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Our Science – Wolff Website

Linda Wolff, Ph.D.

Selected Publications

1)  Humeniuk R, Rosu-Myles M, Fares J, Koller R, Bies J, Wolff L.
The role of tumor suppressor p15Ink4b in the regulation of hematopoietic progenitor cell fate.
Blood Cancer J. 2: e99, 2013.
2)  Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H.
CIZ1, a p21(Cip1/Waf1)-interacting protein, functions as a tumor suppressor in vivo.
FEBS Lett. [Epub ahead of print], 2013.
3)  Wolff L, Humeniuk R.
Erythroid versus Myeloid Lineage Commitment: Regulating the Master Regulators.
Stem Cells. [Epub ahead of print], 2013.
4)  Wolff L, Bies J.
p15Ink4b Functions in determining hematopoietic cell fates: implications for its role as a tumor suppressor.
Blood Cells Mol. Dis. 50: 227-31, 2013.
5)  Humeniuk R, Rosu-Myles M, Fares J, Koller R, Bies J, Wolff L.
The role of tumor suppressor p15Ink4b in the regulation of hematopoietic progenitor cell fate.
Blood Cancer J. 3: e99, 2013.
6)  Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, Lowe SW, O'Sullivan MG, Kogan SC, Adams DJ, Largaespada DA.
An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.
Blood. 119: 4512-23, 2012.
7)  Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, Montini E, Bushman F, Sorrentino BP, Carrondo M, Malech H, Gahrton G, Shapiro R, Wolff L, Rosenthal E, Jambou R, Zaia J, Kohn DB.
Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.
Mol. Ther. 20: 1084-94, 2012.
8)  Baron BW, Anastasi J, Hyjek EM, Bies J, Reddy PL, Dong J, Joseph L, Thirman MJ, Wroblewski K, Wolff L, Baron JM.
PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas.
Proc. Natl. Acad. Sci. U.S.A. 109: 5735-9, 2012.
9)  Sandoval S, Kraus C, Cho EC, Cho M, Bies J, Manara E, Accordi B, Landaw EM, Wolff L, Pigazzi M, Sakamoto KM.
Sox4 cooperates with CREB in myeloid transformation.
Blood. 120: 155-65, 2012.
10)  Fares J, Koller R, Humeniuk R, Wolff L, Bies J.
The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.
Blood. 119: 5005-15, 2012.
11)  Zhang J, Markus J, Bies J, Paul T, Wolff L.
Three murine leukemia virus integration regions within 100kb upstream of c-myb are proximal to the 5' regulatory region of the gene through DNA looping.
J. Virol. 86: 10524-32, 2012.
12)  Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K.
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.
Blood. 117: 2022-32, 2011.
13)  Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S, Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP.
Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1.
Cancer Cell. 17: 455-68, 2010.
14)  Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda ZI, Wolff L, Inaba T, Honda H.
Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.
Oncogene. 29: 1963-75, 2010.
15)  Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K.
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
Proc. Natl. Acad. Sci. U.S.A. 107: 5106-11, 2010.
16)  Bies J, Sramko M, Fares J, Rosu-Myles M, Zhang S, Koller R, Wolff L.
Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia.
Blood. 116: 979-87, 2010.
17)  Paul TA, Bies J, Small D, Wolff L.
Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML.
Blood. 115: 3098-108, 2010.
18)  Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K.
Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.
Blood. 115: 4524-32, 2010.
19)  Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K.
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Nature. 461: 411-4, 2009.
20)  Wolff L, Ackerman SJ, Nucifora G.
Meeting report: Seventh International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, MD, May 13-16, 2007.
Exp. Hematol. 36: 523-32, 2008.
21)  Slape C, Lin YW, Hartung H, Zhang Z, Wolff L, Aplan PD.
NUP98-HOX translocations lead to myelodysplastic syndrome in mice and men.
J. Natl. Cancer Inst. Monographs. 64-8, 2008.
22)  Mizuno T, Yamasaki N, Miyazaki K, Tazaki T, Koller R, Oda H, Honda ZI, Ochi M, Wolff L, Honda H.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Oncogene. 27: 3465-74, 2008.
23)  Rosu-Myles M, Wolff L.
p15Ink4b: Dual function in myelopoiesis and inactivation in myeloid disease.
Blood Cells Mol. Dis. 40: 406-9, 2008.
24)  Ko RM, Kim HG, Wolff L, Klug CA.
Roles of p15(Ink4b) and p16(Ink4a) in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia.
Leuk. Res. 32: 1101-11, 2008.
25)  Rosu-Myles M, Taylor BJ, Wolff L.
Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors.
Exp. Hematol. 35: 394-406, 2007.
26)  Markus J, Garin MT, Bies J, Galili N, Raza A, Thirman MJ, Le Beau MM, Rowley JD, Liu PP, Wolff L.
Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).
Cancer Res. 67: 992-1000, 2007.
27)  Slape C, Hartung H, Lin YW, Bies J, Wolff L, Aplan PD.
Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation.
Cancer Res. 67: 5148-55, 2007.
28)  Wolff L.
Retroviral insertional mutagenesis and its application to genetically engineered mice. In: Progress in Virus Research.
New York: Nova Science Publishers, Inc.; 2006. p. 267-300 [Book Chapter]
29)  Sramko M, Markus J, Kabat J, Wolff L, Bies J.
Stress-induced inactivation of the c-Myb transcription factor through conjugation of SUMO-2/3 proteins.
J. Biol. Chem. 281: 40065-75, 2006.
30)  Hu X, Bies J, Wolff L.
Interferon beta increases c-Myc proteolysis in mouse monocyte/macrophage leukemia cells.
Leuk Res. 29: 1307-1314, 2005.
31)  Wolff L, Ackerman SJ, Nucifora G.
Meeting report: Sixth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, May 1-4, 2005.
Exp Hematol. 33: 1436-42, 2005.
32)  Wolff L, Garin MT, Koller R, Bies J, Tessarollo L, Anver MR, Powell D, Perella C.
A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15(Ink4b) in myeloid cells in vivo.
Blood Cells Mol Dis. 32: 226-31, 2004.
33)  Ramirez JM, Houzet L, Koller R, Bies J, Wolff L, Mougel M.
Activation of c-myb by 5' retrovirus promoter insertion in myeloid neoplasms is dependent upon an intact alternative splice donor site (SD') in gag.
Virology. 330: 398-407, 2004.
34)  Castilla LH, Perrat P, Martinez NJ, Landrette SF, Keys R, Oikemus S, Flanegan J, Heilman S, Garrett L, Dutra A, Anderson S, Pihan GA, Wolff L, Liu PP.
Identification of genes that synergize with.
Proc. Natl. Acad.Sci. U.S.A. 101: 4924-4929, 2004.
35)  Schmidt M, Bies J, Tamura T, Ozato K, Wolff L.
The interferon regulatory factor ICSBP/IRF8 in combination with PU.1 up-regulates p15Ink4b tumor suppressor expression in murine myeloid cells.
Blood. 103: 4142-4149, 2004.
36)  Wolff L, Koller R, Hu X, Anver MR.
A Moloney Murine Leukemia Virus-Based Retrovirus with 4070A Long Terminal Repeat Sequences Induces a High Incidence of Myeloid as Well as Lymphoid Neoplasms.
J Virol. 77: 4965-71, 2003.
37)  Markus J, Feiková S, Sramko M, Wolff L, Bies J.
Cloning and characterization of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains.
Gene. 319: 117-126, 2003.
38)  Haviernik P, Schmidt M, Hu X, Wolff L.
Consistent inactivation of p19(Arf) but not p15(Ink4b) in murine myeloid cells transformed in vivo by deregulated c-Myc.
Oncogene. 22: 1600-10, 2003.
39)  Wolff L, Garin MT, Koller R, Malumbres M, Liao W, Bies J, Tessarollo L, Powell D, Perella C.
Hypermethylation of the Ink4b locus in murine myeloid leukemias and increased susceptibility to leukemia in p15Ink4b-deficient mice.
Oncogene. 22: 9265-9273, 2003.
40)  Hanlon L, Barr NI, Blyth K, Stewart M, Haviernik P, Wolff L, Weston K, Cameron ER, Neil JC.
Long-range effects of retroviral insertion on c-myb: overexpression may be obscured by silencing during tumor growth in vitro.
J Virol. 77: 1059-68, 2003.
41)  Bies J, Markus J, Wolff L.
Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity.
J Biol Chem. 277: 8999-9009, 2002.
42)  Haviernik P, Festin SM, Opavsky R, Koller RP, Barr NI, Neil JC, Wolff L.
Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia.
J Gen Virol. 83: 819-827, 2002.
43)  Schmidt M, Koller R, Haviernik P, Bies J, Maciag K, Wolff L.
Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation.
Oncogene. 20: 6205-6214, 2001.
44)  Opavsky R, Haviernik P, Jurkovicova D, Garin MT, Copeland NG, Gilbert DJ, Jenkins NA, Bies J, Garfield S, Pastorekova S, Oue A, Wolff L.
Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.
J Biol Chem. 276: 38795-807, 2001.
45)  Bies J, Feiková S, Markus J, Wolff L.
Phosphorylation-dependent conformation and proteolytic stability of c-Myb.
Blood Cells Mol Dis. 27: 422-8, 2001.
46)  Wolff L, Schmidt M, Koller R, Haviernik P, Watson R, Bies J, Maciag K.
Three genes with different functions in transformation are regulated by c-Myb in myeloid cells.
Blood Cells Mol Dis. 27: 483-8, 2001.
47)  Bies J, Feiková S, Bottaro DP, Wolff L.
Hyperphosphorylation and increased proteolytic breakdown of c-Myb induced by the inhibition of Ser/Thr protein phosphatases.
Oncogene. 19: 2846-2854, 2000.
48)  Schmidt M, Nazarov V, Stevens L, Watson R, Wolff L.
Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis.
Mol Cell Biol. 20: 1970-1981, 2000.
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This page was last updated on 6/6/2013.