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Our Science – Udey Website

Mark C. Udey, M.D., Ph.D.

Selected Publications
1)  Colmont CS, Benketah A, Reed SH, Hawk NV, Telford WG, Ohyama M, Udey MC, Yee CL, Vogel JC, Patel GK.
CD200-expressing human basal cell carcinoma cells initiate tumor growth.
Proc. Natl. Acad. Sci. U.S.A. 110: 1434-9, 2013. [Journal]
2)  Wu CJ, Mannan P, Lu M, Udey MC.
Epithelial Cell Adhesion Molecule (EpCAM) Regulates Claudin Dynamics and Tight Junctions.
J. Biol. Chem. 288: 12253-68, 2013. [Journal]
3)  Gaiser MR, Lämmermann T, Feng X, Igyarto BZ, Kaplan DH, Tessarollo L, Germain RN, Udey MC.
Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo.
Proc. Natl. Acad. Sci. U.S.A. 109: E889-97, 2012. [Journal]
4)  Udey MC.
Epidermal Langerhans cells tune skin reactivity to contact allergens.
J. Clin. Invest. 122: 1602-5, 2012. [Journal]
5)  Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M.
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.
Nat. Immunol. 13: 744-52, 2012. [Journal]
6)  Mohammed J, Gunderson AJ, Khong H, Koubek RD, Udey MC, Glick AB.
TGFbeta1 Overexpression by Keratinocytes Alters Skin Dendritic Cell Homeostasis and Enhances Contact Hypersensitivity.
J. Invest. Dermatol. 133: 135-43, 2012. [Journal]
7)  Kautz-Neu K, Kostka SL, Dinges S, Iwakura Y, Udey MC, von Stebut E.
A Role for Leukocyte-Derived IL-1RA in DC Homeostasis Revealed by Increased Susceptibility of IL-1RA-Deficient Mice to Cutaneous Leishmaniasis.
J. Invest. Dermatol. 131: 1650-9, 2011. [Journal]
8)  Hwang J, Kita R, Kwon HS, Choi EH, Lee SH, Udey MC, Morasso MI.
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.
Proc. Natl. Acad. Sci. U.S.A. 108: 11566-71, 2011. [Journal]
9)  Kautz-Neu K, Kostka SL, Dinges S, Iwakura Y, Udey MC, von Stebut E.
IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice.
Exp. Dermatol. 20: 76-8, 2011. [Journal]
10)  Udey MC.
Jonathan Carl Vogel, MD (1954-2010).
J. Invest. Dermatol. 131: 1194-5, 2011. [Journal]
11)  Motegi S, Leitner WW, Lu M, Tada Y, Sardy M, Wu C, Chavakis T, Udey MC.
Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis.
Arterioscler. Thromb. Vasc. Biol. 31: 2024-34, 2011. [Journal]
12)  Motegi S, Garfield S, Feng X, Sardy M, Udey MC.
Potentiation of Platelet-Derived Growth Factor Receptor-{beta} Signaling Mediated by Integrin-Associated MFG-E8.
Arterioscler. Thromb. Vasc. Biol. 31: 2653-64, 2011. [Journal]
13)  Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ, Kaplan DH, Kastenmüller W, Germain RN, Seder RA.
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.
J. Clin. Invest. 121: 1782-96, 2011. [Journal]
14)  Tock CL, Turner LR, Altiner A, Batra P, Booher SL, Coelho SG, Warner JA, Therrien J, Turner ML, Miller SA, Beer JZ, Kraemer KH, Udey MC, Vogel JC, Terunuma A.
Transcriptional signatures of full-spectrum and non-UVB-spectrum solar irradiation in human skin.
Pigment Cell Melanoma Res. 24: 972-4, 2011. [Journal]
15)  Becker MR, Choi YS, Millar SE, Udey MC.
Wnt Signaling Influences the Development of Murine Epidermal Langerhans Cells.
J. Invest. Dermatol. 131: 1861-8, 2011. [Journal]
16)  Kronenberg K, Brosch S, Butsch F, Tada Y, Shibagaki N, Udey MC, von Stebut E.
Vaccination with TAT-Antigen Fusion Protein Induces Protective, CD8(+) T Cell-Mediated Immunity Against Leishmania Major.
J. Invest. Dermatol. 130: 2602-10, 2010. [Journal]
17)  Nagao K, Zhu J, Heneghan MB, Hanson JC, Morasso MI, Tessarollo L, Mackem S, Udey MC.
Abnormal placental development and early embryonic lethality in EpCAM-null mice.
PLoS ONE. 4: e8543, 2009. [Journal]
18)  Leitner WW, Baker MC, Berenberg TL, Lu MC, Yannie PJ, Udey MC.
Enhancement of DNA tumor vaccine efficacy by gene gun-mediated codelivery of threshold amounts of plasmid-encoded helper antigen.
Blood. 113: 37-45, 2009. [Journal]
19)  Lopez Kostka S, Dinges S, Griewank K, Iwakura Y, Udey MC, von Stebut E.
IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice.
J. Immunol. 182: 3039-46, 2009. [Journal]
20)  Nagao K, Ginhoux F, Leitner WW, Motegi S, Bennett CL, Clausen BE, Merad M, Udey MC.
Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions.
Proc. Natl. Acad. Sci. U.S.A. 106: 3312-7, 2009. [Journal]
21)  Hüter EN, Lee CC, Sherry RM, Udey MC.
Spontaneous regression and recurrence in a case of nodular fasciitis.
Acta Derm. Venereol. 89: 438-9, 2009. [Journal]
22)  Udey MC, Nagao K.
Characteristics and functions of murine cutaneous dendritic cells: a synopsis of recent developments.
Mucosal immunology. 1: 470-4, 2008. [Journal]
23)  Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T.
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.
Science. 322: 1101-4, 2008. [Journal]
24)  Udey MC, Rosenberg AS.
Langerhans cell dogma: another round of rejections.
J. Invest. Dermatol. 128: 1881-3, 2008. [Journal]
25)  Nigg AP, Zahn S, Ruckerl D, Holscher C, Yoshimoto T, Ehrchen JM, Wolbing F, Udey MC, von Stebut E.
Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice.
J. Immunol. 178: 7251-8, 2007. [Journal]
26)  Neutzner M, Lopez T, Feng X, Bergmann-Leitner ES, Leitner WW, Udey MC.
MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis.
Cancer Res. 67: 6777-85, 2007. [Journal]
27)  Terunuma A, Kapoor V, Yee C, Telford WG, Udey MC, Vogel JC.
Stem cell activity of human side population and alpha6 integrin-bright keratinocytes defined by a quantitative in vivo assay.
Stem Cells. 25: 664-9, 2007. [Journal]
28)  Ohyama M, Terunuma A, Tock CL, Radonovich MF, Pise-Masison CA, Hopping SB, Brady JN, Udey MC, Vogel JC.
Characterization and isolation of stem cell-enriched human hair follicle bulge cells.
J Clin Invest. 116: 249-60, 2006. [Journal]
29)  Kostka SL, Knop J, Konur A, Udey MC, von Stebut E.
Distinct Roles for IL-1 Receptor Type I Signaling in Early Versus Established Leishmania major Infections.
J Invest Dermatol. 126: 1582-9, 2006. [Journal]
30)  Cardones AR, Leitner WW, Fang L, Murakami T, Kapoor V, Udey MC, Hwang ST.
Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein.
Microvasc Res. 71: 32-9, 2006. [Journal]
31)  Tada Y, Riedl E, Lowenthal MS, Liotta LA, Briner DM, Crouch EC, Udey MC.
Identification and Characterization of Endogenous Langerin Ligands in Murine Extracellular Matrix.
J. Invest. Dermatol. 126: 1549-58, 2006. [Journal]
32)  Udey MC.
Langerhans cells on guard in the epidermis: poised to dSEARCH and ...?.
J Invest Dermatol. 126: 705-7, 2006. [Journal]
33)  Woelbing F, Kostka SL, Moelle K, Belkaid Y, Sunderkoetter C, Verbeek S, Waisman A, Nigg AP, Knop J, Udey MC, von Stebut E.
Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity.
J Exp Med. 203: 177-88, 2006. [Journal]
34)  Udey MC.
Gone fishin' in 2005-insights into the inner workings of dendritic cells.
J Invest Dermatol. 124: vi-vii, 2005. [Journal]
35)  Nadiminti H, Ehrlich A, Udey MC.
Oral erosions as a manifestation of allergic contact sensitivity to cinnamon mints.
Contact Dermatitis. 52: 46-7, 2005. [Journal]
36)  Terunuma A, Shaya MB, Udey MC, Vogel JC.
An in vivo competitive repopulation assay system to evaluate human keratinocyte stem cells.
J Invest Dermatol. 123: 993-5, 2004. [Journal]
37)  Riedl E, Tada Y, Udey MC.
Identification and characterization of an alternatively spliced isoform of mouse Langerin/CD207.
J Invest Dermatol. 123: 78-86, 2004. [Journal]
38)  Udey MC, Hornyak TJ.
In this issue--oncogenes, tumor suppressor genes and melanocytic lesions.
J Invest Dermatol. 122: VII-VIII, 2004. [Journal]
39)  von Stebut E, Udey MC.
Requirements for Th1-dependent immunity against infection with Leishmania major.
Microbes Infect. 6: 1102-9, 2004. [Journal]
40)  Udey MC.
Skin dendritic cells in immunity and autoimmunity.
J Investig Dermatol Symp Proc. 9: 15-7, 2004. [Journal]
41)  Blauvelt A, Hwang ST, Udey MC.
11. Allergic and immunologic diseases of the skin.
J Allergy Clin Immunol. 111: S560-70, 2003. [Journal]
42)  Shibagaki N, Udey MC.
Dendritic cells transduced with TAT protein transduction domain-containing tyrosinase-related protein 2 vaccinate against murine melanoma.
Eur J Immunol. 33: 850-60, 2003. [Journal]
43)  Udey MC.
In this issue: progress towards a more complete understanding of two important immune diseases involving skin.
J Invest Dermatol. 120: viii, 2003. [Journal]
44)  Von Stebut E, Ehrchen JM, Belkaid Y, Kostka SL, Molle K, Knop J, Sunderkotter C, Udey MC.
Interleukin 1alpha Promotes Th1 Differentiation and Inhibits Disease Progression in Leishmania major-susceptible BALB/c Mice.
J Exp Med. 198: 191-199, 2003. [Journal]
45)  Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks D.
CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.
J Immunol. 168: 3992-4000, 2002. [Journal]
46)  Shibagaki N, Udey MC.
Dendritic cells transduced with protein antigens induce cytotoxic lymphocytes and elicit antitumor immunity.
J Immunol. 168: 2393-401, 2002. [Journal]
47)  von Stebut E, Belkaid Y, Nguyen B, Wilson M, Sacks DL, Udey MC.
Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA.
J Invest Dermatol. 119: 621-8, 2002. [Journal]
48)  Jakob T, Ring J, Udey MC.
Multistep navigation of Langerhans/dendritic cells in and out of the skin.
J Allergy Clin Immunol. 108: 688-96, 2001. [Journal]
49)  Udey MC, von Stebut E, Mendez S, Sacks DL, Belkaid Y.
Skin dendritic cells in murine cutaneous leishmaniasis.
Immunobiology. 204: 590-4, 2001. [Journal]
50)  Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL.
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.
J Exp Med. 194: 1497-506, 2001. [Journal]
51)  Vogel JC, Udey MC.
Activation of skin dendritic cells by immunostimulatory DNA.
Springer Semin Immunopathol. 22: 45-54, 2000. [Journal]
52)  von Stebut E, Belkaid Y, Nguyen BV, Cushing M, Sacks DL, Udey MC.
Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis.
Eur J Immunol. 30: 3498-506, 2000. [Journal]
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This page was last updated on 5/1/2013.