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Our Science – Zheng Website

Zhi-Ming Zheng, M.D., Ph.D.

Selected Publications

1)  Wang X, Wang H, Li Y, Hafner M, Banerjee NS, Tang S, Briskin D, Meyers C, Chow LT, Xie X, Tuschl T, Zheng ZM.
microRNAs are biomarkers of oncogenic human papillomavirus infections.
Proc. Natl. Acad. Sci. U.S.A. 111: 4264-4267, 2014.
2)  Majerciak V, Ni T, Yang W, Meng B, Zhu J, Zheng ZM.
A Viral Genome Landscape of RNA Polyadenylation from KSHV Latent to Lytic Infection.
PLoS Pathog. 9: e1003749, 2013.
3)  Zheng ZM, Huynen M, Baker CC.
A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly.
Proc. Natl. Acad. Sci. U.S.A. 95: 14088-93, 1998.
4)  Zheng ZM, Zhang JH, Zhu WP, He PJ.
Isolation of enterovirus type 71 from the vesicle fluid of an adult patient with hand-foot-mouth disease in China.
Virol. Sinca. 4 (4): 375-382, 1989.
Full Text Article. [Journal]
5)  Zheng ZM, Zhang JH, Hu JM, Liu SF, Zhu WP.
Poxviruses isolated from epidemic erythromelalgia in China.
Lancet. 1: 296, 1988.
6)  Ajiro M, Zheng Z.
Oncogenes and RNA splicing of human tumor viruses.
Emerging Microbes & Infections. 2014.
In Press. [Journal]
7)  Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan K, Zheng Z, Newton AC, Sun P, Zhou H, Fu X.
Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt.
Mol. Cell. 54: 378-91, 2014.
8)  Wang X, Li Y, Ni T, Xie X, Zhu J, Zheng ZM.
Genome sequencing accuracy by RCA-seq versus long PCR template cloning and sequencing in identification of human papillomavirus type 58.
Cell Biosci. 4: 5, 2014.
9)  Li Y, Wang X, Ni T, Wang F, Lu W, Zhu J, Xie X, Zheng ZM.
Human papillomavirus type 58 genome variations and RNA expression in cervical lesions.
J. Virol. 87: 9313-22, 2013.
10)  Massimelli MJ, Majerciak V, Kruhlak M, Zheng ZM.
Interplay between PABPC1 and KSHV ORF57 in accumulation of PAN, a viral lncRNA.
J. Virol. 87: 243-256, 2013.
11)  Tang Y, Horikawa I, Ajiro M, Robles AI, Fujita K, Mondal AM, Stauffer JK, Zheng ZM, Harris CC.
Downregulation of splicing factor SRSF3 induces p53beta, an alternatively spliced isoform of p53 that promotes cellular senescence.
Oncogene. 32: 2792-2798, 2013.
12)  Majerciak V, Zheng ZM.
Tang Y, Stratton CW, eds.
Detection of Viral RNA Splicing in Diagnostic Virology. In: Advanced Techniques in Diagnostic Microbiology.
New York: Springer; 2013. p. 693-748 [Book Chapter]
13)  Mendez-Rios JD, Martens CA, Bruno DP, Porcella SF, Zheng ZM, Moss B.
Genome Sequence of Erythromelalgia-Related Poxvirus Identifies it as an Ectromelia Virus Strain.
PLoS ONE. 7: e34604, 2012.
14)  Ajiro M, Jia R, Zhang L, Liu X, Zheng ZM.
Intron definition and a branch site adenosine at nt 385 control RNA splicing of HPV16 E6*I and E7 expression.
PLoS One. 7: :e46412., 2012.
15)  Jia R, Zheng ZM.
SRSF3 (serine/arginine-rich splicing factor 3).
Atlas Genet Cytogenet Oncol Haematol. 16: 838-840, 2012.
Full Text Article. [Journal]
16)  Pilkington GR, Majerciak V, Bear J, Uranishi H, Zheng ZM, Felber BK.
The Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor.
J. Virol. 86: 13089-94, 2012.
17)  Wang X, Meyers C, Wang HK, Chow LT, Zheng ZM.
Construction of a Full Transcription Map of Human Papillomavirus Type 18 during Productive Viral Infection.
J. Virol. 85: 8080-92, 2011.
18)  Kang J, Pripuzova N, Majerciak V, Kruhlak M, Le S, Zheng ZM.
Kaposi Sarcoma-associated Herpesvirus ORF57 Promotes Escape of Viral and Human IL6 from MicroRNA-mediated Suppression.
J. Virol. 85: 2620-30, 2011.
19)  Kang JG, Majerciak V, Uldrick TS, Wang X, Kruhlak M, Yarchoan R, Zheng ZM.
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.
J. Pathol. 225: 378-89, 2011.
20)  Majerciak V, Uranishi H, Kruhlak M, Pilkington GR, Massimelli MJ, Bear J, Pavlakis GN, Felber BK, Zheng ZM.
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Interacts with Cellular RNA Export Cofactors RBM15 and OTT3 To Promote Expression of Viral ORF59.
J. Virol. 85: 1528-40, 2011.
21)  Zheng ZM, Wang X.
Regulation of cellular miRNA expression by human papillomaviruses.
Biochimica et biophysica acta. 1809: 668-77, 2011.
22)  Massimelli MJ, Kang J, Majerciak V, Le SL, Liewehr DJ, Steinberg SM, Zheng ZM.
Stability of a Long Noncoding Viral RNA Depends on a 9-nt Core Element at the RNA 5' End to Interact with Viral ORF57 and Cellular PABPC1.
Int. J. Biol. Sci. 7: 1145-1160, 2011.
23)  Wang X, Meyers C, Guo M, Zheng ZM.
Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway.
Int. J. Cancer. 129: 1362-72, 2011.
24)  Majerciak V, Kruhlak M, Dagur PK, McCoy JP, Zheng ZM.
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
J. Biol. Chem. 285: 11297-307, 2010.
25)  Majerciak V, Deng M, Zheng ZM.
Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57.
Virology. 407: 206-12, 2010.
26)  Jia R, Li C, McCoy JP, Deng CX, Zheng ZM.
SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance.
Int. J. Biol. Sci. 6: 806-26, 2010.
27)  Zheng ZM.
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
Int. J. Biol. Sci. 6: 730-55, 2010.
28)  Khan SG, Yamanegi K, Zheng ZM, Boyle J, Imoto K, Oh KS, Baker CC, Gozukara E, Metin A, Kraemer KH.
XPC branch-point sequence mutations disrupt U2 snRNP binding, resulting in abnormal pre-mRNA splicing in xeroderma pigmentosum patients.
Hum. Mutat. 31: 167-75, 2010.
29)  Jia R, Liu X, Tao M, Kruhlak M, Guo M, Meyers C, Baker C, Zheng ZM.
Control of the papillomavirus early-to-late switch by differentially expressed SRp20.
J. Virol. 83: 167-180, 2009.
Full Text Article. [Journal]
30)  Bodaghi S, Jia R, Zheng ZM.
Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sites.
Virology. 386: 32-43, 2009.
31)  Majerciak V, Zheng ZM.
Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing.
Front Biosci. 14: 1516-1528, 2009.
32)  Wang X, Wang H, McCoy J, Banerjee NS, Rader JS, Broker TR, Meyers C, Chow LT, Zheng ZM.
Oncogenic HPV Infection Interrupts the Expression of Tumor-suppressive miR-34a through Viral Oncoprotein E6.
RNA. 15: 637-647, 2009.
33)  Jia R, Zheng ZM.
Regulation of bovine papillomavirus type 1 gene expression by RNA processing.
Front Biosci. 14: 1270-1282, 2009.
34)  Unoki M, Kumamoto K, Robles A, Shen JC, Zheng ZM, Harris C.
A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
FEBS Lett. 582: 3868-3874, 2008.
35)  Wang X, Tang S, Le S, Lu R, Rader J, Meyers C, Zheng ZM.
Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth.
PLoS ONE. 3(7): e2557, 2008.
36)  Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX.
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.
Cancer Cell. 14: 312-23, 2008.
37)  Majerciak V, Yamanegi K, Allemand E, Kruhlak M, Krainer AR, Zheng ZM.
Kaposi sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes the expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.
J Virol. 82: 2792-2801, 2008.
Full Text Article. [Journal]
38)  Majerciak V, Pripuzova N, McCoy JP, Gao S, Zheng ZM.
Targeted Disruption of KSHV ORF57 in the Viral Genome Is Detrimental for the Expression of ORF59, K8{alpha}, and K8.1 and the Production of Infectious Virus.
J Virol. 81: 1062-1071, 2007.
Full Text Article. [Journal]
39)  Majerciak V, Yamanegi K, Zheng ZM.
Gene Structure and Expression of Kaposi's Sarcoma-associated Herpesvirus ORF56, 57, 58, and 59.
J Virol. 80: 11968-11981, 2006.
Full Text Article. [Journal]
40)  Haque M, Wang V, Davis DA, Zheng ZM, Yarchoan R.
Genetic Organization and Hypoxic Activation of the Kaposi's Sarcoma-Associated Herpesvirus ORF34-37 Gene Cluster.
J. Virol. 80: 7037-51, 2006.
41)  Unoki M, Shen JC, Zheng ZM, Harris CC.
Novel splice variants of ING4 and their possible roles in regulation of cell growth and motility.
J Biol Chem. 281: 34677-34686, 2006.
Full Text Article. [Journal]
42)  Zheng ZM, Baker CC.
Papillomavirus genome structure, expression, and post-transcriptional regulation.
Front. Biosci. 11: 2286-302, 2006.
43)  Tang S, Tao M, McCoy JP, Zheng ZM.
Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells.
Oncogene. 25: 2094-2104, 2006.
44)  Majerciak V, Yamanegi K, Nie S, Zheng ZM.
Structural and functional analyses of Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 nuclear localization signals in living cells.
J. Biol. Chem. 281: 28365-28378, 2006.
Full Text Article. [Journal]
45)  Tang S, Tao M, McCoy JP, Zheng ZM.
The high-risk E7 is translated from spliced E6*I transcripts in human papillomavirus 16- or 18-positive cervical cancer cell lines via translation re-initiation.
J. Virol. 80: 4249-4263, 2006.
46)  Bodaghi S, Yamanegi K, Xiao SY, Da Costa M, Palefsky JM, Zheng ZM.
Colorectal papillomavirus infection in patients with colorectal cancer.
Clin Cancer Res. 11: 2862-7, 2005.
47)  Bodaghi S, Wood LV, Roby G, Ryder C, Steinberg SM, Zheng ZM.
Could human papillomaviruses be spread through blood?.
J. Clin. Microbiol. 43: 5428-5434, 2005.
48)  Zheng ZM, Tang S, Tao M.
Development of Resistance to RNAi in Mammalian Cells.
Ann NY Acad Sci. 1058: 105-118, 2005.
49)  Yamanegi K, Tang S, Zheng ZM.
Kaposi's sarcoma-associated herpesvirus K8ß is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8α (K-bZIP) to induce p21 and p53 and blocks K8α-CDK2 interaction.
J. Virol. 79: 14207-14221, 2005.
50)  Zheng ZM.
Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression.
J. Biomed. Sci. 11: 278-294, 2004.
51)  Tang S, Yamanegi K, Zheng ZM.
Requirement of a 12 bp TATT-containing sequence and viral lytic DNA replication in activation of the Kaposi's sarcoma-associated herpesvirus K8.1 late promoter.
J. Virol. 78: 2609-2614, 2004.
52)  Zheng ZM, Tao M, Yamanegi K, Bodaghi S, Xiao W.
Splicing of a cap-proximal human papillomavirus 16 E6E7 intron promotes E7 expression, but can be restrained by distance of the intron from its RNA 5' cap.
J. Mol. Biol. 337: 1091-1108, 2004.
53)  Liu X, Mayeda A, Tao M, Zheng ZM.
Exonic Splicing Enhancer-Dependent Selection of the Bovine Papillomavirus Type 1 Nucleotide 3225 3' Splice Site Can Be Rescued in a Cell Lacking Splicing Factor ASF/SF2 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway.
J. Virol. 77: 2105-2115, 2003.
54)  Tao M, Kruhlak M, Xia S, Androphy E, Zheng ZM.
Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells.
J. Virol. 77: 13232-13247, 2003.
55)  Zheng ZM.
Split Genes and Their Expression in Kaposi's Sarcoma-Associated Herpesvirus.
Rev. Med. Virol. 13: 173-184, 2003.
56)  Tang S, Zheng ZM.
Kaposi's Sarcoma-associated Herpesvirus K8 Exon 3 Contains Three 5'-Splice Sites and Harbors a K8.1 Transcription Start site.
J. Biol. Chem. 277: 14547-56., 2002.
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This page was last updated on 7/6/2014.