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Our Science – Rein Website

Alan Rein, Ph.D.

Selected Publications

1)  Fang X, Wang J, O'Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SF, Rein A, Wang Y.
An Unusual Topological Structure of the HIV-1 Rev Response Element.
Cell. 155: 594-605, 2013.
Full Text Article. [Journal]
2)  Datta SA, Temeselew LG, Crist RM, Soheilian F, Kamata A, Mirro J, Harvin D, Nagashima K, Cachau RE, Rein A.
On the Role of the SP1 Domain in HIV-1 Particle Assembly: a Molecular Switch?.
J. Virol. 85: 4111-21, 2011.
3)  O'Carroll IP, Crist RM, Mirro J, Harvin D, Soheilian F, Kamata A, Nagashima K, Rein A.
Functional Redundancy in HIV-1 Viral Particle Assembly.
J. Virol. 86: 12991-6, 2012.
4)  Rein A.
Murine leukemia viruses: Objects and organisms.
Adv Virol. , vol. 2011, article ID 403419: 1-14, 2011.
Full Text Article. [Journal]
5)  Datta SA, Zuo X, Clark PK, Campbell SJ, Wang YX, Rein A.
Solution Properties of Murine Leukemia Virus Gag Protein: Differences from HIV-1 Gag.
J. Virol. 85: 12733-41, 2011.
6)  Grohman JK, Gorelick RJ, Kottegoda S, Allbritton NL, Rein A, Weeks KM.
An immature retroviral RNA genome resembles a kinetically trapped intermediate state.
J. Virol. 88: 6061-8, 2014.
7)  Nair S, Sanchez-Martinez S, Ji X, Rein A.
Biochemical and biological studies of mouse APOBEC3.
J Virol. 88: 3850-3860, 2014.
Full Text Article. [Journal]
8)  Munro J, Nath A, Farber M, Datta S, Rein A, Rhoades E, Mothes W.
A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles.
J Virol. 88: 3577-3585, 2014.
9)  Jensen SM, Ruscetti FW, Rein A, Bertolette DC, Saucedo CJ, O'Keefe BR, Jones KS.
Differential Inhibitory Effects of Cyanovirin-N, Griffithsin and Scytovirin on Entry Mediated by Envelopes of Gammaretroviruses and Deltaretroviruses.
J. Virol. 88: 2327-2332, 2014.
10)  Aloia A, Duffy L, Pak V, Lee K, Sanchez-Martinez S, Derse D, Heidecker G, Cornetta K, Rein A.
A reporter system for replication-competent gammaretroviruses: The inGluc-MLV-DERSE assay.
Gene Ther. 20: 169-176, 2013.
11)  O'Carroll IP, Soheilian F, Kamata A, Nagashima K, Rein A.
Elements in HIV-1 Gag contributing to virus particle assembly.
Virus Res. 171: 341-5, 2013.
12)  Stavrou S, Nitta T, Kotla S, Ha D, Nagashima K, Rein AR, Fan H, Ross SR.
Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.
Proc. Natl. Acad. Sci. U.S.A. 110: 9078-83, 2013.
Full Text Article. [Journal]
13)  Rein A.
Murine leukemia virus p12 functions include hitchhiking into the nucleus.
Proc Natl Acad Sci U S A. 110: 9195-9196, 2013.
Full Text Article. [Journal]
14)  Sanchez-Martinez S, Aloia AL, Harvin D, Mirro J, Gorelick RJ, Jern P, Coffin JM, Rein A.
Studies on the restriction of murine leukemia viruses by mouse APOBEC3.
PLoS ONE. 7: e38190, 2012.
15)  Sfanos KS, Aloia AL, De Marzo AM, Rein A.
XMRV and prostate cancer-a 'final' perspective.
Nat Rev Urol. 9: 111-8, 2012.
16)  Rein A, Datta SA, Jones CP, Musier-Forsyth K.
Diverse interactions of retroviral Gag proteins with RNAs.
Trends Biochem Sci. 36: 373-80, 2011.
17)  Datta SA, Heinrich F, Raghunandan S, Krueger S, Curtis JE, Rein A, Nanda H.
HIV-1 gag extension: Conformational changes require simultaneous interaction with membrane and nucleic acid.
J Mol Biol. 406: 205-214, 2011.
18)  Sfanos K, Aloia A, Hicks J, Esopi D, Steranka J, Shao W, Sanchez-Martinez S, Yegnasubramanian S, Burns K, Rein A, De Marzo A.
Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines.
PLoS One. 6: e20874, 2011.
19)  Jones CP, Datta SA, Rein A, Rouzina I, Musier-Forsyth K.
Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding.
J Virol. 85: 1594-1603, 2011.
20)  Ramalingam D, Duclair S, Datta SA, Ellington A, Rein A, Prasad VR.
RNA aptamers directed to human immunodeficiency virus type 1 gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production.
J. Virol. 85: 305-14, 2011.
21)  Goicochea NL, Datta SA, Ayaluru M, Kao C, Rein A, Dragnea B.
Structure and Stoichiometry of Template-Directed Recombinant HIV-1 Gag Particles.
J. Mol. Biol. 410: 667-80, 2011.
22)  Gherghe C, Lombo T, Leonard CW, Datta SA, Bess JW, Gorelick RJ, Rein A, Weeks KM.
Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.
Proc. Natl. Acad. Sci. U.S.A. 107: 19248-53, 2010.
23)  Nanda H, Datta SA, Heinrich F, Lösche M, Rein A, Krueger S, Curtis JE.
Electrostatic Interactions and Binding Orientation of HIV-1 Matrix Studied by Neutron Reflectivity.
Biophys. J. 99: 2516-24, 2010.
24)  Wu T, Datta SA, Mitra M, Gorelick RJ, Rein A, Levin JG.
Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications.
Virology. 405: 556-67, 2010.
25)  Rein A.
Nucleic acid chaperone activity of retroviral Gag proteins.
RNA Biol. 7: 61-66, 2010.
26)  Aloia AL, Sfanos KS, Isaacs WB, Zheng Q, Maldarelli F, De Marzo AM, Rein A.
XMRV: A New Virus in Prostate Cancer?.
Cancer Res. 70: 10028-10033, 2010.
27)  Crist RM, Datta SA, Stephen AG, Soheilian F, Mirro J, Fisher RJ, Nagashima K, Rein A.
Assembly properties of human immunodeficiency virus type 1 Gag-leucine zipper chimeras: Implications for retrovirus assembly.
J. Virol. 83: 2216-2225, 2009.
Full Text Article. [Journal]
28)  Datta SA, Rein A.
Preparation of Recombinant HIV-1 Gag Protein and Assembly of Virus-Like Particles In Vitro.
Methods Mol. Biol. 485: 197-208, 2009.
29)  Chen H, Lee JS, Liang X, Zhang H, Zhu T, Zhang Z, Taylor ME, Zahnow C, Feigenbaum L, Rein A, Sukumar S.
Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis.
Cancer Res. 68: 3637-44, 2008.
30)  Ricci EP, Herbreteau CH, Decimo D, Schaupp A, Datta SA, Rein A, Darlix JL, Ohlmann T.
In vitro expression of the HIV-2 genomic RNA is controlled by three distinct internal ribosome entry segments that are regulated by the HIV protease and the Gag polyprotein.
RNA. 14: 1443-55, 2008.
31)  Wilkinson KA, Gorelick RJ, Vasa SM, Guex N, Rein A, Mathews DH, Giddings MC, Weeks KM.
High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states.
PLoS Biol. 6: e96, 2008.
32)  Rulli SJ, Mirro J, Hill SA, Lloyd P, Gorelick RJ, Coffin JM, Derse D, Rein A.
Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses.
J. Virol. 82: 6566-75, 2008.
33)  Datta SA, Curtis JE, Ratcliff W, Clark PK, Crist RM, Lebowitz J, Krueger S, Rein A.
Conformation of the HIV-1 Gag protein in solution.
J. Mol. Biol. 365: 812-24, 2007.
34)  Datta SA, Zhao Z, Clark PK, Tarasov S, Alexandratos JN, Campbell SJ, Kvaratskhelia M, Lebowitz J, Rein A.
Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch.
J. Mol. Biol. 365: 799-811, 2007.
35)  Stephen AG, Datta SA, Worthy KM, Bindu L, Fivash MJ, Turner KB, Fabris D, Rein A, Fisher RJ.
Measuring the binding stoichiometry of HIV-1 Gag to very-low-density oligonucleotide surfaces using surface plasmon resonance spectroscopy.
J Biomol Tech. 18: 259-66, 2007.
36)  Rulli SJ, Hibbert CS, Mirro J, Pederson T, Biswal S, Rein A.
Selective and nonselective packaging of cellular RNAs in retrovirus particles.
J. Virol. 81: 6623-31, 2007.
37)  Fisher RJ, Fivash MJ, Stephen AG, Hagan NA, Shenoy SR, Medaglia MV, Smith LR, Worthy KM, Simpson JT, Shoemaker R, McNitt KL, Johnson DG, Hixson CV, Gorelick RJ, Fabris D, Henderson LE, Rein A.
Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides [Erratum and Supplementary Material].
Nucleic Acids Res. 34: 472-84, 2006.
38)  Kovaleski BJ, Kennedy R, Hong MK, Datta SA, Kleiman L, Rein A, Musier-Forsyth K.
In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase.
J. Biol. Chem. 281: 19449-56, 2006.
39)  Shkriabai N, Datta SA, Zhao Z, Hess S, Rein A, Kvaratskhelia M.
Interactions of HIV-1 Gag with assembly cofactors.
Biochemistry. 45: 4077-83, 2006.
40)  Kol N, Gladnikoff M, Barlam D, Shneck RZ, Rein A, Rousso I.
Mechanical properties of murine leukemia virus particles: effect of maturation.
Biophys. J. 91: 767-74, 2006.
41)  Rulli SJ, Muriaux D, Nagashima K, Mirro J, Oshima M, Baumann JG, Rein A.
Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.
Virology. 347: 364-371, 2006.
42)  Cruceanu M, Urbaneja MA, Hixson CV, Johnson DG, Datta SA, Fivash MJ, Stephen AG, Fisher RJ, Gorelick RJ, Casas-Finet JR, Rein A, Rouzina I, Williams MC.
Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins.
Nucleic Acids Res. 34: 593-605, 2006.
43)  Yang QE, Stephen AG, Adelsberger JW, Roberts PE, Zhu W, Currens MJ, Feng Y, Crise BJ, Gorelick RJ, Rein AR, Fisher RJ, Shoemaker RH, Sei S.
Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4.
J Virol. 79: 6122-33, 2005.
44)  Hibbert CS, Rein A.
Preliminary physical mapping of RNA-RNA linkages in the genomic RNA of Moloney murine leukemia virus.
J Virol. 79: 8142-8148, 2005.
45)  Oshima M, Muriaux D, Mirro J, Nagashima K, Dryden K, Yeager M, Rein A.
Effects of blocking individual maturation cleavages in murine leukemia virus gag.
J Virol. 78: 1411-20, 2004.
46)  Mura M, Murcia P, Caporale M, Spencer TE, Nagashima K, Rein A, Palmarini M.
Late viral interference induced by transdominant Gag of an endogenous retrovirus.
Proc Natl Acad Sci U S A. 101: 11117-22, 2004.
47)  Hibbert CS, Mirro J, Rein A.
mRNA molecules containing MLV packaging signals are encapsidated as dimers.
J Virol. 10927-38: 78, 2004.
48)  Baumann JG, Unutmaz D, Miller MD, Breun SK, Grill SM, Mirro J, Littman DR, Rein A, KewalRamani VN.
Murine T cells potently restrict human immunodeficiency virus infection.
J Virol. 78: 12537-47, 2004.
49)  Muriaux D, Costes S, Nagashima K, Mirro J, Cho E, Lockett S, Rein A.
Role of murine leukemia virus nucleocapsid protein in virus assembly.
J Virol. 78: 12378-85, 2004.
50)  Rein A.
Take two.
Nat Struct Mol Biol. 11: 1034-5, 2004.
51)  Muriaux D, Rein A.
Encapsidation and transduction of cellular genes by retroviruses.
Front Biosci. 8: D135-42, 2003.
52)  Rein A.
Genetic footprinting of a retroviral Gag gene suggests an important role in virus replication.
Proc Natl Acad Sci U S A. 100: 11929-30, 2003.
53)  Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP, Sukumar S.
Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.
Oncogene. 22: 2021-33, 2003.
54)  Rawat SS, Viard M, Gallo SA, Rein A, Blumenthal R, Puri A.
Modulation of entry of enveloped viruses by cholesterol and sphingolipids (Review).
Mol Membr Biol. 20: 243-54, 2003.
55)  Bouamr F, Melillo JA, Wang MQ, Nagashima K, de Los Santos M, Rein A, Goff SP.
PPPYEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101.
J Virol. 77: 11882-95, 2003.
56)  Stephen AG, Rein A, Fisher RJ, Shoemaker R.
The nucleocapsid protein as a target for novel anti-HIV drugs.
Curr Drug Disc. August: 33-36, 2003.
57)  Stephen AG, Worthy KM, Towler E, Mikovits JA, Sei S, Roberts P, Yang QE, Akee RK, Klausmeyer P, McCloud TG, Henderson L, Rein A, Covell DG, Currens M, Shoemaker RH, Fisher RJ.
Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity.
Biochem Biophys Res Commun. 296: 1228-37, 2002.
58)  Muriaux D, Mirro J, Nagashima K, Harvin D, Rein A.
Murine leukemia virus nucleocapsid mutant particles lacking viral RNA encapsidate ribosomes.
J Virol. 76: 11405-13, 2002.
59)  Cen S, Javanbakht H, Kim S, Shiba K, Craven R, Rein A, Ewalt K, Schimmel P, Musier-Forsyth K, Kleiman L.
Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs.
J Virol. 76: 13111-5, 2002.
60)  Campbell S, Oshima M, Mirro J, Nagashima K, Rein A.
Reversal by dithiothreitol treatment of the block in murine leukemia virus maturation induced by disulfide cross-linking.
J Virol. 76: 10050-5, 2002.
61)  Feng YX, Li T, Campbell S, Rein A.
Reversible binding of recombinant human immunodeficiency virus type 1 gag protein to nucleic acids in virus-like particle assembly in vitro.
J Virol. 76: 11757-62, 2002.
62)  Campbell S, Fisher RJ, Towler EM, Fox S, Issaq HJ, Wolfe T, Phillips LR, Rein A.
Modulation of HIV-like particle assembly in vitro by inositol phosphates.
Proc Natl Acad Sci U S A. 98: 10875-9, 2001.
63)  Muriaux D, Mirro J, Harvin D, Rein A.
RNA is a structural element in retrovirus particles.
Proc Natl Acad Sci U S A. 98: 5246-51, 2001.
64)  Yuan B, Campbell S, Bacharach E, Rein A, Goff SP.
Infectivity of Moloney murine leukemia virus defective in late assembly events is restored by late assembly domains of other retroviruses.
J Virol. 74: 7250-60, 2000.
65)  Feng YX, Moore SP, Garfinkel DJ, Rein A.
The genomic RNA in Ty1 virus-like particles is dimeric.
J Virol. 74: 10819-21, 2000.
66)  Nair S, Rein A.
Antiretroviral restriction factors in mice.
Virus Res. 2014.
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This page was last updated on 8/13/2014.