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Our Science – Rubin Website

Jeffrey S. Rubin, M.D., Ph.D.

Selected Publications

1)  Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin JS.
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/ß-catenin signaling.
Cell. Signal. 26: 94-101, 2014.
2)  Greer YE, Fields AP, Brown AM, Rubin JS.
Atypical Protein Kinase C Iota is Required for Wnt3a-Dependent Neurite Outgrowth and Binds to Phosphorylated Dishevelled2.
J. Biol. Chem. 288: 9438-46, 2013.
3)  Gonzalez-Sancho JM, Greer YE, Abrahams CL, Takigawa Y, Baljinnyam B, Lee KH, Lee KS, Rubin JS, Brown AM.
Functional Consequences of Wnt-Induced Dishevelled2 Phosphorylation in Canonical and Non-Canonical Wnt Signaling.
J. Biol. Chem. 288: 9428-37, 2013.
4)  Baljinnyam B, Klauzinska M, Saffo S, Callahan R, Rubin JS.
Recombinant R-spondin2 and Wnt3a Up- and Down-Regulate Novel Target Genes in C57MG Mouse Mammary Epithelial Cells.
PLoS ONE. 7: e29455, 2012.
5)  Greer YE, Rubin JS.
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.
J. Cell Biol. 192: 993-1004, 2011.
6)  Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS.
Casein Kinase 1 Delta Functions at the Centrosome and Golgi to Promote Ciliogenesis.
Mol. Biol. Cell. 25: 1629-40, 2014.
7)  Gao W, Kim H, Feng M, Phung Y, Xavier CP, Rubin JS, Ho M.
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy.
Hepatology. [Epub ahead of print], 2014.
8)  Nagaoka T, Karasawa H, Turbyville T, Rangel M, Castro NP, Gonzales M, Baker A, Seno M, Lockett S, Greer YE, Rubin JS, Salomon DS, Bianco C.
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.
Cell. Signal. 25: 178-89, 2012.
9)  Mao W, Millar JC, Wang WH, Silverman SM, Liu Y, Wordinger RJ, Rubin JS, Pang IH, Clark AF.
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork.
Invest. Ophthalmol. Vis. Sci. 53: 7043-51, 2012.
10)  Klauzinska M, Baljinnyam B, Raafat A, Rodriguez-Canales J, Strizzi L, Greer YE, Rubin JS, Callahan R.
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.
J Cell Physiol. 227: 1960-1971, 2012.
11)  Kele J, Andersson ER, Villaescusa JC, Cajanek L, Parish CL, Bonilla S, Toledo EM, Bryja V, Rubin JS, Shimono A, Arenas E.
SFRP1 and 2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In vivo and in Embryonic Stem Cells.
Stem Cells. 30: 865-875, 2012.
12)  Mao W, Rubin JS, Anoruo N, Wordinger RJ, Clark AF.
SFRP1 promoter methylation and expression in human trabecular meshwork cells.
Exp Eye Res. 97: 130-136, 2012.
13)  Aprelikova O, Palla J, Hibler B, Yu X, Greer YE, Yi M, Stephens R, Maxwell GL, Jazaeri A, Risinger JI, Rubin JS, Niederhuber J.
Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility.
Oncogene. [Epub ahead of print], 2012.
14)  Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA.
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.
Cell. 145: 926-40, 2011.
15)  Martin-Manso G, Calzada MJ, Chuman Y, Sipes JM, Xavier CP, Wolf V, Kuznetsova SA, Rubin JS, Roberts DD.
sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration.
Arch. Biochem. Biophys. 509: 147-56, 2011.
16)  Greer YE, Rubin JS.
The role of centrosomal casein kinase 1 delta in neurite outgrowth and beyond.
Cell Cycle. 10: 2605-6, 2011.
17)  Jones MB, Chu CH, Pendleton JC, Betenbaugh MJ, Shiloach J, Baljinnyam B, Rubin JS, Shamblott MJ.
Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen.
Stem Cells Dev. 19: 1923-1935, 2010.
18)  Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A.
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
J. Biol. Chem. 284: 9074-82, 2009.
19)  Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
Cell. Signal. 21: 916-25, 2009.
20)  Kwon HS, Lee HS, Ji Y, Rubin JS, Tomarev SI.
Myocilin is a modulator of Wnt signaling.
Mol. Cell. Biol. 29: 2139-54, 2009.
21)  Linehan WM, Rubin JS, Bottaro DP.
VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma.
Int. J. Biochem. Cell Biol. 41: 753-6, 2009.
22)  Wang WH, McNatt LG, Pang IH, Millar JC, Hellberg PE, Hellberg MH, Steely HT, Rubin JS, Fingert JH, Sheffield VC, Stone EM, Clark AF.
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure.
J. Clin. Invest. 118: 1056-64, 2008.
23)  Wolf V, Endo Y, Rubin JS.
Purification and Wnt-inhibitory activities of secreted frizzled-related proteins.
Methods Mol. Biol. 468: 31-44, 2008.
24)  Joesting MS, Cheever TR, Volzing KG, Yamaguchi TP, Wolf V, Naf D, Rubin JS, Marker PC.
Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate.
Dev. Biol. 317: 161-73, 2008.
25)  Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS.
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
Mol. Cell. Biol. 28: 2368-79, 2008.
26)  Rubin JS, Bottaro DP.
Loss of secreted frizzled-related protein-1 expression in renal cell carcinoma reveals a critical tumor suppressor function.
Clin. Cancer Res. 13: 4660-3, 2007.
27)  Endo Y, Rubin JS.
Wnt signaling and neurite outgrowth: Insights and questions.
Cancer Sci. 98: 1311-7, 2007.
28)  Wang H, Charles PC, Wu Y, Ren R, Pi X, Moser M, Barshishat-Kupper M, Rubin JS, Perou C, Bautch V, Patterson C.
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells.
Circ. Res. 98: 1331-9, 2006.
29)  Finch PW, Rubin JS.
Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors.
J. Natl. Cancer Inst. 98: 812-24, 2006.
30)  Fok SY, Rubin JS, Pixley F, Condeelis J, Braet F, Soon LL.
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study.
BMC Cancer. 6: 151, 2006.
31)  Rubin JS, Barshishat-Kupper M, Feroze-Merzoug F, Xi ZF.
Secreted WNT antagonists as tumor suppressors: pro and con.
Front. Biosci. 11: 2093-105, 2006.
32)  Joesting MS, Perrin S, Elenbaas B, Fawell SE, Rubin JS, Franco OE, Hayward SW, Cunha GR, Marker PC.
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer.
Cancer Res. 65: 10423-30, 2005.
33)  Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R.
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.
Hepatology. 41: 857-67, 2005.
34)  Liu X, Rubin JS, Kimmel AR.
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins.
Curr. Biol. 15: 1989-97, 2005.
35)  Endo Y, Wolf V, Muraiso K, Kamijo K, Soon L, Uren A, Barshishat-Küpper M, Rubin JS.
Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2.
J Biol Chem. 280: 777-86, 2005.
36)  Qiang YW, Walsh K, Yao L, Kedei N, Blumberg PM, Rubin JS, Shaughnessy J, Rudikoff S.
Wnts induce migration and invasion of myeloma plasma cells.
Blood. 106: 1786-93, 2005.
37)  Chuman Y, Uren A, Cahill J, Regan C, Wolf V, Kay BK, Rubin JS.
Identification of a peptide binding motif for secreted frizzled-related protein-1.
Peptides. 25: 1831-8, 2004.
38)  Finch PW, Rubin JS.
Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair.
Adv Cancer Res. 91: 69-136, 2004.
39)  Häusler KD, Horwood NJ, Chuman Y, Fisher JL, Ellis J, Martin TJ, Rubin JS, Gillespie MT.
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation.
J Bone Miner Res. 19: 1873-81, 2004.
40)  Uren A, Wolf V, Sun YF, Azari A, Rubin JS, Toretsky JA.
Wnt/Frizzled signaling in Ewing's sarcoma.
Pediatr. Blood Cancer. 43: 243-249, 2004.
41)  Qiang YW, Endo Y, Rubin JS, Rudikoff S.
Wnt signaling in B cell neoplasia.
Oncogene. 22: 1536-1545, 2003.
42)  Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW.
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.
Development. 130: 2375-2384, 2003.
43)  Chong JM, Uren A, Rubin JS, Speicher DW.
Disulfide bond assignments of secreted Frizzled related protein-1 provide insights about Frizzled homology and netrin molecules.
J. Biol. Chem. 277: 5134-5144, 2002.
44)  Sen M, Reifert J, Lauterbach K, Wolf V, Rubin JS, Corr M, Carson DA.
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes.
Arthritis Rheum. 46: 2867-2877, 2002.
45)  Chung EJ, Hwang SG, Nguyen P, Lee S, Kim JS, Kim JW, Henkart PA, Bottaro DP, Soon L, Bonvini P, Lee SJ, Karp JE, Oh HJ, Rubin JS, Trepel JB.
Regulation of leukemic cell adhesion, proliferation and survival by beta-catenin.
Blood. 100: 982-990, 2002.
46)  Erickson M, Morkowski S, Lehar S, Gillard G, Beers C, Dooley J, Rubin JS, Rudensky A, Farr AG.
Regulation of thymic epithelium by keratinocyte growth factor.
Blood. 100: 3269-3278, 2002.
47)  Rhee CS, Sen M, Lu D, Wu C, Leoni L, Rubin J, Corr M, Carson DA.
Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas.
Oncogene. 21: 6598-6605, 2002.
48)  Fukumoto S, Hsieh CM, Maemura K, Layne MD, Yet SF, Lee KH, Matsui T, Rosenzweig A, Taylor WG, Rubin JS, Perrella MA, Lee ME.
Akt participation in the Wnt signaling through dishevelled.
J. Biol. Chem. 276: 17479-17483, 2001.
49)  Rubin JS, Day RM, Breckenridge D, Atabey N, Taylor WG, Stahl SJ, Wingfield PT, Kaufman JD, Schwall R, Bottaro DP.
Dissociation of HGF heparin and receptor binding domains reveals that heparin-c Met interaction facilitates signaling.
J. Biol. Chem. 276: 32977-32983, 2001.
50)  Yoshino K, Rubin JS, Higinbotham KG, Uren A, Anest V, Plisov SY, Perantoni AO.
Secreted Frizzled-related proteins can regulate metanephric development.
Mech. Dev. 102: 45-55, 2001.
51)  Plisov SY, Yoshino K, Dove LF, Higinbotham KG, Rubin JS, Perantoni AO.
TGFbeta2, LIF and FGF2 cooperate to induce nephrogenesis.
Development. 128: 1045-1057, 2001.
52)  Sakata H, Rubin JS, Taylor WG, Miki T.
A rho-specific exchange factor Ect-2 is induced from S to M phases in regenerating mouse liver.
Hepatology. 32: 193-199, 2000.
53)  Slayden OD, Rubin JS, Lacey DL, Brenner RM.
Antiapoptotic and arteriotrophic effects of keratinocyte growth factor in the endometrium of rhesus macaques.
J. Clin. Endocrinol. Metab. 85: 275-285, 2000.
54)  Panoskaltsis-Mortari A, Taylor PA, Rubin JS, Uren A, Welniak LA, Murphy WJ, Farrell CL, Lacey DL, Blazar BR.
Keratinocyte growth factor (KGF) facilitates alloengraftment and ameliorates GVHD in mice by a mechanism independent of repair of conditioning-induced tissue injury.
Blood. 96: 4350-4356, 2000.
55)  Uren A, Reichsman F, Anest V, Taylor WG, Muraiso K, Bottaro DP, Cumberledge S, Rubin JS.
Secreted frizzled-related protein-1 binds directly to Wingless and is a binding modulator of Wnt signaling.
J. Biol. Chem. 275: 4374-4382, 2000.
56)  Zhou H, Casas-Finet JR, Heath Coats R, Kaufman JD, Stahl SJ, Wingfield PT, Rubin JS, Bottaro DP, Byrd RA.
Identification and dynamics of a heparin-binding site in hepatocyte growth factor.
Biochemistry. 38: 14793-14802, 1999.
57)  Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS.
Purification and molecular cloning of a secreted Frizzled-related antagonist of Wnt action.
Proc. Natl. Acad. Sci. USA. 94: 6770-6775, 1997.
58)  Rubin JS, Chan AM, Bottaro DP, Burgess WH, Taylor WG, Cech AC, Hirschfield DW, Wong J, Miki T, Finch PW.
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.
Proc. Natl. Acad. Sci. U.S.A. 88: 415-9, 1991.
59)  Miki T, Fleming TP, Bottaro DP, Rubin JS, Ron D, Aaronson SA.
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.
Science. 251: 72-5, 1991.
60)  Chan AM, Rubin JS, Bottaro DP, Hirschfield DW, Chedid M, Aaronson SA.
Identification of a competitive HGF antagonist encoded by an alternative transcript.
Science. 254: 1382-5, 1991.
61)  Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA.
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.
Science. 251: 802-4, 1991.
62)  Bottaro DP, Rubin JS, Ron D, Finch PW, Florio C, Aaronson SA.
Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.
J. Biol. Chem. 265: 12767-70, 1990.
63)  Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA.
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
Science. 245: 752-5, 1989.
64)  Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA.
Purification and characterization of a newly identified growth factor specific for epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 86: 802-6, 1989.
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This page was last updated on 7/30/2014.