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Our Science – Roche Website

Paul A. Roche, Ph.D.

Selected Publications

1)  Wu Z, Chen X, Liu F, Chen W, Wu P, Wieschhaus AJ, Chishti AH, Roche PA, Chen W, Lin T.
Calpain-1 Contributes to IgE-Mediated Mast Cell Activation.
J. Immunol. [Epub ahead of print], 2014.
2)  Cresswell P, Roche PA.
Invariant chain-MHC class II complexes: always odd and never invariant.
Immunol. Cell Biol. [Epub ahead of print], 2014.
3)  Bosch B, Berger AC, Khandelwal S, Heipertz EL, Scharf B, Santambrogio L, Roche PA.
Disruption of Multivesicular Body Vesicles Does Not Affect Major Histocompatibility Complex (MHC) Class II-Peptide Complex Formation and Antigen Presentation by Dendritic Cells.
J. Biol. Chem. 288: 24286-92, 2013.
4)  Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW.
IkappaB kinase (IKK) phosphorylation of SNAP-23 controls platelet secretion.
Blood. 121: 4567-74, 2013.
5)  Furuta K, Walseng E, Roche PA.
Internalizing MHC class II-peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation.
Proc. Natl. Acad. Sci. U.S.A. 110: 20188-93, 2013.
6)  Bosch B, Heipertz EL, Drake JR, Roche PA.
MHC Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-Rich Microclusters.
J. Biol. Chem. 288: 13236-42, 2013.
7)  Suh YH, Park JY, Park S, Jou I, Roche PA, Roche KW.
Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1.
J. Biol. Chem. 288: 17544-51, 2013.
8)  Cho KJ, Roche PA.
Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination.
Front Immunol. 4: 369, 2013.
9)  Furuta K, Ishido S, Roche PA.
Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells.
Proc. Natl. Acad. Sci. U.S.A. 109: 19380-5, 2012.
10)  Hunt D, Wilson JE, Weih KA, Ishido S, Harton JA, Roche PA, Drake JR.
Francisella tularensis elicits IL-10 via a PGE2-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation.
PLoS ONE. 7: e37330, 2012.
Click Here to View Expanded Bibliography.

This page was last updated on 5/15/2014.