Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – Cherukuri Website

Murali Krishna Cherukuri, Ph.D.

Selected Publications

1)  Li F, Pang X, Krausz KW, Jiang C, Chen C, Cook JA, Krishna MC, Mitchell JB, Gonzalez FJ, Patterson AD.
Stable Isotope- and Mass Spectrometry-based Metabolomics as Tools in Drug Metabolism: A Study Expanding Tempol Pharmacology.
J. Proteome Res. 12: 1369-76, 2013.
[Journal]
2)  Subramanian S, Devasahayam N, Matsumoto S, Saito K, Mitchell JB, Krishna MC.
Echo-based Single Point Imaging (ESPI): a novel pulsed EPR imaging modality for high spatial resolution and quantitative oximetry.
J. Magn. Reson. 218: 105-14, 2012.
[Journal]
3)  Krishna MC, Matsumoto S, Yasui H, Saito K, Devasahayam N, Subramanian S, Mitchell JB.
Electron paramagnetic resonance imaging of tumor pO2.
Radiat. Res. 177: 376-86, 2012.
[Journal]
4)  Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC.
EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.
Magn Reson Med. [Epub ahead of print], 2012.
[Journal]
5)  Subramanian S, Chandramouli GV, McMillan A, Gullapalli RP, Devasahayam N, Mitchell JB, Matsumoto S, Krishna MC.
Evaluation of partial k-space strategies to speed up time-domain EPR imaging.
Magn Reson Med. [Epub ahead of print], 2012.
[Journal]
6)  Thavavel V, Basha J, Krishna M, Murugesan R.
Heuristic wavelet approach for low-dose EPR tomographic reconstruction: An applicability analysis wth phantom and in vivo imaging.
Expert Syst Appl. 39: 5717-5726, 2012.
[Journal]
7)  Saito K, Matsumoto S, Yasui H, Devasahayam N, Subramanian S, Munasinghe JP, Patel V, Gutkind JS, Mitchell JB, Krishna MC.
Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.
PLoS ONE. 7: e49456, 2012.
[Journal]
8)  Subramanian S, Devasahayam N, McMillan A, Matsumoto S, Munasinghe JP, Saito K, Mitchell JB, Chandramouli GV, Krishna MC.
Reporting of quantitative oxygen mapping in EPR imaging.
J. Magn. Reson. 214: 244-51, 2012.
[Journal]
9)  Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM.
Targeting HIF2a translation with Tempol in VHL-deficient clear cell renal cell carcinoma.
Oncotarget. 3: 1472-82, 2012.
[Journal]
10)  Mitchell JB, Anver MR, Sowers AL, Rosenberg PS, Figueroa M, Thetford A, Krishna MC, Albert PS, Cook JA.
The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.
Cancer Res. 72: 4846-55, 2012.
[Journal]
11)  Hyodo F, Davis RM, Hyodo E, Matsumoto S, Krishna MC, Mitchell JB.
The relationship between tissue oxygenation and redox status using magnetic resonance imaging.
Int. J. Oncol. 41: 2103-8, 2012.
[Journal]
12)  Saito K, Matsumoto S, Devasahayam N, Subramanian S, Munasinghe JP, Morris HD, Lizak MJ, Ardenkjaer-Larsen JH, Mitchell JB, Krishna MC.
Transient decrease in tumor oxygenation after intravenous administration of pyruvate.
Magn Reson Med. 67: 801-7, 2012.
[Journal]
13)  Davis RM, Sowers AL, DeGraff W, Bernardo M, Thetford A, Krishna MC, Mitchell JB.
A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.
Free Radic. Biol. Med. 51: 780-90, 2011.
[Journal]
14)  Matsumoto K, Hyodo F, Anzai K, Utsumi H, Mitchell JB, Krishna MC.
Brain redox imaging.
Methods Mol. Biol. 711: 397-419, 2011.
[Journal]
15)  Day SE, Kettunen MI, Cherukuri MK, Mitchell JB, Lizak MJ, Morris HD, Matsumoto S, Koretsky AP, Brindle KM.
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
Magn Reson Med. 65: 557-63, 2011.
[Journal]
16)  Matsumoto A, Matsumoto K, Matsumoto S, Hyodo F, Sowers AL, Koscielniak JW, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.
Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes.
Biol. Pharm. Bull. 34: 142-5, 2011.
[Journal]
17)  Davis RM, Matsumoto S, Bernardo M, Sowers A, Matsumoto K, Krishna MC, Mitchell JB.
Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape.
Free Radic. Biol. Med. 50: 459-68, 2011.
[Journal]
18)  Davis RM, Mitchell JB, Krishna MC.
Nitroxides as cancer imaging agents.
Anticancer Agents Med Chem. 11: 347-58, 2011.
[Journal]
19)  Flores-Santana W, Moody T, Chen W, Gorczynski MJ, Shoman ME, Velazquez C, Thetford A, Mitchell JB, Cherukuri MK, King SB, Wink DA.
Redox-Modified Non-Steroidal Anti-Inflammatory Drugs as Potential Anti-Cancer Agents with the SOD Mimetic Nitroxide.
British journal of pharmacology. 2011.
[Journal]
20)  Fabre KM, Saito K, DeGraff W, Sowers AL, Thetford A, Cook JA, Krishna MC, Mitchell JB.
The effects of resveratrol and selected metabolites on the radiation and antioxidant response.
Cancer Biol. Ther. 12: 915-23, 2011.
[Journal]
21)  Takeshita K, Kawaguchi K, Fujii-Aikawa K, Ueno M, Okazaki S, Ono M, Krishna MC, Kuppusamy P, Ozawa T, Ikota N.
Heterogeneity of regional redox status and relation of the redox status to oxygenation in a tumor model, evaluated using electron paramagnetic resonance imaging.
Cancer Res. 70: 4133-40, 2010.
[Journal]
22)  Matsumoto S, Yasui H, Mitchell JB, Krishna MC.
Imaging cycling tumor hypoxia.
Cancer Res. 70: 10019-23, 2010.
[Journal]
23)  Hyodo F, Matsumoto S, Hyodo E, Matsumoto A, Matsumoto K, Krishna MC.
In vivo measurement of tissue oxygen using electron paramagnetic resonance spectroscopy with oxygen-sensitive paramagnetic particle, lithium phthalocyanine.
Methods Mol. Biol. 610: 29-39, 2010.
[Journal]
24)  Samuni Y, Cook JA, Choudhuri R, Degraff W, Sowers AL, Krishna MC, Mitchell JB.
Inhibition of adipogenesis by Tempol in 3T3-L1 cells.
Free Radic. Biol. Med. 49: 667-73, 2010.
[Journal]
25)  Yasui H, Matsumoto S, Devasahayam N, Munasinghe JP, Choudhuri R, Saito K, Subramanian S, Mitchell JB, Krishna MC.
Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice.
Cancer Res. 70: 6427-36, 2010.
[Journal]
26)  Citrin D, Cotrim AP, Hyodo F, Baum BJ, Krishna MC, Mitchell JB.
Radioprotectors and mitigators of radiation-induced normal tissue injury.
Oncologist. 15: 360-71, 2010.
[Journal]
27)  Samuni Y, Ishii H, Hyodo F, Samuni U, Krishna MC, Goldstein S, Mitchell JB.
Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.
Free Radic. Biol. Med. 48: 1559-63, 2010.
[Journal]
28)  Matsumoto K, Okajo A, Nagata K, Degraff WG, Nyui M, Ueno M, Nakanishi I, Ozawa T, Mitchell JB, Krishna MC, Yamamoto H, Endo K, Anzai K.
Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation.
Biol. Pharm. Bull. 32: 542-7, 2009.
[Journal]
29)  Meenakshisundaram G, Eteshola E, Pandian RP, Bratasz A, Selvendiran K, Lee SC, Krishna MC, Swartz HM, Kuppusamy P.
Oxygen sensitivity and biocompatibility of an implantable paramagnetic probe for repeated measurements of tissue oxygenation.
Biomedical microdevices. 11: 817-26, 2009.
[Journal]
30)  Hyodo F, Matsumoto S, Devasahayam N, Dharmaraj C, Subramanian S, Mitchell JB, Krishna MC.
Pulsed EPR imaging of nitroxides in mice.
J. Magn. Reson. 197: 181-5, 2009.
[Journal]
31)  Dharmaraj CD, Thadikonda K, Fletcher AR, Doan PN, Devasahayam N, Matsumoto S, Johnson CA, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Reconstruction for Time-Domain In Vivo EPR 3D Multigradient Oximetric Imaging-A Parallel Processing Perspective.
International journal of biomedical imaging. 2009: 528639, 2009.
[Journal]
32)  Samuni Y, Flores-Santana W, Krishna MC, Mitchell JB, Wink DA.
The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.
Free Radic. Biol. Med. 47: 419-23, 2009.
[Journal]
33)  Isenberg JS, Frazier WA, Krishna MC, Wink DA, Roberts DD.
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.
Current drug targets. 9: 833-41, 2008.
[Journal]
34)  Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M.
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Proc. Natl. Acad. Sci. U.S.A. 105: 11105-9, 2008.
[Journal]
35)  Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA.
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.
Proc. Natl. Acad. Sci. U.S.A. 105: 12028-33, 2008.
[Journal]
36)  Isenberg JS, Hyodo F, Ridnour LA, Shannon CS, Wink DA, Krishna MC, Roberts DD.
Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow.
Neoplasia. 10: 886-96, 2008.
[Journal]
37)  Devasahayam N, Subramanian S, Krishna M.
A novel programmable pulse generator with nanosecond resolution for pulsed electron paramagnetic resonance applications.
Rev Sci Instrum. 79: 026106, 2008.
[Journal]
38)  Hyodo F, Soule BP, Matsumoto K, Matusmoto S, Cook JA, Hyodo E, Sowers AL, Krishna MC, Mitchell JB.
Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging.
J. Pharm. Pharmacol. 60: 1049-60, 2008.
[Journal]
39)  Hyodo F, Chuang KH, Goloshevsky AG, Sulima A, Griffiths GL, Mitchell JB, Koretsky AP, Krishna MC.
Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent.
J. Cereb. Blood Flow Metab. 28: 1165-74, 2008.
[Journal]
40)  Matsumoto S, Espey MG, Utsumi H, Devasahayam N, Matsumoto K, Matsumoto A, Hirata H, Wink DA, Kuppusamy P, Subramanian S, Mitchell JB, Krishna MC.
Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice.
Magn Reson Med. 59: 619-25, 2008.
[Journal]
41)  Hyodo F, Subramanian S, Devasahayam N, Murugesan R, Matsumoto K, Mitchell JB, Krishna MC.
Evaluation of sub-microsecond recovery resonators for in vivo electron paramagnetic resonance imaging.
J. Magn. Reson. 190: 248-54, 2008.
[Journal]
42)  Matsumoto S, Hyodo F, Subramanian S, Devasahayam N, Munasinghe J, Hyodo E, Gadisetti C, Cook JA, Mitchell JB, Krishna MC.
Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice.
J. Clin. Invest. 118: 1965-73, 2008.
[Journal]
43)  Hyodo F, Murugesan R, Matsumoto K, Hyodo E, Subramanian S, Mitchell JB, Krishna MC.
Monitoring redox-sensitive paramagnetic contrast agent by EPRI, OMRI and MRI.
J. Magn. Reson. 190: 105-12, 2008.
[Journal]
44)  Durairaj DC, Krishna MC, Murugesan R.
A neural network approach for image reconstruction in electron magnetic resonance tomography.
Comput. Biol. Med. 37: 1492-501, 2007.
[Journal]
45)  Subramanian S, Koscielniak JW, Devasahayam N, Pursley RH, Pohida TJ, Krishna MC.
A new strategy for fast radiofrequency CW EPR imaging: direct detection with rapid scan and rotating gradients.
J. Magn. Reson. 186: 212-9, 2007.
[Journal]
46)  Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Proc. Natl. Acad. Sci. U.S.A. 104: 8749-54, 2007.
[Journal]
47)  Isenberg JS, Hyodo F, Pappan LK, Abu-Asab M, Tsokos M, Krishna MC, Frazier WA, Roberts DD.
Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia.
Arterioscler. Thromb. Vasc. Biol. 27: 2582-8, 2007.
[Journal]
48)  Hama Y, Matsumoto KI, Murugesan R, Subramanian S, Devasahayam N, Koscielniak JW, Hyodo F, Cook JA, Mitchell JB, Krishna MC.
Continuous Wave EPR Oximetric Imaging at 300 MHz Using Radiofrequency Power Saturation Effects.
Antioxid Redox Signal. 2007.
[Journal]
49)  Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, Krishna MC, Mitchell JB.
Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging.
Clin. Cancer Res. 13: 4928-33, 2007.
[Journal]
50)  Aronovitch Y, Godinger D, Israeli A, Krishna MC, Samuni A, Goldstein S.
Dual activity of nitroxides as pro- and antioxidants: catalysis of copper-mediated DNA breakage and H2O2 dismutation.
Free Radic. Biol. Med. 42: 1317-25, 2007.
[Journal]
51)  Hama Y, Bernardo M, Regino CA, Koyama Y, Brechbiel MW, Krishna MC, Choyke PL, Kobayashi H.
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magn Reson Med. 57: 431-6, 2007.
[Journal]
52)  Matsumoto K, Subramanian S, Murugesan R, Mitchell JB, Krishna MC.
Spatially resolved biologic information from in vivo EPRI, OMRI, and MRI.
Antioxid. Redox Signal. 9: 1125-41, 2007.
[Journal]
53)  Devasahayam N, Subramanian S, Murugesan R, Hyodo F, Matsumoto K, Mitchell JB, Krishna MC.
Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR.
Magn Reson Med. 57: 776-83, 2007.
[Journal]
54)  Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB.
The chemistry and biology of nitroxide compounds.
Free Radic. Biol. Med. 42: 1632-50, 2007.
[Journal]
55)  Matsumoto K, Szajek L, Krishna MC, Cook JA, Seidel J, Grimes K, Carson J, Sowers AL, English S, Green MV, Bacharach SL, Eckelman WC, Mitchell JB.
The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.
Int. J. Oncol. 30: 873-81, 2007.
[Journal]
56)  Soule BP, Hyodo F, Matsumoto KI, Simone NL, Cook JA, Krishna MC, Mitchell JB.
Therapeutic and Clinical Applications of Nitroxide Compounds.
Antioxid Redox Signal. 2007.
[Journal]
57)  Isenberg JS, Hyodo F, Matsumoto K, Romeo MJ, Abu-Asab M, Tsokos M, Kuppusamy P, Wink DA, Krishna MC, Roberts DD.
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
Blood. 109: 1945-52, 2007.
[Journal]
58)  Okajo A, Matsumoto K, Mitchell JB, Krishna MC, Endo K.
Competition of nitroxyl contrast agents as an in vivo tissue redox probe: Comparison of pharmacokinetics by the bile flow monitoring (BFM) and blood circulating monitoring (BCM) methods using X-band EPR and simulation of decay profiles.
Magn Reson Med. 56: 422-31, 2006.
[Journal]
59)  Matsumoto K, Subramanian S, Devasahayam N, Aravalluvan T, Murugesan R, Cook JA, Mitchell JB, Krishna MC.
Electron paramagnetic resonance imaging of tumor hypoxia: enhanced spatial and temporal resolution for in vivo pO2 determination.
Magn Reson Med. 55: 1157-63, 2006.
[Journal]
60)  Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC.
High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.
Clin. Cancer Res. 12: 2455-62, 2006.
[Journal]
61)  Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Krishna MC, Choyke PL, Kobayashi H.
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent.
Neoplasia. 8: 607-12, 2006.
[Journal]
62)  Pursley RH, Salem G, Devasahayam N, Subramanian S, Koscielniak J, Krishna MC, Pohida TJ.
Integration of digital signal processing technologies with pulsed electron paramagnetic resonance imaging.
J. Magn. Reson. 178: 220-7, 2006.
[Journal]
63)  Matsumoto K, Bernardo M, Subramanian S, Choyke P, Mitchell JB, Krishna MC, Lizak MJ.
MR assessment of changes of tumor in response to hyperbaric oxygen treatment.
Magn Reson Med. 56: 240-6, 2006.
[Journal]
64)  Hyodo F, Matsumoto K, Matsumoto A, Mitchell JB, Krishna MC.
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents.
Cancer Res. 66: 9921-8, 2006.
[Journal]
65)  Chan LW, Hapdey S, English S, Seidel J, Carson J, Sowers AL, Krishna MC, Green MV, Mitchell JB, Bacharach SL.
The influence of tumor oxygenation on 18F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET).
Radiat Oncol. 1: 3, 2006.
[Journal]
66)  Matsumoto A, Matsumoto S, Sowers AL, Koscielniak JW, Trigg NJ, Kuppusamy P, Mitchell JB, Subramanian S, Krishna MC, Matsumoto K.
Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR.
Magn Reson Med. 54: 1530-5, 2005.
[Journal]
67)  Pursley RH, Salem G, Pohida TJ, Devasahayam N, Subramanian S, Krishna MC.
Direct detection and time-locked subsampling applied to pulsed electron paramagnetic resonance imaging.
Rev Sci Instrum. 76: 1-6, 2005.
[Journal]
68)  Pursley R, Salem G, Devasayaham D, Subramanian S, Krishna M, Pohida T.
Direct detection and time-locked subsampling applied to pulsed electron paramagnetic resonance imaging.
Rev. Sci. Instrum. 76: 1-6, 2005.
[Journal]
69)  Samuni AM, Kasid U, Chuang EY, Suy S, Degraff W, Krishna MC, Russo A, Mitchell JB.
Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells.
Cancer Res. 65: 579-86, 2005.
[Journal]
70)  Matsumoto K, Okajo A, Kobayashi T, Mitchell JB, Krishna MC, Endo K.
Estimation of free radical formation by beta-ray irradiation in rat liver.
J Biochem Biophys Methods. 63: 79-90, 2005.
[Journal]
71)  Camphausen K, Citrin D, Krishna MC, Mitchell JB.
Implications for tumor control during protection of normal tissues with antioxidants.
J. Clin. Oncol. 23: 5455-7, 2005.
[Journal]
72)  Matsumoto S, Utsumi H, Aravalluvan T, Matsumoto K, Matsumoto A, Devasahayam N, Sowers AL, Mitchell JB, Subramanian S, Krishna MC.
Influence of proton T1 on oxymetry using Overhauser enhanced magnetic resonance imaging.
Magn Reson Med. 54: 213-7, 2005.
[Journal]
73)  Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Proc. Natl. Acad. Sci. U.S.A. 102: 13604-9, 2005.
[Journal]
74)  Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clin Cancer Res. 10: 7712-20, 2004.
[Journal]
75)  Samuni Y, Gamson J, Samuni A, Yamada K, Russo A, Krishna MC, Mitchell JB.
Factors influencing nitroxide reduction and cytotoxicity in vitro.
Antioxid Redox Signal. 6: 587-95, 2004.
[Journal]
76)  Samuni Y, Gamson J, Samuni A, Yamada K, Russo A, Krishna MC, Mitchell JB.
Factors influencing nitroxide reduction and cytotoxicity in vitro.
Antioxid Redox Signal. Jun; 6 (3): 587-95, 2004.
[Journal]
77)  Reijnders K, English SJ, Krishna MC, Cook JA, Sowers AL, Mitchell JB, Zhang Y.
Influence of body temperature on the BOLD effect in murine SCC tumors dagger.
Magn Reson Med. 51: 389-93, 2004.
[Journal]
78)  Durairaj DC, Krishna MC, Murugesan R.
Integration of color and boundary information for improved region of interest identification in electron magnetic resonance images.
Comput Med Imaging Graph. 28: 445-52, 2004.
[Journal]
79)  Mitchell JB, Yamada K, Devasahayam N, Cook JA, Subramanian S, Krishna MC.
Novel functional imaging for tissue oxygen concentration and redox status.
J Nutr. 134: 3210S, 2004.
[Journal]
80)  Matsumoto K, Krishna MC, Mitchell JB.
Novel pharmacokinetic measurement using electron paramagnetic resonance spectroscopy and simulation of in vivo decay of various nitroxyl spin probes in mouse blood.
J Pharmacol Exp Ther. Sep; 310 (3): 1076-83, 2004.
[Journal]
81)  Cook JA, Gius D, Wink DA, Krishna MC, Russo A, Mitchell JB.
Oxidative stress, redox, and the tumor microenvironment.
Semin. Radiat Oncol. Jul; 14 (3): 259-66, 2004.
[Journal]
82)  Matsumoto K, English S, Yoo J, Yamada K, Devasahayam N, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Pharmacokinetics of a triarylmethyl-type paramagnetic spin probe used in EPR oximetry.
Magn. Reson. Med. Sep 23; 52 (4): 885, 2004.
[Journal]
83)  Subramanian S, Matsumoto K, Mitchell JB, Krishna MC.
Radio-frequency continuous-wave and time-domain EPR imaging and Overhauser-enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for functional imaging.
NMR Biomed. Aug; 17 (5): 263-66, 2004.
[Journal]
84)  Devasahayam N, Murugesan R, Matsumoto K, Mitchell JB, Cook JA, Subramanian S, Krishna MC.
Tailored sinc pulses for uniform excitation and artifact-free radio frequency time-domain EPR imaging.
J Magn Reson. May; 168 (1): 110-7, 2004.
[Journal]
85)  Samuni AM, DeGraff W, Cook JA, Krishna MC, Russo A, Mitchell JB.
The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells.
Free Radic. Biol. Med. 37: 1648-55, 2004.
[Journal]
86)  Mitchell JB, Xavier S, DeLuca AM, Sowers AL, Cook JA, Krishna MC, Hahn SM, Russo A.
A low molecular weight antioxidant decreases weight and lowers tumor incidence.
Free Radic Biol Med. 34: 93-102, 2003.
[Journal]
87)  Taube AG, Subramanian S, Murugesan R, Devasahayam N, Mitchell JB, Krishna MC, Cook JA.
An Application System for Automation of Constant-Time Radio Frequency electron Paramagnetic Resonance Imaging.
Comput Methods Programs Biomed. 72 (2) Oct.: 127-138, 2003.
[Journal]
88)  Matsumoto K, Chandrika B, Lohman JA, Mitchell JB, Krishna MC, Subramanian S.
Application of continuous-wave EPR spectral-spatial image reconstruction techniques for in vivo oxymetry: comparison of projection reconstruction and constant-time modalities.
Magn Reson Med. 50: 865-74, 2003.
[Journal]
89)  Stein W, Subramanian S, Mitchell JB, Krishna MC.
EPR imaging of vascular changes in oxygen in response to carbogen breathing.
Adv Exp Med Biol. 510: 231-6, 2003.
[Journal]
90)  Samuni AM, Chuang EY, Krishna MC, Stein W, DeGraff W, Russo A, Mitchell JB.
Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: chemoprevention strategies with antioxidants.
Proc Natl Acad Sci U S A. 100: 5390-5, 2003.
[Journal]
91)  Pursley RH, Kakareka J, Salem G, Devasahayam N, Subramanian S, Tschudin RG, Krishna MC, Pohida TJ.
Stochastic excitation and Hadamard correlation spectroscopy with bandwidth extension in RF FT-EPR.
J Magn Reson. 162: 35-45, 2003.
[Journal]
92)  Zigler JS, Qin C, Kamiya T, Krishna MC, Cheng Q, Tumminia S, Russell P.
Tempol-H inhibits opacification of lenses in organ culture.
Free Radic Biol Med. 35: 1194-202, 2003.
[Journal]
93)  Yordanov AT, Yamada K, Krishna MC, Russo A, Yoo J, English S, Mitchell JB, Brechbiel MW.
Acyl-protected hydroxylamines as spin label generators for EPR brain imaging.
J Med Chem. 45: 2283-8, 2002.
[Journal]
94)  Xavier S, Yamada K, Samuni AM, Samuni A, DeGraff W, Krishna MC, Mitchell JB.
Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.
Biochim Biophys Acta. 1573: 109-20, 2002.
[Journal]
95)  Xavier S, Yamada K, Samuni AM, Samuni A, DeGraff W, Krishna MC, Mitchell JB.
Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.
Biochim Biophys Acta. 1573: 109-20, 2002.
[Journal]
96)  Yamada K, Murugesan R, Devasahayam N, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Evaluation and comparison of pulsed and continuous wave radiofrequency electron paramagnetic resonance techniques for in vivo detection and imaging of free radicals.
J Magn Reson. 154: 287-97, 2002.
[Journal]
97)  Devasahayam N, Murugesan R, Yamada K, Reijnders K, Mitchell J, Subramanian S, Krishna M, Cook J.
Evaluation of a High-Speed Signal-Averager for Sensitivity Enhancement in Radio Frequency Fourier Transforms Electron Paramagnetic Resonance Imaging.
Rev Sci Instrum. 73: 3920-3925, 2002.
[Journal]
98)  Yamada KI, Kuppusamy P, English S, Yoo J, Irie A, Subramanian S, Mitchell JB, Krishna MC.
Feasibility and assessment of non-invasive in vivo redox status using electron paramagnetic resonance imaging.
Acta Radiol. 43: 433-40, 2002.
[Journal]
99)  Murugesan R, English S, Reijnders K, Yamada K, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Fluorine electron double resonance imaging for 19F MRI in low magnetic fields.
Magn Reson Med. 48: 523-9, 2002.
[Journal]
100)  Miranda KM, Yamada K, Espey MG, Thomas DD, DeGraff W, Mitchell JB, Krishna MC, Colton CA, Wink DA.
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
Arch Biochem Biophys. 401: 134-44, 2002.
[Journal]
101)  Ilangovan G, Li H, Zweier JL, Krishna MC, Mitchell JB, Kuppusamy P.
In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing.
Magn Reson Med. 48: 723-30, 2002.
[Journal]
102)  Samuni A, Goldstein S, Russo A, Mitchell JB, Krishna MC, Neta P.
Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.
J Am Chem Soc. 124: 8719-24, 2002.
[Journal]
103)  Samuni AM, Krishna MC, DeGraff W, Russo A, Planalp RP, Brechbiel MW, Mitchell JB.
Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.
Biochem Biophys Acta. 1571: 211-8, 2002.
[Journal]
104)  Samuni AM, DeGraff W, Krishna MC, Mitchell JB.
Nitroxides as antioxidants: tempol protects against EO9 cytotoxicity.
Mol Cell Biochem. 234-235: 327-33, 2002.
[Journal]
105)  Mitchell JB, Krishna MC.
Nitroxides as Radiation Protectors.
Military Medicine. 167: 49-50, 2002.
[Journal]
106)  Kuppusamy P, Li H, Ilangovan G, Cardounel AJ, Zweier JL, Yamada K, Krishna MC, Mitchell JB.
Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.
Cancer Res. 62: 307-12, 2002.
[Journal]
107)  Subramanian S, Yamada K, Irie A, Murugesan R, Cook JA, Devasahayam N, Van Dam GM, Mitchell JB, Krishna MC.
Noninvasive in vivo oximetric imaging by radiofrequency FT EPR.
Magn Reson Med. 47: 1001-8, 2002.
[Journal]
108)  Krishna MC, English S, Yamada K, Yoo J, Murugesan R, Devasahayam N, Cook JA, Golman K, Ardenkjaer-Larsen JH, Subramanian S, Mitchell JB.
Overhauser enhanced magnetic resonance imaging for tumor oximetry: coregistration of tumor anatomy and tissue oxygen concentration.
Proc Natl Acad Sci U S A. 99: 2216-21, 2002.
[Journal]
109)  Subramanian S, Devasahayam N, Murugesan R, Yamada K, Cook J, Taube A, Mitchell JB, Lohman JA, Krishna MC.
Single-point (constant-time) imaging in radiofrequency Fourier transform electron paramagnetic resonance dagger.
Magn Reson Med. 48: 370-9, 2002.
[Journal]
110)  Samuni AM, DeGraff W, Krishna MC, Mitchell JB.
Cellular sites of H2O2-induced damage and their protection by nitroxides.
Biochim Biophys Acta. 1525: 70-6, 2001.
[Journal]
111)  Krishna MC, Devasahayam N, Cook JA, Subramanian S, Kuppusamy P, Mitchell JB.
Electron paramagnetic resonance for small animal imaging applications.
ILAR J. 42: 209-18, 2001.
[Journal]
112)  Krishna MC, Subramanian S, Kuppusamy P, Mitchell JB.
Magnetic resonance imaging for in vivo assessment of tissue oxygen concentration.
Semin Radiat Oncol. 11: 58-69, 2001.
[Journal]
113)  Samuni AM, Afeworki M, Stein W, Yordanov AT, DeGraff W, Krishna MC, Mitchell JB, Brechbiel MW.
Multifunctional antioxidant activity of HBED iron chelator.
Free Radic Biol Med. 30: 170-7, 2001.
[Journal]
114)  Mitchell JB, Krishna MC, Kuppusamy P, Cook JA, Russo A.
Protection against oxidative stress by nitroxides.
Exp Biol Med (Maywood). 226: 620-1, 2001.
[Journal]
115)  Yordanov AT, Yamada Ki Ken-ichi, Krishna MC, Mitchell JB, Woller E, Cloninger M, Brechbiel MW.
Spin-Labeled Dendrimers in EPR Imaging with Low Molecular Weight Nitroxides.
Angew Chem Int Ed Engl. 40: 2690-2692, 2001.
[Journal]
116)  Miranda KM, Espey MG, Yamada K, Krishna M, Ludwick N, Kim S, Jourd'heuil D, Grisham MB, Feelisch M, Fukuto JM, Wink DA.
Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion.
J Biol Chem. 276: 1720-7, 2001.
[Journal]
117)  Koscielniak J, Devasahayam N, Moni M, Kuppusamy P, Yamada K, Mitchell J, Krishna M, Subramanian S.
300 MHz Continuous Wave Electron Paramagnetic Resonance Spectrometer for Small Animal In Vivo Imaging.
Rev Sci Instrum. 71: 4273-4281, 2000.
[Journal]
118)  Hahn SM, Krishna MC, DeLuca AM, Coffin D, Mitchell JB.
Evaluation of the hydroxylamine Tempol-H as an in vivo radioprotector.
Free Radic Biol Med. 28: 953-8, 2000.
[Journal]
119)  Devasahayam N, Subramanian S, Murugesan R, Cook JA, Afeworki M, Tschudin RG, Mitchell JB, Krishna MC.
Parallel coil resonators for time-domain radiofrequency electron paramagnetic resonance imaging of biological objects.
J Magn Reson. 142: 168-76, 2000.
[Journal]
120)  Mitchell JB, Russo A, Kuppusamy P, Krishna MC.
Radiation, radicals, and images.
Ann N Y Acad Sci. 899: 28-43, 2000.
[Journal]
121)  Afeworki M, van Dam GM, Devasahayam N, Murugesan R, Cook J, Coffin D, Larsen JH, Mitchell JB, Subramanian S, Krishna MC.
Three-dimensional whole body imaging of spin probes in mice by time-domain radiofrequency electron paramagnetic resonance.
Magn Reson Med. 43: 375-82, 2000.
[Journal]
122)  Krishna MC, Kuppusamy P, Afeworki M, Zweier JL, Cook JA, Subramanian S, Mitchell JB.
Development of functional electron paramagnetic resonance imaging.
Breast disease. 10: 209-20, 1998.
[Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 4/8/2013.