Our Science – Phang Website
James M. Phang, M.D.
Selected Publications |
 |
| 1)
Phang JM, Liu W, Hancock C. Bridging epigenetics and metabolism: Role of non-essential amino acids. Epigenetics. 8: 231-6, 2013. [Journal] |
|
| 2)
Liu W, Phang JM. Proline dehydrogenase (oxidase) in cancer. Biofactors. 38: 398-406, 2012. [Journal] |
|
| 3)
Liu W, Phang JM. Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment. Autophagy. 8: 1407-9, 2012. [Journal] |
|
| 4)
Phang JM, Liu W. Proline metabolism and cancer. Front. Biosci. 17: 1835-45, 2012. [Journal] |
|
| 5)
Liu W, Glunde K, Bhujwalla ZM, Raman V, Sharma A, Phang JM. Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments. Cancer Res. 72: 3677-86, 2012. [Journal] |
|
| 6)
Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci U S A. 109: 8983-8, 2012. [Journal] |
|
| 7)
Phang JM, Liu W, Hancock C, Christian KJ. The proline regulatory axis and cancer. Front Oncol. 2: 60, 2012. [Journal] |
|
| 8)
Jung S, Silvius D, Nolan KA, Borchert GL, Millet YH, Phang JM, Gunn TM. Developmental cardiac hypertrophy in a mouse model of prolidase deficiency. Birth Defects Res. Part A Clin. Mol. Teratol. 91: 204-17, 2011. [Journal] |
|
| 9)
Tokar EJ, Qu W, Liu J, Liu W, Webber MM, Phang JM, Waalkes MP. Arsenic-specific stem cell selection during malignant transformation. J. Natl. Cancer Inst. 102: 638-49, 2010. [Journal] |
|
| 10)
Liu W, Zabirnyk O, Wang H, Shiao YH, Nickerson ML, Khalil S, Anderson LM, Perantoni AO, Phang JM. miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer. Oncogene. 29: 4914-24, 2010. [Journal] |
|
| 11)
Zabirnyk O, Liu W, Khalil S, Sharma A, Phang JM. Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. Carcinogenesis. 31: 446-54, 2010. [Journal] |
|
| 12)
Phang JM, Liu W, Zabirnyk O. Proline metabolism and microenvironmental stress. Annu. Rev. Nutr. 30: 441-63, 2010. [Journal] |
|
| 13)
Hong SY, Borchert GL, Maciag AE, Nandurdikar RS, Saavedra JE, Keefer LK, Phang JM, Chakrapani H. The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline. ACS Med Chem Lett. 1: 386-389, 2010. [Journal] |
|
| 14)
Liu Y, Borchert GL, Donald SP, Diwan BA, Anver M, Phang JM. Proline oxidase functions as a mitochondrial tumor suppressor in human cancers. Cancer Res. 69: 6414-22, 2009. [Journal] |
|
| 15)
Pandhare J, Donald SP, Cooper SK, Phang JM. Regulation and function of proline oxidase under nutrient stress. J. Cell. Biochem. 107: 759-768, 2009. [Journal] |
|
| 16)
Seleverstov O, Phang JM, Zabirnyk O. Semiconductor nanocrystals in autophagy research: methodology improvement at nanosized scale. Meth. Enzymol. 452: 277-96, 2009. [Journal] |
|
| 17)
Cooper SK, Pandhare J, Donald SP, Phang JM. A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. J. Biol. Chem. 283: 10485-92, 2008. [Journal] |
|
| 18)
Surazynski A, Donald SP, Cooper SK, Whiteside MA, Salnikow K, Liu Y, Phang JM. Extracellular matrix and HIF-1 signaling: the role of prolidase. Int. J. Cancer. 122: 1435-40, 2008. [Journal] |
|
| 19)
McCue PP, Phang JM. Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast. J. Agric. Food Chem. 56: 11011-7, 2008. [Journal] |
|
| 20)
Phang JM. Introduction to second proline symposium. Amino Acids. 35: 653-4, 2008. [Journal] |
|
| 21)
Phang JM, Pandhare J, Zabirnyk O, Liu Y. PPARgamma and Proline Oxidase in Cancer. PPAR Res. 2008: 542694, 2008. [Journal] |
|
| 22)
Surazynski A, Miltyk W, Palka J, Phang JM. Prolidase-dependent regulation of collagen biosynthesis. Amino Acids. 35: 731-8, 2008. [Journal] |
|
| 23)
Hu CA, Phang JM, Valle D. Proline metabolism in health and disease. Preface. Amino Acids. 35: 651-2, 2008. [Journal] |
|
| 24)
Liu Y, Borchert GL, Surazynski A, Phang JM. Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. Oncogene. 27: 6729-37, 2008. [Journal] |
|
| 25)
Phang JM, Pandhare J, Liu Y. The metabolism of proline as microenvironmental stress substrate. J. Nutr. 138: 2008S-2015S, 2008. [Journal] |
|
| 26)
Phang JM, Donald SP, Pandhare J, Liu Y. The metabolism of proline, a stress substrate, modulates carcinogenic pathways. Amino Acids. 35: 681-90, 2008. [Journal] |
|
| 27)
Hu CA, Donald SP, Yu J, Lin WW, Liu Z, Steel G, Obie C, Valle D, Phang JM. Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis. Mol. Cell. Biochem. 295: 85-92, 2007. [Journal] |
|
| 28)
Liu Y, Borchert GL, Surazynski A, Hu C, Phang JM. Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. Oncogene. 25: 5640-7, 2006. [Journal] |
|
| 29)
Pandhare J, Cooper SK, Phang JM. Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. J Biol Chem. 281: 2044-52, 2006. [Journal] |
|
| 30)
Dabrowski K, Terjesen BF, Zhang Y, Phang JM, Lee KJ. A concept of dietary dipeptides: a step to resolve the problem of amino acid availability in the early life of vertebrates. J Exp Biol. 208: 2885-94, 2005. [Journal] |
|
| 31)
Miltyk W, Surazynski A, Kasprzak KS, Fivash MJ, Buzard GS, Phang JM. Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells. J Cell Biochem. 94: 1210-7, 2005. [Journal] |
|
| 32)
Liu Y, Borchert GL, Donald SP, Surazynski A, Hu CA, Weydert CJ, Oberley LW, Phang JM. MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells. Carcinogenesis. 26: 1335-42, 2005. [Journal] |
|
| 33)
Surazynski A, Liu Y, Miltyk W, Phang JM. Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. J Cell Biochem. 96: 1086-1094, 2005. [Journal] |
|
| 34)
Phang JM. Goldman L, Ausiello D, eds. The hyperprolinemias and hydroxyprolinemia. In: Cecil Textbook of Medicine. Volume 22nd edition. Philadelphia: Saunders; 2004. p. 1285 [Book Chapter] |
|
| 35)
Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem. 24: 40337-44, 2004. [Journal] |
|
| 36)
Hursting SD, Lavigne JA, Berrigan D, Donehower LA, Davis BJ, Phang JM, Barrett JC, Perkins SN. Diet-gene interactions in p53-deficient mice: Insulin-like growth factor-1 as a mechanistic target. J Nutr. 134: 2482S-2486S, 2004. [Journal] |
|
| 37)
Liu Y, Borchert GL, Phang JM. Polyoma enhancer activator 3, an Ets transcriptional factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. J Biol Chem. 279: 18694-700, 2004. [Journal] |
|
| 38)
Mei JM, Borchert GL, Donald SP, Phang JM. Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex. Carcinognesis. 23: 2119-2122, 2002. [Journal] |
|
| 39)
Hursting SD, Shen JC, Sun XY, Wang TT, Phang JM, Perkins SN. Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis. Mol Carcinog. 33: 16-24, 2002. [Journal] |
|
| 40)
Peng Y, Xu RH, Mei JM, Li XP, Yan D, Kung HF, Phang JM. Neural inhibition by c-Jun as a synergizing factor in bone morphogenetic protein 4 signaling. Neuroscience. 109: 657-64, 2002. [Journal] |
|
| 41)
Phang JM. Creighton T, eds. Prolidase. In: Encyclopedia of Molecular Medicine. New York: John Wiley & Sons; 2001. p. 2585-9 [Book Chapter] |
|
| 42)
Phang JM, Hu CA, Valle D. Scriver CR, Beaudet AL, Sly WS, Valle D, eds. Disorders of proline and hydroxyproline metabolism. In: Metabolic and Molecular Basis of Inherited Disease. Volume 8th edition. New York: McGraw-Hill; 2001. p. 1821-38 [Book Chapter] |
|
| 43)
Hursting SD, Perkins SN, Phang JM, Barrett JC. Diet and cancer prevention studies in p53-deficient mice. J. Nutr. 131: 3092S-4S, 2001. [Journal] |
|
| 44)
Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D, Phang JM. Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res. 61: 1810–5, 2001. [Journal] |
|
| 45)
Sun XY, Donald SP, Phang JM. Testosterone and prostate specific antigen stimulate generation of reactive. Carcinogenesis. 22: 1775-80, 2001. [Journal] |
|
| 46)
Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM. Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype. Cancer Res. 60: 3379-83, 2000. [Journal] |
|
| 47)
Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM. Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in. FASEB J. 14: 1188-201, 2000. [Journal] |
|
| 48)
Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM. Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc. Carcinogenesis. 20: 737-40, 1999. [Journal] |
|
| 49)
Hursting SD, Slaga TJ, Fischer SM, DiGiovanni J, Phang JM. Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice. J. Natl. Cancer Inst. 91: 215-25, 1999. [Journal] |
|
| Click Here to View Collapsed Bibliography. |
This page was last updated on 4/26/2013.
