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Our Science – Bosselut Website

Remy Bosselut, M.D., Ph.D.

Selected Publications

1)  Williams L, Bosselut R.
[Interleukin 22 may represent a new therapeutic tool towards thymic regeneration in vivo].
Med Sci (Paris). 29: 11-4, 2013.
2)  Vacchio MS, Bosselut R.
T cell metabolism: microRNAs cap PTEN to feed the expanding crowd.
Immunity. 38: 847-8, 2013.
3)  Xiong Y, Castro E, Yagi R, Zhu J, Lesourne R, Love PE, Feigenbaum L, Bosselut R.
Thpok-independent repression of Runx3 by Gata3 during CD4(+) T-cell differentiation in the thymus.
Eur. J. Immunol. [Epub ahead of print], 2013.
4)  Xiong Y, Bosselut R.
CD4-CD8 differentiation in the thymus: connecting circuits and building memories.
Curr. Opin. Immunol. 24: 139-45, 2012.
5)  Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.
Coreceptor gene imprinting governs thymocyte lineage fate.
EMBO J. 31: 366-77, 2012.
6)  Carpenter AC, Grainger JR, Xiong Y, Kanno Y, Chu HH, Wang L, Naik S, dos Santos L, Wei L, Jenkins MK, O'Shea JJ, Belkaid Y, Bosselut R.
The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.
Immunity. 37: 622-33, 2012.
7)  Konkel JE, Maruyama T, Carpenter AC, Xiong Y, Zamarron BF, Hall BE, Kulkarni AB, Zhang P, Bosselut R, Chen W.
Control of the development of CD8aa+ intestinal intraepithelial lymphocytes by TGFbeta.
Nat. Immunol. 12: 312-9, 2011.
8)  Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y.
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.
J. Clin. Invest. 121: 4503-15, 2011.
9)  Wang L, Xiong Y, Bosselut R.
Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.
Semin. Immunol. 23: 360-7, 2011.
10)  Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA.
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.
Immunity. 34: 303-14, 2011.
11)  Xiong Y, Bosselut R.
The enigma of CD4-lineage specification.
Eur. J. Immunol. 41: 568-74, 2011.
12)  Carpenter AC, Bosselut R.
Decision checkpoints in the thymus.
Nat. Immunol. 11: 666-73, 2010.
13)  Wang L, Carr T, Xiong Y, Wildt KF, Zhu J, Feigenbaum L, Bendelac A, Bosselut R.
The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.
Eur. J. Immunol. 40: 2385-90, 2010.
14)  Wang L, Xiong Y, Bosselut R.
Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection.
Semin Immunol. 22: 294-302, 2010.
15)  Wang L, Bosselut R.
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.
J. Immunol. 183: 2903-10, 2009.
16)  Zamisch M, Tian L, Grenningloh R, Xiong Y, Wildt KF, Ehlers M, Ho IC, Bosselut R.
The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus.
J. Exp. Med. 206: 2685-99, 2009.
17)  Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE.
Themis, a T cell-specific protein important for late thymocyte development.
Nat. Immunol. 10: 840-7, 2009.
18)  Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R.
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.
Nat. Immunol. 9: 1122-30, 2008.
19)  Wang L, Wildt KF, Castro E, Xiong Y, Feigenbaum L, Tessarollo L, Bosselut R.
The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells.
Immunity. 29: 876-87, 2008.
20)  Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A.
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Nat. Immunol. 8: 1049-59, 2007.
21)  Zhao L, Cannons JL, Anderson S, Kirby M, Xu L, Castilla LH, Schwartzberg PL, Bosselut R, Liu PP.
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus.
Blood. 109: 3432-40, 2007.
22)  Jenkinson SR, Intlekofer AM, Sun G, Feigenbaum L, Reiner SL, Bosselut R.
Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.
J. Exp. Med. 204: 267-72, 2007.
23)  Berthet C, Rodriguez-Galan MC, Hodge DL, Gooya J, Pascal V, Young HA, Keller J, Bosselut R, Kaldis P.
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.
Mol. Cell. Biol. 27: 5079-89, 2007.
24)  Wildt KF, Sun G, Grueter B, Fischer M, Zamisch M, Ehlers M, Bosselut R.
The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer.
J. Immunol. 179: 4405-14, 2007.
25)  Bosselut R.
Retroviral TCR gene transduction: 2A for two.
Nat. Methods. 3: 162-4, 2006.
26)  Liu X, Taylor BJ, Sun G, Bosselut R.
Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes.
J. Immunol. 175: 4465-74, 2005.
27)  Sun G, Liu X, Mercado P, Jenkinson SR, Kypriotou M, Feigenbaum L, Galéra P, Bosselut R.
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.
Nat Immunol. 6: 373-81, 2005.
28)  Bosselut R.
CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals.
Nat Rev Immunol. 4: 529-40, 2004.
29)  Liu X, Bosselut R.
Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.
Nat Immunol. 5: 280-8, 2004.
30)  Liu X, Adams A, Wildt KF, Aronow B, Feigenbaum L, Bosselut R.
Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.
J. Exp. Med. 197: 363-73, 2003.
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This page was last updated on 9/11/2013.