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Our Science – Callahan Website

Robert Callahan, Ph.D.

Selected Publications

1)  Gallahan D, Callahan R.
Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors.
J. Virol. 61: 66-74, 1987.
2)  Robbins J, Blondel BJ, Gallahan D, Callahan R.
Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells.
J. Virol. 66: 2594-9, 1992.
3)  Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith GH, Callahan R.
Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia.
J. Virol. 69: 1932-8, 1995.
4)  Lowther W, Wiley K, Smith GH, Callahan R.
A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences.
J Virol. 79: 10093-6, 2005.
5)  Callahan R, Mudunur U, Bargo S, Raafat A, McCurdy D, Boulanger C, Lowther W, Stephens R, Luke BT, Stewart C, Wu X, Munroe D, Smith GH.
Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors.
Oncotarget. 3: 1320-34, 2012.
6)  Raafat A, Strizzi L, Lashin K, Ginsburg E, McCurdy D, Salomon D, Smith GH, Medina D, Callahan R.
Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice.
PLoS ONE. 7: e43624, 2012.
7)  Baljinnyam B, Klauzinska M, Saffo S, Callahan R, Rubin JS.
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells.
PLoS ONE. 7: e29455, 2012.
8)  Klauzinska M, Baljinnyam B, Raafat A, Rodriguez-Canales J, Strizzi L, Greer YE, Rubin JS, Callahan R.
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.
J. Cell. Physiol. 227: 1960-71, 2012.
9)  Raafat A, Goldhar AS, Klauzinska M, Xu K, Amirjazil I, McCurdy D, Lashin K, Salomon D, Vonderhaar BK, Egan S, Callahan R.
Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland.
J. Cell. Physiol. 226: 1940-52, 2011.
10)  Chiluiza D, Bargo S, Callahan R, Rhoads RE.
Expression of truncated eIF3e resulting from integration of MMTV causes a shift from Cap-dependent to Cap-independent translation.
The Journal of biological chemistry. 2011.
11)  Sun Y, Klauzinska M, Lake RJ, Lee JM, Santopietro S, Raafat A, Salomon D, Callahan R, Artavanis-Tsakonas S.
Trp53 regulates Notch 4 signaling through Mdm2.
J. Cell. Sci. 124: 1067-76, 2011.
12)  Bargo S, Raafat A, McCurdy D, Amirjazil I, Shu Y, Traicoff J, Plant J, Vonderhaar BK, Callahan R.
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Biochem. Biophys. Res. Commun. 400: 606-12, 2010.
13)  Watanabe K, Nagaoka T, Lee JM, Bianco C, Gonzales M, Castro NP, Rangel MC, Sakamoto K, Sun Y, Callahan R, Salomon DS.
Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1.
J. Cell Biol. 187: 343-53, 2009.
14)  Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
Cell. Signal. 21: 916-25, 2009.
15)  Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS, Buono K, Salomon D, Vonderhaar BK, Callahan R.
Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.
Oncogene. 28: 219-30, 2009.
16)  Callahan R, Smith GH.
Common integration sites for MMTV in viral induced mouse mammary tumors.
J Mammary Gland Biol Neoplasia. 13: 309-21, 2008.
17)  Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS.
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland.
J. Cell. Physiol. 216: 824-34, 2008.
18)  Callahan R, Smith GH.
The mouse as a model for mammary tumorigenesis: history and current aspects.
J Mammary Gland Biol Neoplasia. 13: 269, 2008.
19)  Mack DL, Boulanger CA, Callahan R, Smith GH.
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.
Breast Cancer Res. 9: R42, 2007.
20)  Raafat A, Zoltan-Jones A, Strizzi L, Bargo S, Kimura K, Salomon D, Callahan R.
Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis.
Oncogene. 26: 662-72, 2007.
21)  Buttitta F, Martella C, Barassi F, Felicioni L, Salvatore S, Rosini S, D'Antuono T, Chella A, Mucilli F, Sacco R, Mezzetti A, Cuccurullo F, Callahan R, Marchetti A.
Int6 expression can predict survival in early-stage non-small cell lung cancer patients.
Clin Cancer Res. 11: 3198-204, 2005.
22)  Strizzi L, Bianco C, Raafat A, Abdallah W, Chang C, Raafat D, Hirota M, Hamada S, Sun Y, Normanno N, Callahan R, Hinck L, Salomon D.
Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo.
J. Cell. Sci. 118: 4633-43, 2005.
23)  Sun Y, Lowther W, Kato K, Bianco C, Kenney N, Strizzi L, Raafat D, Hirota M, Khan NI, Bargo S, Jones B, Salomon D, Callahan R.
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.
Oncogene. 24: 5365-74, 2005.
24)  Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, Kenney N, Wechselberger C, Callahan R, Salomon DS.
Overexpression of human cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.
Am J Pathol. 167: 585-97, 2005.
25)  De Marchis L, Cropp C, Sheng ZM, Bargo S, Callahan R, DeMarchis L.
Candidate target genes for loss of heterozygosity on human chromosome 17qq21.
Br J Cancer. 90: 2384-2389, 2004.
26)  Raafat A, Bargo S, Anver MR, Callahan R.
Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh).
Oncogene. 23: 9401-7, 2004.
27)  Callahan R, Egan SE.
Notch signaling in mammary development and oncogenesis.
J Mammary Gland Biol Neoplasia. 9: 145-63, 2004.
28)  Rasmussen SB, Kordon E, Callahan R, Smith GH.
Evidence for the transforming activity of a truncated Int6 gene, in vitro.
Oncogene. 20: 5291-301, 2001.
29)  Marchetti A, Buttitta F, Pellegrini S, Bertacca G, Callahan R.
Reduced expression of INT-6/eIF3-p48 in human tumors.
Int J Oncol. 18: 175-9, 2001.
30)  Imatani A, Callahan R.
Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines.
Oncogene. 19: 223-31, 2000.
31)  Callahan R, Smith GH.
MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways.
Oncogene. 19: 992-1001, 2000.
32)  Krebs LT, Xue Y, Norton CR, Shutter JR, Maguire M, Sundberg JP, Gallahan D, Closson V, Kitajewski J, Callahan R, Smith GH, Stark KL, Gridley T.
Notch signaling is essential for vascular morphogenesis in mice.
Genes Dev. 14: 1343-52, 2000.
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This page was last updated on 6/16/2014.