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Our Science – Lee Website

Maxwell P. Lee, Ph.D.

Selected Publications

1)  Lee MP.
Allele-specific gene expression and epigenetic modifications and their application to understanding inheritance and cancer.
Biochim. Biophys. Acta. 1819: 739-42, 2012.
[Journal]
2)  Abnet CC, Wang Z, Song X, Hu N, Zhou FY, Freedman ND, Li XM, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Liao LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Chung CC, Wang C, Wheeler W, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF, Tucker MA, Chow WH, Zhao XK, Li JM, Li AL, Sun LD, Wei W, Li JL, Zhang P, Li HL, Cui WY, Wang WP, Liu ZC, Yang X, Fu WJ, Cui JL, Lin HL, Zhu WL, Liu M, Chen X, Chen J, Guo L, Han JJ, Zhou SL, Huang J, Wu Y, Yuan C, Huang J, Ji AF, Kul JW, Fan ZM, Wang JP, Zhang DY, Zhang LQ, Zhang W, Chen YF, Ren JL, Li XM, Dong JC, Xing GL, Guo ZG, Yang JX, Mao YM, Yuan Y, Guo ET, Zhang W, Hou ZC, Liu J, Li Y, Tang S, Chang J, Peng XQ, Han M, Yin WL, Liu YL, Hu YL, Liu Y, Yang LQ, Zhu FG, Yang XF, Feng XS, Wang Z, Li Y, Gao SG, Liu HL, Yuan L, Jin Y, Zhang YR, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Zhang GF, Yue WB, Feng CW, Qige Q, Zhao JT, Yang WJ, Lei GY, Chen LQ, Li EM, Xu LY, Wu ZY, Bao ZQ, Chen JL, Li XC, Zhuang X, Zhou YF, Zuo XB, Dong ZM, Wang LW, Fan XP, Wang J, Zhou Q, Ma GS, Zhang QX, Liu H, Jian XY, Lian SY, Wang JS, Chang FB, Lu CD, Miao JJ, Chen ZG, Wang R, Guo M, Fan ZL, Tao P, Liu TJ, Wei JC, Kong QP, Fan L, Wang XZ, Gao FS, Wang TY, Xie D, Wang L, Chen SQ, Yang WC, Hong JY, Wang L, Qiu SL, Goldstein AM, Yuan ZQ, Chanock SJ, Zhang XJ, Taylor PR, Wang LD.
Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.
Hum. Mol. Genet. 21: 2132-41, 2012.
[Journal]
3)  Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford R, Hewitt SM, Shou JZ, Goldstein AM, Lee MP, Taylor PR.
Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes.
Clin. Cancer Res. 17: 2955-66, 2011.
[Journal]
4)  Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Wang C, Wheeler W, Gail MH, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF, Tucker MA, Chow WH, Goldstein AM, Chanock SJ, Taylor PR.
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
Nat. Genet. 42: 764-7, 2010.
[Journal]
5)  Kadota M, Yang HH, Gomez B, Sato M, Clifford RJ, Meerzaman D, Dunn BK, Wakefield LM, Lee MP.
Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines.
PLoS ONE. 5: e9201, 2010.
[Journal]
6)  Hu N, Clifford RJ, Yang HH, Wang C, Goldstein AM, Ding T, Taylor PR, Lee MP.
Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma.
BMC Genomics. 11: 576, 2010.
[Journal]
7)  Yang HH, Hu N, Wang C, Ding T, Dunn BK, Goldstein AM, Taylor PR, Lee MP.
Influence of genetic background and tissue types on global DNA methylation patterns.
PLoS ONE. 5: e9355, 2010.
[Journal]
8)  Devaiah BN, Lu H, Gegonne A, Sercan Z, Zhang H, Clifford RJ, Lee MP, Singer DS.
Novel functions for TAF7, a regulator of TAF1-independent transcription.
J. Biol. Chem. 285: 38772-80, 2010.
[Journal]
9)  Hu N, Wang C, Ng D, Clifford R, Yang HH, Tang ZZ, Wang QH, Han XY, Giffen C, Goldstein AM, Taylor PR, Lee MP.
Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China.
Cancer Res. 69: 5908-17, 2009.
[Journal]
10)  Kadota M, Sato M, Duncan B, Ooshima A, Yang HH, Diaz-Meyer N, Gere S, Kageyama S, Fukuoka J, Nagata T, Tsukada K, Dunn BK, Wakefield LM, Lee MP.
Identification of Novel Gene Amplifications in Breast Cancer and Coexistence of Gene Amplification with an Activating Mutation of PIK3CA.
Cancer Res. 69: 7357-65, 2009.
[Journal]
11)  Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, Lee MP, Ozato K, Hunter KW.
Bromodomain 4 activation predicts breast cancer survival.
Proc. Natl. Acad. Sci. U.S.A. 105: 6380-5, 2008.
[Journal]
12)  Lee MP, Dunn BK.
Influence of genetic inheritance on global epigenetic states and cancer risk prediction with DNA methylation signature: challenges in technology and data analysis.
Nutr. Rev. 66 Suppl 1: S69-72, 2008.
[Journal]
13)  Ng D, Hu N, Hu Y, Wang C, Giffen C, Tang ZZ, Han XY, Yang HH, Lee MP, Goldstein AM, Taylor PR.
Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.
Int. J. Cancer. 123: 1610-5, 2008.
[Journal]
14)  Yang HH, Hu N, Taylor PR, Lee MP.
Whole genome-wide association study using affymetrix SNP chip: a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases.
Methods Mol. Med. 141: 23-35, 2008.
[Journal]
15)  Kadota M, Yang HH, Hu N, Wang C, Hu Y, Taylor PR, Buetow KH, Lee MP.
Allele-specific chromatin immunoprecipitation studies show genetic influence on chromatin state in human genome.
PLoS Genet. 3: e81, 2007.
[Journal]
16)  Mao G, Pan X, Zhu BB, Zhang Y, Yuan F, Huang J, Lovell MA, Lee MP, Markesbery WR, Li GM, Gu L.
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease.
Nucleic Acids Res. 35: 2759-66, 2007.
[Journal]
17)  Riss J, Khanna C, Koo S, Chandramouli GV, Yang HH, Hu Y, Kleiner DE, Rosenwald A, Schaefer CF, Ben-Sasson SA, Yang L, Powell J, Kane DW, Star RA, Aprelikova O, Bauer K, Vasselli JR, Maranchie JK, Kohn KW, Buetow KH, Linehan WM, Weinstein JN, Lee MP, Klausner RD, Barrett JC.
Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.
Cancer Res. 66: 7216-7224, 2006.
[Journal]
18)  Hu N, Wang C, Hu Y, Yang HH, Kong LH, Lu N, Su H, Wang QH, Goldstein AM, Buetow KH, Emmert-Buck MR, Taylor PR, Lee MP.
Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10 K array.
BMC Genomics. 7: 299, 2006.
[Journal]
19)  Lin W, Yang HH, Lee MP.
Allelic variation in gene expression identified through computational analysis of the dbEST database.
Genomics. 86: 518-27, 2005.
[Journal]
20)  Lee MP, Howcroft K, Kotekar A, Yang HH, Buetow KH, Singer DS.
ATG deserts define a novel core promoter subclass.
Genome Res. 15: 1189-97, 2005.
[Journal]
21)  Lee MP.
Genome-wide analysis of allele-specific gene expression using oligo microarrays.
Methods Mol Biol. 311: 39-48, 2005.
[Journal]
22)  Hu N, Wang C, Hu Y, Yang HH, Giffen C, Tang ZZ, Han XY, Goldstein AM, Emmert-Buck MR, Buetow KH, Taylor PR, Lee MP.
Genome-wide association study in esophageal cancer using GeneChip mapping 10K array.
Cancer Res. 65: 2542-6, 2005.
[Journal]
23)  Yang HH, Hu Y, Buetow KH, Lee MP.
A computational approach to measuring coherence of gene expression in pathways.
Genomics. 84: 211-7, 2004.
[Journal]
24)  Yang HH, Lee MP.
Application of bioinformatics in cancer epigenetics.
Ann N Y Acad Sci. 1020: 67-76, 2004.
[Journal]
25)  Wang Z, Fan H, Yang HH, Hu Y, Buetow KH, Lee MP.
Comparative sequence analysis of imprinted genes between human and mouse to reveal imprinting signatures.
Genomics. 83: 395-401, 2004.
[Journal]
26)  Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fosså SD, Feinberg AP, Lothe RA.
Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors.
Cancer Genet Cytogenet. 147: 1-8, 2003.
[Journal]
27)  Lo HS, Wang Z, Hu Y, Yang HH, Gere S, Buetow KH, Lee MP.
Allelic variation in gene expression is common in the human genome.
Genome Res. 13: 1855-62, 2003.
[Journal]
28)  Goldin LR, Ishibe N, Sgambati M, Marti GE, Fontaine L, Lee MP, Kelley JM, Scherpbier T, Buetow KH, Caporaso NE.
A genome scan of 18 families with chronic lymphocytic leukaemia.
Br J Haematol. 121: 866-73, 2003.
[Journal]
29)  Yang HH, Hu Y, Edmonson M, Buetow K, Lee MP.
Computation method to identify differential allelic gene expression and novel imprinted genes.
Bioinformatics. 19: 952-5, 2003.
[Journal]
30)  Lee MP.
Genome-wide analysis of epigenetics in cancer.
Ann N Y Acad Sci. 983: 101-9, 2003.
[Journal]
31)  Wang Z, Lo HS, Yang H, Gere S, Hu Y, Buetow KH, Lee MP.
Computational analysis and experimental validation of tumor-associated alternative RNA splicing in human cancer.
Cancer Res. 63: 655-7, 2003.
[Journal]
32)  Lo HS, Hu N, Gere S, Lu N, Su H, Goldstein AM, Taylor PR, Lee MP.
Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma.
Cancer Res. 62: 4191-3, 2002.
[Journal]
33)  DeBaun MR, Niemitz EL, McNeil DE, Brandenburg SA, Lee MP, Feinberg AP.
Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects.
Am J Hum Genet. 70: 604-11, 2002.
[Journal]
34)  Lee MP, Ravenel JD, Hu RJ, Lustig LR, Tomaselli G, Berger RD, Brandenburg SA, Litzi TJ, Bunton TE, Limb C, Francis H, Gorelikow M, Gu H, Washington K, Argani P, Goldenring JR, Coffey RJ, Feinberg AP.
Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.
J Clin Invest. 106: 1447-55, 2000.
[Journal]
35)  Uejima H, Lee MP, Cui H, Feinberg AP.
Hot-stop PCR: a simple and general assay for linear quantitation of allele ratios.
Nat Genet. 25: 375-6, 2000.
[Journal]
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This page was last updated on 5/8/2013.