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Our Science – Aplan Website

Peter D. Aplan, M.D.

Selected Publications

1)  Maegawa S, Gough SM, Watanabe-Okochi N, Lu Y, Zhang N, Castoro RJ, Estecio MR, Jelinek J, Liang S, Kitamura T, Aplan PD, Issa JP.
Age-related epigenetic drift in the pathogenesis of MDS and AML.
Genome Res. 24: 580-91, 2014.
2)  Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD.
NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function.
Cancer Discov. [Epub ahead of print], 2014.
3)  Bailey EJ, Duffield AS, Greenblatt SM, Aplan PD, Small D.
Effect of FLT3 ligand on survival and disease phenotype in murine models harboring a FLT3 internal tandem duplication mutation.
Comp. Med. 63: 218-26, 2013.
4)  Lacombe J, Krosl G, Tremblay M, Gerby B, Martin R, Aplan PD, Lemieux S, Hoang T.
Genetic interaction between Kit and Scl.
Blood. 122: 1150-61, 2013.
5)  Goldberg L, Tijssen MR, Birger Y, Hannah RL, Kinston SJ, Schütte J, Beck D, Knezevic K, Schiby G, Jacob-Hirsch J, Biran A, Kloog Y, Marcucci G, Bloomfield CD, Aplan PD, Pimanda JE, Göttgens B, Izraeli S.
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Blood. 122: 2694-703, 2013.
6)  Beachy SH, Onozawa M, Silverman D, Chung YJ, Rivera MM, Aplan PD.
Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.
Exp. Hematol. 41: 518-529, 2013.
7)  Levens D, Aplan PD.
Notching up MYC gives a LIC.
Cell Stem Cell. 13: 8-9, 2013.
8)  Chung YJ, Robert C, Gough SM, Rassool FV, Aplan PD.
Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.
Leuk. Res. 38: 95-102, 2013.
9)  Saw J, Curtis DJ, Hussey DJ, Dobrovic A, Aplan PD, Slape CI.
The fusion partner specifies the oncogenic potential of NUP98 fusion proteins.
Leuk. Res. 37: 1668-73, 2013.
10)  Métais JY, Winkler T, Geyer JT, Calado RT, Aplan PD, Eckhaus MA, Dunbar CE.
BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation.
PLoS ONE. 7: e48267, 2012.
Click Here to View Expanded Bibliography.

This page was last updated on 4/21/2014.