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Our Science – Samelson Website

Lawrence E. Samelson, M.D.

Selected Publications

1)  Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE.
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Cell. 92: 83-92, 1998.
[Journal]
2)  Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE.
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.
J. Cell. Biol. 158: 1263-1275, 2002.
[Journal]
3)  Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Nat Struct Mol Biol. 13: 798-805, 2006.
[Journal]
4)  Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.
Proc. Natl. Acad. Sci. U.S.A. 108: 2885-90, 2011.
[Journal]
5)  Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.
Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor.
Immunity. 35: 705-20, 2011.
[Journal]
6)  Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.
A Phospholipase C-gamma1-Independent, RasGRP1-ERK-Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells-Y136F Mutant Mice.
J. Immunol. 190: 147-58, 2013.
[Journal]
7)  Parker J, Sherman E, van de Raa M, van der Meer D, Samelson LE, Losert W.
Automatic sorting of point pattern sets using Minkowski functionals.
Phys Rev E Stat Nonlin Soft Matter Phys. 88: 022720, 2013.
[Journal]
8)  Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.
Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.
J. Immunol. 190: 3849-53, 2013.
[Journal]
9)  Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH.
Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.
Hum. Gene Ther. 24: 27-37, 2013.
[Journal]
10)  Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E.
Functional redundancy of sos1 and sos2 for lymphopoiesis and organismal homeostasis and survival.
Mol. Cell. Biol. 33: 4562-78, 2013.
[Journal]
11)  Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.
miRNA Signature of Mouse Helper T Cell Hyper-Proliferation.
PLoS ONE. 8: e66709, 2013.
[Journal]
12)  Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.
Multipoint binding of the SLP-76 SH2 domain to ADAP is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T cells.
Mol. Cell. Biol. 2013.
[Journal]
13)  Kortum RL, Rouquette-Jazdanian AK, Samelson LE.
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
Trends Immunol. [Epub ahead of print], 2013.
[Journal]
14)  Sherman E, Barr V, Samelson LE.
Super-resolution characterization of TCR-dependent signaling clusters.
Immunol. Rev. 251: 21-35, 2013.
[Journal]
15)  Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.
Deconstructing Ras signaling in the thymus.
Mol Cell Biol. 32: 2748-59, 2012.
[Journal]
16)  Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.
Interchangeability of themis1 and themis2 in thymocyte development reveals two related proteins with conserved molecular function.
J. Immunol. 189: 1154-61, 2012.
[Journal]
17)  Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.
LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.
Mol. Cell. 48: 298-312, 2012.
[Journal]
18)  Sherman E, Barr VA, Samelson LE.
Resolving multi-molecular protein interactions by photoactivated localization microscopy.
Methods. 59: 261-9, 2012.
[Journal]
19)  Balagopalan L, Sherman E, Barr VA, Samelson LE.
Imaging techniques for assaying lymphocyte activation in action.
Nat. Rev. Immunol. 11: 21-33, 2011.
[Journal]
20)  Samelson LE.
Immunoreceptor signaling.
Cold Spring Harb Perspect Biol. 3: a011510, 2011.
[Journal]
21)  Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE.
Targeted Sos1 deletion reveals its critical role in early T-cell development.
Proc. Natl. Acad. Sci. U.S.A. 108: 12407-12, 2011.
[Journal]
22)  Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, Balbo A, Yamaguchi H, Houtman JC, Appella E, Schuck P, Samelson LE.
Cooperative interactions at the SLP-76 complex are critical for actin polymerization.
EMBO J. 29: 2315-28, 2010.
[Journal]
23)  Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL.
The LAT Story: A Tale of Cooperativity, Coordination, and Choreography.
Cold Spring Harb Perspect Biol. 2: a005512, 2010.
[Journal]
24)  Balagopalan L, Barr VA, Samelson LE.
Endocytic events in TCR signaling: focus on adapters in microclusters.
Immunol. Rev. 232: 84-98, 2009.
[Journal]
25)  Barr VA, Bernot KM, Shaffer MH, Burkhardt JK, Samelson LE.
Formation of STIM and Orai complexes: puncta and distal caps.
Immunol. Rev. 231: 148-59, 2009.
[Journal]
26)  Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Proc. Natl. Acad. Sci. U.S.A. 106: 14502-7, 2009.
[Journal]
27)  Kortum RL, Samelson LE.
Priming the pump: adhesion enhances T cell antigen receptor-induced signaling.
Immunity. 30: 3-5, 2009.
[Journal]
28)  Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.
Bam32: a novel mediator of Erk activation in T cells.
Int. Immunol. 20: 811-8, 2008.
[Journal]
29)  Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.
Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T Cells: Puncta and Distal Caps.
Mol. Biol. Cell. 19: 2802-2817, 2008.
[Journal]
30)  Patino-Lopez G, Dong X, Ben-Aissa K, Bernot KM, Itoh T, Fukuda M, Kruhlak MJ, Samelson LE, Shaw S.
RAB35 and its GAP EPI64C in T-cells regulate receptor recycling and immunological synapse formation.
J. Biol. Chem. 283: 18323-18330, 2008.
[Journal]
31)  Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.
Mol. Cell. Biol. 27: 8622-36, 2007.
[Journal]
32)  Fukumoto R, Dundr M, Nicot C, Adams A, Valeri VW, Samelson LE, Franchini G.
Inhibition of T-Cell Receptor Signal Transduction and Viral Expression by the Linker for Activation of T Cells-Interacting p12I Protein of Human T-Cell Leukemia/Lymphoma Virus Type 1.
J. Virol. 81: 9088-99, 2007.
[Journal]
33)  Houtman JC, Brown PH, Bowden B, Yamaguchi H, Appella E, Samelson LE, Schuck P.
Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: Application to adaptor protein complexes in cell signaling.
Protein Sci. 16: 30-42, 2007.
[Journal]
34)  Bunnell SC, Singer AL, Hong DI, Jacque BH, Jordan MS, Seminario MC, Barr VA, Koretzky GA, Samelson LE.
Persistence of cooperatively stabilized signaling clusters drives T-cell activation.
Mol. Cell. Biol. 26: 7155-66, 2006.
[Journal]
35)  Braiman A, Barda-Saad M, Sommers CL, Samelson LE.
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.
EMBO J. 25: 774-84, 2006.
[Journal]
36)  Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.
T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.
Traffic. 7: 1143-62, 2006.
[Journal]
37)  Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE.
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.
Nat Immunol. 6: 80-9, 2005.
[Journal]
38)  Houtman JC, Houghtling RA, Barda-Saad M, Toda Y, Samelson LE.
Early Phosphorylation Kinetics of Proteins Involved in Proximal TCR-Mediated Signaling Pathways.
J Immunol. 175: 2449-58, 2005.
[Journal]
39)  Houtman JC, Barda-Saad M, Samelson LE.
Examining multiprotein signaling complexes from all angles.
FEBS J. 272: 5426-35, 2005.
[Journal]
40)  Sommers CL, Lee J, Steiner KL, Gurson JM, Depersis CL, El-Khoury D, Fuller CL, Shores EW, Love PE, Samelson LE.
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
J Exp Med. 201: 1125-34, 2005.
[Journal]
41)  Houtman JC, Higashimoto Y, Dimasi N, Cho S, Yamaguchi H, Bowden B, Regan C, Malchiodi EL, Mariuzza R, Schuck P, Appella E, Samelson LE.
Binding Specificity of Multiprotein Signaling Complexes is Determined by Both Cooperative Interactions and Affinity Preferences.
Biochemistry. 43: 4170-4178, 2004.
[Journal]
42)  Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Satterthwaite AB, Nahm DH, Metcalfe DD, Gilfillan AM.
Identification of the major small MW adaptor molecule tyrosine phosphorylated following FceRI aggregation in human mast cells as Non-T cell Activation Linker (NTAL).
Blood. 104: 207-214, 2004.
[Journal]
43)  Chiang YJ, Sommers CL, Jordan MS, Gu H, Samelson LE, Koretzky GA, Hodes RJ.
Inactivation of c-Cbl reverses neonatal lethality and T cell development arrest of SLP-76-deficient mice and leads to peripheral CD4 hyperplasia.
J. Exp. Med. 200: 25-34, 2004.
[Journal]
44)  Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R.
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
Genome Biol. 6: R9, 2004.
[Journal]
45)  Sommers CL, Samelson LE, Love PE.
LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways.
BioEssays. 26(1): 61-67, 2004.
[Journal]
46)  Wilson BS, Steinberg SL, Liederman K, Pfeiffer JR, Surviladze Z, Zhang J, Samelson LE, Yang LH, Kotula PG, Oliver JM.
Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes.
Mol. Biol. Cell. 15: 2580-2592, 2004.
[Journal]
47)  Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA.
Roles of the Proline-Rich Domain in SLP-76 Subcellular Localization and T cell Function.
J. Biol. Chem. 279: 15481-15490, 2004.
[Journal]
48)  Cho S, Velikovsky CA, Swaminathan CP, Houtman JC, Samelson LE, Mariuzza RA.
Structural basis for differential recognition of tyrosine phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor protein gads.
EMBO J. 23: 1441-1451, 2004.
[Journal]
49)  Fuller CL, Braciale VL, Samelson LE.
All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton.
Immunol Rev. 191: 220-236, 2003.
[Journal]
50)  Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE.
CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc-42 in human T cells.
J. Immunology. 171: 2225-2232, 2003.
[Journal]
51)  Bunnell SC, Barr VA, Fuller CL, Samelson LE.
High-Resolution Multicolor Imaging of Dynamic Signaling Complexes in T Cells Stimulated by Planar Substrates.
Science STKE. Apr. 8 (177): PL8, 2003.
[Journal]
52)  Weiss A, Samelson LE.
T lymphocyte activation. In: Fundamental Immunology, Fifth Edition (W.E. Paul ed.).
Lippincott-Raven Publishers, Philadelphia, New York,. pp.: 321-363, 2003.
[Journal]
53)  Saitoh S, Odom S, Gomez G, Sommers CL, Young HA, Rivera J, Samelson LE.
The four distal tyrosine for LAT-dependent signaling in FceRI-mediated Mast Cell Activation.
J. Exp. Med. 198: 831-843, 2003.
[Journal]
54)  Parravicini V, Gadina M, Kovarova M, Odom S, Gonzalez-Espinosa C, Furumoto Y, Saitoh S, Samelson LE, O'Shea JJ, Rivera J.
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranuation.
Nat Immunol. 3: 741-748, 2002.
[Journal]
55)  Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacaná E, Menon RK, Shores EW, Samelson LE, Love PE.
Mutation of a single tyrosine in LAT inhibits T cell development and induces lympoproliferation in mice.
Science. 296: 2040-2043, 2002.
[Journal]
56)  Yamazaki T, Zaal K, Hailey D, Presley J, Lippincott-Schwartz J, Samelson LE.
Role of Grb2 in EGF-stimulated EGFR internalization: Grb2 is necessary for EGF-stimulated EGFR uptake.
J. Cell Sci. 115: 1791-1802, 2002.
[Journal]
57)  Samelson LE.
Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins.
Ann. Rev. Immunol. 20: 371-394, 2002.
[Journal]
58)  Samelson LE.
Diagonal gel electrophoresis.
Curr Protoc Immunol. Chapter 8: Unit 8.6, 2001.
[Journal]
59)  Bunnell SC, Kapoor V, Trible RP, Zhang W, Samelson LE.
Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT.
Immunity. 14: 315-329, 2001.
[Journal]
60)  Samelson LE.
Iodination of soluble and membrane-bound proteins.
Curr Protoc Immunol. Chapter 8: Unit 8.11, 2001.
[Journal]
61)  O'Shea JJ, Johnston JA, Kehrl J, Koretzky G, Samelson LE.
Key molecules involved in receptor-mediated lymphocyte activation.
Curr Protoc Immunol. Chapter 11: Unit 11.9A, 2001.
[Journal]
62)  Sommers CL, Menon RK, Grinberg A, Zhang W, Samelson LE, Love PE.
Knock-in mutation of the distal four tyrosines of LAT blocks murine T cell development.
J. Exp. Med. 194: 135-142, 2001.
[Journal]
63)  Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE.
Association of Grb2, Gads, and Phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues: effect of LAT tyrosine mutations on T Cell Receptor-mediated signaling.
J. Biol. Chem. 275: 23355-23361, 2000.
[Journal]
64)  Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE.
LAT is required for Fc-epsilon-RI-mediated mast cell activation.
Immunity. 12: 525-535, 2000.
[Journal]
65)  Sloan-Lancaster J, Samelson LE.
Proximal events in T cell activation. In: Signal Transduction and Cell Cycle Inhibitors. (J.S. Gutkind, ed.).
The Humana Press, Totowa, NJ. 6: 99-111, 2000.
[Journal]
66)  Martelli MP, Lin H, Zhang W, Samelson LE, Bierer BE.
Signaling via LAT (linker for T cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
Blood. 96: 2181-2190, 2000.
[Journal]
67)  Zhang W, Samelson LE.
The role of membrane-associated adptors in T cell receptor signaling.
Semin Immunol. 12: 35-41, 2000.
[Journal]
68)  van Leeuwen JE, Paik PK, Samelson LE.
Activation of NFAT and AP1 by oncogenic 70Z Cbl requires an intact PTB domain but not Crk(L) or p85 PI3K association.
J. Biol. Chem. 274: 5153-5162, 1999.
[Journal]
69)  Samelson LE.
Adaptor proteins and T cell antigen receptor signaling.
Prog. Biophys. and Molec. Biol. 71: 393-403, 1999.
[Journal]
70)  Bosselut R, Zhang W, Ashe JM, Kopacz JL, Samelson LE, Singer A.
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.
J. Exp. Med. 190: 1517-1525, 1999.
[Journal]
71)  Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Irvin BJ, Zhang W, Samelson LE, Abraham RT, Leibson PJ.
Cutting Edge: A role for the adaptor protein LAT in human NK cell-mediated cytotoxicity.
J. Immunol. 162: 2453-2456, 1999.
[Journal]
72)  Zhang W, Sommers CL, Burshtyn DN, Stebbins CC, DeJarnette JB, Trible RP, Grinberg A, Tsay HC, Jacobs HM, Kessler CM, Long EO, Love PE, Samelson LE.
Essential role of LAT in T cell development.
Immunity. 10: 323-332, 1999.
[Journal]
73)  Zhang W, Irvin BJ, Trible RP, Abraham RT, Samelson LE.
Functional analysis of LAT in T cell receptor-mediated signaling pathways using a LAT-deficient Jurkat cell line.
Int. Immunol. 11: 943-950, 1999.
[Journal]
74)  Facchetti F, Chan JK, Zhang W, Tironi A, Chilosi M, Parolini S, Notarangelo LD, Samelson LE.
LAT (Linker for activation of T cells): A novel immunohistochemical marker for T, NK, mast cells and megakaryocytes. Evaluation in normal pathological conditions.
Am. J. Path. 154: 1037-1046, 1999.
[Journal]
75)  Pasquet JM, Gross B, Quek L, Asazuma N, Zhang W, Sommers CL, Schweighoffer E, Tybulewicz V, Judd B, Lee JR, Koretzky G, Love PE, Samelson LE, Watson SP.
LAT is required for tyrosine phosphorylation of phospholipase C-gamma2 and platelet activation by the collagen receptor GPVI.
Mol. Cell. Biol. 19: 8326-8334, 1999.
[Journal]
76)  Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M.
Requirement of the src homology 2 domain Protein Shb for T cell receptor-dependent activation of the interleukin-2 gene NFAT-element in Jurkat T Cells.
J. Biol. Chem. 274: 28050-28057, 1999.
[Journal]
77)  Samelson LE, Bunnell SC, Trible RP, Yamazaki T, Zhang W.
Studies on the adaptor molecule LAT. Cold Spring Harbor Symposia on Quantitative Biology: Signaling and Gene Expression in the Immune System.
Cold Spring Harb Symp Quant Biol. 64: 259-263, 1999.
[Journal]
78)  van Leeuwen JE, Samelson LE.
T cell receptor signal transduction.
Curr Opin Immunol. 11: 242-248, 1999.
[Journal]
79)  van Leeuwen JE, Paik PK, Samelson LE.
Te oncogenic 70Z Cbl mutation blocks the PTB domain-dependent negative regulation of ZAP-70 by Cbl in Jurkat cells.
Mol. Cell. Biol. 19: 6652-6664, 1999.
[Journal]
80)  Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A.
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Immunity. 9: 617-26, 1998.
[Journal]
81)  Zhang W, Trible RP, Samelson LE.
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
Immunity. 9: 239-46, 1998.
[Journal]
82)  Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA.
Molecular basis of T cell inactivation by CTLA-4.
Science. 282: 2263-6, 1998.
[Journal]
83)  Sloan-Lancaster J, Presley J, Ellenberg J, Yamazaki T, Lippincott-Schwartz J, Samelson LE.
ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.
J. Cell Biol. 143: 613-24, 1998.
[Journal]
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This page was last updated on 11/20/2013.