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Our Science – Ashwell Website

Jonathan D. Ashwell, M.D.

Selected Publications
1)  Giardino Torchia ML, Conze DB, Jankovic D, Ashwell JD.
Balance between NF-?B p100 and p52 regulates T cell costimulation dependence.
J. Immunol. 190: 549-55, 2013. [Journal]
2)  Munitic I, Kuka M, Allam A, Scoville JP, Ashwell JD.
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.
J. Immunol. 190: 1169-79, 2013. [Journal]
3)  Kuka M, Munitic I, Ashwell JD.
Identification and characterization of polyclonal aß-T cells with dendritic cell properties.
Nat Commun. 3: 1223, 2012. [Journal]
4)  Shen Y, Torchia ML, Lawson GW, Karp CL, Ashwell JD, Mazmanian SK.
Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.
Cell Host Microbe. 12: 509-20, 2012. [Journal]
5)  Mittelstadt PR, Monteiro JP, Ashwell JD.
Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness.
J. Clin. Invest. 122: 2384-94, 2012. [Journal]
6)  Srinivasula SM, Ashwell JD.
A20: more than one way to skin a cat.
Mol. Cell. 44: 511-2, 2011. [Journal]
7)  Jirmanova L, Giardino Torchia ML, Sarma ND, Mittelstadt PR, Ashwell JD.
Lack of the T-cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.
Blood. 118: 3280-9, 2011. [Journal]
8)  Conze DB, Zhao Y, Ashwell JD.
Non-canonical NF-kappaB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.
PLoS Biol. 8: e1000518, 2010. [Journal]
9)  Jirmanova L, Ashwell JD.
T cell priming: let there be light.
Cell Res. 20: 608-10, 2010. [Journal]
10)  Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD.
Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.
Blood. 113: 2229-37, 2009. [Journal]
11)  Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H.
Structural basis for recognition of diubiquitins by NEMO.
Mol. Cell. 33: 602-15, 2009. [Journal]
12)  Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD.
T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.
J. Biol. Chem. 284: 15469-74, 2009. [Journal]
13)  Allam A, Conze DB, Giardino Torchia ML, Munitic I, Yagita H, Sowell RT, Marzo AL, Ashwell JD.
The CD8+ memory T cell state of readiness is actively maintained and reversible.
Blood. 114: 2121-30, 2009. [Journal]
14)  Srinivasula SM, Ashwell JD.
IAPs: what's in a name?.
Mol. Cell. 30: 123-35, 2008. [Journal]
15)  Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD.
Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.
Mol. Cell. Biol. 28: 3538-47, 2008. [Journal]
16)  Wu CJ, Ashwell JD.
NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.
Proc. Natl. Acad. Sci. U.S.A. 105: 3023-8, 2008. [Journal]
17)  Ashwell JD.
TWEAKing death.
J. Cell Biol. 182: 15-7, 2008. [Journal]
18)  Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Lohr F, Wu C, Ashwell JD, Dotsch V, Dikic I, Beyaert R.
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.
Oncogene. 27: 3739-45, 2008. [Journal]
19)  Jirmanova L, Jankovic D, Fornace AJ, Ashwell JD.
Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.
J. Immunol. 178: 4153-8, 2007. [Journal]
20)  Zhu G, Wu C, Zhao Y, Ashwell JD.
Optineurin Negatively Regulates TNFalpha- Induced NF-kappaB Activation by Competing with NEMO for Ubiquitinated RIP.
Curr Biol. 17: 1438-43, 2007. [Journal]
21)  Zhao Y, Conze DB, Hanover JA, Ashwell JD.
Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.
J. Biol. Chem. 282: 7777-82, 2007. [Journal]
22)  Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD.
NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-kappaB activation.
Nat. Cell Biol. 8: 398-406, 2006. [Journal]
23)  Ashwell JD.
The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Nat. Rev. Immunol. 6: 532-40, 2006. [Journal]
24)  Schito ML, Demidov ON, Saito S, Ashwell JD, Appella E.
Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.
J. Immunol. 176: 4818-25, 2006. [Journal]
25)  Mittelstadt PR, Salvador JM, Fornace AJ, Ashwell JD.
Activating p38 MAPK: new tricks for an old kinase.
Cell Cycle. 4: 1189-92, 2005. [Journal]
26)  Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ, Ashwell JD.
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Nat Immunol. 6: 390-5, 2005. [Journal]
27)  Conze DB, Albert L, Ferrick DA, Goeddel DV, Yeh WC, Mak T, Ashwell JD.
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.
Mol Cell Biol. 25: 3348-56, 2005. [Journal]
28)  Munitic I, Ryan PE, Ashwell JD.
T cells in G1 provide a memory-like response to secondary stimulation.
J Immunol. 174: 4010-8, 2005. [Journal]
29)  Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ, Ashwell JD.
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Nat Immunol. 6: 396-402, 2005. [Journal]
30)  Wu CJ, Conze DB, Li X, Ying SX, Hanover JA, Ashwell JD.
TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.
EMBO J. 24: 1886-98, 2005. [Journal]
31)  Munitic I, Williams JA, Yang Y, Dong B, Lucas PJ, El Kassar N, Gress RE, Ashwell JD.
Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.
Blood. 104: 4165-72, 2004. [Journal]
32)  Mittelstadt PR, Ashwell JD.
Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression.
Mol. Endo. 17: 1534-1542, 2003. [Journal]
33)  D'Oro U, Munitic I, Chacko G, Karpova T, McNally J, Ashwell JD.
Regulation of constitutive T cell receptor internalization by the zeta chain.
J. Immunol. 169: 6269-6278, 2002. [Journal]
34)  Li X, Yang Y, Ashwell JD.
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
Nature. 416: 345-7, 2002. [Journal]
35)  Mittelstadt PR, Ashwell JD.
Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.
J Biol Chem. 276: 29603-10, 2001. [Journal]
36)  Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD.
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
Science. 288: 874-7, 2000. [Journal]
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This page was last updated on 4/5/2013.