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Our Science – Roche Website

Paul A. Roche, Ph.D.

Selected Publications

1)  Wu Z, Chen X, Liu F, Chen W, Wu P, Wieschhaus AJ, Chishti AH, Roche PA, Chen W, Lin T.
Calpain-1 Contributes to IgE-Mediated Mast Cell Activation.
J. Immunol. [Epub ahead of print], 2014.
2)  Cresswell P, Roche PA.
Invariant chain-MHC class II complexes: always odd and never invariant.
Immunol. Cell Biol. [Epub ahead of print], 2014.
3)  Bosch B, Berger AC, Khandelwal S, Heipertz EL, Scharf B, Santambrogio L, Roche PA.
Disruption of Multivesicular Body Vesicles Does Not Affect Major Histocompatibility Complex (MHC) Class II-Peptide Complex Formation and Antigen Presentation by Dendritic Cells.
J. Biol. Chem. 288: 24286-92, 2013.
4)  Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW.
IkappaB kinase (IKK) phosphorylation of SNAP-23 controls platelet secretion.
Blood. 121: 4567-74, 2013.
5)  Furuta K, Walseng E, Roche PA.
Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation.
Proc. Natl. Acad. Sci. U.S.A. 110: 20188-93, 2013.
6)  Bosch B, Heipertz EL, Drake JR, Roche PA.
MHC Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-Rich Microclusters.
J. Biol. Chem. 288: 13236-42, 2013.
7)  Suh YH, Park JY, Park S, Jou I, Roche PA, Roche KW.
Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1.
J. Biol. Chem. 288: 17544-51, 2013.
8)  Cho KJ, Roche PA.
Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination.
Front Immunol. 4: 369, 2013.
9)  Furuta K, Ishido S, Roche PA.
Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells.
Proc. Natl. Acad. Sci. U.S.A. 109: 19380-5, 2012.
10)  Hunt D, Wilson JE, Weih KA, Ishido S, Harton JA, Roche PA, Drake JR.
Francisella tularensis elicits IL-10 via a PGE2-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation.
PLoS ONE. 7: e37330, 2012.
11)  Suh YH, Yoshimoto-Furusawa A, Weih KA, Tessarollo L, Roche KW, Mackem S, Roche PA.
Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice.
PLoS ONE. 6: e18444, 2011.
12)  Suh YH, Terashima A, Petralia RS, Wenthold RJ, Isaac JT, Roche KW, Roche PA.
A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking.
Nat. Neurosci. 13: 338-43, 2010.
13)  Langer HF, Chung K, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, Deangelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T.
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.
Blood. 116: 4395-403, 2010.
14)  Walseng E, Furuta K, Goldszmid RS, Weih KA, Sher A, Roche PA.
Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus.
J. Biol. Chem. 285: 41749-54, 2010.
15)  Khandelwal S, Roche PA.
Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.
J. Biol. Chem. 285: 35303-10, 2010.
16)  Tang TT, Badger JD, Roche PA, Roche KW.
Novel approach to probe subunit-specific contributions to N-methyl-D-aspartate (NMDA) receptor trafficking reveals a dominant role for NR2B in receptor recycling.
J. Biol. Chem. 285: 20975-81, 2010.
17)  Danielian S, Basile N, Rocco C, Prieto E, Rossi J, Barsotti D, Roche PA, Bernasconi A, Oleastro M, Zelazko M, Braier J.
Novel syntaxin 11 gene (STX11) mutation in three Argentinean patients with hemophagocytic lymphohistiocytosis.
J. Clin. Immunol. 30: 330-7, 2010.
18)  Walseng E, Furuta K, Bosch B, Weih KA, Matsuki Y, Bakke O, Ishido S, Roche PA.
Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells.
Proc. Natl. Acad. Sci. U.S.A. 107: 20465-70, 2010.
19)  Berger AC, Roche PA.
MHC class II transport at a glance.
J. Cell. Sci. 122: 1-4, 2009.
20)  Lee JH, Lee J, Choi KY, Hepp R, Lee JY, Lim MK, Chatani-Hinze M, Roche PA, Kim DG, Ahn YS, Kim CH, Roche KW.
Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5.
Proc. Natl. Acad. Sci. U.S.A. 105: 12575-80, 2008.
21)  Suh YH, Pelkey KA, Lavezzari G, Roche PA, Huganir RL, McBain CJ, Roche KW.
Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.
Neuron. 58: 736-48, 2008.
22)  Walseng E, Bakke O, Roche PA.
Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathway.
J. Biol. Chem. 283: 14717-27, 2008.
23)  Puri N, Roche PA.
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.
Proc. Natl. Acad. Sci. U.S.A. 105: 2580-5, 2008.
24)  Bryceson YT, Rudd E, Zheng C, Edner J, Ma D, Wood SM, Bechensteen AG, Boelens JJ, Celkan T, Farah RA, Hultenby K, Winiarski J, Roche PA, Nordenskjold M, Henter J, Long EO, Ljunggren H.
Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.
Blood. 110: 1906-15, 2007.
25)  Muntasell A, Berger AC, Roche PA.
T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes.
EMBO J. 26: 4263-72, 2007.
26)  Poloso NJ, Denzin LK, Roche PA.
CDw78 defines MHC class II-peptide complexes that require Ii chain-dependent lysosomal trafficking, not localization to a specific tetraspanin membrane microdomain.
J. Immunol. 177: 5451-8, 2006.
27)  Roche PA.
Gold-plating MHC class II molecules.
Nat. Chem. Biol. 2: 178-9, 2006.
28)  Puri N, Roche PA.
Ternary SNARE Complexes Are Enriched in Lipid Rafts during Mast Cell Exocytosis.
Traffic. 7: 1482-94, 2006.
29)  Hepp R, Puri N, Hohenstein AC, Crawford GL, Whiteheart SW, Roche PA.
Phosphorylation of SNAP-23 regulates exocytosis from mast cells.
J Biol Chem. 280: 6610-20, 2005.
30)  Poloso NJ, Roche PA.
Association of MHC class II-peptide complexes with plasma membrane lipid microdomains.
Curr Opin Immunol. 16: 103-7, 2004.
31)  Poloso NJ, Muntasell A, Roche PA.
MHC Class II Molecules Traffic into Lipid Rafts during Intracellular Transport.
J Immunol. 173: 4539-46, 2004.
32)  Puri N, Kruhlak MJ, Whiteheart SW, Roche PA.
Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.
J Immunol. 171: 5345-52, 2003.
33)  Hiltbold EM, Poloso NJ, Roche PA.
MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse.
J Immunol. 170: 1329-38, 2003.
34)  Hepp R, Cabaniols JP, Roche PA.
Differential phosphorylation of SNAP-25 in vivo by protein kinase C and protein kinase A.
FEBS Lett. 532: 52-6, 2002.
35)  Hiltbold EM, Roche PA.
Trafficking of MHC class II molecules in the late secretory pathway.
Curr Opin Immunol. 14: 30-35, 2002.
36)  Hohenstein AC, Roche PA.
SNAP-29 is a promiscuous syntaxin-binding SNARE.
Biochem Biophys Res Commun. 285: 167-71, 2001.
37)  Vaidyanathan VV, Puri N, Roche PA.
The last exon of SNAP-23 regulates granule exocytosis from mast cells.
J Biol Chem. 276: 25101-25106, 2001.
38)  Anderson HA, Hiltbold EM, Roche PA.
Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation.
Nat Immunol. 1: 156-162, 2000.
39)  Smith SK, Anderson HA, Yu G, Robertson AG, Allen SJ, Tyler SJ, Naylor RL, Mason G, Wilcock GW, Roche PA, Fraser PE, Dawbarn D.
Identification of syntaxin 1A as a novel binding protein for presenilin-1.
Brain Res. Mol. Brain Res. 78: 100-7, 2000.
40)  Low SH, Miura M, Roche PA, Valdez AC, Mostov KE, Weimbs T.
Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity.
Mol. Biol. Cell. 11: 3045-60, 2000.
41)  Vaidyanathan VV, Roche PA.
Structure and chromosomal localization of the mouse SNAP-23 gene.
Gene. 247: 181-189, 2000.
42)  Vogel K, Cabaniols JP, Roche PA.
Targeting of SNAP-25 to membranes is mediated by its association with the target SNARE syntaxin.
J. Biol. Chem. 275: 2959-65, 2000.
43)  Roche PA.
Intracellular protein traffic in lymphocytes:.
Immunity. 11: 391-8, 1999.
44)  Cabaniols JP, Ravichandran V, Roche PA.
Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly.
Mol. Biol. Cell. 10: 4033-41, 1999.
45)  Anderson HA, Bergstralh DT, Kawamura T, Blauvelt A, Roche PA.
Phosphorylation of the invariant chain by protein kinase C regulates MHC class II trafficking to antigen-processing compartments.
J. Immunol. 163: 5435-43, 1999.
46)  Vogel K, Roche PA.
SNAP-23 and SNAP-25 are palmitoylated in vivo.
Biochem. Biophys. Res. Commun. 258: 407-10, 1999.
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This page was last updated on 5/15/2014.