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Our Science – Mitchell Website

James B. Mitchell, Ph.D.

Selected Publications

1)  Mitchell JB, Anver MR, Sowers A, Rosenberg PS, Figueroa M, Thetford A, Krishna MC, Albert PS, Cook JA.
The Antioxidant Tempol Reduces Carcinogenesis and Enhances Survival in Mice when Administered After Non-Lethal Total Body Radiation.
Cancer Res. 72: 4846-55, 2012.
2)  Davis RM, Sowers AL, Degraff W, Bernardo M, Thetford A, Krishna MC, Mitchell JB.
A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector.
Free Radic. Biol. Med. 51: 780-90, 2011.
3)  Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, Cook JA.
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.
Clin. Cancer Res. 16: 2076-84, 2010.
4)  Cotrim AP, Yoshikawa M, Sunshine AN, Zheng C, Sowers AL, Thetford AD, Cook JA, Mitchell JB, Baum BJ.
Pharmacological Protection from Radiation ± Cisplatin-induced Oral Mucositis.
Int. Radiat. Oncol. Biol. Phys. 83: 1284-90, 2012.
5)  Li F, Jiang C, Krausz KW, Li Y, Albert I, Hao H, Fabre KM, Mitchell JB, Patterson AD, Gonzalez FJ.
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.
Nat Commun. 4: 2384, 2013.
6)  Dan T, Hewitt SM, Ohri N, Ly D, Soule BP, Smith SL, Matsuda K, Council C, Shankavaram U, Lippman ME, Mitchell JB, Camphausen K, Simone NL.
CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up.
Breast Cancer Res. Treat. 143: 11-8, 2014.
7)  Matsumoto S, Saito K, Takakusagi Y, Matsuo M, Munasinghe JP, Morris HD, Lizak MJ, Merkle H, Yasukawa K, Devasahayam N, Suburamanian S, Mitchell JB, Krishna MC.
In Vivo Imaging of Tumor Physiological, Metabolic, and Redox Changes in Response to the Anti-Angiogenic Agent Sunitinib: Longitudinal Assessment to Identify Transient Vascular Renormalization.
Antioxid. Redox Signal. [Epub ahead of print], 2014.
8)  Salem GH, Dennis JU, Krynitsky J, Garmendia-Cedillos M, Swaroop K, Malley JD, Pajevic S, Abuhatzira L, Bustin M, Gillet J, Gottesman MM, Mitchell JB, Pohida TJ.
SCORHE: A novel and practical approach to video monitoring of laboratory mice housed in vivarium cage racks.
Behav Res Methods. [Epub ahead of print], 2014.
9)  Liu Y, Shim E, Nguyen P, Gibbons AT, Mitchell JB, Poirier MC.
Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.
Toxicol. Sci. 139: 133-41, 2014.
10)  Saleh AD, Simone BA, Palazzo J, Savage JE, Sano Y, Dan T, Jin L, Champ CE, Zhao S, Lim M, Sotgia F, Camphausen K, Pestell RG, Mitchell JB, Lisanti MP, Simone NL.
Caloric restriction augments radiation efficacy in breast cancer.
Cell Cycle. 12: 1955-63, 2013.
11)  Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC.
EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.
Magn Reson Med. 69: 1443-1450, 2013.
12)  Friedman JA, Wise SC, Hu M, Gouveia C, Vander Broek R, Freudlsperger C, Kannabiran VR, Arun P, Mitchell JB, Chen Z, Van Waes C.
HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.
Transl Oncol. 6: 429-41, 2013.
13)  Horton JA, Chung EJ, Hudak KE, Sowers A, Thetford A, White AO, Mitchell JB, Citrin DE.
Inhibition of radiation-induced skin fibrosis with imatinib.
Int. J. Radiat. Biol. 89: 162-70, 2013.
14)  Krishna MC, Matsumoto S, Saito K, Matsuo M, Mitchell JB, Ardenkjaer-Larsen JH.
Magnetic resonance imaging of tumor oxygenation and metabolic profile.
Acta Oncol. 52: 1248-56, 2013.
15)  Li F, Patterson AD, Krausz KW, Jiang C, Bi H, Sowers AL, Cook JA, Mitchell JB, Gonzalez FJ.
Metabolomics reveals that tumor xenografts induce liver dysfunction.
Mol. Cell Proteomics. 12: 2126-35, 2013.
16)  Herzog A, Bian Y, Vander Broek R, Hall B, Coupar J, Cheng H, Sowers AL, Cook JD, Mitchell JB, Chen Z, Kulkarni AB, Van Waes C.
PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer.
Clin. Cancer Res. 19: 3808-19, 2013.
17)  Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, Ten Dijke P, Refaeli Y, Zhang Q, Wang XJ.
Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis.
Nat. Med. 19: 421-8, 2013.
18)  Li F, Pang X, Krausz KW, Jiang C, Chen C, Cook JA, Krishna MC, Mitchell JB, Gonzalez FJ, Patterson AD.
Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology.
J. Proteome Res. 12: 1369-76, 2013.
19)  Baum BJ, Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Goldsmith CM, Burbelo PD, Citrin DE, Mitchell JB, Nottingham LK, Rudy SF, Van Waes C, Whatley MA, Brahim JS, Chiorini JA, Danielides S, Turner RJ, Patronas NJ, Chen CC, Nikolov NP, Illei GG.
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.
Proc. Natl. Acad. Sci. U.S.A. 109: 19403-7, 2012.
20)  Subramanian S, Devasahayam N, Matsumoto S, Saito K, Mitchell JB, Krishna MC.
Echo-based Single Point Imaging (ESPI): A novel pulsed EPR imaging modality for high spatial resolution and quantitative oximetry.
J. Magn. Reson. 218: 105-14, 2012.
21)  Krishna MC, Matsumoto S, Yasui H, Saito K, Devasahayam N, Subramanian S, Mitchell JB.
Electron paramagnetic resonance imaging of tumor pO2.
Radiat. Res. 177: 376-86, 2012.
22)  Subramanian S, Chandramouli GV, McMillan A, Gullapalli RP, Devasahayam N, Mitchell JB, Matsumoto S, Krishna MC.
Evaluation of partial k-space strategies to speed up time-domain EPR imaging.
Magn Reson Med. [Epub ahead of print], 2012.
23)  Saito K, Matsumoto S, Yasui H, Devasahayam N, Subramanian S, Munasinghe JP, Patel V, Gutkind JS, Mitchell JB, Krishna MC.
Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.
PLoS ONE. 7: e49456, 2012.
24)  Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS.
mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.
Cell Stem Cell. 11: 401-14, 2012.
25)  Subramanian S, Devasahayam N, McMillan A, Matsumoto S, Munasinghe JP, Saito K, Mitchell JB, Chandramouli GV, Krishna MC.
Reporting of quantitative oxygen mapping in EPR imaging.
J. Magn. Reson. 214: 244-51, 2012.
26)  Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, Degraff W, Krishna MC, Mitchell JB, Rouault TA, Linehan WM.
Targeting HIF2a translation with Tempol in VHL-deficient clear cell renal cell carcinoma.
Oncotarget. 3: 1472-82, 2012.
27)  Hyodo F, Davis RM, Hyodo E, Matsumoto S, Krishna MC, Mitchell JB.
The relationship between tissue oxygenation and redox status using magnetic resonance imaging.
Int. J. Oncol. 41: 2103-8, 2012.
28)  Saito K, Matsumoto S, Devasahayam N, Subramanian S, Munasinghe JP, Morris HD, Lizak MJ, Ardenkjaer-Larsen JH, Mitchell JB, Krishna MC.
Transient decrease in tumor oxygenation after intravenous administration of pyruvate.
Magn Reson Med. 67: 801-7, 2012.
29)  Fabre K, DeGraff W, Cook J, Krishna M, Mitchell J.
Basu S, Wiklund L, eds.
Experimental Models for Ionizing Radiation Research. In: Studies on Experimental Models.
New York: Humana Press; 2011. p. 371-397 [Book Chapter]
30)  Mitchell JB.
2010 FAILLA AWARD LECTURE: Chasing Free Radicals in Cells and Tissues.
Radiat. Res. 176: 1-7, 2011.
31)  Matsumoto S, Batra S, Saito K, Yasui H, Choudhuri R, Gadisetti C, Subramanian S, Devasahayam N, Munasinghe JP, Mitchell JB, Krishna MC.
Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.
Cancer Res. 71: 6350-9, 2011.
32)  Matsumoto K, Hyodo F, Anzai K, Utsumi H, Mitchell JB, Krishna MC.
Brain redox imaging.
Methods Mol. Biol. 711: 397-419, 2011.
33)  Saleh AD, Savage JE, Cao L, Soule BP, Ly D, DeGraff W, Harris CC, Mitchell JB, Simone NL.
Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.
PLoS ONE. 6: e24429, 2011.
34)  Day SE, Kettunen MI, Cherukuri MK, Mitchell JB, Lizak MJ, Morris HD, Matsumoto S, Koretsky AP, Brindle KM.
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
Magn Reson Med. 65: 557-63, 2011.
35)  Urick ME, Chung EJ, Shield WP, Gerber N, White A, Sowers A, Thetford A, Camphausen K, Mitchell J, Citrin DE.
Enhancement of 5-Fluorouracil-induced In Vitro and In Vivo Radiosensitization with MEK Inhibition.
Clin. Cancer Res. 17: 5038-47, 2011.
36)  Choudhuri R, Degraff W, Gamson J, Mitchell JB, Cook JA.
Guggulsterone-mediated enhancement of radiosensitivity in human tumor cell lines.
Front Oncol. 1: 19, 2011.
37)  Matsumoto A, Matsumoto K, Matsumoto S, Hyodo F, Sowers AL, Koscielniak JW, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.
Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes.
Biol. Pharm. Bull. 34: 142-5, 2011.
38)  Jeong SY, Crooks DR, Wilson-Ollivierre H, Ghosh MC, Sougrat R, Lee J, Cooperman S, Mitchell JB, Beaumont C, Rouault TA.
Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.
PLoS ONE. 6: e25404, 2011.
39)  Davis RM, Matsumoto S, Bernardo M, Sowers A, Matsumoto K, Krishna MC, Mitchell JB.
Magnetic resonance imaging of organic contrast agents in mice: capturing the whole-body redox landscape.
Free Radic. Biol. Med. 50: 459-68, 2011.
40)  Davis RM, Mitchell JB, Krishna MC.
Nitroxides as cancer imaging agents.
Anticancer Agents Med Chem. 11: 347-58, 2011.
41)  Zheng C, Cotrim AP, Rowzee A, Swaim W, Sowers A, Mitchell JB, Baum BJ.
Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands.
Clin. Cancer Res. 17: 2842-51, 2011.
42)  Flores-Santana W, Moody T, Chen W, Gorczynski MJ, Shoman ME, Velazquez C, Thetford A, Mitchell JB, Cherukuri MK, King SB, Wink DA.
Redox-Modified Non-Steroidal Anti-Inflammatory Drugs as Potential Anti-Cancer Agents with the SOD Mimetic Nitroxide.
Br. J. Pharmacol. 165: 1058-67, 2011.
43)  Fabre KM, Saito K, DeGraff W, Sowers AL, Thetford A, Cook JA, Krishna MC, Mitchell JB.
The effects of resveratrol and selected metabolites on the radiation and antioxidant response.
Cancer Biol. Ther. 12:10: 915-23, 2011.
44)  Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, Elting LS, Langendijk JA, Coppes RP, Reyland ME.
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.
Int. J. Radiat. Oncol. Biol. Phys. 78: 983-91, 2010.
45)  Lu TP, Lai LC, Lin BI, Chen LH, Hsiao TH, Liber HL, Cook JA, Mitchell JB, Tsai MH, Chuang EY.
Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 76: 212-9, 2010.
46)  Brown AP, Chung EJ, Urick ME, Shield WP, Sowers AL, Thetford A, Shankavaram UT, Mitchell JB, Citrin DE.
Evaluation of the fullerene compound DF-1 as a radiation protector.
Radiat Oncol. 5: 34, 2010.
47)  Cook A, Choudhuri R, DeGraff W, Gamson J, Mitchell J.
Halofuginone Enhances the radiation sensitivity of human tumor cell lines by halofuginone.
Cancer Lett. 289: 119-26, 2010.
48)  Matsumoto S, Yasui H, Mitchell JB, Krishna MC.
Imaging cycling tumor hypoxia.
Cancer Res. 70: 10019-23, 2010.
49)  Kagiya G, Ogawa R, Cook JA, Choudhuri R, Hatashita M, Tanaka Y, DeGraff BG, Mitchell JB.
Improvement and induction property of radiation-responsive promoter through DNA shuffling of 5'-flanking regions of the human p21 gene.
J. Biosci. Bioeng. 110: 118-23, 2010.
50)  Samuni Y, Cook JA, Choudhuri R, Degraff W, Sowers AL, Krishna MC, Mitchell JB.
Inhibition of adipogenesis by Tempol in 3T3-L1 cells.
Free Radic. Biol. Med. 49: 667-73, 2010.
51)  Soule BP, Simone NL, DeGraff WG, Choudhuri R, Cook JA, Mitchell JB.
Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines.
Radiat Oncol. 5: 8, 2010.
52)  Yasui H, Matsumoto S, Devasahayam N, Munasinghe JP, Choudhuri R, Saito K, Subramanian S, Mitchell JB, Krishna MC.
Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice.
Cancer Res. 70: 6427-36, 2010.
53)  Citrin D, Cotrim A, Hyodo F, Baum B, Krishna M, Mitchell J.
Radioprotectors and mitigators of radiation-induced normal tissue injury.
The Oncologist14. 360-71, 2010.
54)  Samuni Y, Ishii H, Hyodo F, Samuni U, Krishna MC, Goldstein S, Mitchell JB.
Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.
Free Radic. Biol. Med. 48: 1559-63, 2010.
55)  Singh AK, Chen J, Calado R, Sowers A, Mitchell JB, Barrett AJ.
TBI with lung dose reduction does not improve hematopoietic cell homing to BM during allogeneic transplantation.
Bone Marrow Transplant. 25-30, 2010.
56)  Matsumoto K, Okajo A, Nagata K, Degraff WG, Nyui M, Ueno M, Nakanishi I, Ozawa T, Mitchell JB, Krishna MC, Yamamoto H, Endo K, Anzai K.
Detection of free radical reactions in an aqueous sample induced by low linear-energy-transfer irradiation.
Biol. Pharm. Bull. 32: 542-7, 2009.
57)  Hyodo F, Chandramouli GV, Matsumoto S, Matsumoto K, Mitchell JB, Krishna MC, Munasinghe JP.
Estimation of tumor microvessel density by MRI using a blood pool contrast agent.
Int. J. Oncol. 35: 797-804, 2009.
58)  Ishii H, Choudhuri R, Mathias A, Sowers AL, Flanders KC, Cook JA, Mitchell JB.
Halofuginone mediated protection against radiation-induced leg contracture.
Int. J. Oncol. 35: 315-9, 2009.
59)  Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB.
Ionizing radiation-induced oxidative stress alters miRNA expression.
PLoS ONE. 4: e6377, 2009.
60)  Zheng C, Cotrim AP, Sunshine AN, Sugito T, Liu L, Sowers A, Mitchell JB, Baum BJ.
Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands.
Clin. Cancer Res. 15: 4641-8, 2009.
61)  Hyodo F, Matsumoto S, Devasahayam N, Dharmaraj C, Subramanian S, Mitchell JB, Krishna MC.
Pulsed EPR imaging of nitroxides in mice.
J. Magn. Reson. 197: 181-5, 2009.
62)  Dharmaraj CD, Thadikonda K, Fletcher AR, Doan PN, Devasahayam N, Matsumoto S, Johnson CA, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Reconstruction for Time-Domain In Vivo EPR 3D Multigradient Oximetric Imaging-A Parallel Processing Perspective.
Int. J. Biomed. Imaging. 2009: 1-12, 2009.
63)  Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.
Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI.
Proc. Natl. Acad. Sci. U.S.A. 106: 17898-903, 2009.
64)  Samuni Y, Flores-Santana W, Krishna MC, Mitchell JB, Wink DA.
The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.
Free Radic. Biol. Med. 47: 419-23, 2009.
65)  Flanders KC, Ho BM, Arany PR, Stuelten C, Mamura M, Paterniti MO, Sowers A, Mitchell JB, Roberts AB.
Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection.
Am. J. Pathol. 173: 68-76, 2008.
66)  Hyodo F, Soule BP, Matsumoto K, Matusmoto S, Cook JA, Hyodo E, Sowers AL, Krishna MC, Mitchell JB.
Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging.
J. Pharm. Pharmacol. 60: 1049-60, 2008.
67)  Hyodo F, Chuang KH, Goloshevsky AG, Sulima A, Griffiths GL, Mitchell JB, Koretsky AP, Krishna MC.
Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent.
J. Cereb. Blood Flow Metab. 28: 1165-74, 2008.
68)  Kennedy CH, Catallo WJ, Wilson VL, Mitchell JB.
Combustion products of 1,3-butadiene inhibit catalase activity and induce expression of oxidative DNA damage repair enzymes in human bronchial epithelial cells.
Cell Biol. Toxicol. 25: 457-70, 2008.
69)  Guo Z, Tsai MH, Shiao YH, Chen LH, Wei ML, Lv X, Gius D, Little JB, Mitchell JB, Chuang EY.
DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.
J. Biomed. Sci. 15: 163-8, 2008.
70)  Matsumoto S, Espey MG, Utsumi H, Devasahayam N, Matsumoto K, Matsumoto A, Hirata H, Wink DA, Kuppusamy P, Subramanian S, Mitchell JB, Krishna MC.
Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice.
Magn. Reson. Med. 59: 619-25, 2008.
71)  Hyodo F, Subramanian S, Devasahayam N, Murugesan R, Matsumoto K, Mitchell JB, Krishna MC.
Evaluation of sub-microsecond recovery resonators for in vivo electron paramagnetic resonance imaging.
J. Magn. Reson. 190: 248-54, 2008.
72)  Matsumoto S, Hyodo F, Subramanian S, Devasahayam N, Munasinghe J, Hyodo E, Gadisetti C, Cook JA, Mitchell JB, Krishna MC.
Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice.
J. Clin. Invest. 118: 1965-73, 2008.
73)  Hyodo F, Murugesan R, Matsumoto K, Hyodo E, Subramanian S, Mitchell JB, Krishna MC.
Monitoring redox-sensitive paramagnetic contrast agent by EPRI, OMRI and MRI.
J. Magn. Reson. 190: 105-12, 2008.
74)  Palayoor ST, Mitchell JB, Cerna D, Degraff W, John-Aryankalayil M, Coleman CN.
PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.
Int. J. Cancer. 123: 2430-7, 2008.
75)  Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA.
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Circulation. 117: 2626-36, 2008.
76)  Zhang QS, Eaton L, Snyder ER, Houghtaling S, Mitchell JB, Finegold M, Van Waes C, Grompe M.
Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.
Cancer Res. 68: 1601-8, 2008.
77)  Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA.
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.
Proc. Natl. Acad. Sci. U.S.A. 105: 12028-33, 2008.
78)  Arany PR, Flanders KC, Degraff W, Cook J, Mitchell JB, Roberts AB.
Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts.
J. Dermatol. Sci. 48: 35-42, 2007.
79)  Hama Y, Matsumoto K, Murugesan R, Subramanian S, Devasahayam N, Koscielniak JW, Hyodo F, Cook JA, Mitchell JB, Krishna MC.
Continuous Wave EPR Oximetric Imaging at 300 MHz Using Radiofrequency Power Saturation Effects.
Antioxid. Redox. Signal. 9: 1709-16, 2007.
80)  Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, Krishna MC, Mitchell JB.
Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging.
Clin. Cancer Res. 13: 4928-33, 2007.
81)  Soule BP, Brown JM, Kushnir-Sukhov NM, Simone NL, Mitchell JB, Metcalfe DD.
Effects of Gamma Radiation on Fc{epsilon}RI and TLR-Mediated Mast Cell Activation.
J. Immunol. 179: 3276-86, 2007.
82)  Tsai MH, Cook JA, Chandramouli GV, DeGraff W, Yan H, Zhao S, Coleman CN, Mitchell JB, Chuang EY.
Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation.
Cancer Res. 67: 3845-52, 2007.
83)  Simone NL, Soule BP, Gerber L, Augustine E, Smith S, Altemus RM, Mitchell JB, Camphausen KA.
Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study.
Radiat. Oncol. 2: 19, 2007.
84)  Cotrim AP, Sowers A, Mitchell JB, Baum BJ.
Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands.
Mol. Ther. 15: 2101-6, 2007.
85)  Matsumoto K, Subramanian S, Murugesan R, Mitchell JB, Krishna MC.
Spatially resolved biologic information from in vivo EPRI, OMRI, and MRI.
Antioxid. Redox Signal. 9: 1125-41, 2007.
86)  Devasahayam N, Subramanian S, Murugesan R, Hyodo F, Matsumoto K, Mitchell JB, Krishna MC.
Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR.
Magn. Reson. Med. 57: 776-83, 2007.
87)  Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB.
The chemistry and biology of nitroxide compounds.
Free Radic. Biol. Med. 42: 1632-50, 2007.
88)  Matsumoto K, Szajek L, Krishna MC, Cook JA, Seidel J, Grimes K, Carson J, Sowers AL, English S, Green MV, Bacharach SL, Eckelman WC, Mitchell JB.
The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.
Int. J. Oncol. 30: 873-81, 2007.
89)  Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB.
Therapeutic and Clinical Applications of Nitroxide Compounds.
Antioxid. Redox Signal. 9: 1731-43, 2007.
90)  Chuang EY, Chen X, Tsai MH, Yan H, Li CY, Mitchell JB, Nagasawa H, Wilson PF, Peng Y, Fitzek MM, Bedford JS, Little JB.
Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma.
Cancer Res. 66: 3428-33, 2006.
91)  Patel K, Chen Y, Dennehy K, Blau J, Connors S, Mendonca M, Tarpey M, Krishna M, Mitchell JB, Welch WJ, Wilcox CS.
Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 290: R37-43, 2006.
92)  Okajo A, Matsumoto K, Mitchell JB, Krishna MC, Endo K.
Competition of nitroxyl contrast agents as an in vivo tissue redox probe: Comparison of pharmacokinetics by the bile flow monitoring (BFM) and blood circulating monitoring (BCM) methods using X-band EPR and simulation of decay profiles.
Magn Reson Med. 422-31, 2006.
93)  Matsumoto K, Subramanian S, Devasahayam N, Aravalluvan T, Murugesan R, Cook JA, Mitchell JB, Krishna MC.
Electron paramagnetic resonance imaging of tumor hypoxia: enhanced spatial and temporal resolution for in vivo pO2 determination.
Magn Reson Med. 55: 1157-63, 2006.
94)  Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC.
High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.
Clin. Cancer Res. 12: 2455-62, 2006.
95)  Matsumoto K, Bernardo M, Subramanian S, Choyke P, Mitchell JB, Krishna MC, Lizak MJ.
MR assessment of changes of tumor in response to hyperbaric oxygen treatment.
Magn Reson Med. 240-6, 2006.
96)  Hyodo F, Matsumoto K, Matsumoto A, Mitchell JB, Krishna MC.
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents.
Cancer Res. 66: 9921-8, 2006.
97)  Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, Degraff W, Roberts DD, Mitchell JB, Wink DA.
Superoxide fluxes limit nitric oxide-induced signaling.
J Biol Chem. 25984-93, 2006.
98)  Chan LW, Hapdey S, English S, Seidel J, Carson J, Sowers AL, Krishna MC, Green MV, Mitchell JB, Bacharach SL.
The influence of tumor oxygenation on 18F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET).
Radiat Oncol. 1: 3, 2006.
Full Text Article. [Journal]
99)  Tsai MH, Chen X, Chandramouli GV, Chen Y, Yan H, Zhao S, Keng P, Liber HL, Coleman CN, Mitchell JB, Chuang EY.
Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells.
Oncogene. 25: 622-32, 2006.
100)  Baum BJ, Zheng C, Cotrim AP, Goldsmith CM, Atkinson JC, Brahim JS, Chiorini JA, Voutetakis A, Leakan RA, Van Waes C, Mitchell JB, Delporte C, Wang S, Kaminsky SM, Illei GG.
Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.
Biochim Biophys Acta. 1071-7, 2006.
101)  Matsumoto A, Matsumoto S, Sowers AL, Koscielniak JW, Trigg NJ, Kuppusamy P, Mitchell JB, Subramanian S, Krishna MC, Matsumoto K.
Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR.
Magn Reson Med. 54: 1530-5, 2005.
102)  Ridnour LA, Thomas DA, Mancardi D, Donzelli S, Paolocci N, Pagliaro P, Miranda KM, Krishna M, Fukuto J, Grisham MB, Mitchell JB, Espey MG, Wink DA.
Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms: the implications of.
Curr Med Chem. 3: 181-188, 2005.
103)  Erker L, Schubert R, Yakushiji H, Barlow C, Larson D, Mitchell JB, Wynshaw-Boris A.
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor.
Hum Mol Genet. 14: 1699-708, 2005.
104)  Samuni AM, Kasid U, Chuang EY, Suy S, Degraff W, Krishna MC, Russo A, Mitchell JB.
Effects of hypoxia on radiation-responsive stress-activated protein kinase, p53, and caspase 3 signals in TK6 human lymphoblastoid cells.
Cancer Res. 65: 579-86, 2005.
105)  Matsumoto K, Okajo A, Kobayashi T, Mitchell JB, Krishna MC, Endo K.
Estimation of free radical formation by beta-ray irradiation in rat liver.
J Biochem Biophys Methods. 63: 79-90, 2005.
106)  Tsai MH, Yan H, Chen X, Chandramouli GV, Zhao S, Coffin D, Coleman CN, Mitchell JB, Chuang EY.
Evaluation of hybridization conditions for spotted oligonucleotide-based DNA microarrays.
Mol Biotechnol. 29: 221-4, 2005.
107)  Muanza TM, Cotrim AP, McAuliffe M, Sowers AL, Baum BJ, Cook JA, Feldchtein F, Amazeen P, Coleman CN, Mitchell JB.
Evaluation of radiation-induced oral mucositis by optical coherence tomography.
Clin. Cancer Res. 11: 5121-7, 2005.
108)  Camphausen K, Citrin D, Krishna MC, Mitchell JB.
Implications for tumor control during protection of normal tissues with antioxidants.
J. Clin. Oncol. 23: 5455-7, 2005.
109)  Matsumoto S, Utsumi H, Aravalluvan T, Matsumoto K, Matsumoto A, Devasahayam N, Sowers AL, Mitchell JB, Subramanian S, Krishna MC.
Influence of proton T1 on oxymetry using Overhauser enhanced magnetic resonance imaging.
Magn Reson Med. 54: 213-7, 2005.
110)  Van Waes C, Chang AA, Lebowitz PF, Druzgal CH, Chen Z, Elsayed YA, Sunwoo JB, Rudy SF, Morris JC, Mitchell JB, Camphausen K, Gius D, Adams J, Sausville EA, Conley BA.
Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma.
Int. J. Radiat. Oncol. Biol. Phys. 63: 1400-12, 2005.
111)  Cotrim AP, Sowers AL, Lodde BM, Vitolo JM, Kingman A, Russo A, Mitchell JB, Baum BJ.
Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model.
Clin. Cancer Res. 11: 7564-8, 2005.
112)  Sostaric JZ, Miyoshi N, Riesz P, DeGraff WG, Mitchell JB.
n-Alkyl glucopyranosides completely inhibit ultrasound-induced cytolysis.
Free Radic. Biol. Med. 39: 1539-48, 2005.
113)  Suy S, Mitchell JB, Samuni A, Mueller S, Kasid U.
Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice.
Cancer. 103: 1302-13, 2005.
114)  Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Proc. Natl. Acad. Sci. U.S.A. 102: 13604-9, 2005.
115)  Metz JM, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM.
A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy.
Clin Cancer Res. 10: 6411-7, 2004.
116)  Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A.
Amelioration of radiation-induced fibrosis: Inhibtion of transforming growth factor-b signaling by halofuginone.
J Biol Chem. 279: 15167-76, 2004.
117)  Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clin Cancer Res. 10: 7712-20, 2004.
118)  Schubert R, Erker L, Barlow C, Yakushiji H, Larson D, Russo A, Mitchell JB, Wynshaw-Boris A.
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
Hum Mol Genet. 13: 1793-802, 2004.
119)  Gius D, Cui H, Bradbury CM, Cook J, Smart DK, Zhao S, Young L, Brandenburg SA, Hu Y, Bisht KS, Ho AS, Mattson D, Sun L, Munson PJ, Chuang EY, Mitchell JB, Feinberg AP.
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.
Cancer Cell. 6: 361-71, 2004.
120)  Samuni Y, Gamson J, Samuni A, Yamada K, Russo A, Krishna MC, Mitchell JB.
Factors influencing nitroxide reduction and cytotoxicity in vitro.
Antioxid Redox Signal. 6: 587-95, 2004.
121)  Rosenwald A, Chuang EY, Davis RE, Wiestner A, Alizadeh AA, Arthur DC, Mitchell JB, Marti GE, Fowler DH, Wilson WH, Staudt LM.
Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response.
Blood. 104: 1428-34, 2004.
122)  Reijnders K, English SJ, Krishna MC, Cook JA, Sowers AL, Mitchell JB, Zhang Y.
Influence of body temperature on the BOLD effect in murine SCC tumors dagger.
Magn Reson Med. 51: 389-93, 2004.
123)  Mitchell JB, Yamada K, Devasahayam N, Cook JA, Subramanian S, Krishna MC.
Novel functional imaging for tissue oxygen concentration and redox status.
J Nutr. 134: 3210S, 2004.
124)  Matsumoto K, Krishna MC, Mitchell JB.
Novel pharmacokinetic measurement using electron paramagnetic resonance spectroscopy and simulation of in vivo decay of various nitroxyl spin probes in mouse blood.
J Pharmacol Exp Ther. 310: 1076-83, 2004.
125)  Loercher A, Lee TL, Ricker JL, Howard A, Geoghegen J, Chen Z, Sunwoo JB, Sitcheran R, Chuang EY, Mitchell JB, Baldwin AS, Van Waes C.
Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.
Cancer Res. 64: 6511-23, 2004.
126)  Cook JA, Gius D, Wink DA, Krishna MC, Russo A, Mitchell JB.
Oxidative stress, redox, and the tumor microenvironment.
Semin. Radiat Oncol. Jul; 14 (3): 259-66, 2004.
127)  Matsumoto K, English S, Yoo J, Yamada K, Devasahayam N, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Pharmacokinetics of a triarylmethyl-type paramagnetic spin probe used in EPR oximetry.
Magn. Reson. Med. Oct; 52 (4): 885, 2004.
128)  Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP.
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Cancer Res. 64: 3350-6, 2004.
129)  Subramanian S, Matsumoto K, Mitchell JB, Krishna MC.
Radio-frequency continuous-wave and time-domain EPR imaging and Overhauser-enhanced magnetic resonance imaging of small animals: instrumental developments and comparison of relative merits for functional imaging.
NMR Biomed. Aug; 17 (5): 263-66, 2004.
130)  Devasahayam N, Murugesan R, Matsumoto K, Mitchell JB, Cook JA, Subramanian S, Krishna MC.
Tailored sinc pulses for uniform excitation and artifact-free radio frequency time-domain EPR imaging.
J Magn Reson. 168: 110-7, 2004.
131)  Samuni AM, DeGraff W, Cook JA, Krishna MC, Russo A, Mitchell JB.
The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells.
Free Radic Biol Med. 37: 1648-55, 2004.
132)  Vitolo JM, Cotrim AP, Sowers AL, Russo A, Wellner RB, Pillemer SR, Mitchell JB, Baum BJ.
The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model.
Clin Cancer Res. 10: 1807-12, 2004.
133)  Mitchell JB, Xavier S, DeLuca AM, Sowers AL, Cook JA, Krishna MC, Hahn SM, Russo A.
A Low Molecular Weight Antioxidant Decreases Weight and Lowers Tumor Incidence.
Free Rad. Biol. Med. 34: 93-102, 2003.
134)  Taube AG, Subramanian S, Murugesan R, Devasahayam N, Mitchell JB, Krishna MC, Cook JA.
An Application System for Automation of Constant-Time Radio Frequency Electron Paramagnetic Resonance Imaging.
Comput. Methods Programs Biomed. 72: 127-138, 2003.
135)  Matsumoto K, Chandrika B, Lohman JA, Mitchell JB, Krishna MC, Subramanian S.
Application of continuous-wave EPR spectral-spatial image reconstruction techniques for in vivo oxymetry: comparison of projection reconstruction and constant-time modalities.
Magn Reson Med. 50: 865-74, 2003.
136)  Colevas AD, Brown JM, Hahn S, Mitchell J, Camphausen K, Coleman CN, Radiation Modifier Working Group of the National Cancer Institute .
Development of investigational radiation modifiers.
J Natl Cancer Inst. 95: 646-51, 2003.
137)  Stein W, Subramanian S, Mitchell JB, Krishna MC.
EPR imaging of vascular changes in oxygen in response to carbogen breathing.
Adv Exp Med Biol. 510: 231-6, 2003.
138)  Stein W, Subramanian S, Mitchell JB, Krishna MC.
EPR imaging of vascular changes in oxygen in response to carbogen breathing.
Adv Exp Med Biol. 510: 231-6, 2003.
139)  Kennedy CH, Pass HI, Mitchell JB.
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Free Radic Biol Med. 34: 1447-57, 2003.
140)  Yordanov AT, Kobayashi H, English SJ, Reijnders K, Milenic D, Krishna MC, Mitchell JB, Brechbiel MW.
Gadolinium-labeled dendrimers as biometric nanoprobes to detect vascular permeability.
J. Materials Chem. 13: 1523-1525, 2003.
141)  Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D.
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
Cancer Res. 63: 8984-95, 2003.
142)  Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA, Mitchell JB, Russo A, Roberts AB.
Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin.
Am J Pathol. 163: 2247-57, 2003.
143)  Coleman CN, Blakely WF, Fike JR, MacVittie TJ, Metting NF, Mitchell JB, Moulder JE, Preston RJ, Seed TM, Stone HB, Tofilon PJ, Wong RS.
Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001.
Radiat Res. 159: 812-34, 2003.
144)  Hu G, Lyeth BG, Zhao X, Mitchell JB, Watson JC.
Neuroprotection by the stable nitroxide 3-carbamoyl-proxyl during reperfusion in a rat model of transient focal ischemia.
J Neurosurg. 98: 393-6, 2003.
145)  Wink DA, Mitchell JB.
Nitric oxide and cancer: an introduction.
Free Radic Biol Med. 34: 951-4, 2003.
146)  De Graff WG, Myers LS, Mitchell JB, Hahn SM.
Protection against Adriamycin cytotoxicity and inhibition of DNA topoisomerase II activity by 3,4-dihydroxybenzoic acid.
Int J Oncol. 23: 159-63, 2003.
147)  Samuni AM, Chuang EY, Krishna MC, Stein W, DeGraff W, Russo A, Mitchell JB.
Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: Chemoprevention strategies with antioxidants.
Proc. Natl. Acad. Sci. USA. 100 (9): 5390-5395, 2003.
148)  Yordanov AT, Yamada K, Krishna MC, Russo A, Yoo J, English S, Mitchell JB, Brechbiel MW.
Acyl-protected hydroxylamines as spin label generators for EPR brain imaging.
J Med Chem. 45: 2283-8, 2002.
149)  Chandrasekharan S, Qiu TH, Alkharouf N, Brantley K, Mitchell JB, Liu ET.
Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.
Mol Cell Biol. 22: 5235-47, 2002.
150)  Xavier S, Yamada K, Samuni AM, Samuni A, DeGraff W, Krishna MC, Mitchell JB.
Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage.
Biochim Biophys Acta. 1573: 109-20, 2002.
151)  Yamada K, Murugesan R, Devasahayam N, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Evaluation and comparison of pulsed and continuous wave radiofrequency electron paramagnetic resonance techniques for in vivo detection and imaging of free radicals.
J Magn Reson. 154: 287-97, 2002.
152)  Devasahayam N, Murugesan R, Yamada K, Reijnders K, Mitchell JB, Subramanian S, Krishna MC, Cook JA.
Evaluation of a high-speed signal-averager for sensitivity enhancement in radio frequency Fourier transform electron paramagnetic resonance imaging.
Rev. Sci. Instrum. 73 (11): 3920-3925, 2002.
153)  Yamada KI, Kuppusamy P, English S, Yoo J, Irie A, Subramanian S, Mitchell JB, Krishna MC.
Feasibility and assessment of non-invasive in vivo redox status using electron paramagnetic resonance imaging.
Acta Radiol. 43: 433-40, 2002.
154)  Murugesan R, English S, Reijnders K, Yamada K, Cook JA, Mitchell JB, Subramanian S, Krishna MC.
Fluorine electron double resonance imaging for 19F MRI in low magnetic fields.
Magn Reson Med. 48: 523-9, 2002.
155)  Miranda KM, Yamada K, Espey MG, Thomas DD, DeGraff W, Mitchell JB, Krishna MC, Colton CA, Wink DA.
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
Arch Biochem Biophys. 401: 134-44, 2002.
156)  Chuang YY, Chen Y, Gadisetti , Chandramouli VR, Cook JA, Coffin D, Tsai MH, DeGraff W, Yan H, Zhao S, Russo A, Liu ET, Mitchell JB.
Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.
Cancer Res. 62: 6246-54, 2002.
157)  Ilangovan G, Li H, Zweier JL, Krishna MC, Mitchell JB, Kuppusamy P.
In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing.
Magn Reson Med. 48: 723-30, 2002.
158)  Samuni A, Goldstein S, Russo A, Mitchell JB, Krishna MC, Neta P.
Kinetics and mechanism of hydroxyl radical and OH-adduct radical reactions with nitroxides and with their hydroxylamines.
J Am Chem Soc. 124: 8719-24, 2002.
159)  Goldstein S, Samuni A, Aronovitch Y, Godinger D, Russo A, Mitchell JB.
Kinetics of paraquat and copper reactions with nitroxides: the effects of nitroxides on the aerobic and anoxic toxicity of paraquat.
Chem Res Toxicol. 15: 686-91, 2002.
160)  Samuni AM, Krishna MC, DeGraff W, Russo A, Planalp RP, Brechbiel MW, Mitchell JB.
Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.
Biochim Biophys Acta. 1571: 211-8, 2002.
161)  Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, Arabshahi A, Major C, Deng C, Russo A, Mitchell JB, Roberts AB.
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation.
Am J Pathol. 160: 1057-68, 2002.
162)  Samuni AM, DeGraff W, Krishna MC, Mitchell JB.
Nitroxides as antioxidants: tempol protects against EO9 cytotoxicity.
Mol Cell Biochem. 234-235: 327-33, 2002.
163)  Mitchell JB, Krishna MC.
Nitroxides as radiation protectors.
Mil Med. 167: 49-50, 2002.
164)  Kuppusamy P, Li H, Ilangovan G, Cardounel AJ, Zweier JL, Yamada K, Krishna MC, Mitchell JB.
Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.
Cancer Res. 62: 307-12, 2002.
165)  Subramanian S, Yamada K, Irie A, Murugesan R, Cook JA, Devasahayam N, Van Dam GM, Mitchell JB, Krishna MC.
Noninvasive in vivo oximetric imaging by radiofrequency FT EPR.
Magn Reson Med. 47: 1001-8, 2002.
166)  Krishna MC, English S, Yamada K, Yoo J, Murugesan R, Devasahayam N, Cook JA, Golman K, Ardenkjaer-Larsen JH, Subramanian S, Mitchell JB.
Overhauser enhanced magnetic resonance imaging for tumor oximetry: coregistration of tumor anatomy and tissue oxygen concentration.
Proc Natl Acad Sci U S A. 99: 2216-21, 2002.
167)  Poggi MM, Kroog GS, Russo A, Muir C, Cook J, Smith J, Mitchell JB, Herscher LL.
Phase I study of weekly gemcitabine as a radiation sensitizer for unresectable pancreatic cancer.
Int J Radiat Oncol Biol Phys. 54: 670-6, 2002.
168)  Subramanian S, Devasahayam N, Murugesan R, Yamada K, Cook J, Taube A, Mitchell JB, Lohman JA, Krishna MC.
Single-point (constant-time) imaging in radiofrequency Fourier transform electron paramagnetic resonance.
Magn Reson Med. 48: 370-9, 2002.
169)  Coleman CN, Mitchell JB, Camphausen K.
Tumor hypoxia: chicken, egg, or a piece of the farm.
J Clin Oncol. 20: 610-5, 2002.
170)  Samuni AM, DeGraff W, Krishna MC, Mitchell JB.
Cellular sites of H2O2-induced damage and their protection by nitroxides.
Biochim Biophys Acta. 1525: 70-6, 2001.
171)  Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A.
Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listeriocidal activity of oxidative and nitrosative stress.
Free Radic Biol Med. 30: 268-76, 2001.
172)  Sunwoo JB, Herscher LL, Kroog GS, Thomas GR, Ondrey FG, Duffey DC, Solomon BI, Boss C, Albert PS, McCullugh L, Rudy S, Muir C, Zhai S, Figg WD, Cook JA, Mitchell JB, Van Waes C.
Concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer.
J Clin Oncol. 19: 800-11, 2001.
173)  Krishna MC, Devasahayam N, Cook JA, Subramanian S, Kuppusamy P, Mitchell JB.
Electron paramagnetic resonance for small animal imaging applications.
ILAR J. 42: 209-18, 2001.
174)  Ling CC, Mitchell JB.
Semin Radiat Oncol. 11: 1-2, 2001.
175)  Roberts AB, Piek E, Böttinger EP, Ashcroft G, Mitchell JB, Flanders KC.
Is Smad3 a major player in signal transduction pathways leading to fibrogenesis.
Chest. 120: 43S-47S, 2001.
176)  Krishna MC, Subramanian S, Kuppusamy P, Mitchell JB.
Magnetic resonance imaging for in vivo assessment of tissue oxygen concentration.
Semin Radiat Oncol. 11: 58-69, 2001.
177)  Samuni AM, Afeworki M, Stein W, Yordanov AT, DeGraff W, Krishna MC, Mitchell JB, Brechbiel MW.
Multifunctional antioxidant activity of HBED iron chelator.
Free Radic Biol Med. 30: 170-7, 2001.
178)  Mitchell JB, Krishna MC, Kuppusamy P, Cook JA, Russo A.
Protection against oxidative stress by nitroxides.
Exp Biol Med (Maywood). 226: 620-1, 2001.
179)  Cook J.
Radiation sensitization of mammalian cells by metal chelators.
Radiat Res. 155: 304-10, 2001.
180)  Poggi MM, Coleman CN, Mitchell JB.
Sensitizers and protectors of radiation and chemotherapy.
Curr Probl Cancer. 25: 334-411, 2001.
181)  Yordanov AT, Yamada Ki Ken-ichi, Krishna MC, Mitchell JB, Woller E, Cloninger M, Brechbiel MW.
Spin-Labeled Dendrimers in EPR Imaging with Low Molecular Weight Nitroxides.
Angew Chem Int Ed Engl. 40: 2690-2692, 2001.
182)  Kosceilniak J, Devasahayam N, Moni MS, Kuppusamy P, Yamada K, Mitchell JB, Krishna MC, Subramanian S.
300 MHz Continuous Wave Electron Paramagnetic Resonance Spectrometer for Small Animal In Vivo Imaging.
Review of Scientific Instruments. 71: 4273-4281, 2000.
183)  Kato T, Duffey DC, Ondrey FG, Dong G, Chen Z, Cook JA, Mitchell JB, Van Waes C.
Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB.
Head Neck. 22: 748-59, 2000.
184)  Hahn SM, Krishna MC, DeLuca AM, Coffin D, Mitchell JB.
Evaluation of the hydroxylamine Tempol-H as an in vivo radioprotector.
Free Radic Biol Med. 28: 953-8, 2000.
185)  Mitchell JB, Cook JA, Stein W, Coffin D, Espey MG, Miranda KM, Wink DA.
Is There a Role for NItric Oxide in Cancer Treatment?.
Radiat. Res. 2, Congress Proceedings: 618-621, 2000.
186)  Vodovotz Y, Mitchell JB, Lucia MS, McKinney L, Kollum M, Cottin Y, Chan RC, Barcellos-Hoff MH, Waksman R.
Modulation of protein expression and activity by radiation: relevance to intracoronary radiation for the prevention of restenosis.
Cardiovasc Radiat Med. 1: 336-43, 2000.
187)  Devasahayam N, Subramanian S, Murugesan R, Cook JA, Afeworki M, Tschudin RG, Mitchell JB, Krishna MC.
Parallel coil resonators for time-domain radiofrequency electron paramagnetic resonance imaging of biological objects.
J Magn Reson. 142: 168-76, 2000.
188)  Zhou Q, Fukushima P, DeGraff W, Mitchell JB, Stetler Stevenson M, Ashkenazi A, Steeg PS.
Radiation and the Apo2L/TRAIL apoptotic pathway preferentially inhibit the colonization of premalignant human breast cells overexpressing cyclin D1.
Cancer Res. 60: 2611-5, 2000.
189)  Mitchell JB, Russo A, Kuppusamy P, Krishna MC.
Radiation, radicals, and images.
Ann N Y Acad Sci. 899: 28-43, 2000.
190)  Bernhard EJ, Mitchell JB, Deen D, Cardell M, Rosenthal DI, Brown JM.
Re-evaluating gadolinium(III) texaphyrin as a radiosensitizing agent.
Cancer Res. 60: 86-91, 2000.
191)  Vodovotz Y, Lucia MS, DeLucca AM, Mitchell JB, Kopp JB.
Reduced hematopoietic function and enhanced radiosensitivity of transforming growth factor-beta1 transgenic mice.
Int J Cancer. 90: 13-21, 2000.
192)  Vodovotz Y, Waksman R, Cook JA, Kim WH, Chan R, Seabron R, Collins SD, Pierre A, Bramwell O, Wink D, Mitchell JB, Leon MB.
S-nitrosoglutathione reduces nonocclusive thrombosis rate following balloon overstretch injury and intracoronary irradiation of porcine coronary arteries.
Int J Radiat Oncol Biol Phys. 48: 1167-74, 2000.
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