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Our Science – Hodes Website

Richard J. Hodes, M.D.

Selected Publications

1)  Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ.
Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4(+) T Cell Responses.
Immunity. 40: 681-91, 2014.
2)  Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.
Proc. Natl. Acad. Sci. U.S.A. 110: 21107-12, 2013.
3)  Hathcock KS, Laszlo G, Dickler HB, Bradshaw J, Linsley P, Hodes RJ.
Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.
Science. 262: 905-7, 1993.
4)  Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ.
Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.
J. Exp. Med. 180: 631-40, 1994.
5)  Weng NP, Levine BL, June CH, Hodes RJ.
Human naive and memory T lymphocytes differ in telomeric length and replicative potential.
Proc. Natl. Acad. Sci. U.S.A. 92: 11091-4, 1995.
6)  Bowen S, Sun P, Livak F, Sharrow S, Hodes RJ.
A novel T cell subset with trans-rearranged V?-Cß TCRs shows Vß expression is dispensable for lineage choice and MHC restriction.
J. Immunol. 192: 169-77, 2014.
7)  Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ.
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.
J. Immunol. 192: 630-40, 2014.
8)  Hathcock KS, Bowen S, Livak F, Hodes RJ.
ATM influences the efficiency of TCRß rearrangement, subsequent TCRß-dependent T cell development, and generation of the pre-selection TCRß CDR3 repertoire.
PLoS ONE. 8: e62188, 2013.
9)  Bowen S, Wangsa D, Ried T, Livak F, Hodes RJ.
Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes.
Nucleic Acids Res. 41: 4535-48, 2013.
10)  Lucas CR, Cordero-Nieves HM, Erbe RS, McAlees JW, Bhatia S, Hodes RJ, Campbell KS, Sanders VM.
Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.
J. Immunol. 190: 723-36, 2013.
11)  Hodes RJ, Insel TR, Landis SC.
The NIH Toolbox: Setting a standard for biomedical research.
Neurology. 80: S1, 2013.
12)  Akbar AN, Hodes RJ.
Editorial overview.
Curr. Opin. Immunol. 24: 467-9, 2012.
13)  Chiang YJ, Difilippantonio MJ, Tessarollo L, Morse HC, Hodes RJ.
Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.
PLoS ONE. 7: e49305, 2012.
14)  Nagy CL, Bernard MA, Hodes RJ.
National Institute on Aging at middle age--its past, present, and future.
J Am Geriatr Soc. 60: 1165-9, 2012.
15)  Chiang J, Hodes RJ.
Cbl enforces Vav1 dependence and a restricted pathway of T cell development.
PLoS ONE. 6: e18542, 2011.
16)  Hathcock KS, Farrington L, Ivanova I, Livak F, Selimyan R, Sen R, Williams J, Tai X, Hodes RJ.
The Requirement for Pre-TCR during Thymic Differentiation Enforces a Developmental Pause That Is Essential for V-DJβ Rearrangement.
PLoS ONE. 6: e20639, 2011.
17)  Lu J, Chiang J, Iyer RR, Thompson E, Kaneski CR, Xu DS, Yang C, Chen M, Hodes RJ, Lonser RR, Brady RO, Zhuang Z.
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.
Proc. Natl. Acad. Sci. U.S.A. 107: 21665-70, 2010.
18)  Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ.
Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.
J. Immunol. 184: 1821-8, 2010.
19)  Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG.
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.
J. Biol. Chem. 285: 11023-30, 2010.
20)  Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS, Hodes RJ.
Telomere length is inherited with resetting of the telomere set-point.
Proc Natl Acad Sci U S A. 107: 10148-53, 2010.
21)  Dicarlo AL, Fuldner R, Kaminski J, Hodes R.
Aging in the context of immunological architecture, function and disease outcomes.
Trends Immunol. 30: 293-4, 2009.
22)  Chiang YJ, Jordan MS, Horai R, Schwartzberg PL, Koretzky GA, Hodes RJ.
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.
J. Biol. Chem. 284: 4429-38, 2009.
23)  Lu J, Kovach JS, Johnson F, Chiang J, Hodes R, Lonser R, Zhuang Z.
Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.
Proc. Natl. Acad. Sci. U.S.A. 106: 11697-702, 2009.
24)  Sierra F, Hadley E, Suzman R, Hodes R.
Prospects for life span extension.
Annu. Rev. Med. 60: 457-69, 2009.
25)  Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM.
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.
Epigenetics & chromatin. 1: 6, 2008.
26)  Williams JA, Lumsden JM, Yu X, Feigenbaum L, Zhang J, Steinberg SM, Hodes RJ.
Regulation of thymic NKT cell development by the B7-CD28 costimulatory pathway.
J. Immunol. 181: 907-17, 2008.
27)  Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ.
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
PLoS ONE. 3: e2639, 2008.
28)  Chiang JY, Jang IK, Hodes R, Gu H.
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.
J. Clin. Invest. 117: 1029-36, 2007.
29)  Vacchio MS, Olaru A, Livak F, Hodes RJ.
ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor {alpha} locus coding end breaks.
Proc Natl Acad Sci U S A. 104: 6323-8, 2007.
30)  Shen X, Zhou J, Hathcock KS, Robbins P, Powell DJ, Rosenberg SA, Hodes RJ.
Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length.
J. Immunother. 30: 123-9, 2007.
31)  Song H, Zhang J, Chiang YJ, Siraganian RP, Hodes RJ.
Redundancy in B Cell Developmental Pathways: c-Cbl Inactivation Rescues Early B Cell Development through a B Cell Linker Protein-Independent Pathway.
J. Immunol. 178: 926-35, 2007.
32)  Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ.
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
Mol Cell Biol. 26: 2037-43, 2006.
33)  Vacchio MS, Williams JA, Hodes RJ.
A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection.
Eur J Immunol. 35: 418-427, 2005.
34)  Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, Larionov V, Hodes RJ, Barrett JC.
Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.
Proc Natl Acad Sci U S A. 102: 18437-42, 2005.
35)  Vacchio MS, Hodes RJ.
Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy.
J Immunol. 174: 4657-61, 2005.
36)  Hathcock KS, Jeffrey Chiang Y, Hodes RJ.
In vivo regulation of telomerase activity and telomere length.
Immunol Rev. 205: 104-13, 2005.
37)  Williams JA, Hathcock KS, Klug D, Harada Y, Choudhury B, Allison JP, Abe R, Hodes RJ.
Regulated Costimulation in the Thymus Is Critical for T Cell Development: Dysregulated CD28 Costimulation Can Bypass the Pre-TCR Checkpoint.
J Immunol. 175: 4199-207, 2005.
38)  Fritsch RD, Shen X, Sims GP, Hathcock KS, Hodes RJ, Lipsky PE.
Stepwise Differentiation of CD4 Memory T Cells Defined by Expression of CCR7 and CD27.
J Immunol. 175: 6489-97, 2005.
39)  Zhou J, Shen X, Huang J, Hodes RJ, Rosenberg SA, Robbins PF.
Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.
J Immunol. 175: 7046-52, 2005.
40)  Hadley EC, Lakatta EG, Morrison-Bogorad M, Warner HR, Hodes RJ.
The future of aging therapies.
Cell. 120: 557-67, 2005.
41)  Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, Hahn WC, Hodes RJ.
Expression of telomerase RNA template (mTR), but not telomerase reverse transcriptase (mTERT), is limiting for telomere length maintenance in vivo.
Mol Cell Biol. 24: 7024-31, 2004.
42)  Lumsden JM, McCarty T, Petiniot LK, Shen R, Barlow C, Wynn TA, Morse HC, Gearhart PJ, Wynshaw-Boris A, Max EE, Hodes RJ.
Immunoglobulin class switch recombination is impaired in Atm-deficient mice.
J. Exp. Med. 200: 1111-1121, 2004.
43)  Zhang J, Chiang YJ, Hodes RJ, Siraganian RP.
Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.
J Immunol. 173: 1811-8, 2004.
44)  Chiang YJ, Sommers CL, Jordan MS, Gu H, Samelson LE, Koretzky GA, Hodes RJ.
Inactivation of c-Cbl Reverses Neonatal Lethality and T Cell Developmental Arrest of SLP-76-deficient Mice.
J Exp Med. 200: 25-34, 2004.
45)  Chiang YJ, Kim SH, Tessarollo L, Campisi J, Hodes RJ.
Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.
Mol Cell Biol. 24: 6631-4, 2004.
46)  Vacchio MS, Hodes RJ.
CD28 costimulation is required for in vivo induction of peripheral tolerance in CD8 T cells.
J Exp Med. 197: 19-26, 2003.
47)  Lumsden JM, Williams JA, Hodes RJ.
Differential requirements for expression of CD80/86 and CD40 on B cells for T-dependent antibody responses in vivo.
J Immunol. 170: 781-7, 2003.
48)  Hathcock KS, Kaech SM, Ahmed R, Hodes RJ.
Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells.
J Immunol. 170: 147-52, 2003.
49)  Williams JA, Sharrow SO, Adams AJ, Hodes RJ.
CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
J Immunol. 168: 2759-2765, 2002.
50)  Hathcock KS, Hemann MT, Opperman KK, Strong MA, Greider CW, Hodes RJ.
Haploinsufficiency of mTR results in defects in telomere elongation.
Proc Natl Acad Sci U S A. 99: 3591-3596, 2002.
51)  Petiniot LK, Weaver Z, Vacchio M, Shen R, Wangsa D, Barlow C, Eckhaus M, Steinberg SM, Wynshaw-Boris A, Ried T, Hodes RJ.
RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.
Mol Cell Biol. 22: 3174-3177, 2002.
52)  Hodes RJ, Hathcock KS, Weng NP.
Telomeres in T and B cells.
Nat Rev Immunol. 2: 699-706, 2002.
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This page was last updated on 6/19/2014.