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Our Science – Singer Website

Dinah S. Singer, Ph.D.

Selected Publications

1)  Devaiah BN, Lewis BA, Cherman N, Hewitt MC, Albrecht BK, Robey PG, Ozato K, Sims RJ, Singer DS.
BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain.
Proc. Natl. Acad. Sci. U.S.A. 109: 6927-32, 2012.
[Journal]
2)  Barbash ZS, Weissman JD, Campbell JA, Mu J, Singer DS.
Major Histocompatibility Complex Class I Core Promoter Elements Are Not Essential for Transcription in vivo.
Mol. Cell. Biol. 33: 4395-407, 2013.
[Journal]
3)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen Q, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
[Journal]
4)  Devaiah BN, Singer DS.
Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation.
J. Biol. Chem. 287: 38755-66, 2012.
[Journal]
5)  Soe KC, Devaiah BN, Singer DS.
Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.
Biochim. Biophys. Acta. 1829: 1184-90, 2013.
[Journal]
6)  Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals.
Immunity. 38: 1116-28, 2013.
[Journal]
7)  Gegonne A, Devaiah BN, Singer DS.
TAF7: traffic controller in transcription initiation.
Transcription. 4: 29-33, 2013.
[Journal]
8)  Devaiah BN, Singer DS.
Two faces of brd4: mitotic bookmark and transcriptional lynchpin.
Transcription. 4: 13-7, 2012.
[Journal]
9)  Devaiah BN, Lu H, Gegonne A, Sercan Z, Zhang H, Clifford RJ, Lee MP, Singer DS.
Novel functions for TAF7: a regulator of TAF1-independent transcription.
J Biol Chem. 285: 38772-80, 2010.
[Journal]
10)  Giuliani C, Bucci I, Montani V, Singer DS, Monaco F, Kohn LD, Napolitano G.
Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole.
J. Endocrinol. 204: 57-66, 2010.
[Journal]
11)  Lee N, Iyer SS, Mu J, Weissman JD, Ohali A, Howcroft TK, Lewis BA, Singer DS.
Three novel downstream promoter elements regulate MHC class I promoter activity in mammalian cells.
PLoS ONE. 5: e15278, 2010.
[Journal]
12)  Charni S, Aguilo JI, Garaude J, de Bettignies G, Jacquet C, Hipskind RA, Singer D, Anel A, Villalba M.
ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis.
J. Immunol. 182: 3398-405, 2009.
[Journal]
13)  Cohen H, Parekh P, Sercan Z, Kotekar A, Weissman J, Singer D.
In Vivo Expression of MHC Class I Genes Depends on the Presence of a Downstream Barrier Element.
PLoS One. 4: e6748, 2009.
[Journal]
14)  Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B.
Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008).
Mol Oncol. 3: 9-17, 2009.
[Journal]
15)  Kotekar AS, Weissman JD, Gegonne A, Cohen H, Singer DS.
Histone modifications, but not nucleosomal positioning, correlate with major histocompatibility complex class I promoter activity in different tissues in vivo.
Mol. Cell. Biol. 28: 7323-36, 2008.
[Journal]
16)  Gegonne A, Weissman JD, Lu H, Zhou M, Dasgupta A, Ribble R, Brady JN, Singer DS.
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
Proc. Natl. Acad. Sci. U.S.A. 105: 5367-72, 2008.
[Journal]
17)  Grassadonia A, Tinari N, Fiorentino B, Nakazato M, Chung HK, Giuliani C, Napolitano G, Iacobelli S, Howcroft TK, Singer DS, Kohn LD.
Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (Mac-2BP) protein.
Endocrinology. 148: 3507-17, 2007.
[Journal]
18)  Gegonne A, Weissman JD, Zhou M, Brady JN, Singer DS.
TAF7: a possible transcription initiation check-point regulator.
Proc. Natl. Acad. Sci. U.S.A. 103: 602-7, 2006.
[Journal]
19)  Giuliani C, Saji M, Bucci I, Fiore G, Liberatore M, Singer DS, Monaco F, Kohn LD, Napolitano G.
Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid cells.
J. Endocrinol. 189: 605-15, 2006.
[Journal]
20)  Howcroft TK, Weissman JD, Gegonne A, Singer DS.
A T lymphocyte-specific transcription complex containing RUNX1 activates MHC class I expression.
J Immunol. 174: 2106-15, 2005.
[Journal]
21)  Lee MP, Howcroft K, Kotekar A, Yang HH, Buetow KH, Singer DS.
ATG deserts define a novel core promoter subclass.
Genome Res. 15: 1189-97, 2005.
[Journal]
22)  Sogn JA, Anton-Culver H, Singer DS.
Meeting report: NCI think tanks in cancer biology.
Cancer Res. 65: 9117-20, 2005.
[Journal]
23)  Mozes E, Lovchik J, Zinger H, Singer D.
MHC class I expression regulates susceptibility to spontaneous autoimmune.
Lupus. 14: 308-14, 2005.
[Journal]
24)  Grassadonia A, Tinari N, Fiorentino B, Suzuki K, Nakazato M, De Tursi M, Giuliani C, Napolitano G, Singer DS, Iacobelli S, Kohn LD.
The 90K protein increases major histocompatibility complex class I expression.
Endocrinology. 145: 4728-36, 2004.
[Journal]
25)  Weissman JD, Raval A, Singer DS.
Assay of an intrinsic acetyltransferase activity of the transcriptional coactivator CIITA.
Methods Enzymol. 370: 378-86, 2003.
[Journal]
26)  Howcroft TK, Raval A, Weissman JD, Gegonne A, Singer DS.
Distinct transcriptional pathways regulate basal and activated major histocompatibility complex class I expression.
Mol Cell Biol. 23: 3377-91, 2003.
[Journal]
27)  Howcroft TK, Singer DS.
Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.
Immunol Res. 27: 1-30, 2003.
[Journal]
28)  Howcroft TK, Singer DS.
Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.
Immunol Res. 27: 1-30, 2003.
[Journal]
29)  Raval A, Weissman JD, Howcroft TK, Singer DS.
The GTP-binding domain of class II transactivator regulates its nuclear export.
J Immunol. 170: 922-30, 2003.
[Journal]
30)  Raval A, Weissman JD, Howcroft TK, Singer DS.
The GTP-binding domain of class II transactivator regulates its nuclear export.
J Immunol. 170: 922-30, 2003.
[Journal]
31)  Buetow KH, Klausner RD, Fine H, Kaplan R, Singer DS, Strausberg RL.
Cancer Molecular Analysis Project: weaving a rich cancer research tapestry.
Cancer Cell. 1: 315-8, 2002.
[Journal]
32)  Weissman JD, Hwang JR, Singer DS.
Extensive interactions between HIV TAT and TAF(II)250.
Biochim Biophys Acta. 1546: 156-63, 2001.
[Journal]
33)  Weissman JD, Hwang JR, Singer DS.
Extensive interactions between HIV TAT and TAF(II)250.
Biochim Biophys Acta. 1546: 156-163, 2001.
[Journal]
34)  Gegonne A, Weissman JD, Singer DS.
TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.
Proc Natl Acad Sci U S A. 98: 12432-12437, 2001.
[Journal]
35)  Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS.
Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.
Mol Cell. 7: 105-115, 2001.
[Journal]
36)  Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS.
Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.
Mol Cell. 7: 105-15, 2001.
[Journal]
37)  Weissman JD, Howcroft TK, Singer DS.
TAF(II)250-independent transcription can be conferred on a TAF(II)250-dependent basal promoter by upstream activators.
J Biol Chem. 275: 10160-10167, 2000.
[Journal]
38)  Singer DS, Zinger H, Kohn LD, Mozes E.
Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus.
Eur J Immunol. 29: 2259-2268, 1999.
[Journal]
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This page was last updated on 11/26/2013.