Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – Nussenzweig Website

Andre Nussenzweig, Ph.D.

Selected Publications

1)  Ira G, Nussenzweig A.
A new Riff: Rif1 eats its cake and has it too.
EMBO Rep. [Epub ahead of print], 2014.
[Journal]
2)  Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Cell. 153: 1266-80, 2013.
[Journal]
3)  Bunting SF, Nussenzweig A.
End-joining, translocations and cancer.
Nat. Rev. Cancer. 13: 443-54, 2013.
[Journal]
4)  Lee B, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.
Functional Intersection of ATM and DNA-PKcs in Coding End Joining During V(D)J Recombination.
Mol. Cell. Biol. 33: 3568-79, 2013.
[Journal]
5)  Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A.
Identification of early replicating fragile sites that contribute to genome instability.
Cell. 152: 620-32, 2013.
[Journal]
6)  Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, Robbiani DF.
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
J. Exp. Med. 210: 115-23, 2013.
[Journal]
7)  Fernandez-Capetillo O, Nussenzweig A.
Naked replication forks break apRPArt.
Cell. 155: 979-80, 2013.
[Journal]
8)  Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM.
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
Proc. Natl. Acad. Sci. U.S.A. 110: 8632-7, 2013.
[Journal]
9)  Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC.
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.
Science. 339: 711-5, 2013.
[Journal]
10)  Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R.
RPA accumulation during class switch recombination represents 5"-3" DNA-end resection during the S-G2/M phase of the cell cycle.
Cell Rep. 3: 138-47, 2013.
[Journal]
11)  Daniel JA, Nussenzweig A.
The AID-induced DNA damage response in chromatin.
Mol. Cell. 50: 309-21, 2013.
[Journal]
12)  Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A.
BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair.
Mol. Cell. 46: 125-35, 2012.
[Journal]
13)  Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, Nussenzweig A, Hager GL, Nussenzweig MC, Casellas R.
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
Nature. 484: 69-74, 2012.
[Journal]
14)  Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A.
Loss of ATM kinase activity leads to embryonic lethality in mice.
J. Cell Biol. 198: 295-304, 2012.
[Journal]
15)  Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.
RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.
J. Biol. Chem. 287: 40618-28, 2012.
[Journal]
16)  Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH.
RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids.
Genes Dev. 26: 2737-48, 2012.
[Journal]
17)  Daniel JA, Nussenzweig A.
Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination.
Biochim. Biophys. Acta. 1819: 733-8, 2012.
[Journal]
18)  Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A.
The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Immunity. 37: 971-85, 2012.
[Journal]
19)  Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC.
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
EMBO J. 31: 4045-56, 2012.
[Journal]
20)  Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP.
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Proc. Natl. Acad. Sci. U.S.A. 108: 2022-7, 2011.
[Journal]
21)  Fernando RN, Eleuteri B, Abdelhady S, Nussenzweig A, Andäng M, Ernfors P.
Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells.
Proc. Natl. Acad. Sci. U.S.A. 108: 5837-42, 2011.
[Journal]
22)  Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, Zhang CC, Chen DJ, Chen BP.
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
J. Cell Biol. 193: 295-305, 2011.
[Journal]
23)  Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH.
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.
Genes Dev. 25: 959-71, 2011.
[Journal]
24)  Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.
Mol. Cell. 42: 319-29, 2011.
[Journal]
25)  Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A.
Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase.
J. Cell. Sci. 124: 91-9, 2011.
[Journal]
26)  Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, Casellas R, Nussenzweig MC.
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Cell. 147: 95-106, 2011.
[Journal]
27)  Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A.
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Cell. 141: 243-54, 2010.
[Journal]
28)  Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC.
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.
J. Exp. Med. 207: 855-65, 2010.
[Journal]
29)  Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
J. Exp. Med. 207: 417-27, 2010.
[Journal]
30)  Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW.
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Proc. Natl. Acad. Sci. U.S.A. 107: 3034-9, 2010.
[Journal]
31)  Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.
J. Exp. Med. 207: 973-81, 2010.
[Journal]
32)  Bunting SF, Nussenzweig A.
Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair.
Mol. Cell. 39: 164-6, 2010.
[Journal]
33)  Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J.
Impact papers on aging in 2009.
Aging (Albany NY). 2: 111-21, 2010.
[Journal]
34)  Nussenzweig A, Nussenzweig MC.
Origin of chromosomal translocations in lymphoid cancer.
Cell. 141: 27-38, 2010.
[Journal]
35)  Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A.
PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination.
Science. 329: 917-23, 2010.
[Journal]
36)  Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC.
Role of the translocation partner in protection against AID-dependent chromosomal translocations.
Proc. Natl. Acad. Sci. U.S.A. 107: 187-92, 2010.
[Journal]
37)  Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O.
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.
Nat. Genet. 41: 891-8, 2009.
[Journal]
38)  Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T.
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.
Mol. Cell. 35: 534-41, 2009.
[Journal]
39)  Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, Bustin M.
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.
Nat. Cell Biol. 11: 92-6, 2009.
[Journal]
40)  Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC.
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.
Mol. Cell. 36: 631-41, 2009.
[Journal]
41)  Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A.
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.
Cell Cycle. 8: 2408-12, 2009.
[Journal]
42)  Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M.
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.
Mol. Cell. 34: 285-97, 2009.
[Journal]
43)  Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.
Histone H2AX is integral to hypoxia-driven neovascularization.
Nat. Med. 15: 553-8, 2009.
[Journal]
44)  Dmitrieva NI, Chen HT, Nussenzweig A, Burg MB.
Knockout of Ku86 accelerates cellular senescence induced by high NaCl.
Aging (Albany NY). 1: 245-53, 2009.
[Journal]
45)  Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.
Mechanisms promoting translocations in editing and switching peripheral B cells.
Nature. 460: 231-6, 2009.
[Journal]
46)  Kruhlak MJ, Celeste A, Nussenzweig A.
Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy.
Methods Mol. Biol. 523: 125-40, 2009.
[Journal]
47)  Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD.
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome.
PLoS Genet. 5: e1000650, 2009.
[Journal]
48)  Takizawa M, Tolarova H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R.
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.
J. Exp. Med. 2008.
In Press. [Journal]
49)  Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
Nature. 456: 529-33, 2008.
[Journal]
50)  Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T.
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Genes Dev. 22: 2048-61, 2008.
[Journal]
51)  Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC.
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.
Cell. 135: 1028-38, 2008.
[Journal]
52)  Fernandez-Capetillo O, Nussenzweig A.
ATM breaks into heterochromatin.
Mol. Cell. 31: 303-4, 2008.
[Journal]
53)  Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A.
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
J. Cell Biol. 183: 777-83, 2008.
[Journal]
54)  Nussenzweig A, Nussenzweig MC.
A backup DNA repair pathway moves to the forefront.
Cell. 131: 223-5, 2007.
[Journal]
55)  Jankovic M, Nussenzweig A, Nussenzweig MC.
Antigen receptor diversification and chromosome translocations.
Nat. Immunol. 8: 801-8, 2007.
[Journal]
56)  Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.
Cell. 130: 63-75, 2007.
[Journal]
57)  Callen E, Nussenzweig MC, Nussenzweig A.
Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly.
Oncogene. 26: 7759-64, 2007.
[Journal]
58)  Nussenzweig A.
Causes and consequences of the DNA damage response.
Cell Cycle. 6: 2339-40, 2007.
[Journal]
59)  Downs JA, Nussenzweig MC, Nussenzweig A.
Chromatin dynamics and the preservation of genetic information.
Nature. 447: 951-8, 2007.
[Journal]
60)  Curry JD, Schulz D, Guidos CJ, Danska JS, Nutter L, Nussenzweig A, Schlissel MS.
Chromosomal reinsertion of broken RSS ends during T cell development.
J Exp Med. 2007.
[Journal]
61)  Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL.
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.
Nature. 447: 725-9, 2007.
[Journal]
62)  Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A.
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis.
J. Exp. Med. 204: 1003-11, 2007.
[Journal]
63)  Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC.
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells.
Eur. J. Immunol. 37: 235-9, 2007.
[Journal]
64)  Kim JA, Kruhlak M, Dotiwala F, Nussenzweig A, Haber JE.
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals.
J. Cell Biol. 178: 209-18, 2007.
[Journal]
65)  Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T.
Positional stability of single double-strand breaks in mammalian cells.
Nat. Cell Biol. 9: 675-82, 2007.
[Journal]
66)  Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK.
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
J. Cell Biol. 176: 581-92, 2007.
[Journal]
67)  Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R.
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Nature. 447: 730-4, 2007.
[Journal]
68)  Difilippantonio S, Nussenzweig A.
The NBS1-ATM connection revisited.
Cell Cycle. 6: 2366-70, 2007.
[Journal]
69)  Ramiro A, San-Martin BR, McBride K, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC.
The role of activation-induced deaminase in antibody diversification and chromosome translocations.
Adv. Immunol. 94: 75-107, 2007.
[Journal]
70)  Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A.
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.
Nature. 443: 222-5, 2006.
[Journal]
71)  Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, Bazett-Jones DP, Nussenzweig A.
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.
J. Cell Biol. 172: 823-34, 2006.
[Journal]
72)  Nussenzweig A, Paull T.
DNA repair: tails of histones lost.
Nature. 439: 406-7, 2006.
[Journal]
73)  Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J.
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
Mol. Cell. 21: 187-200, 2006.
[Journal]
74)  Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC.
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Nature. 440: 105-9, 2006.
[Journal]
75)  Kruhlak MJ, Celeste A, Nussenzweig A.
Spatio-Temporal Dynamics of Chromatin Containing DNA Breaks.
Cell Cycle. 5, 2006.
[Journal]
76)  Ramiro AR, Nussenzweig MC, Nussenzweig A.
Switching on chromosomal translocations.
Cancer Res. 66: 7837-9, 2006.
[Journal]
77)  Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J.
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.
Mol. Cell. Biol. 25: 10079-86, 2005.
[Journal]
78)  Lan L, Nakajima S, Komatsu K, Nussenzweig A, Shimamoto A, Oshima J, Yasui A.
Accumulation of Werner protein at DNA double-strand breaks in human cells.
J Cell Sci. 2005.
[Journal]
79)  Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S.
Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.
Proc Natl Acad Sci U S A. 102: 1590-5, 2005.
[Journal]
80)  Dmitrieva NI, Celeste A, Nussenzweig A, Burg MB.
Ku86 preserves chromatin integrity in cells adapted to high NaCl.
Proc Natl Acad Sci U S A. 102: 10730-5, 2005.
[Journal]
81)  Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.
Nat Cell Biol. 7: 675-85, 2005.
[Journal]
82)  Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS.
Silencing of unsynapsed meiotic chromosomes in the mouse.
Nat Genet. 37: 41-7, 2005.
[Journal]
83)  Lee AC, Fernandez-Capetillo O, Pisupati V, Jackson SP, Nussenzweig A.
Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage.
Cell Cycle. 4: 177-82, 2005.
[Journal]
84)  Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J.
53BP1 is required for class switch recombination.
J Cell Biol. 165: 459-64, 2004.
[Journal]
85)  Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L.
Ablation of TrkA function in the immune system causes B cell abnormalities.
Development. 131: 5185-95, 2004.
[Journal]
86)  Fernandez-Capetillo O, Nussenzweig A.
Aging counts on chromosomes.
Nat Genet. 36: 672-4, 2004.
[Journal]
87)  Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC.
AID is required for c-myc/IgH chromosome translocations in vivo.
Cell. 118: 431-8, 2004.
[Journal]
88)  Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC.
AID is required for c-myc/IgH chromosome translocations in vivo.
Cell. 118: 431-8, 2004.
[Journal]
89)  Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC.
ATM is required for efficient recombination between immunoglobulin switch regions.
J. Exp. Med. 200: 1103-10, 2004.
[Journal]
90)  Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M.
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.
Genes Dev. 18: 1293-304, 2004.
[Journal]
91)  Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
J Cell Biol. 166: 801-13, 2004.
[Journal]
92)  Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC.
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
J Cell Biol. 166: 801-13, 2004.
[Journal]
93)  Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A.
H2AX: the histone guardian of the genome.
DNA Repair (Amst). 3: 959-67, 2004.
[Journal]
94)  Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A.
H2AX: the histone guardian of the genome.
DNA Repair (Amst). 3: 959-67, 2004.
[Journal]
95)  Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM.
Histone H2AX is phosphorylated at sites of retroviral DNA integration, but is dispensable for post-integration repair.
J Biol Chem. 2004.
[Journal]
96)  Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM.
Histone H2AX is phosphorylated at sites of retroviral DNA integration, but is dispensable for post-integration repair.
J Biol Chem. 2004.
[Journal]
97)  Fernandez-Capetillo O, Nussenzweig A.
Linking histone deacetylation with the repair of DNA breaks.
Proc Natl Acad Sci U S A. 101: 1427-8, 2004.
[Journal]
98)  Fernandez-Capetillo O, Allis CD, Nussenzweig A.
Phosphorylation of histone H2B at DNA double-strand breaks.
J Exp Med. 199: 1671-7, 2004.
[Journal]
99)  Fernandez-Capetillo O, Celeste A, Nussenzweig A.
Focusing on foci: H2AX and the recruitment of DNA-damage response factors.
Cell Cycle. 2: 426-7, 2003.
[Journal]
100)  Fernandez-Capetillo O, Celeste A, Nussenzweig A.
Focusing on Foci: H2AX and the Recruitment of DNA-Damage Response Factors.
Cell Cycle. 2: 426-7, 2003.
[Journal]
101)  Fernandez-Capetillo O, Celeste A, Nussenzweig A.
Focusing on Foci: H2AX and the Recruitment of DNA-Damage Response Factors.
Cell Cycle. 2: 426-7, 2003.
[Journal]
102)  Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Cell. 114: 371-83, 2003.
[Journal]
103)  Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Cell. 114: 371-83, 2003.
[Journal]
104)  Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Cell. 114: 1-40, 2003.
[Journal]
105)  Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Cell. 114: 371-83, 2003.
[Journal]
106)  Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A.
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.
Dev Cell. 4: 497-508, 2003.
[Journal]
107)  Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC.
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.
J Exp Med. 197: 1767-78, 2003.
[Journal]
108)  Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC.
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.
J Exp Med. 197: 1767-78, 2003.
[Journal]
109)  Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC.
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.
J Exp Med. 197: 1767-78, 2003.
[Journal]
110)  Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, Honjo T.
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatin hypermutation.
J. Exp Med. 197: 1767-78, 2003.
[Journal]
111)  Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A.
H2AX regulates meiotic telomere clustering.
J Cell Biol. 163: 15-20, 2003.
[Journal]
112)  Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A.
H2AX regulates meiotic telomere clustering.
J Cell Biol. 163: 15-20, 2003.
[Journal]
113)  Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A.
H2AX regulates meiotic telomere clustering.
J Cell Biol. 163: 15-20, 2003.
[Journal]
114)  Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A.
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Nat Cell Biol. 2003.
[Journal]
115)  Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes.
J Biol Chem. 278: 20303-12, 2003.
[Journal]
116)  Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A.
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Nat Cell Biol. 4: 993-7, 2002.
[Journal]
117)  Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A.
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.
J Exp Med. 196: 469-80, 2002.
[Journal]
118)  Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A.
Genomic instability in mice lacking histone H2AX.
Science. 296: 922-7, 2002.
[Journal]
119)  Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature. 414: 660-5, 2001.
[Journal]
120)  Zhu J, Petersen S, Tessarollo L, Nussenzweig A.
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.
Curr Biol. 11: 105-9, 2001.
[Journal]
121)  Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A.
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
Nature. 404: 510-4, 2000.
[Journal]
122)  Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A.
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks.
J Exp Med. 192: 891-7, 2000.
[Journal]
123)  Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A.
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Science. 290: 1962-5, 2000.
[Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 5/14/2014.