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Our Science – Durum Website

Scott K. Durum, Ph.D.

Selected Publications

1)  Chen K, Liu M, Liu Y, Yoshimura T, Shen W, Le Y, Durum S, Gong W, Wang C, Gao JL, Murphy PM, Wang JM.
Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis.
J. Clin. Invest. 123: 1694-704, 2013.
[Journal]
2)  Hasley RB, Hong C, Li W, Friesen T, Nakamura Y, Kim GY, Park JH, Hixon JA, Durum S, Hu Z, Sneller MC, Oguariri R, Imamichi T, Lane HC, Catalfamo M.
HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.
AIDS. 27: 1867-77, 2013.
[Journal]
3)  Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y.
IL-7Rα deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis.
Cell Death Differ. 19: 1139-51, 2012.
[Journal]
4)  Patel ES, Okada S, Hachey K, Yang LJ, Durum SK, Moreb JS, Chang LJ.
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC Immunol. 13: 46, 2012.
[Journal]
5)  Mazzucchelli RI, Riva A, Durum SK.
The human IL-7 receptor gene: Deletions, polymorphisms and mutations.
Semin. Immunol. 24: 225-30, 2012.
[Journal]
6)  Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
Biochim. Biophys. Acta. 1823: 1877-93, 2012.
[Journal]
7)  Zappacosta R, Aiello FB, D'Antuono T, Procopio AD, Durum SK, Conti P, Rosini S.
Detection of nuclear and membrane antigens by liquid-based cytology following long-term storage of d1 cells, karpas cells, and peripheral blood mononuclear cells.
Ann. Clin. Lab. Sci. 41: 353-9, 2011.
[Journal]
8)  Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Nat. Genet. 43: 932-9, 2011.
[Journal]
9)  Muranski P, Borman ZA, Kerkar SP, Klebanoff CA, Ji Y, Sanchez-Perez L, Sukumar M, Reger RN, Yu Z, Kern SJ, Roychoudhuri R, Ferreyra GA, Shen W, Durum SK, Feigenbaum L, Palmer DC, Antony PA, Chan CC, Laurence A, Danner RL, Gattinoni L, Restifo NP.
Th17 cells are long lived and retain a stem cell-like molecular signature.
Immunity. 35: 972-85, 2011.
[Journal]
10)  Kittipatarin C, Li W, Durum SK, Khaled AR.
Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7.
Exp. Hematol. 38: 1143-56, 2010.
[Journal]
11)  Li WQ, Guszczynski T, Hixon JA, Durum SK.
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.
Mol. Cell. Biol. 30: 590-600, 2010.
[Journal]
12)  Shen W, Durum SK.
Synergy of IL-23 and Th17 Cytokines: New Light on Inflammatory Bowel Disease.
Neurochemical research. 2009.
[Journal]
13)  Mazzucchelli RI, Warming S, Lawrence SM, Ishii M, Abshari M, Washington AV, Feigenbaum L, Warner AC, Sims DJ, Li WQ, Hixon JA, Gray DH, Rich BE, Morrow M, Anver MR, Cherry J, Naf D, Sternberg LR, McVicar DW, Farr AG, Germain RN, Rogers K, Jenkins NA, Copeland NG, Durum SK.
Visualization and identification of IL-7 producing cells in reporter mice.
PLoS ONE. 4: e7637, 2009.
[Journal]
14)  Durum SK, Mazzucchelli RI.
Live from the liver: hepatocyte IL-7.
Immunity. 30: 320-1, 2009.
[Journal]
15)  Mazzucchelli R, Hixon JA, Spolski R, Chen X, Li WQ, Hall VL, Willette-Brown J, Hurwitz AA, Leonard WJ, Durum SK.
Development of regulatory T cells requires IL-7R{alpha} stimulation by IL-7 or TSLP.
Blood. 112: 3283-3292, 2008.
[Journal]
16)  Wuest TY, Willette-Brown J, Durum SK, Hurwitz AA.
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.
J. Leukoc. Biol. Epub ahead of print, 2008.
[Journal]
17)  Mazzucchelli R, Durum SK.
Interleukin-7 receptor expression: intelligent design.
Nat. Rev. Immunol. 7: 144-54, 2007.
[Journal]
18)  Aiello FB, Keller JR, Klarmann KD, Dranoff G, Mazzucchelli R, Durum SK.
IL-7 induces myelopoiesis and erythropoiesis.
J. Immunol. 178: 1553-63, 2007.
[Journal]
19)  Jiang Q, Huang J, Li WQ, Cavinato T, Keller JR, Durum SK.
Role of the intracellular domain of IL-7 receptor in T cell development.
J. Immunol. 178: 228-34, 2007.
[Journal]
20)  Kittipatarin C, Li WQ, Bulavin DV, Durum SK, Khaled AR.
Cell cycling through Cdc25A: transducer of cytokine proliferative signals.
Cell Cycle. 5: 907-12, 2006.
[Journal]
21)  Li WQ, Jiang Q, Aleem E, Kaldis P, Khaled AR, Durum SK.
IL-7 promotes T cell proliferation through destabilization of p27Kip1.
J. Exp. Med. 203: 573-82, 2006.
[Journal]
22)  Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ.
Stat5a/b are essential for normal lymphoid development and differentiation.
Proc. Natl. Acad. Sci. U.S.A. 103: 1000-5, 2006.
[Journal]
23)  Takase H, Yu C, Ham D, Chan C, Chen J, Vistica BP, Wawrousek EF, Durum SK, Egwuagu CE, Gery I.
Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations.
J Leukoc Biol. 80: 538-45, 2006.
[Journal]
24)  Leviton A, Dammann O, Durum SK.
The adaptive immune response in neonatal cerebral white matter damage.
Ann Neurol. 58: 821-828, 2005.
[Journal]
25)  Jiang Q, Li WQ, Aiello FB, Klarmann KD, Keller JR, Durum SK.
Retroviral transduction of IL-7Ralpha into IL-7Ralpha-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.
Gene Ther. 12: 1761-8, 2005.
[Journal]
26)  Khaled AR, Bulavin DV, Kittipatarin C, Li WQ, Alvarez M, Kim K, Young HA, Fornace AJ, Durum SK.
Cytokine-driven cell cycling is mediated through Cdc25A.
J Cell Biol. 169: 755-63, 2005.
[Journal]
27)  Jiang Q, Li WQ, Aiello FB, Mazzucchelli R, Asefa B, Khaled AR, Durum SK.
Cell biology of IL-7, a key lymphotrophin.
Cyto.Growth Fact. Rev. 16: 513-533, 2005.
[Journal]
28)  Jiang Q, Benbernou N, Chertov O, Khaled AR, Wooters J, Durum SK.
IL-7 induces tyrosine phosphorylation of clathrin heavy chain.
Cell Signal. 16: 281-286, 2004.
[Journal]
29)  Li WQ, Jiang Q, Khaled AR, Keller JR, Durum SK.
Interleukin-7 inactivates the pro-apoptotic protein bad promoting T cell survival.
J Biol Chem. 279: 29160-6, 2004.
[Journal]
30)  Jiang Q, Li WQ, Hofmeister RR, Young HA, Hodge DR, Keller JR, Khaled AR, Durum SK.
Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
Mol Cell Biol. 24: 6501-13, 2004.
[Journal]
31)  Ashktorab H, Frank S, Khaled AR, Durum SK, Kifle B, Smoot DT.
Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori.
Gut. 53: 805-13, 2004.
[Journal]
32)  Durum SK.
Bcl11: sibling rivalry in lymphoid development.
Nat Immunol. 4: 512-514, 2003.
[Journal]
33)  Khaled AR, Durum SK.
Death and Baxes: mechanisms of lymphotrophic cytokines.
Immunol Rev. 193: 48-57, 2003.
[Journal]
34)  Durum SK, Aiello FB.
Interleukin-7 Induces MUC1.
Cancer Biol Ther. 2: 194-195, 2003.
[Journal]
35)  Kim K, Khaled AR, Reynolds D, Young HA, Lee CK, Durum SK.
Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse.
J Immunol Methods. 274: 177-184, 2003.
[Journal]
36)  Khaled AR, Durum SK.
The role of cytokines in lymphocyte homeostasis.
Biotechniques. Suppl: 40-45, 2002.
[Journal]
37)  Szocinski JL, Khaled AR, Hixon J, Halverson D, Funakoshi S, Fanslow WC, Boyd A, Taub DD, Durum SK, Siegall CB, Longo DL, Murphy WJ.
Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax.
Blood. 100: 217-223, 2002.
[Journal]
38)  Khaled AR, Durum SK.
Lymphocide. Cytokines and Control of lymphoid Homeostasis.
Nature Immun. Rev. 2: 817-830, 2002.
[Journal]
39)  Rajnavolgyi E, Benbernou N, Rethi B, Reynolds D, Young HA, Magocsi M, Muegge K, Durum SK.
IL-7 withdrawal induces a stress pathway activating p38 and June N-terminal kinaes.
Cell Signalling. 14: 761-769, 2002.
[Journal]
40)  Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK.
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Immunity. 17: 561-573, 2002.
[Journal]
41)  Khaled AR, Reynolds DA, Young HA, Thompson CB, Muegge K, Durum SK.
Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP Transport, and FoF1-ATPase.
J. Biol. Chem. 276: 6453-6462, 2001.
[Journal]
42)  Lee CK, Kim K, Welniak LA, Murphy WJ, Muegge K, Durum SK.
Thymic emigrants isolated by a new method possess unique phenotypic and functional properties.
Blood. 97: 1360-1369, 2001.
[Journal]
43)  Dammann O, Durum S, Leviton A.
Do white cells matter in white matter damage?.
Trends Neurosci. 24: 320-4, 2001.
[Journal]
44)  Huang J, Durum SK, Muegge K.
Cutting edge: histone acetylation and recombination at the TCR gamma locus follows IL-7 induction.
J Immunol. 167: 6073-7, 2001.
[Journal]
45)  Steiner T, Junker U, Henzgen B, Nuske K, Durum SK, Schubert J.
Interferon-alpha suppresses the antiapoptotic effect of NF-kB and sensitizes renal cell carcinoma cells in vitro to chemotherapeutic drugs.
Eur Urol. 39: 478-83, 2001.
[Journal]
46)  Lee CK, Kim JK, Kim Y, Lee MK, Kim K, Kang JK, Hofmeister R, Durum SK, Han SS.
Generation of macrophages from early T progenitors in vitro.
J Immunol. 166: 5964-9, 2001.
[Journal]
47)  Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK.
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.
Mol Cell Biol. 21: 7545-7557, 2001.
[Journal]
48)  Dinarello CA, Muegge K, Durum SK.
Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay.
Curr Protoc Immunol. Chapter 6: Unit 6.2, 2001.
[Journal]
49)  Benbernou N, Muegge K, Durum SK.
Interleukin(IL)-7 induces rapid activation of Pyk2 which is bound to Jak1and IL-7R alpha.
J. Biol. Chem. 275(10): 7060-7065, 2000.
[Journal]
50)  Nathan I, Dizdaroglu M, Bernstein L, Junker U, Lee C, Muegge K, Durum SK.
Induction of oxidative DNA damage in U937 cells by TNF and anti-Fas stimulation.
Cytokine. 12: 881-887, 2000.
[Journal]
51)  Durum SK.
Overview of interleukins 1 through 18.
In Rosenberg, S. A. (Ed) Biological Therapy of Cancer: Principles and Practice. 1999.
[Journal]
52)  Khaled AR, Kim K, Hofmeister R, Muegge K, Durum SK.
Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.
PNAS. 96: 14476-14481, 1999.
[Journal]
53)  Osipovich O, Duhe RJ, Hasty P, Durum SK, Muegge K.
Defining functional domains of Ku80: DNA end binding and survival after radiation.
Biochem. Biophys. Res. Commun. 261: 802-7, 1999.
[Journal]
54)  Hofmeister R, Khaled AR, Benbernou N, Rajnavolgyi E, Muegge K, Durum SK.
Interleukin-7: physiological roles and mechanisms of action.
Cytokine Growth Factor Rev. 10: 41-60, 1999.
[Journal]
55)  Lee CK, Kim K, Geiman TM, Murphy WJ, Muegge K, Durum SK.
Cloning thymic precursor cells: demonstration that individual pro-T1 cells have dual T-NK potential and individual pro-T2 cells have dual alphabeta-gammadelta T cell potential.
Cell. Immunol. 191: 139-44, 1999.
[Journal]
56)  Geiman TM, Durum SK, Muegge K.
Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh).
Genomics. 54: 477-83, 1998.
[Journal]
57)  Durum SK, Candeias S, Nakajima H, Leonard WJ, Baird AM, Berg LJ, Muegge K.
Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.
J. Exp. Med. 188: 2233-41, 1998.
[Journal]
58)  Durum SK, Lee CK, Geiman TM, Murphy WJ, Muegge K.
CD16 cross-linking blocks rearrangement of the TCR beta locus and development of alpha beta T cells and induces development of NK cells from thymic progenitors.
J. Immunol. 161: 3325-9, 1998.
[Journal]
59)  Kim K, Lee CK, Sayers TJ, Muegge K, Durum SK.
The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways.
J. Immunol. 160: 5735-41, 1998.
[Journal]
60)  Candeias SM, Durum SK, Muegge K.
p53-dependent apoptosis and transcription of p21waf/cip1/sdi1 in SCID mice following gamma-irradiation.
Biochimie. 79: 607-12, 1997.
[Journal]
61)  Smith MR, Kung H, Durum SK, Colburn NH, Sun Y.
TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells.
Cytokine. 9: 770-80, 1997.
[Journal]
62)  Candeias S, Peschon JJ, Muegge K, Durum SK.
Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice.
Immunol. Lett. 57: 9-14, 1997.
[Journal]
63)  Osipovich O, Durum SK, Muegge K.
Defining the minimal domain of Ku80 for interaction with Ku70.
J. Biol. Chem. 272: 27259-65, 1997.
[Journal]
64)  Kitazawa H, Muegge K, Badolato R, Wang JM, Fogler WE, Ferris DK, Lee CK, Candeias S, Smith MR, Oppenheim JJ, Durum SK.
IL-7 activates alpha4beta1 integrin in murine thymocytes.
J. Immunol. 159: 2259-64, 1997.
[Journal]
65)  Candeias S, Muegge K, Durum SK.
IL-7 receptor and VDJ recombination: trophic versus mechanistic actions.
Immunity. 6: 501-8, 1997.
[Journal]
66)  Jarvis CD, Geiman T, Vila-Storm MP, Osipovich O, Akella U, Candeias S, Nathan I, Durum SK, Muegge K.
A novel putative helicase produced in early murine lymphocytes.
Gene. 169: 203-7, 1996.
[Journal]
67)  Candeias S, Muegge K, Durum SK.
Junctional diversity in signal joints from T cell receptor beta and delta loci via terminal deoxynucleotidyl transferase and exonucleolytic activity.
J. Exp. Med. 184: 1919-26, 1996.
[Journal]
68)  Casciari JJ, Sato H, Durum SK, Fiege J, Weinstein JN.
Reference databases of cytokine structure and function.
Cancer chemotherapy and biological response modifiers. 16: 315-46, 1996.
[Journal]
69)  Taub DD, Tsarfaty G, Lloyd AR, Durum SK, Longo DL, Murphy WJ.
Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment.
J. Clin. Invest. 94: 293-300, 1994.
[Journal]
70)  Murphy WJ, Durum SK, Anver MR, Ferris DK, McVicar DW, O'Shea JJ, Ruscetti SK, Smith MR, Young HA, Longo DL.
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID).
J. Immunol. 153: 1004-14, 1994.
[Journal]
71)  Murphy WJ, Durum SK, Longo DL.
Differential effects of growth hormone and prolactin on murine T cell development and function.
J. Exp. Med. 178: 231-6, 1993.
[Journal]
72)  Bristol LA, Durum SK, Eisenberg SP.
Differential regulation of group A streptococcal peptidoglycan-polysaccharide (PG-APS)-stimulated macrophage production of IL-1 by rat strains susceptible and resistant to PG-APS-induced arthritis.
Cell. Immunol. 149: 130-43, 1993.
[Journal]
73)  Aiello FB, Gusella L, Longo DL, Birchenall-Roberts M, Takacs L, Takei F, Ruscetti F, Musiani P, Durum SK.
Inducible accessory function of a macrophage cell line.
Immunopharmacology and immunotoxicology. 15: 327-53, 1993.
[Journal]
74)  Muegge K, Vila M, Gusella GL, Musso T, Herrlich P, Stein B, Durum SK.
Interleukin 1 induction of the c-jun promoter.
Proc. Natl. Acad. Sci. U.S.A. 90: 7054-8, 1993.
[Journal]
75)  Muegge K, Vila MP, Durum SK.
Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene.
Science. 261: 93-5, 1993.
[Journal]
76)  Muegge K, West M, Durum SK.
Recombination sequence-binding protein in thymocytes undergoing T-cell receptor gene rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 90: 4151-5, 1993.
[Journal]
77)  Gotlieb WH, Bristol LA, Weissman AM, Durum SK, Takács L.
Upregulation of T cell receptor gamma chain transcription by interleukin-2.
Cell. Immunol. 151: 345-55, 1993.
[Journal]
78)  Smith MR, Ramsburg EA, Kung HF, Durum SK.
Components of the protein kinase C pathway induce Ia expression after injection into macrophages.
J. Immunol. 149: 1304-10, 1992.
[Journal]
79)  Murphy WJ, Durum SK, Longo DL.
Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice.
Proc. Natl. Acad. Sci. U.S.A. 89: 4481-5, 1992.
[Journal]
80)  Murphy WJ, Durum SK, Anver MR, Longo DL.
Immunologic and hematologic effects of neuroendocrine hormones. Studies on DW/J dwarf mice.
J. Immunol. 148: 3799-805, 1992.
[Journal]
81)  Murphy WJ, Durum SK, Anver M, Frazier M, Longo DL.
Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in an increased incidence of human Epstein Barr virus-induced B-cell lymphoma.
Brain Behav. Immun. 6: 355-64, 1992.
[Journal]
82)  Murphy WJ, Durum SK, Longo DL.
Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo.
J. Immunol. 149: 3851-7, 1992.
[Journal]
83)  Gotlieb WH, Takacs L, Finch LR, Kopp W, Weissman AM, Durum SK.
CD8 gamma delta cells: presence in the adult rat thymus and generation in vitro from CD4-/CD8- thymocytes in the presence of interleukin 2.
Cytokine. 3: 598-608, 1991.
[Journal]
84)  Bristol LA, Smith MR, Bhat NK, Durum SK.
IL-1 induces ornithine decarboxylase in normal T lymphocytes.
J. Immunol. 146: 1509-15, 1991.
[Journal]
85)  Durum SK, Quinn DG, Muegge K.
New cytokines and receptors make their debut in San Antonio.
Immunol. Today. 12: 54-7, 1991.
[Journal]
86)  Gotlieb WH, Durum SK, Gregorio TA, Mathieson BJ.
Selective stimulation of thymocyte precursors mediated by specific cytokines. Different CD3+ subsets are generated by IL-1 versus IL-2.
J. Immunol. 146: 2262-71, 1991.
[Journal]
87)  Aiello FB, Longo DL, Overton R, Takacs L, Durum SK.
A role for cytokines in antigen presentation: IL-1 and IL-4 induce accessory functions of antigen-presenting cells.
J. Immunol. 144: 2572-81, 1990.
[Journal]
88)  Muegge K, Durum SK.
Cytokines and transcription factors.
Cytokine. 2: 1-8, 1990.
[Journal]
89)  Smith MR, Muegge K, Keller JR, Kung HF, Young HA, Durum SK.
Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.
J. Immunol. 144: 1777-82, 1990.
[Journal]
90)  Smith MR, Munger WE, Kung HF, Takacs L, Durum SK.
Direct evidence for an intracellular role for tumor necrosis factor-alpha 1. Microinjection of tumor necrosis factor kills target cells.
J. Immunol. 144: 162-9, 1990.
[Journal]
91)  Gotlieb WH, Takacs L, Young HA, Gusella L, Durum SK.
Growth of immature (double negative) rat thymocytes in the presence of IL-1.
J. Immunol. 144: 2072-81, 1990.
[Journal]
92)  Durum SK, Mealy K.
Hilton Head revisited--cytokine explosion of the 80s takes shape for the 90s.
Immunol. Today. 11: 103-6, 1990.
[Journal]
93)  Bristol LA, Ruscetti FW, Brody DT, Durum SK.
IL-1 alpha induces expression of active transforming growth factor-beta in nonproliferating T cells via a post-transcriptional mechanism.
J. Immunol. 145: 4108-14, 1990.
[Journal]
94)  Apte RN, Durum SK, Oppenheim JJ.
Opioids modulate interleukin-1 production and secretion by bone-marrow macrophages.
Immunol. Lett. 24: 141-8, 1990.
[Journal]
95)  Apte RN, Oppenheim JJ, Durum SK.
Beta-endorphin regulates interleukin 1 production and release by murine bone marrow macrophages.
Int. Immunol. 1: 465-70, 1989.
[Journal]
96)  Young HA, Komschlies KL, Ciccarone V, Beckwith M, Rosenberg M, Jenkins NA, Copeland NG, Durum SK.
Expression of human IFN-gamma genomic DNA in transgenic mice.
J. Immunol. 143: 2389-94, 1989.
[Journal]
97)  Muegge K, Durum SK.
From cell code to gene code: cytokines and transcription factors.
New Biol. 1: 239-46, 1989.
[Journal]
98)  Romero R, Wu YK, Brody DT, Oyarzun E, Duff GW, Durum SK.
Human decidua: a source of interleukin-1.
Obstetrics and gynecology. 73: 31-4, 1989.
[Journal]
99)  Romero R, Brody DT, Oyarzun E, Mazor M, Wu YK, Hobbins JC, Durum SK.
Infection and labor. III. Interleukin-1: a signal for the onset of parturition.
Am. J. Obstet. Gynecol. 160: 1117-23, 1989.
[Journal]
100)  Muegge K, Williams TM, Kant J, Karin M, Chiu R, Schmidt A, Siebenlist U, Young HA, Durum SK.
Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
Science. 246: 249-51, 1989.
[Journal]
101)  Brody DT, Durum SK.
Membrane IL-1: IL-1 alpha precursor binds to the plasma membrane via a lectin-like interaction.
J. Immunol. 143: 1183-7, 1989.
[Journal]
102)  Takács L, Kovacs EJ, Smith MR, Young HA, Durum SK.
Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization. Tissue localization of IL-1 mRNA in the normal C57BL/6 mouse.
J. Immunol. 141: 3081-95, 1988.
[Journal]
103)  Tartakovsky B, Finnegan A, Muegge K, Brody DT, Kovacs EJ, Smith MR, Berzofsky JA, Young HA, Durum SK.
IL-1 is an autocrine growth factor for T cell clones.
J. Immunol. 141: 3863-7, 1988.
[Journal]
104)  Ozaki S, Durum SK, Muegge K, York-Jolley J, Berzofsky JA.
Production of T-T hybrids from T cell clones. Direct comparison between cloned T cells and T hybridoma cells derived from them.
J. Immunol. 141: 71-8, 1988.
[Journal]
105)  Blasi E, Radzioch D, Durum SK, Varesio L.
A murine macrophage cell line, immortalized by v-raf and v-myc oncogenes, exhibits normal macrophage functions.
Eur. J. Immunol. 17: 1491-8, 1987.
[Journal]
106)  Takacs L, Berzofsky JA, York-Jolley J, Akahoshi T, Blasi E, Durum SK.
IL 1 induction by murine T cell clones: detection of an IL 1-inducing lymphokine.
J. Immunol. 138: 2124-31, 1987.
[Journal]
107)  Durum SK, Brody DT, Tartakovsky B.
IL-1 as a self-serving principle in T-cell clones.
Ann. Inst. Pasteur Immunol. 138: 469-72, 1987.
[Journal]
108)  Tartakovsky B, Kovacs EJ, Takacs L, Durum SK.
T cell clone producing an IL 1-like activity after stimulation by antigen-presenting B cells.
J. Immunol. 137: 160-6, 1986.
[Journal]
109)  Kupper TS, Green DR, Durum SK, Baker CC.
Defective antigen presentation to a cloned T helper cell by macrophages from burned mice can be restored with interleukin-1.
Surgery. 98: 199-206, 1985.
[Journal]
110)  Durum SK, Schmidt JA, Oppenheim JJ.
Interleukin 1: an immunological perspective.
Annu. Rev. Immunol. 3: 263-87, 1985.
[Journal]
111)  Matsushima K, Durum SK, Kimball ES, Oppenheim JJ.
Purification of human interleukin 1 from human monocyte culture supernatants and identity of thymocyte comitogenic factor, fibroblast-proliferation factor, acute-phase protein-inducing factor, and endogenous pyrogen.
Cell. Immunol. 92: 290-301, 1985.
[Journal]
112)  Durum SK, Higuchi C, Ron Y.
Accessory cells and T cell activation. The relationship between two components of macrophage accessory cell function: I-A and IL1.
Immunobiology. 168: 213-31, 1984.
[Journal]
113)  Jampel HD, Duff GW, Gershon RK, Atkins E, Durum SK.
Fever and immunoregulation. III. Hyperthermia augments the primary in vitro humoral immune response.
J. Exp. Med. 157: 1229-38, 1983.
[Journal]
114)  Duff GW, Durum SK.
The pyrogenic and mitogenic actions of interleukin-1 are related.
Nature. 304: 449-51, 1983.
[Journal]
115)  Duff GW, Durum SK.
Fever and immunoregulation: hyperthermia, interleukins 1 and 2, and T-cell proliferation.
Yale J Biol Med. 55: 437-42, 1982.
[Journal]
116)  Durum SK, Gershon RK.
Interleukin 1 can replace the requirement for I-A-positive cells in the proliferation of antigen-primed T cells.
Proc. Natl. Acad. Sci. U.S.A. 79: 4747-50, 1982.
[Journal]
117)  Ptak W, Green DR, Durum SK, Kimura A, Murphy DB, Gershon RK.
Immunoregulatory circuits which modulate responsiveness to suppressor cell signals: contrasuppressor cells can convert an in vivo tolerogenic signal into an immunogenic one.
Eur. J. Immunol. 11: 980-3, 1981.
[Journal]
118)  Durum SK, Gengozian N.
The comparative radiosensitivity of T and B lymphocytes.
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 34: 1-15, 1978.
[Journal]
119)  Kuhn RE, Durum SK.
The onset of immune protection in acute experimental Chagas' disease in C3H(HE) mice.
Int. J. Parasitol. 5: 241-4, 1975.
[Journal]
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