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Susan O. Sharrow, B.Sc.

Selected Publications

1)  Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Cell. 153: 1266-80, 2013.
2)  Hathcock KS, Bowen S, Livak F, Hodes RJ.
ATM influences the efficiency of TCRß rearrangement, subsequent TCRß-dependent T cell development, and generation of the pre-selection TCRß CDR3 repertoire.
PLoS ONE. 8: e62188, 2013.
3)  Bowen S, Wangsa D, Ried T, Livak F, Hodes RJ.
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.
Nucleic Acids Res. 41: 4535-48, 2013.
4)  Bosch B, Berger AC, Khandelwal S, Heipertz EL, Scharf B, Santambrogio L, Roche PA.
Disruption of Multivesicular Body Vesicles Does Not Affect Major Histocompatibility Complex (MHC) Class II-Peptide Complex Formation and Antigen Presentation by Dendritic Cells.
J. Biol. Chem. 288: 24286-92, 2013.
5)  Tinsley KW, Hong C, Luckey MA, Park JY, Kim GY, Yoon HW, Keller HR, Sacks AJ, Feigenbaum L, Park JH.
Ikaros is required to survive positive selection and to maintain clonal diversity during T cell development in the thymus.
Blood. 2013.
6)  Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
IL-7 signaling must be intermittent, not continuous, during CD8? T cell homeostasis to promote cell survival instead of cell death.
Nat. Immunol. 14: 143-51, 2013.
7)  Hong C, Nam AS, Keller HR, Ligons DL, Park JY, Yoon HW, Park JJ, Luckey MA, Park JH.
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine. 2013.
8)  Bosch B, Heipertz EL, Drake JR, Roche PA.
Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters.
J. Biol. Chem. 288: 13236-42, 2013.
9)  Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH.
Pim1 permits generation and survival of CD4(+) T cells in the absence of ?c cytokine receptor signaling.
Eur. J. Immunol. 2013.
10)  Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Möröy T, Ersahin T, Atalay R, Erman B, Park JH.
CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.
J. Biol. Chem. 287: 34386-99, 2012.
11)  Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Möröy T, Ersahin T, Atalay R, Erman B, Park JH.
CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.
J. Biol. Chem. 287: 34386-99, 2012.
12)  McCaughtry TM, Etzensperger R, Alag A, Tai X, Kurtulus S, Park JH, Grinberg A, Love P, Feigenbaum L, Erman B, Singer A.
Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.
J. Exp. Med. 209: 2263-76, 2012.
13)  Furuta K, Ishido S, Roche PA.
Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells.
Proc. Natl. Acad. Sci. U.S.A. 109: 19380-5, 2012.
14)  Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A.
Loss of ATM kinase activity leads to embryonic lethality in mice.
J. Cell Biol. 198: 295-304, 2012.
15)  Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Immunity. 37: 971-85, 2012.
16)  Bowen S, Sun P, Livak F, Sharrow S, Hodes RJ.
A novel T cell subset with trans-rearranged V?-Cß TCRs shows Vß expression is dispensable for lineage choice and MHC restriction.
J. Immunol. 192: 169-77, 2014.
17)  Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim GY, Keller HR, Etzensperger R, Tai X, Lazarevic V, Feigenbaum L, Catalfamo M, Walsh ST, Park JH.
Activated T cells secrete an alternatively spliced form of common ?-chain that inhibits cytokine signaling and exacerbates inflammation.
Immunity. 40: 910-23, 2014.
18)  Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A.
CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
J. Exp. Med. 211: 1027-36, 2014.
19)  Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A.
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.
Nature. 2014.
20)  Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ.
Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4(+) T cell responses.
Immunity. 40: 681-91, 2014.
21)  Mu J, Tai X, Iyer SS, Weissman JD, Singer A, Singer DS.
Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function.
J. Immunol. 192: 2892-903, 2014.
22)  Luckey MA, Kimura MY, Waickman AT, Feigenbaum L, Singer A, Park JH.
The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
Nat. Immunol. 15: 638-45, 2014.
23)  Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V.
The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-?-producing T helper 17 cells.
Immunity. 40: 355-66, 2014.
24)  Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.
J. Immunol. 192: 630-40, 2014.
25)  Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity. 38: 1116-28, 2013.
26)  Furuta K, Walseng E, Roche PA.
Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation.
Proc. Natl. Acad. Sci. U.S.A. 110: 20188-93, 2013.
27)  Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell. 154: 1326-41, 2013.
28)  Barbash ZS, Weissman JD, Campbell JA, Mu J, Singer DS.
Major histocompatibility complex class I core promoter elements are not essential for transcription in vivo.
Mol. Cell. Biol. 33: 4395-407, 2013.
29)  Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
Proc. Natl. Acad. Sci. U.S.A. 110: 21107-12, 2013.
30)  Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park J, Yang JC, Sun PD, Singer A.
Alpha-beta T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.
Immunity. 36: 79-91, 2012.
31)  Kim GY, Ligons DL, Hong C, Luckey MA, Keller HR, Tai X, Lucas PJ, Gress RE, Park J.
An In Vivo IL-7 Requirement for Peripheral Foxp3+ Regulatory T Cell Homeostasis.
J Immunol. 188: 5859-66, 2012.
32)  Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells.
Blood. 119: 5155-63, 2012.
33)  Pobezinsky LA, Angelov GS, Tai X, Jeurling S, Van Laethem F, Feigenbaum L, Park JH, Singer A.
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
Nat. Immunol. 13: 569-78, 2012.
34)  Liu Y, Belkina NV, Park C, Nambiar R, Loughhead SM, Patino-Lopez G, Ben-Aissa K, Hao JJ, Kruhlak MJ, Qi H, von Andrian UH, Kehrl JH, Tyska MJ, Shaw S.
Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.
Blood. 119: 445-53, 2012.
35)  Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J. 31: 366-77, 2012.
36)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The General Transcription Factor TAF7 Is Essential for Embryonic Development but Not Essential for the Survival or Differentiation of Mature T Cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
37)  Langer HF, Orlova VV, Xie C, Kaul S, Schneider D, Lonsdorf AS, Fahrleitner M, Choi EY, Dutoit V, Pellegrini M, Grossklaus S, Nawroth PP, Baretton G, Santoso S, Hwang ST, Arnold B, Chavakis T.
A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis.
Cancer Res. 71: 4096-105, 2011.
38)  Chiang J, Hodes RJ.
Cbl enforces Vav1 dependence and a restricted pathway of T cell development.
PLoS ONE. 6: e18542, 2011.
39)  Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.
Mol. Cell. 42: 319-29, 2011.
40)  Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ.
The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
PLoS ONE. 6: e20639, 2011.
41)  Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, Wang Y, Venzon D, Epstein SL, Segal DM.
TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.
J. Immunol. 186: 2422-9, 2011.
42)  Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A.
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Cell. 141: 243-54, 2010.
43)  Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.
J. Exp. Med. 207: 973-81, 2010.
44)  Walseng E, Furuta K, Goldszmid RS, Weih KA, Sher A, Roche PA.
Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus.
J. Biol. Chem. 285: 41749-54, 2010.
45)  Khandelwal S, Roche PA.
Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.
J. Biol. Chem. 285: 35303-10, 2010.
46)  Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ.
Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.
J. Immunol. 184: 1821-8, 2010.
47)  Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A.
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Science. 329: 917-23, 2010.
48)  Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A.
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Nat. Immunol. 11: 257-64, 2010.
49)  Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ.
Telomere length is inherited with resetting of the telomere set-point.
Proc. Natl. Acad. Sci. U.S.A. 107: 10148-53, 2010.
50)  Walseng E, Furuta K, Bosch B, Weih KA, Matsuki Y, Bakke O, Ishido S, Roche PA.
Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells.
Proc. Natl. Acad. Sci. U.S.A. 107: 20465-70, 2010.
51)  Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O.
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.
Nat. Genet. 41: 891-8, 2009.
52)  Chiang YJ, Jordan MS, Horai R, Schwartzberg PL, Koretzky GA, Hodes RJ.
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
J. Biol. Chem. 284: 4429-38, 2009.
53)  Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M.
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Mol. Cell. 34: 285-97, 2009.
54)  Cohen H, Parekh P, Sercan Z, Kotekar A, Weissman JD, Singer DS.
In vivo expression of MHC class I genes depends on the presence of a downstream barrier element.
PLoS ONE. 4: e6748, 2009.
55)  Belkina NV, Liu Y, Hao JJ, Karasuyama H, Shaw S.
LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.
Proc. Natl. Acad. Sci. U.S.A. 106: 4707-12, 2009.
56)  Sarafova SD, Van Laethem F, Adoro S, Guinter T, Sharrow SO, Feigenbaum L, Singer A.
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
Immunity. 31: 480-90, 2009.
57)  Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Nature. 456: 529-33, 2008.
58)  Terabe M, Tagaya Y, Zhu Q, Granger L, Roederer M, Waldmann TA, Berzofsky JA.
IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells.
J. Immunol. 180: 7276-86, 2008.
59)  Walseng E, Bakke O, Roche PA.
Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathway.
J. Biol. Chem. 283: 14717-27, 2008.
60)  Puri N, Roche PA.
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.
Proc. Natl. Acad. Sci. U.S.A. 105: 2580-5, 2008.
61)  Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A.
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
J. Cell Biol. 183: 777-83, 2008.
62)  Dubois S, Patel HJ, Zhang M, Waldmann TA, Müller JR.
Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action.
J. Immunol. 180: 2099-106, 2008.
63)  Patino-Lopez G, Dong X, Ben-Aissa K, Bernot KM, Itoh T, Fukuda M, Kruhlak MJ, Samelson LE, Shaw S.
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
J. Biol. Chem. 283: 18323-30, 2008.
64)  Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, Gahmberg CG, Chavakis T.
Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.
Blood. 111: 3607-14, 2008.
65)  Williams JA, Lumsden JM, Yu X, Feigenbaum L, Zhang J, Steinberg SM, Hodes RJ.
Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.
J. Immunol. 181: 907-17, 2008.
66)  Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ.
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
PLoS ONE. 3: e2639, 2008.
67)  Adoro S, Erman B, Sarafova SD, Van Laethem F, Park JH, Feigenbaum L, Singer A.
Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.
J. Immunol. 181: 6975-83, 2008.
68)  Catalfamo M, Tai X, Karpova T, McNally J, Henkart PA.
TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells.
Immunology. 125: 70-9, 2008.
69)  Leonard JN, Ghirlando R, Askins J, Bell JK, Margulies DH, Davies DR, Segal DM.
The TLR3 signaling complex forms by cooperative receptor dimerization.
Proc. Natl. Acad. Sci. U.S.A. 105: 258-63, 2008.
70)  Lutsiak ME, Tagaya Y, Adams AJ, Schlom J, Sabzevari H.
Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells.
J. Immunol. 180: 5871-81, 2008.
71)  Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A.
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Nat. Immunol. 8: 1049-59, 2007.
72)  Chiang JY, Jang IK, Hodes R, Gu H.
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.
J. Clin. Invest. 117: 1029-36, 2007.
73)  Vacchio MS, Olaru A, Livak F, Hodes RJ.
ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.
Proc. Natl. Acad. Sci. U.S.A. 104: 6323-8, 2007.
74)  Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Cell. 130: 63-75, 2007.
75)  Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A.
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Immunity. 27: 735-50, 2007.
76)  Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A.
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.
J. Exp. Med. 204: 1003-11, 2007.
77)  Tai X, Van Laethem F, Sharpe AH, Singer A.
Induction of autoimmune disease in CTLA-4 / mice depends on a specific CD28 motif that is required for in vivo costimulation.
Proc. Natl. Acad. Sci. U.S.A. 104: 13756-61, 2007.
78)  Fukumoto R, Dundr M, Nicot C, Adams A, Valeri VW, Samelson LE, Franchini G.
Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1.
J. Virol. 81: 9088-99, 2007.
79)  Shen X, Zhou J, Hathcock KS, Robbins P, Powell DJ, Rosenberg SA, Hodes RJ.
Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length.
J. Immunother. 30: 123-9, 2007.
80)  Liu Y, Kruhlak MJ, Hao JJ, Shaw S.
Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity.
J. Leukoc. Biol. 82: 742-51, 2007.
81)  Song H, Zhang J, Chiang YJ, Siraganian RP, Hodes RJ.
Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.
J. Immunol. 178: 926-35, 2007.
82)  Muntasell A, Berger AC, Roche PA.
T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes.
EMBO J. 26: 4263-72, 2007.
83)  Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A.
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.
Nature. 443: 222-5, 2006.
84)  Poloso NJ, Denzin LK, Roche PA.
CDw78 defines MHC class II-peptide complexes that require Ii chain-dependent lysosomal trafficking, not localization to a specific tetraspanin membrane microdomain.
J. Immunol. 177: 5451-8, 2006.
85)  Erman B, Alag AS, Dahle O, van Laethem F, Sarafova SD, Guinter TI, Sharrow SO, Grinberg A, Love PE, Singer A.
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
J. Immunol. 177: 6613-25, 2006.
86)  Yu Q, Park JH, Doan LL, Erman B, Feigenbaum L, Singer A.
Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection.
J. Exp. Med. 203: 165-75, 2006.
87)  Leifer CA, Brooks JC, Hoelzer K, Lopez JL, Kennedy MN, Mazzoni A, Segal DM.
Cytoplasmic targeting motifs control localization of toll-like receptor 9.
J Biol Chem. 281: 35585-92, 2006.
88)  Mazzoni A, Siraganian RP, Leifer CA, Segal DM.
Dendritic cell modulation by mast cells controls the TH1/TH2 balance in responding T cells.
J. Immunol. 177: 3577-81, 2006.
89)  Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ.
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
Mol. Cell. Biol. 26: 2037-43, 2006.
90)  Dubois S, Waldmann TA, Müller JR.
ITK and IL-15 support two distinct subsets of CD8+ T cells.
Proc. Natl. Acad. Sci. U.S.A. 103: 12075-80, 2006.
91)  Vacchio MS, Williams JA, Hodes RJ.
A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection.
Eur J Immunol. 35: 418-27, 2005.
92)  Tai X, Cowan M, Feigenbaum L, Singer A.
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
Nat Immunol. 6: 152-62, 2005.
93)  Liu K, Caldwell SA, Abrams SI.
Cooperative disengagement of Fas and intercellular adhesion molecule-1 function in neoplastic cells confers enhanced colonization efficiency.
Cancer Res. 65: 1045-54, 2005.
94)  Collier-Hyams LS, Sloane V, Batten BC, Neish AS.
Cutting edge: bacterial modulation of epithelial signaling via changes in neddylation of cullin-1.
J. Immunol. 175: 4194-8, 2005.
95)  Vacchio MS, Hodes RJ.
Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy.
J Immunol. 174: 4657-61, 2005.
96)  Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S.
Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.
Proc Natl Acad Sci U S A. 102: 1590-5, 2005.
97)  Sarafova SD, Erman B, Yu Q, Van Laethem F, Guinter T, Sharrow SO, Feigenbaum L, Wildt KF, Ellmeier W, Singer A.
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.
Immunity. 23: 75-87, 2005.
98)  Williams JA, Hathcock KS, Klug D, Harada Y, Choudhury B, Allison JP, Abe R, Hodes RJ.
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint.
J. Immunol. 175: 4199-207, 2005.
99)  Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.
Nat Cell Biol. 7: 675-85, 2005.
100)  Dubois SP, Waldmann TA, Müller JR.
Survival adjustment of mature dendritic cells by IL-15.
Proc. Natl. Acad. Sci. U.S.A. 102: 8662-7, 2005.
101)  Kennedy MN, Mullen GE, Leifer CA, Lee C, Mazzoni A, Dileepan KN, Segal DM.
A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.
J Biol Chem. 279: 34698-704, 2004.
102)  El Kassar N, Lucas PJ, Klug DB, Zamisch M, Merchant M, Bare CV, Choudhury B, Sharrow SO, Richie E, Mackall CL, Gress RE.
A dose effect of IL-7 on thymocyte development.
Blood. 104: 1419-27, 2004.
103)  Singer A, Bosselut R.
CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision.
Adv Immunol. 83: 91-131, 2004.
104)  Erman B, Guinter TI, Singer A.
Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation.
J Exp Med. 199: 1719-24, 2004.
105)  Liu X, Bosselut R.
Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.
Nat Immunol. 5: 280-8, 2004.
106)  Chu YW, Memon SA, Sharrow SO, Hakim FT, Eckhaus M, Lucas PJ, Gress RE.
Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function.
Blood. 104: 1110-9, 2004.
107)  Catalfamo M, Karpova T, McNally J, Costes SV, Lockett SJ, Bos E, Peters PJ, Henkart PA.
Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation.
Immunity. 20: 219-30, 2004.
108)  Yu Q, Erman B, Park JH, Feigenbaum L, Singer A.
IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.
J Exp Med. 200: 797-803, 2004.
109)  Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ.
Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
J Exp Med. 200: 1111-21, 2004.
110)  Zhang J, Chiang YJ, Hodes RJ, Siraganian RP.
Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.
J Immunol. 173: 1811-8, 2004.
111)  Chiang YJ, Sommers CL, Jordan MS, Gu H, Samelson LE, Koretzky GA, Hodes RJ.
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.
J Exp Med. 200: 25-34, 2004.
112)  Fernandez-Capetillo O, Allis CD, Nussenzweig A.
Phosphorylation of histone H2B at DNA double-strand breaks.
J Exp Med. 199: 1671-7, 2004.
113)  Nijhara R, van Hennik PB, Gignac ML, Kruhlak MJ, Hordijk PL, Delon J, Shaw S.
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes.
J Immunol. 173: 4985-93, 2004.
114)  Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, Grimes HL, Singer A.
Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival.
Immunity. 21: 289-302, 2004.
115)  Leifer CA, Kennedy MN, Mazzoni A, Lee C, Kruhlak MJ, Segal DM.
TLR9 is localized in the endoplasmic reticulum prior to stimulation.
J Immunol. 173: 1179-83, 2004.
116)  Lucas PJ, McNeil N, Hilgenfeld E, Choudhury B, Kim SJ, Eckhaus MA, Ried T, Gress RE.
Transforming growth factor-beta pathway serves as a primary tumor suppressor in CD8+ T cell tumorigenesis.
Cancer Res. 64: 6524-9, 2004.
117)  Vacchio MS, Hodes RJ.
CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells.
J Exp Med. 197: 19-26, 2003.
118)  Mazzoni A, Leifer CA, Mullen GE, Kennedy MN, Klinman DM, Segal DM.
Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells.
J Immunol. 170: 2269-73, 2003.
119)  Lumsden JM, Williams JA, Hodes RJ.
Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo.
J Immunol. 170: 781-7, 2003.
120)  Yu Q, Erman B, Bhandoola A, Sharrow SO, Singer A.
In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells.
J Exp Med. 197: 475-87, 2003.
121)  Bosselut R, Guinter TI, Sharrow SO, Singer A.
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes.
J Exp Med. 197: 1709-19, 2003.
122)  Williams JA, Sharrow SO, Adams AJ, Hodes RJ.
CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
J Immunol. 168: 2759-65, 2002.
123)  McKean DJ, Huntoon CJ, Bell MP, Tai X, Sharrow S, Hedin KE, Conley A, Singer A.
Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation.
J Immunol. 166: 3468-75, 2001.
124)  Bosselut R, Feigenbaum L, Sharrow SO, Singer A.
Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes.
Immunity. 14: 483-94, 2001.
125)  Cibotti R, Bhandoola A, Guinter TI, Sharrow SO, Singer A.
CD8 coreceptor extinction in signaled CD4(+)CD8(+) thymocytes: coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes.
Mol Cell Biol. 20: 3852-9, 2000.
126)  Brugnera E, Bhandoola A, Cibotti R, Yu Q, Guinter TI, Yamashita Y, Sharrow SO, Singer A.
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.
Immunity. 13: 59-71, 2000.
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