Barbara M, Iscove NN, Nimer SD, Slape C, Aplan PD.
OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.
Cancer Res. 65: 7151-8, 2005.
59)  Lin YW, Perkins JJ, Zhang Z, Aplan PD.
Distinct mechanisms lead to HPRT gene mutations in leukemic cells.
Genes Chromosomes Cancer. 39: 311-23, 2004.
60)  Lin YW, Aplan PD.
Leukemic transformation.
Cancer Biol Ther. 3: 13-20, 2004.
61)  Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, Letterio JJ.
Loss of Smad3 in acute T-cell lymphoblastic leukemia.
N Engl J Med. 351: 552-9, 2004.
62)  Gurevich RM, Aplan PD, Humphries RK.
NUP98-Topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation.
Blood. 104: 1127-36, 2004.
63)  Slape C, Aplan PD.
The role of NUP98 gene fusions in hematologic malignancy.
Leuk Lymphoma. 45: 1341-50, 2004.
64)  Colaizzo-Anas T, Aplan PD.
Cloning and characterization of the SIL promoter.
Biochim Biophys Acta. 1625: 207-13, 2003.
65)  Pineault N, Buske C, Feuring-Buske M, Abramovich C, Rosten P, Hogge DE, Aplan PD, Humphries RK.
Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1.
Blood. 101: 4529-38, 2003.
66)  Deveney R, Chervinsky DS, Jani-Sait SN, Grossi M, Aplan PD.
Insertion of MLL sequences into chromosome band 5q31 results in an MLL-AF5Q31 fusion and is a rare but recurrent abnormality associated with infant leukemia.
Genes Chromosomes Cancer. 37: 326-31, 2003.
67)  Ramage JG, Vallera DA, Black JH, Aplan PD, Kees UR, Frankel AE.
The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells.
Leuk Res. 27: 79-84, 2003.
68)  Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MC.
Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.
Proc Natl Acad Sci U S A. 100: 10299-303, 2003.
69)  Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MC.
Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.
Proc Natl Acad Sci U S A. 100: 10299-303, 2003.
70)  Herblot S, Aplan PD, Hoang T.
Gradient of E2A activity in B-cell development.
Mol Cell Biol. 22: 886-900, 2002.
71)  Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K, Cross NC, Cheng JF, Aplan PD, Kearney L, Boultwood J, Wainscoat JS.
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.
Blood. 98: 1264-1267, 2001.
72)  Ploski JE, Aplan PD.
Characterization of DNA fragmentation events caused by genotoxic and non-genotoxic agents.
Mutat Res. 473: 169-180, 2001.
73)  Chervinsky DS, Lam DH, Zhao XF, Melman MP, Aplan PD.
Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice.
Leukemia. 15: 141-147, 2001.
74)  Stanulla M, Chhalliyil P, Wang J, Jani-Sait SN, Aplan PD.
Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context.
Hum Mol Genet. 10: 2481-2491, 2001.
75)  Lam DH, Aplan PD.
NUP98 gene fusions in hematologic malignancies.
Leukemia. 15: 1689-1695, 2001.
76)  Chervinsky DS, Lam DH, Melman MP, Gross KW, Aplan PD.
scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes.
Cancer Res. 61: 6382-6387, 2001.
77)  Zhao XF, Nowak NJ, Shows TB, Aplan PD.
MAGOH interacts with a novel RNA-binding protein.
Genomics. 63: 145-148, 2000.
78)  Ahuja HG, Felix CA, Aplan PD.
Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.
Genes Chromosomes Cancer. 29: 96-105, 2000.
79)  Herblot S, Steff AM, Hugo P, Aplan PD, Hoang T.
SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression.
Nat Immunol. 1: 138-144, 2000.
80)  Schunemann HJ, Stanulla M, Trevisan M, Aplan PD, Freudenheim JL, Muti P.
Short-term storage of blood samples and DNA isolation in serum separator tubes for application in epidemiological studies and clinical research.
Ann Epidemiol. 10: 538-544, 2000.
81)  Ahuja HG, Hong J, Aplan PD, Tcheurekdjian L, Forman SJ, Slovak ML.
t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).
Cancer Res. 60: 6227-6229, 2000.
82)  Wang J, Jani-Sait SN, Escalon EA, Carroll AJ, de Jong PJ, Kirsch IR, Aplan PD.
The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene.
Proc Natl Acad Sci U S A. 97: 3497-3502, 2000.
83)  Chervinsky DS, Zhao XF, Lam DH, Ellsworth M, Gross KW, Aplan PD.
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.
Mol. Cell. Biol. 19: 5025-35, 1999.
84)  Thandla SP, Ploski JE, Raza-Egilmez SZ, Chhalliyil PP, Block AW, de Jong PJ, Aplan PD.
ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene.
Blood. 93: 293-9, 1999.
85)  Zhao XF, Aplan PD.
The hematopoietic transcription factor SCL binds the p44 subunit of TFIIH.
J. Biol. Chem. 274: 1388-93, 1999.
86)  Ahuja HG, Felix CA, Aplan PD.
The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion.
Blood. 94: 3258-61, 1999.
87)  Thandla S, Alashari M, Green DM, Aplan PD.
Therapy-related T cell lymphoblastic lymphoma with t(11;19)(q23;p13) and MLL gene rearrangement.
Leukemia. 13: 2116-8, 1999.
88)  Felix CA, Megonigal MD, Chervinsky DS, Leonard DG, Tsuchida N, Kakati S, Block AM, Fisher J, Grossi M, Salhany KI, Jani-Sait SN, Aplan PD.
Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia.
Blood. 91: 4451-6, 1998.
89)  Sood R, Stewart CC, Aplan PD, Murai H, Ward P, Barcos M, Baer MR.
Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells.
Blood. 91: 3372-8, 1998.
90)  Raza-Egilmez SZ, Jani-Sait SN, Grossi M, Higgins MJ, Shows TB, Aplan PD.
NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia.
Cancer Res. 58: 4269-73, 1998.
91)  Stanulla M, Schunemann HJ, Thandla S, Brecher ML, Aplan PD.
Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients.
Mol Pathol. 51: 85-9, 1998.
92)  Zhao XF, Aplan PD.
SCL binds the human homologue of DRG in vivo.
Biochim. Biophys. Acta. 1448: 109-14, 1998.
93)  Zhao XF, Colaizzo-Anas T, Nowak NJ, Shows TB, Elliott RW, Aplan PD.
The mammalian homologue of mago nashi encodes a serum-inducible protein.
Genomics. 47: 319-22, 1998.
94)  Aplan PD, Jones CA, Chervinsky DS, Zhao X, Ellsworth M, Wu C, McGuire EA, Gross KW.
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.
EMBO J. 16: 2408-19, 1997.
95)  Stanulla M, Wang J, Chervinsky DS, Thandla S, Aplan PD.
DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis.
Mol. Cell. Biol. 17: 4070-9, 1997.
96)  Izraeli S, Colaizzo-Anas T, Bertness VL, Mani K, Aplan PD, Kirsch IR.
Expression of the SIL gene is correlated with growth induction and cellular proliferation.
Cell Growth Differ. 8: 1171-9, 1997.
97)  Thandla S, Aplan PD.
Molecular biology of acute lymphocytic leukemia.
Semin. Oncol. 24: 45-56, 1997.
98)  Stanulla M, Wang J, Chervinsky DS, Aplan PD.
Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus.
Leukemia. 11: 490-6, 1997.
99)  Strout MP, Mrozek K, Heinonen K, Sait SN, Shows TB, Aplan PD.
ML-1 cell line lacks a germline MLL locus.
Genes Chromosomes Cancer. 16: 204-10, 1996.
100)  Aplan PD, Chervinsky DS, Stanulla M, Burhans WC.
Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.
Blood. 87: 2649-58, 1996.
101)  Collazo-Garcia N, Scherer P, Aplan PD.
Cloning and characterization of a murine SIL gene.
Genomics. 30: 506-13, 1995.
102)  Aplan PD, Johnson BE, Russell E, Chervinsky DS, Kirsch IR.
Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation.
Cancer Res. 55: 1917-21, 1995.
103)  Chervinsky DS, Sait SN, Nowak NJ, Shows TB, Aplan PD.
Complex MLL rearrangement in a patient with T-cell acute lymphoblastic leukemia.
Genes Chromosomes Cancer. 14: 76-84, 1995.
104)  Chervinsky DS, Grossi M, Kakati S, Block AW, Aplan PD.
Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia.
Genes Chromosomes Cancer. 12: 229-36, 1995.
105)  Stock W, Westbrook C, Sher D, Dodge R, Sobol R, Wurster-Hill D, Davey F, Larson R, LeBeau M, Aplan P, Frankel S, Stewart C, Bloomfield C.
Low incidence of TAL1 gene rearrangements in adult acute lymphoblastic leukemia: A cancer and leukemia group B study.
Clin Cancer Res. 1: 459-63, 1995.
106)  Bhatia K, Spangler G, Advani S, Kamel A, Hamdy N, Iyer R, Aplan P, Magrath I.
Molecular characterization of scl rearrangements in T-cell all from India and egypt.
Int. J. Oncol. 2: 725-30, 1993.
107)  Aplan PD, Raimondi SC, Kirsch IR.
Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia.
J. Exp. Med. 176: 1303-10, 1992.
108)  Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR.
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.
Blood. 79: 1327-33, 1992.
109)  Aplan PD, Nakahara K, Orkin SH, Kirsch IR.
The SCL gene product: a positive regulator of erythroid differentiation.
EMBO J. 11: 4073-81, 1992.
110)  Begley CG, Visvader J, Green AR, Aplan PD, Metcalf D, Kirsch IR, Gough NM.
Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.
Proc. Natl. Acad. Sci. U.S.A. 88: 869-73, 1991.
111)  Aplan PD, Lombardi DP, Kirsch IR.
Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.
Mol. Cell. Biol. 11: 5462-9, 1991.
112)  Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR.
The SCL gene is formed from a transcriptionally complex locus.
Mol. Cell. Biol. 10: 6426-35, 1990.
113)  Begley CG, Aplan PD, Davey MP, Nakahara K, Tchorz K, Kurtzberg J, Hershfield MS, Haynes BF, Cohen DI, Waldmann TA.
Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript.
Proc. Natl. Acad. Sci. U.S.A. 86: 2031-5, 1989.
114)  Begley CG, Aplan PD, Davey MP, de Villartay JP, Cohen DI, Waldmann TA, Kirsch IR.
Demonstration of delta rec-pseudo J alpha rearrangement with deletion of the delta locus in a human stem-cell leukemia.
J. Exp. Med. 170: 339-42, 1989.
115)  Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR.
The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.
Proc. Natl. Acad. Sci. U.S.A. 86: 10128-32, 1989.
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