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Our Science – Shearer Website

Gene M. Shearer, Ph.D.

Selected Publications

1)  Vaccari M, Fenizia C, Ma ZM, Hryniewicz A, Boasso A, Doster MN, Miller CJ, Lindegardh N, Tarning J, Landay AL, Shearer GM, Franchini G.
Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.
AIDS Res. Hum. Retroviruses. 30: 355-62, 2014.
2)  Vaccari M, Boasso A, Fenizia C, Fuchs D, Hryniewicz A, Morgan T, Weiss D, Doster MN, Heraud JM, Shearer GM, Franchini G.
Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2",3"-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade.
J. Virol. 86: 108-13, 2012.
3)  Shearer GM, Boasso A.
Alloantigen-based AIDS vaccine: revisiting a "rightfully" discarded promising strategy.
F1000 Med Rep. 3: 12, 2011.
4)  Boasso A, Royle CM, Doumazos S, Aquino VN, Biasin M, Piacentini L, Tavano B, Fuchs D, Mazzotta F, Lo Caputo S, Shearer GM, Clerici M, Graham DR.
Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis.
Blood. 118: 5152-62, 2011.
5)  Via CS, Shearer GM.
Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus.
Autoimmunity. 43: 23-31, 2010.
6)  Kemp TJ, Hildesheim A, García-Piñeres A, Williams MC, Shearer GM, Rodriguez AC, Schiffman M, Burk R, Freer E, Bonilla J, Herrero R, Pinto LA.
Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection.
Cancer Epidemiol. Biomarkers Prev. 19: 1954-9, 2010.
7)  Biasin M, Piacentini L, Lo Caputo S, Naddeo V, Pierotti P, Borelli M, Trabattoni D, Mazzotta F, Shearer GM, Clerici M.
TLR activation pathways in HIV-1-exposed seronegative individuals.
J. Immunol. 184: 2710-7, 2010.
8)  Poirier MC, Olivero OA, Hardy AW, Franchini G, Borojerdi JP, Walker VE, Walker DM, Shearer GM.
Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.
AIDS Res Ther. 6: 24, 2009.
9)  Boasso A, Vaccari M, Fuchs D, Hardy AW, Tsai WP, Tryniszewska E, Shearer GM, Franchini G.
Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques.
J. Immunol. 182: 4313-20, 2009.
10)  Herbeuval JP, Nilsson J, Boasso A, Hardy AW, Vaccari M, Cecchinato V, Valeri V, Franchini G, Andersson J, Shearer GM.
HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques.
AIDS. 23: 35-40, 2009.
Click Here to View Expanded Bibliography.

This page was last updated on 4/11/2014.