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David S. Salomon, Ph.D.

Selected Publications

1)  Mertins SD, Scudiero DA, Hollingshead MG, Divelbiss RD, Alley MC, Monks A, Covell DG, Hite KM, Salomon DS, Niederhuber JE.
A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
PLoS ONE. 8: e57099, 2013.
2)  Nagaoka T, Karasawa H, Turbyville T, Rangel MC, Castro NP, Gonzales M, Baker A, Seno M, Lockett S, Greer YE, Rubin JS, Salomon DS, Bianco C.
Cripto-1 enhances the canonical Wnt/ß-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.
Cell. Signal. 25: 178-89, 2013.
3)  Jin G, Mizutani A, Fukuda T, Otani T, Yan T, Prieto Vila M, Murakami H, Kudoh T, Hirohata S, Kasai T, Salomon DS, Seno M.
Eosinophil cationic protein enhances stabilization of ß-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Mol. Biol. Rep. 40: 3165-71, 2013.
4)  Bianco C, Castro NP, Baraty C, Rollman K, Held N, Rangel MC, Karasawa H, Gonzales M, Strizzi L, Salomon DS.
Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
J. Cell. Physiol. 228: 1174-88, 2013.
5)  Strizzi L, Margaryan NV, Gilgur A, Hardy KM, Normanno N, Salomon DS, Hendrix MJ.
The significance of a Cripto-1 positive subpopulation of human melanoma cells exhibiting stem cell-like characteristics.
Cell Cycle. 12: [Epub ahead of print], 2013.
6)  Chen L, Kasai T, Li Y, Sugii Y, Jin G, Okada M, Vaidyanath A, Mizutani A, Satoh A, Kudoh T, Hendrix MJ, Salomon DS, Fu L, Seno M.
A model of cancer stem cells derived from mouse induced pluripotent stem cells.
PLoS ONE. 7: e33544, 2012.
7)  Nagaoka T, Karasawa H, Castro NP, Rangel MC, Salomon DS, Bianco C.
An evolving web of signaling networks regulated by Cripto-1.
Growth Factors. 30: 13-21, 2012.
8)  Jin G, Mizutani A, Fukuda T, Chen L, Nakanishi K, Yan T, Kudoh T, Hirohata S, Kasai T, Murakami H, Salomon DS, Seno M.
Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.
Growth Factors. 30: 344-55, 2012.
9)  Rangel MC, Karasawa H, Castro NP, Nagaoka T, Salomon DS, Bianco C.
Role of Cripto-1 during Epithelial-To-Mesenchymal Transition in Development and Cancer.
Am J Pathol. 180: 2188-200, 2012.
10)  De Luca A, Lamura L, Strizzi L, Roma C, D'Antonio A, Margaryan N, Pirozzi G, Hsu MY, Botti G, Mari E, Hendrix MJ, Salomon DS, Normanno N.
Expression and functional role of CRIPTO-1 in cutaneous melanoma.
Br. J. Cancer. 105: 1030-8, 2011.
11)  Watanabe K, Meyer MJ, Strizzi L, Lee JM, Gonzales M, Bianco C, Nagaoka T, Farid SS, Margaryan N, Hendrix MJ, Vonderhaar BK, Salomon DS.
Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells.
Stem Cells. 28: 1303-14, 2010.
12)  de Castro NP, Rangel MC, Nagaoka T, Salomon DS, Bianco C.
Cripto-1: an embryonic gene that promotes tumorigenesis.
Future Oncol. 6: 1127-42, 2010.
13)  Hardy KM, Booth BW, Hendrix MJ, Salomon DS, Strizzi L.
ErbB/EGF signaling and EMT in mammary development and breast cancer.
J Mammary Gland Biol Neoplasia. 15: 191-9, 2010.
14)  Watanabe K, Salomon DS.
Intercellular transfer regulation of the paracrine activity of GPI-anchored Cripto-1 as a Nodal co-receptor.
Biochem. Biophys. Res. Commun. 403: 108-13, 2010.
15)  Stuelten CH, Salomon DS.
miR-31 in cancer: location matters.
Cell Cycle. 9: 4608-9, 2010.
16)  Hirai M, Minematsu H, Hiramatsu Y, Kitagawa H, Otani T, Iwashita S, Kudoh T, Chen L, Li Y, Okada M, Salomon DS, Igarashi K, Chikuma M, Seno M.
Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells.
Int J Pharm. 391: 274-83, 2010.
17)  Otani T, Hashizume T, Nagaoka T, Fukuda T, Tang CK, Salomon DS, Seno M.
Production of biologically active IgG hinge-tag soluble epidermal growth factor receptors (ErbB).
Biotechnol. Lett. 32: 361-6, 2010.
18)  Bianco C, Rangel MC, Castro NP, Nagaoka T, Rollman K, Gonzales M, Salomon DS.
Role of Cripto-1 in stem cell maintenance and malignant progression.
Am. J. Pathol. 177: 532-40, 2010.
19)  Bianco C, Salomon DS.
Targeting the embryonic gene Cripto-1 in cancer and beyond.
Expert Opin Ther Pat. 20: 1739-49, 2010.
20)  Bianco C, Cotten C, Lonardo E, Strizzi L, Baraty C, Mancino M, Gonzales M, Watanabe K, Nagaoka T, Berry C, Arai AE, Minchiotti G, Salomon DS.
Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells.
Am. J. Pathol. 175: 2146-58, 2009.
21)  Watanabe K, Nagaoka T, Lee JM, Bianco C, Gonzales M, Castro NP, Rangel MC, Sakamoto K, Sun Y, Callahan R, Salomon DS.
Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1.
J. Cell Biol. 187: 343-53, 2009.
22)  Bianco C, Salomon DS.
Human Cripto-1 as a target for a cancer vaccine: WO2008040759.
Expert Opin Ther Pat. 19: 141-4, 2009.
23)  Fukuda T, Iwata M, Kitazoe M, Maeda T, Salomon D, Hirohata S, Tanizawa K, Kuroda S, Seno M.
Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes.
Growth Factors. 27: 228-36, 2009.
24)  di Bari MG, Ginsburg E, Plant J, Strizzi L, Salomon DS, Vonderhaar BK.
Msx2 induces epithelial-mesenchymal transition in mouse mammary epithelial cells through upregulation of Cripto-1.
J. Cell. Physiol. 219: 659-66, 2009.
25)  Mancino M, Esposito C, Watanabe K, Nagaoka T, Gonzales M, Bianco C, Normanno N, Salomon DS, Strizzi L.
Neuronal guidance protein Netrin-1 induces differentiation in human embryonal carcinoma cells.
Cancer Res. 69: 1717-21, 2009.
26)  Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS, Buono K, Salomon D, Vonderhaar BK, Callahan R.
Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.
Oncogene. 28: 219-30, 2009.
27)  Smith GH, Salomon DS, Vonderhar BK.
Stem Cells. 27: 1223; author reply 1224-5, 2009.
28)  Nagaoka T, Fukuda T, Hashizume T, Nishiyama T, Tada H, Yamada H, Salomon DS, Yamada S, Kojima I, Seno M.
A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1.
J. Mol. Biol. 380: 83-94, 2008.
29)  Bianco C, Mysliwiec M, Watanabe K, Mancino M, Nagaoka T, Gonzales M, Salomon DS.
Activation of a Nodal-independent signaling pathway by Cripto-1 mutants with impaired activation of a Nodal-dependent signaling pathway.
FEBS Lett. 582: 3997-4002, 2008.
30)  Hashizume T, Fukuda T, Nagaoka T, Tada H, Yamada H, Watanabe K, Salomon DS, Seno M.
Cell type dependent endocytic internalization of ErbB2 with an artificial peptide ligand that binds to ErbB2.
Cell Biol. Int. 32: 814-26, 2008.
31)  Watanabe K, Nagaoka T, Strizzi L, Mancino M, Gonzales M, Bianco C, Salomon DS.
Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension.
Biochim. Biophys. Acta. 1778: 2671-81, 2008.
32)  Strizzi L, Postovit L, Margaryan NV, Seftor EA, Abbott DE, Seftor RE, Salomon DS, Hendrix MJ.
Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression.
Breast Dis. 29: 91-103, 2008.
33)  Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS.
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.
J. Cell. Physiol. 216: 824-34, 2008.
34)  Strizzi L, Abbott DE, Salomon DS, Hendrix MJ.
Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma.
Cell Cycle. 7: 1931-5, 2008.
35)  Bianco C, Strizzi L, Mancino M, Watanabe K, Gonzales M, Hamada S, Raafat A, Sahlah L, Chang C, Sotgia F, Normanno N, Lisanti M, Salomon DS.
Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells.
Am. J. Pathol. 172: 345-57, 2008.
36)  Mancino M, Strizzi L, Wechselberger C, Watanabe K, Gonzales M, Hamada S, Normanno N, Salomon DS, Bianco C.
Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells.
J. Cell. Physiol. 215: 192-203, 2008.
37)  Hirota M, Watanabe K, Hamada S, Sun Y, Strizzi L, Mancino M, Nagaoka T, Gonzales M, Seno M, Bianco C, Salomon DS.
Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300.
Cell. Signal. 20: 1632-1641, 2008.
38)  Hamada S, Watanabe K, Hirota M, Bianco C, Strizzi L, Mancino M, Gonzales M, Salomon DS.
beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1.
Biochem. Biophys. Res. Commun. 355: 240-4, 2007.
39)  Strizzi L, Bianco C, Hirota M, Watanabe K, Mancino M, Hamada S, Raafat A, Lawson S, Ebert AD, D'Antonio A, Losito S, Normanno N, Salomon DS.
Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice.
J. Pathol. 211: 36-44, 2007.
40)  Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS.
Growth factor induction of cripto-1 shedding by GPI-phospholipase D and enhancement of endothelial cell migration.
J Biol Chem. 282: 31643-55, 2007.
41)  Mechsner S, Schwarz J, Thode J, Loddenkemper C, Salomon DS, Ebert AD.
Growth-associated protein 43-positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions.
Fertil Steril. 88: 581-7, 2007.
42)  Raafat A, Zoltan-Jones A, Strizzi L, Bargo S, Kimura K, Salomon D, Callahan R.
Kit and PDGFR-a activities are necessary for Notch4/Int3 induced tumorigenesis.
Oncogene. 26: 662-672, 2007.
43)  Watanabe K, Hamada S, Bianco C, Mancino M, Nagaoka T, Gonzales M, Bailly V, Strizzi L, Salomon DS.
Requirement of glycosylphosphatidylinositol anchor of Cripto-1 for trans activity as a Nodal co-receptor.
J. Biol. Chem. 282: 35772-86, 2007.
44)  Stephens EB, Jackson M, Cui L, Pacyniak E, Choudhuri R, Liverman CS, Salomon DS, Berman NE.
Early dysregulation of cripto-1 and immunomodulatory genes in the cerebral cortex in a macaque model of neuroAIDS.
Neurosci. Lett. 410: 94-9, 2006.
45)  Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS.
Epidermal growth factor receptor (EGFR) signaling in cancer.
Gene. 366: 2-16, 2006.
46)  Bianco C, Strizzi L, Mancino M, Rehman A, Hamada S, Watanabe K, De Luca A, Jones B, Balogh G, Russo J, Mailo D, Palaia R, D'Aiuto G, Botti G, Perrone F, Salomon DS, Normanno N.
Identification of cripto-1 as a novel serologic marker for breast and colon cancer.
Clin. Cancer Res. 12: 5158-64, 2006.
47)  Salomon DS.
Melanoma pathogenesis and Nodal: a partial picture?.
Nat. Med. 12: 1231; author reply 1231, 2006.
48)  Strizzi L, Bianco C, Normanno N, Salomon D.
Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis.
Oncogene. 24: 5731-41, 2005.
49)  Bianco C, Strizzi L, Normanno N, Khan N, Salomon DS.
Cripto-1: an oncofetal gene with many faces.
Curr Top Dev Biol. 67: 85-133, 2005.
50)  Wechselberger C, Strizzi L, Kenney N, Hirota M, Sun Y, Ebert A, Orozco O, Bianco C, Khan NI, Wallace-Jones B, Normanno N, Adkins H, Sanicola M, Salomon DS.
Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma.
Oncogene. 24: 4094-105, 2005.
51)  Wechselberger C, Bianco C, Strizzi L, Ebert AD, Kenney N, Sun Y, Salomon DS.
Modulation of TGF-beta signaling by EGF-CFC proteins.
Exp. Cell Res. 310: 249-55, 2005.
52)  Strizzi L, Bianco C, Raafat A, Abdallah W, Chang C, Raafat D, Hirota M, Hamada S, Sun Y, Normanno N, Callahan R, Hinck L, Salomon D.
Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo.
J. Cell. Sci. 118: 4633-43, 2005.
53)  Sun Y, Lowther W, Kato K, Bianco C, Kenney N, Strizzi L, Raafat D, Hirota M, Khan NI, Bargo S, Jones B, Salomon D, Callahan R.
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.
Oncogene. 24: 5365-74, 2005.
54)  Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, Kenney N, Wechselberger C, Callahan R, Salomon DS.
Overexpression of human cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.
Am J Pathol. 167: 585-97, 2005.
55)  Mechsner S, Bartley J, Loddenkemper C, Salomon DS, Starzinski-Powitz A, Ebert AD.
Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts.
Fertil. Steril. 83 Suppl 1: 1220-31, 2005.
56)  Bianco C, Strizzi L, Ebert A, Chang C, Rehman A, Normanno N, Guedez L, Salloum R, Ginsburg E, Sun Y, Khan N, Hirota M, Wallace-Jones B, Wechselberger C, Vonderhaar BK, Tosato G, Stetler-Stevenson WG, Sanicola M, Salomon DS.
Role of human cripto-1 in tumor angiogenesis.
J Natl Cancer Inst. 97: 132-41, 2005.
57)  Normanno N, Bianco C, Strizzi L, Mancino M, Maiello MR, De Luca A, Caponigro F, Salomon DS.
The ErbB receptors and their ligands in cancer: an overview.
Curr Drug Targets. 6: 243-57, 2005.
58)  Normanno N, De Luca A, Bianco C, Maiello MR, Carriero MV, Rehman A, Wechselberger C, Arra C, Strizzi L, Sanicola M, Salomon DS.
Cripto-1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF-7 breast cancer cells.
J Cell Physiol. 198: 31-9, 2004.
59)  Normanno N, De Luca A, Maiello MR, Bianco C, Mancino M, Strizzi L, Arra C, Ciardiello F, Agrawal S, Salomon DS.
CRIPTO-1: a novel target for therapeutic intervention in human carcinoma.
Int. J. Oncol. 25: 1013-20, 2004.
60)  Salomon DS, Lewis MT.
Embryogenesis and oncogenesis: dr jekyll and mr hyde.
J Mammary Gland Biol Neoplasia. 9: 105-7, 2004.
61)  Strizzi L, Bianco C, Normanno N, Seno M, Wechselberger C, Wallace-Jones B, Khan NI, Hirota M, Sun Y, Sanicola M, Salomon DS.
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice.
J Cell Physiol. 201: 266-76, 2004.
62)  Bianco C, Normanno N, Salomon DS, Ciardiello F.
Role of the cripto (EGF-CFC) family in embryogenesis and cancer.
Growth Factors. 22: 133-9, 2004.
63)  Bianco C, Strizzi L, Rehman A, Normanno N, Wechselberger C, Sun Y, Khan N, Hirota M, Adkins H, Williams K, Margolis RU, Sanicola M, Salomon DS.
A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.
Cancer Res. 63: 1192-7, 2003.
64)  Adkins HB, Bianco C, Schiffer SG, Rayhorn P, Zafari M, Cheung AE, Orozco O, Olson D, De Luca A, Chen LL, Miatkowski K, Benjamin C, Normanno N, Williams KP, Jarpe M, LePage D, Salomon D, Sanicola M.
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.
J. Clin. Invest. 112: 575-87, 2003.
65)  Kenney NJ, Bowman A, Korach KS, Barrett JC, Salomon DS.
Effect of exogenous epidermal-like growth factors on mammary gland development and differentiation in the estrogen receptor-alpha knockout (ERKO) mouse.
Breast Cancer Res Treat. 79: 161-73, 2003.
66)  Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS.
Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.
Endocr Relat Cancer. 10: 1-21, 2003.
67)  Normanno N, Campiglio M, De LA, Somenzi G, Maiello M, Ciardiello F, Gianni L, Salomon DS, Menard S.
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth.
Ann Oncol. 13: 65-72, 2002.
68)  Bianco C, Adkins HB, Wechselberger C, Seno M, Normanno N, De Luca A, Sun Y, Khan N, Kenney N, Ebert A, Williams KP, Sanicola M, Salomon DS.
Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.
Mol Cell Biol. 22: 2586-97, 2002.
69)  Adamson ED, Minchiotti G, Salomon DS.
Cripto: a tumor growth factor and more.
J Cell Physiol. 190: 267-78, 2002.
70)  Bianco C, Normanno N, De Luca A, Maiello MR, Wechselberger C, Sun Y, Khan N, Adkins H, Sanicola M, Vonderhaar B, Cohen B, Seno M, Salomon D.
Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein.
J Cell Physiol. 190: 74-82, 2002.
71)  D'Antonio A, Losito S, Pignata S, Grassi M, Perrone F, De Luca A, Tambaro R, Bianco C, Gullick WJ, Johnson GR, Iaffaioli VR, Salomon DS, Normanno N.
Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas.
Int J Oncol. 21: 941-8, 2002.
72)  Kenney NJ, Smith GH, Lawrence E, Barrett JC, Salomon DS.
Identification of Stem Cell Units in the Terminal End Bud and Duct of the Mouse Mammary Gland.
J Biomed Biotechnol. 1: 133-143, 2001.
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This page was last updated on 4/29/2013.