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Our Science – Brechbiel Website

Martin W. Brechbiel, Ph.D.

Selected Publications

1)  Brechbiel M, Gansow O, Atcher R, Schlom J, Esteban J, Simpson D, Colcher D.
Synthesis of 1-(p-Isothiocyanatobenzyl) derivatives of DTPA and EDTA: Antibody labeling and tumor-imaging studies.
Inorg Chem. 25: 2772, 1986.
2)  Wu C, Kobayashi H, Sun B, Yoo TM, Paik CH, Gansow OA, Carrasquillo JA, Pastan I, Brechbiel MW.
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorg. Med. Chem. 5: 1925-34, 1997.
3)  Jurcic JG, Larson SM, Sgouros G, McDevitt MR, Finn RD, Divgi CR, Ballangrud AM, Hamacher KA, Ma D, Humm JL, Brechbiel MW, Molinet R, Scheinberg DA.
Targeted alpha particle immunotherapy for myeloid leukemia.
Blood. 100: 1233-9, 2002.
4)  Milenic DE, Garmestani K, Brady ED, Albert PS, Ma D, Abdulla A, Brechbiel MW.
Targeting of HER2 antigen for the treatment of disseminated peritoneal disease.
Clin Cancer Res. 10: 7834-41, 2004.
5)  Yong KJ, Milenic DE, Baidoo KE, Brechbiel MW.
(212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease.
Mol. Cancer Ther. 11: 639-48, 2012.
6)  Guérard F, Lee Y, Brechbiel MW.
Rational Design, Synthesis, and Evaluation of Tetrahydroxamic Acid Chelators for Stable Complexation of Zirconium(IV).
Chemistry. [Epub ahead of print], 2014.
7)  Sarkar SK, Bumb A, Wu X, Sochacki KA, Kellman P, Brechbiel MW, Neuman KC.
Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence.
Biomed Opt Express. 5: 1190-202, 2014.
8)  Yong KJ, Milenic DE, Baidoo KE, Brechbiel MW.
212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpoint.
Br. J. Cancer. 108: 2013-20, 2013.
9)  Milenic DE, Baidoo KE, Shih JH, Wong KJ, Brechbiel MW.
Evaluation of platinum chemotherapy in combination with HER2-targeted a-particle radiation.
Cancer Biother. Radiopharm. 28: 441-9, 2013.
10)  Yong KJ, Milenic DE, Baidoo KE, Kim YS, Brechbiel MW.
Gene expression profiling upon (212) Pb-TCMC-trastuzumab treatment in the LS-174T i.p. xenograft model.
Cancer Med. 2: 646-53, 2013.
Click Here to View Expanded Bibliography.

This page was last updated on 6/16/2014.