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Our Science – Sterneck Website

Esta Sterneck, Ph.D.

Selected Publications

1)  Balamurugan K, Sterneck E.
The Many Faces of C/EBPdelta and their Relevance for Inflammation and Cancer.
Int J Biol Sci. 9(9): 917-933, 2013.
Full Text Article. [Journal]
2)  Veltmaat JM, Ramsdell AF, Sterneck E.
Positional Variations in Mammary Gland Development and Cancer.
J Mammary Gland Biol Neoplasia. 18: 179-88, 2013.
3)  Balamurugan K, Sharan S, Klarmann KD, Zhang Y, Coppola V, Summers GH, Roger T, Morrison DK, Keller JR, Sterneck E.
FBXW7a attenuates inflammatory signalling by downregulating C/EBPd and its target gene Tlr4.
Nat Commun. 4: 1662, 2013.
4)  Sarkar TR, Sharan S, Wang J, Pawar SA, Cantwell C, Johnson PF, Morrison DK, Wang J, Sterneck E.
Identification of a Src Tyrosine Kinase/SIAH2 E3 Ubiquitin Ligase Pathway that Regulates C/EBPδ Expression and Contributes to Transformation of Breast Tumor Cells.
Mol. Cell Biol. 32: 320-32, 2012.
5)  Pawar SA, Sarkar TR, Balamurugan K, Sharan S, Wang J, Zhang Y, Dowdy SF, Huang A, Sterneck E.
C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.
Proc. Natl. Acad. Sci. U.S.A. 107: 9210-5, 2010.
6)  Ko CY, Chang LH, Lee YC, Sterneck E, Cheng CP, Chen SH, Huang AM, Tseng JT, Wang JM.
CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells.
Neurobiol. Aging. 33: 422.e11-25, 2012.
7)  Wang J, Sarkar TR, Zhou M, Sharan S, Ritt DA, Veenstra TD, Morrison DK, Huang AM, Sterneck E.
CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Proc. Natl. Acad. Sci. U.S.A. 107: 16131-6, 2010.
8)  Pan YC, Li CF, Ko CY, Pan MH, Chen PJ, Tseng JT, Wu WC, Chang WC, Huang AM, Sterneck E, Wang JM.
CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells.
Clin. Cancer Res. 16: 5770-80, 2010.
9)  Balamurugan K, Wang J, Tsai H, Sharan S, Anver M, Leighty R, Sterneck E.
The tumour suppressor C/EBPdelta inhibits FBXW7 expression and promotes mammary tumour metastasis.
EMBO J. 29: 4106-17, 2010.
10)  Hour T, Lai Y, Kuan C, Chou C, Wang J, Tu H, Hu H, Lin C, Wu W, Pu Y, Sterneck E, Huang A.
Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells.
Biochem. Pharmacol. 80: 325-34, 2010.
11)  Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS.
MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.
Science. 324: 938-41, 2009.
12)  Smink JJ, Bégay V, Schoenmaker T, Sterneck E, de Vries TJ, Leutz A.
Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
EMBO J. 28: 1769-81, 2009.
13)  Huang AM, Rudelius M, Sharan S, McAllister JM, Raffeld M, Christenson LK, Sterneck E.
The Cebpd (C/EBPdelta) gene is induced by luteinizing hormones in ovarian theca and interstitial cells but is not essential for mouse ovary function.
PLoS ONE. 2: e1334, 2007.
14)  Sterneck E, Zhu S, Ramirez A, Jorcano JL, Smart RC.
Conditional Ablation of C/EBP beta Demonstrates its Keratinocyte Specific Requirement for Cell Survival and Mouse Skin Tumorigenesis.
Oncogene. 23:25 (8): 1272-76, 2006.
15)  Thangaraju M, Gopal E, Martin PM, Ananth S, Smith SB, Prasad PD, Sterneck E, Ganapathy V.
SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.
Cancer Res. 66: 11560-4, 2006.
16)  Thangaraju M, Rudelius M, Bierie B, Raffeld M, Sharan S, Hennighausen L, Huang AM, Sterneck E.
C/EBP delta is a critical regulator of pro-apoptotic gene expression during mammary gland involution.
Development. 132: 4675-85, 2005.
17)  Thangaraju M, Sharan S, Sterneck E.
Comparison of Mammary Gland Involution between 129S1 and C57BL/6 Inbred Mouse Strains: Differential Regulation of Bcl2a1, Trp53, Cebpb and Cebpd Expression.
Oncogene. 23: 2548-2553, 2004.
18)  Huang AM, Montagna C, Sharan S, Ni Y, Ried T, Sterneck E.
Loss of CCAAT/Enhancer Binding protein delta Promotes Chromosomal Instability.
Oncogene. 23: 1549-1557, 2004.
19)  Sterneck E, Johnson PF.
CCAAT/Enhancer Binding Proteins (C/EBPs) in Ovulation and Luteinization.
In: Adashi EY (Ed.), Ovulation: Evolving Scientific and Clinical Concepts. Serono Symposia USA: Springer-Verlag, New York, 2000.
20)  Sterneck E, Paylor R, Jackson-Lewis V, Libbey M, Przedborski S, Tessarollo L, Crawley JN, Johnson PF.
Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta.
Proc Natl Acad Sci USA. 95: 10908-13, 1998.
21)  Robinson GW, Johnson PF, Hennighausen L, Sterneck E.
The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland.
Genes Dev. 12: 1907, 1998.
22)  Sterneck E, Tessarollo L, Johnson PF.
An essential role for C/EBPbeta in female reproduction.
Genes Dev. 11: 2153-62, 1997.
Click Here to View Collapsed Bibliography.

This page was last updated on 11/7/2013.