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Our Science – Samelson Website

Lawrence E. Samelson, M.D.

Selected Publications

1)  Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.
Sci Signal. 6: ra99, 2013.
2)  Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE.
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Cell. 92: 83-92, 1998.
3)  Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE.
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.
J. Cell. Biol. 158: 1263-1275, 2002.
4)  Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Nat Struct Mol Biol. 13: 798-805, 2006.
5)  Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.
Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.
Proc. Natl. Acad. Sci. U.S.A. 108: 2885-90, 2011.
6)  Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.
Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor.
Immunity. 35: 705-20, 2011.
7)  Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.
A Phospholipase C-gamma1-Independent, RasGRP1-ERK-Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells-Y136F Mutant Mice.
J. Immunol. 190: 147-58, 2013.
8)  Parker J, Sherman E, van de Raa M, van der Meer D, Samelson LE, Losert W.
Automatic sorting of point pattern sets using Minkowski functionals.
Phys Rev E Stat Nonlin Soft Matter Phys. 88: 022720, 2013.
9)  Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.
Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.
J. Immunol. 190: 3849-53, 2013.
10)  Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH.
Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.
Hum. Gene Ther. 24: 27-37, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 4/23/2014.