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Our Science – Singer Website

Alfred Singer, M.D.

Selected Publications

1)  Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.
Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.
Cell. 154: 1326-1341, 2013.
[Journal]
2)  Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A.
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.
Immunity. 38: 1116-28, 2013.
[Journal]
3)  Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.
IL-7 signaling must be intermittent, not continuous, during CD8? T cell homeostasis to promote cell survival instead of cell death.
Nat. Immunol. 14: 143-51, 2013.
[Journal]
4)  McCaughtry TM, Etzensperger R, Alag A, Tai X, Kurtulus S, Park JH, Grinberg A, Love P, Feigenbaum L, Erman B, Singer A.
Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.
J. Exp. Med. 209: 2263-76, 2012.
[Journal]
5)  Van Laethem F, Tikhonova AN, Singer A.
MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection.
Trends Immunol. 33: 437-41, 2012.
[Journal]
6)  Pobezinsky LA, Angelov GS, Tai X, Jeurling S, Van Laethem F, Feigenbaum L, Park JH, Singer A.
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.
Nat. Immunol. 13: 569-78, 2012.
[Journal]
7)  Gegonne A, Tai X, Zhang J, Wu G, Zhu J, Yoshimoto A, Hanson J, Cultraro C, Chen QR, Guinter T, Yang Z, Hathcock K, Singer A, Rodriguez-Canales J, Tessarollo L, Mackem S, Meerzaman D, Buetow K, Singer DS.
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Mol. Cell. Biol. 32: 1984-97, 2012.
[Journal]
8)  Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood. 119: 5155-63, 2012.
[Journal]
9)  Adoro S, Park J, Singer A.
Coreceptor gene.
Cell Cycle. 11: 833-4, 2012.
[Journal]
10)  Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park J, Yang JC, Sun PD, Singer A.
alpha-beta T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.
Immunity. 36: 79-91, 2012.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 9/13/2013.