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David A. Wink Jr., Ph.D.

Selected Publications

1)  Miranda KM, Wink DA.
Persulfides and the cellular thiol landscape.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print], 2014.
2)  Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA.
Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.
Proc. Natl. Acad. Sci. U.S.A. 111: 6323-8, 2014.
3)  Basudhar D, Bharadwaj G, Cheng RY, Jain S, Shi S, Heinecke JL, Holland RJ, Ridnour LA, Caceres VM, Spadari-Bratfisch RC, Paolocci N, Velázquez-Martínez CA, Wink DA, Miranda KM.
Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives.
J. Med. Chem. 56: 7804-20, 2013.
4)  Heinrich TA, Dasilva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM.
Biological Nitric Oxide Signaling: Chemistry and Terminology (NO Chemical Biology and Terminology).
Br. J. Pharmacol. 169: 1417-29, 2013.
5)  Soto-Pantoja DR, Ridnour LA, Wink DA, Roberts DD.
Blockade of CD47 increases survival of mice exposed to lethal total body irradiation.
Sci Rep. 3: 1038, 2013.
6)  Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA.
Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity.
Clin. Cancer Res. 19: 1340-6, 2013.
7)  Schoenfeld MP, Ansari RR, Nakao A, Wink D.
A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures.
Med Gas Res. 2: 8, 2012.
8)  Horváth B, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P.
Beta-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner.
Free Radic. Biol. Med. 52: 1325-33, 2012.
9)  Soto-Pantoja DR, Miller TW, Pendrak ML, DeGraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD.
CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.
Autophagy. 8: 1628-42, 2012.
10)  Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA.
Dithiolethiones Inhibit NF-kappaB Activity via Covalent Modification in Human Estrogen Receptor-Negative Breast Cancer.
Cancer Res. 72: 2394-404, 2012.
11)  Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA.
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.
Breast Cancer Res. 14: R125, 2012.
12)  Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease.
PLoS ONE. 7: e44156, 2012.
13)  Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA.
Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation.
PLoS ONE. 7: e44081, 2012.
14)  Ridnour LA, Dhanapal S, Hoos M, Wilson J, Lee J, Cheng RY, Brueggemann EE, Hines HB, Wilcock DM, Vitek MP, Wink DA, Colton CA.
Nitric oxide-mediated regulation of ß-amyloid clearance via alterations of MMP-9/TIMP-1.
J. Neurochem. 123: 736-49, 2012.
15)  Gao WD, Murray CI, Tian Y, Zhong X, DuMond JF, Shen X, Stanley BA, Foster DB, Wink DA, King SB, Van Eyk JE, Paolocci N.
Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.
Circ. Res. 111: 1002-11, 2012.
16)  Moody TW, Osefo N, Nuche-Berenguer B, Ridnour L, Wink D, Jensen RT.
Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells.
J. Pharmacol. Exp. Ther. 341: 873-81, 2012.
17)  Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA.
S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer.
For Immunopathol Dis Therap. 3: 117-124, 2012.
18)  Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA.
S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer.
Mol. Cancer Res. 10: 1203-15, 2012.
19)  Fukuto JM, Carrington SJ, Tantillo DJ, Harrison JG, Ignarro LJ, Freeman BA, Chen A, Wink DA.
Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species.
Chem. Res. Toxicol. 25: 769-93, 2012.
20)  Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA.
Activation of matrix metalloproteinases following anti-Abeta immunotherapy; implications for microhemorrhage occurrence.
J Neuroinflammation. 8: 115, 2011.
21)  Mukhopadhyay P, Rajesh M, Horváth B, Bátkai S, Park O, Tanchian G, Gao RY, Patel V, Wink DA, Liaudet L, Haskó G, Mechoulam R, Pacher P.
Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death.
Free Radic. Biol. Med. 50: 1368-81, 2011.
22)  Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, Nakao A.
Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.
Med. Hypotheses. 76: 117-8, 2011.
23)  Switzer CH, Glynn SA, Ridnour LA, Cheng RY, Vitek MP, Ambs S, Wink DA.
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
Trends Pharmacol. Sci. 32: 644-51, 2011.
24)  Wink DA, Hines HB, Cheng RY, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA.
Nitric oxide and redox mechanisms in the immune response.
J. Leukoc. Biol. 89: 873-91, 2011.
25)  Tocchetti CG, Stanley BA, Murray CI, Sivakumaran V, Donzelli S, Mancardi D, Pagliaro P, Gao WD, van Eyk J, Kass DA, Wink DA, Paolocci N.
Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function.
Antioxid. Redox Signal. 14: 1687-98, 2011.
26)  Flores-Santana W, Moody T, Chen W, Gorczynski MJ, Shoman ME, Velazquez C, Thetford A, Mitchell JB, Cherukuri MK, King SB, Wink DA.
Redox-Modified Non-Steroidal Anti-Inflammatory Drugs as Potential Anti-Cancer Agents with the SOD Mimetic Nitroxide.
Br. J. Pharmacol. 165: 1058-67, 2011.
27)  Switzer CH, Cheng RY, Vitek TM, Christensen DJ, Wink DA, Vitek MP.
Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy.
Oncogene. 30: 2504-13, 2011.
28)  Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA, Paolocci N, Fukuto JM, Miranda KM, Wink DA.
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
Antioxid. Redox Signal. 14: 1659-74, 2011.
29)  Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S, Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L, Haskó G, Liaudet L, Wink DA, Veves A, Mechoulam R, Pacher P.
Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.
J. Am. Coll. Cardiol. 56: 2115-25, 2010.
30)  Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, Goodman JE, Yfantis HG, Lee DH, Ambs S.
COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer.
BMC Cancer. 10: 626, 2010.
31)  Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA.
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.
Lung Cancer. 68: 154-60, 2010.
32)  Andrei D, Salmon DJ, Donzelli S, Wahab A, Klose JR, Citro ML, Saavedra JE, Wink DA, Miranda KM, Keefer LK.
Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.
J. Am. Chem. Soc. 132: 16526-32, 2010.
33)  Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S.
Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.
J. Clin. Invest. 120: 3843-54, 2010.
34)  Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
J. Exp. Med. 207: 2455-67, 2010.
35)  Moody TW, Berna MJ, Mantey S, Sancho V, Ridnour L, Wink DA, Chan D, Giaccone G, Jensen RT.
Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.
Eur. J. Pharmacol. 637: 38-45, 2010.
36)  Jourd'heuil D, Lancaster JR, Fukuto J, Roberts DD, Miranda KM, Mayer B, Grisham MB, Wink DA.
The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well.
J. Biol. Chem. 285: le15; author reply le16, 2010.
37)  Jia Y, Wu S, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD.
Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton.
Cell Stress Chaperones. 15: 165-81, 2010.
38)  Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale A, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S.
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.
Clin. Cancer Res. 15: 4165-73, 2009.
39)  Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM, Fukuto JM, Wink DA.
Comparing the chemical biology of NO and HNO.
Arch. Pharm. Res. 32: 1139-53, 2009.
40)  Switzer CH, Ridnour LA, Cheng RY, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD, Wink DA.
Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.
Oncogene. 28: 3837-46, 2009.
41)  Jackson MI, Han TH, Serbulea L, Dutton A, Ford E, Miranda KM, Houk KN, Wink DA, Fukuto JM.
Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.
Free Radic. Biol. Med. 47: 1130-9, 2009.
42)  Macdonald CJ, Cheng RY, Roberts DD, Wink DA, Yeh GC.
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.
J. Biol. Chem. 284: 22099-107, 2009.
43)  Bass SE, Sienkiewicz P, Macdonald CJ, Cheng RY, Sparatore A, Del Soldato P, Roberts DD, Moody TW, Wink DA, Yeh GC.
Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.
Clin. Cancer Res. 15: 1964-72, 2009.
44)  Mancardi D, Penna C, Merlino A, Del Soldato P, Wink DA, Pagliaro P.
Physiological and pharmacological features of the novel gasotransmitter: Hydrogen sulfide.
Biochim. Biophys. Acta. 1787: 864-72, 2009.
45)  Maxhimer JB, Soto-Pantoja DR, Ridnour LA, Shih HB, Degraff WG, Tsokos M, Wink DA, Isenberg JS, Roberts DD.
Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling.
Sci Transl Med. 1: 3ra7, 2009.
46)  Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM, Paolocci N, Wink DA.
The emergence of nitroxyl (HNO) as a pharmacological agent.
Biochim. Biophys. Acta. 1787: 835-40, 2009.
47)  Samuni Y, Flores-Santana W, Krishna MC, Mitchell JB, Wink DA.
The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.
Free Radic. Biol. Med. 47: 419-23, 2009.
48)  Paolocci N, Wink DA.
The shy Angeli and his elusive creature: the HNO route to vasodilation.
Am. J. Physiol. Heart Circ. Physiol. 296: H1217-20, 2009.
49)  Isenberg JS, Pappan LK, Romeo MJ, Abu-Asab M, Tsokos M, Wink DA, Frazier WA, Roberts DD.
Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts.
Ann. Surg. 247: 180-90, 2008.
50)  Dai S, Jia Y, Wu S, Isenberg JS, Ridnour LA, Bandle RW, Wink DA, Roberts DD, Karger BL.
Comprehensive Characterization of Heat Shock Protein 27 Phosphorylation in Human Endothelial Cells Stimulated by the Microbial Dithiole Thiolutin.
J. Proteome Res. 7: 4384-95, 2008.
51)  Matsumoto S, Espey MG, Utsumi H, Devasahayam N, Matsumoto K, Matsumoto A, Hirata H, Wink DA, Kuppusamy P, Subramanian S, Mitchell JB, Krishna MC.
Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice.
Magn Reson Med. 59: 619-25, 2008.
52)  Isenberg JS, Frazier WA, Krishna MC, Wink DA, Roberts DD.
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.
Curr Drug Targets. 9: 833-41, 2008.
53)  Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang SJ, Stuehr DJ, King SB, Miranda KM, Wink DA.
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine.
Free Radic. Biol. Med. 45: 578-84, 2008.
54)  Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA.
Molecular mechanisms for discrete nitric oxide levels in cancer.
Nitric Oxide. 19: 73-6, 2008.
55)  Wink DA, Paolocci N.
Mother was right: eat your vegetables and do not spit! When oral nitrate helps with high blood pressure.
Hypertension. 51: 617-9, 2008.
56)  Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C, Paolocci N, Ambs S, Colton CA, Harris CC, Roberts DD, Wink DA.
The chemical biology of nitric oxide: implications in cellular signaling.
Free Radic. Biol. Med. 45: 18-31, 2008.
57)  Colton CA, Wilcock DM, Wink DA, Davis J, Van Nostrand WE, Vitek MP.
The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.
J. Alzheimers Dis. 15: 571-87, 2008.
58)  Wink DA, Ridnour LA, Hussain SP, Harris CC.
The reemergence of nitric oxide and cancer.
Nitric Oxide. 19: 65-7, 2008.
59)  Isenberg JS, Hyodo F, Ridnour LA, Shannon CS, Wink DA, Krishna MC, Roberts DD.
Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow.
Neoplasia. 10: 886-96, 2008.
60)  Martin-Manso G, Galli S, Ridnour LA, Tsokos M, Wink DA, Roberts DD.
Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells.
Cancer Res. 68: 7090-9, 2008.
61)  Isenberg JS, Maxhimer JB, Hyodo F, Pendrak ML, Ridnour LA, DeGraff WG, Tsokos M, Wink DA, Roberts DD.
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury.
Am. J. Pathol. 173: 1100-12, 2008.
62)  Isenberg JS, Romeo MJ, Yu C, Yu CK, Nghiem K, Monsale J, Rick ME, Wink DA, Frazier WA, Roberts DD.
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.
Blood. 111: 613-23, 2008.
63)  Isenberg JS, Romeo MJ, Abu-Asab M, Tsokos M, Oldenborg A, Pappan L, Wink DA, Frazier WA, Roberts DD.
Increasing survival of ischemic tissue by targeting CD47.
Circ. Res. 100: 712-20, 2007.
64)  Prueitt RL, Boersma BJ, Howe TM, Goodman JE, Thomas DD, Ying L, Pfiester CM, Yfantis HG, Cottrell JR, Lee DH, Remaley AT, Hofseth LJ, Wink DA, Ambs S.
Inflammation and IGF-I activate the Akt pathway in breast cancer.
Int. J. Cancer. 120: 796-805, 2007.
65)  Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD.
Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.
Br. J. Pharmacol. 151: 63-72, 2007.
66)  Roberts DD, Isenberg JS, Ridnour LA, Wink DA.
Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis.
Clin. Cancer Res. 13: 795-8, 2007.
67)  Ridnour LA, Windhausen AN, Isenberg JS, Yeung N, Thomas DD, Vitek MP, Roberts DD, Wink DA.
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.
Proc. Natl. Acad. Sci. U.S.A. 104: 16898-903, 2007.
68)  Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, Kass DA, Paolocci N.
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Circ. Res. 100: 96-104, 2007.
69)  Lopez BE, Wink DA, Fukuto JM.
The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO).
Arch Biochem Biophys. 465: 430-6, 2007.
70)  Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA, Hobbs AJ, Fukuto JM.
The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO.
Pharmacol. Ther. 113: 442-58, 2007.
71)  Isenberg JS, Jia Y, Fukuyama J, Switzer CH, Wink DA, Roberts DD.
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake.
J. Biol. Chem. 282: 15404-15, 2007.
72)  Isenberg JS, Hyodo F, Matsumoto K, Romeo MJ, Abu-Asab M, Tsokos M, Kuppusamy P, Wink DA, Krishna MC, Roberts DD.
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
Blood. 109: 1945-52, 2007.
73)  Thomas DD, Ridnour L, Donzelli S, Espey MG, Mancardi D, Isenberg J, Feelisch M, Roberts D, Wink DA.
Dalle-Done I, Scaloni A, Butterfield A, eds.
Nitric Oxide and Related Nitrogen Oxides: Chemistry of Protein Adducts. In: Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases.
New York: Wiley Interscience; 2006. p. 25-58 [Book Chapter]
74)  Thomas DD, Espey MG, Pociask DA, Ridnour LA, Donzelli S, Wink DA.
Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite.
Cancer Res. 66: 11600-4, 2006.
75)  Isenberg JS, Ridnour LA, Dimitry J, Frazier WA, Wink DA, Roberts DD.
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1.
J. Biol. Chem. 281: 26069-80, 2006.
76)  Donzelli S, Espey MG, Thomas DD, Mancardi D, Tocchetti CG, Ridnour LA, Paolocci N, King SB, Miranda KM, Lazzarino G, Fukuto JM, Wink DA.
Discriminating formation of HNO from other reactive nitrogen oxide species.
Free Radic. Biol. Med. 40: 1056-66, 2006.
77)  Isenberg JS, Ridnour LA, Thomas DD, Wink DA, Roberts DD, Espey MG.
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients.
Free Radic. Biol. Med. 40: 1028-33, 2006.
78)  Dutton AS, Suhrada CP, Miranda KM, Wink DA, Fukuto JM, Houk KN.
Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations.
Inorg Chem. 45: 2448-56, 2006.
79)  Colton CA, Vitek MP, Wink DA, Xu Q, Cantillana V, Previti ML, Van Nostrand WE, Weinberg JB, Weinberg B, Dawson H.
NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.
Proc. Natl. Acad. Sci. U.S.A. 103: 12867-72, 2006.
80)  Katori T, Donzelli S, Tocchetti CG, Miranda KM, Cormaci G, Thomas DD, Ketner EA, Lee MJ, Mancardi D, Wink DA, Kass DA, Paolocci N.
Peroxynitrite and myocardial contractility: in vivo versus in vitro effects.
Free Radic. Biol. Med. 41: 1606-18, 2006.
81)  Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, DeGraff W, Roberts DD, Mitchell JB, Wink DA.
Superoxide fluxes limit nitric oxide-induced signaling.
J. Biol. Chem. 281: 25984-93, 2006.
82)  Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB, Lazzarino G, Miranda KM, Roberts DD, Feelisch M, Wink DA.
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.
Antioxid. Redox Signal. 8: 1363-71, 2006.
83)  Ridnour LA, Thomas DD, Donzelli S, Espey MG, Roberts DD, Wink DA, Isenberg JS.
The biphasic nature of nitric oxide responses in tumor biology.
Antioxid. Redox Signal. 8: 1329-37, 2006.
84)  Isenberg JS, Wink DA, Roberts DD.
Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses.
Cardiovasc. Res. 71: 785-93, 2006.
85)  Miranda KM, Dutton AS, Ridnour LA, Foreman CA, Ford E, Paolocci N, Katori T, Tocchetti CG, Mancardi D, Thomas DD, Espey MG, Houk KN, Fukuto JM, Wink DA.
A discussion of the mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
J. Am. Chem. Soc. 127: 722-731, 2005.
86)  Hamelink C, Hampson A, Wink DA, Eiden LE, Eskay RL.
Comparison of cannabidiol, antioxidants and diuretics in reversing binge ethanol-induced neurotoxicity.
J Pharmacol Exp Ther. 2005.
87)  Miranda KM, Katori T, Torres de Holding CL, Thomas L, Ridnour LA, McLendon WJ, Cologna SM, Dutton AS, Champion HC, Mancardi D, Tocchetti CG, Saavedra JE, Keefer LK, Houk KN, Fukuto JM, Kass DA, Paolocci N, Wink DA.
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.
J. Med. Chem. 48: 8220-8, 2005.
88)  Miranda KM, Dutton AS, Ridnour LA, Foreman CA, Ford E, Paolocci N, Katori T, Tocchetti CG, Mancardi D, Thomas DD, Espey MG, Houk KN, Fukuto JM, Wink DA.
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
J Am Chem Soc. 127: 722-31, 2005.
89)  Hewett SJ, Espey MG, Uliasz TF, Wink DA.
Neurotoxicity of nitroxyl: insights into HNO and NO biochemical imbalance.
Free Radic. Biol. Med. 39: 1478-88, 2005.
90)  Isenberg JS, Ridnour LA, Espey MG, Wink DA, Roberts DD.
Nitric oxide in wound-healing.
Microsurgery. 25: 442-51, 2005.
91)  Ridnour LA, Isenberg JS, Espey MG, Thomas DD, Roberts DD, Wink DA.
Nitric Oxide regulates angiogenesis through a functional switch involving Thrombospondin-1.
Proc. Natl. Acad. Sci. U S A. 102: 13147-52, 2005.
92)  Fukuto JM, Switzer CH, Miranda KM, Wink DA.
Nitroxyl (HNO): chemistry, biochemistry, and pharmacology.
Annu Rev Pharmacol Toxicol. 45: 335-55, 2005.
93)  Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Feelisch M, Lundberg JO.
The emerging biology of the nitrite anion.
Nat. Chem. Biol. 1: 308-14, 2005.
94)  Fukuto JM, Bartberger MD, Dutton AS, Paolocci N, Wink DA, Houk KN.
The Physiological Chemistry and Biological Activity of Nitroxyl (HNO): The Neglected, Misunderstood, and Enigmatic Nitrogen Oxide.
Chem Res Toxicol. 18: 790-801, 2005.
95)  Isenberg JS, Ridnour LA, Perruccio EM, Espey MG, Wink DA, Roberts DD.
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-Dependent Manner.
Proc. Natl. Acad. Sci. U S A. 102: 13141-6, 2005.
96)  Ridnour LA, Thomas DD, Mancardi D, Donzelli S, Paolocci N, Pagliaro P, Miranda KM, Krishna MC, Fukuto J, Grisham MB, Mitchell JB, Espey MG, Wink DA.
Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between NO and oxidative stress.
Med. Chem. in press, 2004.
97)  Miranda KM, Ridnour LA, Espey MG, Katori T, Tocchetti CG, Citrin D, Thomas DD, Mancardi D, Ferlito M, Donzelli S, Fukuto JM, Paolocci N, Wink DA.
Comparison of the Chemical Biology of NO and HNO: An Inorganic Perspective.
Progress Inorg. Chem. in press, 2004.
98)  Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, Wink DA.
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.
Proc Natl Acad Sci U S A. 101: 8894-9, 2004.
99)  Tarpey MM, Wink DA, Grisham MB.
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
Am J Physiol Regul Integr Comp Physiol. 286: R431-44, 2004.
100)  Xu Q, Wink DA, Colton CA.
Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons.
Exp Neurol. 188: 341-50, 2004.
101)  Cook JA, Gius D, Wink DA, Krishna MC, Russo A, Mitchell JB.
Oxidative stress, redox, and the tumor microenvironment.
Semin Radiat Oncol. 14: 259-66, 2004.
102)  Mancardi D, Ridnour LA, Thomas DD, Katori T, Tocchetti CG, Espey MG, Miranda KM, Paolocci N, Wink DA.
The chemical dynamics of NO and reactive nitrogen oxides: a practical guide.
Curr Mol Med. 4: 723-40, 2004.
103)  Ridnour LA, Thomas DD, Mancardi D, Espey MG, Miranda KM, Paolocci N, Feelisch M, Fukuto J, Wink DA.
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.
Biol Chem. 385: 1-10, 2004.
104)  Miranda KM, Paolocci N, Katori T, Thomas DD, Ford E, Bartberger MD, Espey MG, Kass DA, Feelisch M, Fukuto JM, Wink DA.
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.
Proc. Natl. Acad. Sci. USA. 100: 9196-201, 2003.
105)  Miranda KM, Nims RW, Thomas DD, Espey MG, Citrin D, Bartberger MD, Paolocci N, Fukuto JM, Feelisch M, Wink DA.
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.
J Inorg Biochem. 93: 52-60, 2003.
106)  Thomas DD, Miranda KM, Colton CA, Citrin D, Espey MG, Wink DA.
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.
Antioxid Redox Signal. 5: 307-17, 2003.
107)  Sidorkina O, Espey MG, Miranda KM, Wink DA, Laval J.
Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species.
Free Radic Biol Med. 35: 1431-8, 2003.
108)  Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, Harris CC.
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Proc Natl Acad Sci U S A. 100: 143-8, 2003.
109)  Pagliaro P, Mancardi D, Rastaldo R, Penna C, Gattullo D, Miranda KM, Feelisch M, Wink DA, Kass DA, Paolocci N.
Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.
Free Radic Biol Med. 34: 33-43, 2003.
110)  Paolocci N, Katori T, Champion HC, St John ME, Miranda KM, Fukuto JM, Wink DA, Kass DA.
Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling.
Proc. Natl. Acad. Sci. US A. 100: 5537-42, 2003.
111)  Wink DA, Miranda KM, Katori T, Mancardi D, Thomas DD, Ridnour L, Espey MG, Feelisch M, Colton CA, Fukuto JM, Pagliaro P, Kass DA, Paolocci N.
The Orthogonal Properties of the Redox Siblings Nitroxyl (HNO) and Nitric Oxide (NO) in the Cardiovascular System: A Novel Redox Paradigm.
Am. J. Physiol. Heart Circ. Physiol. 285: H2264-76, 2003.
112)  Espey MG, Miranda KM, Thomas DD, Xavier S, Citrin D, Vitek MP, Wink DA.
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.
Ann N Y Acad Sci. 962: 195-206, 2002.
113)  Wink DA, Citrin D, Vitek MP, Colton C, Pacelli R, Ogawa R, Thomas DD, Miranda KM, Espey MG.
Chemical Role of Reactive Nitrogen Oxide Species in Immunological Response.
Encyclopedia of Life - Nature Publishing (on line). 2002.
114)  Espey MG, Xavier S, Thomas DD, Miranda KM, Wink DA.
Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms.
Proc Natl Acad Sci U S A. 99: 3481-6, 2002.
115)  Espey MG, Thomas DD, Miranda KM, Wink DA.
Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide.
Proc Natl Acad Sci U S A. 99: 11127-32, 2002.
116)  Miranda KM, Yamada K, Espey MG, Thomas DD, DeGraff W, Mitchell JB, Krishna MC, Colton CA, Wink DA.
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
Arch Biochem Biophys. 401: 134-44, 2002.
117)  Thomas DD, Miranda KM, Espey MG, Citrin D, Jourd'heuil D, Paolocci N, Hewett SJ, Colton CA, Grisham MB, Feelisch M, Wink DA.
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems.
Methods Enzymol. 359: 84-105, 2002.
118)  Espey MG, Miranda KM, Thomas DD, Wink DA.
Ingress and reactive chemistry of nitroxyl-derived species within human cells.
Free Radic Biol Med. 33: 827-34, 2002.
119)  Thomas DD, Espey MG, Vitek MP, Miranda KM, Wink DA.
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction.
Proc Natl Acad Sci U S A. 99: 12691-6, 2002.
120)  Bartberger MD, Liu W, Ford E, Miranda KM, Switzer C, Fukuto JM, Farmer PJ, Wink DA, Houk KN.
The reduction potential of nitric oxide (NO) and its importance to NO biochemistry.
Proc Natl Acad Sci U S A. 99: 10958-63, 2002.
121)  Miranda KM, Espey MG, Wink DA.
A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite.
Nitric Oxide. 5: 62-71, 2001.
122)  Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A.
Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listeriocidal activity of oxidative and nitrosative stress.
Free Radic Biol Med. 30: 268-76, 2001.
123)  Wink DA, Miranda KM, Espey MG.
Cytotoxicity related to oxidative and nitrosative stress by nitric oxide.
Exp Biol Med (Maywood). 226: 621-3, 2001.
124)  Espey MG, Miranda KM, Thomas DD, Wink DA.
Distinction between nitrosating mechanisms within human cells and aqueous solution.
J Biol Chem. 276: 30085-91, 2001.
125)  Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C, Vitek M, Feelisch M, Grisham MB.
Mechanisms of the antioxidant effects of nitric oxide.
Antioxid Redox Signal. 3: 203-13, 2001.
126)  Paolocci N, Saavedra WF, Miranda KM, Martignani C, Isoda T, Hare JM, Espey MG, Fukuto JM, Feelisch M, Wink DA, Kass DA.
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.
Proc Natl Acad Sci U S A. 98: 10463-8, 2001.
127)  Colton CA, Gbadegesin M, Wink DA, Miranda KM, Espey MG, Vicini S.
Nitroxyl anion regulation of the NMDA receptor.
J Neurochem. 78: 1126-34, 2001.
128)  Miranda KM, Espey MG, Yamada K, Krishna M, Ludwick N, Kim S, Jourd'heuil D, Grisham MB, Feelisch M, Fukuto JM, Wink DA.
Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion.
J Biol Chem. 276: 1720-7, 2001.
129)  Miranda KM, Espey MG, Wink DA.
A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity.
J Inorg Biochem. 79: 237-40, 2000.
130)  Wink DA, Miranda KM, Espey MG.
Effects of oxidative and nitrosative stress in cytotoxicity.
Semin Perinatol. 24: 20-3, 2000.
131)  Zhou X, Espey MG, Chen JX, Hofseth LJ, Miranda KM, Hussain SP, Wink DA, Harris CC.
Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase.
J Biol Chem. 275: 21241-6, 2000.
132)  Espey MG, Miranda KM, Feelisch M, Fukuto J, Grisham MB, Vitek MP, Wink DA.
Mechanisms of cell death governed by the balance between nitrosative and oxidative stress.
Ann N Y Acad Sci. 899: 209-21, 2000.
133)  Espey MG, Miranda KM, Pluta RM, Wink DA.
Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals.
J Biol Chem. 275: 11341-7, 2000.
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This page was last updated on 5/21/2014.